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The map label for this gene is putP_2 [H]

Identifier: 15602453

GI number: 15602453

Start: 677344

End: 678846

Strand: Direct

Name: putP_2 [H]

Synonym: PM0588

Alternate gene names: 15602453

Gene position: 677344-678846 (Clockwise)

Preceding gene: 15602451

Following gene: 15602454

Centisome position: 30.0

GC content: 41.32

Gene sequence:

>1503_bases
ATGTTTGGATATAATGCCACCATCATTACATTTACCATTTATATTTTAGGTATGATTTTAATCGGTTTTATCGCTTATCG
TTATACCAATAATTTGTCTGATTATATTTTAGGAGGGCGTCGTCTTGGCAGCTTTGTGACGGGACTCTCTGCAGGGGCGT
CAGATATGTCAGGCTGGTTATTAATGGGGCTTCCCGGCGCTGTTTATGCCGCAGGTCTGGTTGAAGGTTGGATTGCCATT
GGTCTAACGATTGGTGCTTACCTTAACTGGTTATTTGTGGCAGGACGTTTACGTGTTTATACAGAATTTAATCAAAATGC
TTTAACCTTGCCAGAATATTTCCAACACCGTTTTCACGATCAGAGCAAAATATTAAAAATTGTTTCCGCAACAATTATTT
TATTCTTTTTTGCCATTTATTGTGCTTCTGGTGTAGTCGCTGGGGCACGTTTATTTGAAAATCTGTTTGAAGTGCCTTAT
GCCACGGCGCTTTGGTATGGTGCCTTAGCGACAATCCTTTATACTTTTATTGGCGGTTTTTTAGCTGTCAGTTGGACCGA
TACCATTCAAGCGTCGTTAATGTTGTTTGCTTTATTCCTTACCCCTATTTTTGTGTTAATTCATCTTGGTGGTTTTGAAG
CAACACATACGGTGATTGTCAATGCGGGTGTGGCTGCTCAGCGGGATTTTACTGATTTATTCACAGGAACTAGCTTTATC
GGCTTATTAAGCTTATCCGCTTGGGGCTTAGGTTATTTTGGTCAACCACACATTTTAGCGCGTTTTATGAGTGCAAAAGA
TGCGAAATCATTAGTGAATGCGCGCCGTATTAGTATTATGTGGATGATTATCTGCTTATTTGGTGCGGTCGGTATTGGGT
TCTTTGGTCAAGCTTATTTCTTTGCAAATCCACAGGTGGCAGACACCGTGAACGCGAACCACGAACAAGTTTTTATTGAA
TTAGCGAAATTGTTATTTAATCCTTGGATTGCAGGGATTTTGTTATCAGCCATTTTAGCCGCGGTAATGAGTACTTTAAG
TTGCCAGTTATTGATTTGTTCAAGTGCGATTACAGAAGACTTTTATAAAGGCATGATTCGCCCAAATGCCTCACAAAAAG
AATTGGTGTGGTTAGGGCGTATTATGGTCTTAGTCATTGCACTACTGGCTATTTATCTTGCACAAGATCCAAACAGTAAA
GTATTGGGACTTGTGTCTTATGCGTGGGCAGGTTTTGGTTGTGCCTTTGGTCCTGTGGTGATTTTCTCTTTATTCTGGAA
ACGCATGAACATGGCGGGCGCGATGGCAGGCATGCTGACCGGGGCGTTAGTGGTAGTGTTCTGGAATGATGTGGTGCCAC
AGAGCGGTATTTATGAAATGATCCCAGGCTTTATTTTAGCTGCCGTGGCGATTGTCGTAGTGTCGTTAATTACGCCAGCA
CCAAGCCAACAAACGGTTTCTAATTTTGAACAAGCAGAGTTAGCTTATCAACAGCAAAAATAA

Upstream 100 bases:

>100_bases
GATCTATGTTGAAAAAATAGAAAACAGTTGTTGAACATTTGTTAATGTTATGTAATTTTTGCCAAGTTTATTTCCCCTCC
CTCTCTTTAGGAGCCGATCT

Downstream 100 bases:

>100_bases
TCGGTAAAAGAGCGGTATCTTCGGGTGCCGCTTTTTCTATGTTTAATTTGATTATGTGAGTGAGAAAGAAAGATGACATA
CCAATTACTTCCCAAATTAA

Product: hypothetical protein

Products: NA

Alternate protein names: Proline permease [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MFGYNATIITFTIYILGMILIGFIAYRYTNNLSDYILGGRRLGSFVTGLSAGASDMSGWLLMGLPGAVYAAGLVEGWIAI
GLTIGAYLNWLFVAGRLRVYTEFNQNALTLPEYFQHRFHDQSKILKIVSATIILFFFAIYCASGVVAGARLFENLFEVPY
ATALWYGALATILYTFIGGFLAVSWTDTIQASLMLFALFLTPIFVLIHLGGFEATHTVIVNAGVAAQRDFTDLFTGTSFI
GLLSLSAWGLGYFGQPHILARFMSAKDAKSLVNARRISIMWMIICLFGAVGIGFFGQAYFFANPQVADTVNANHEQVFIE
LAKLLFNPWIAGILLSAILAAVMSTLSCQLLICSSAITEDFYKGMIRPNASQKELVWLGRIMVLVIALLAIYLAQDPNSK
VLGLVSYAWAGFGCAFGPVVIFSLFWKRMNMAGAMAGMLTGALVVVFWNDVVPQSGIYEMIPGFILAAVAIVVVSLITPA
PSQQTVSNFEQAELAYQQQK

Sequences:

>Translated_500_residues
MFGYNATIITFTIYILGMILIGFIAYRYTNNLSDYILGGRRLGSFVTGLSAGASDMSGWLLMGLPGAVYAAGLVEGWIAI
GLTIGAYLNWLFVAGRLRVYTEFNQNALTLPEYFQHRFHDQSKILKIVSATIILFFFAIYCASGVVAGARLFENLFEVPY
ATALWYGALATILYTFIGGFLAVSWTDTIQASLMLFALFLTPIFVLIHLGGFEATHTVIVNAGVAAQRDFTDLFTGTSFI
GLLSLSAWGLGYFGQPHILARFMSAKDAKSLVNARRISIMWMIICLFGAVGIGFFGQAYFFANPQVADTVNANHEQVFIE
LAKLLFNPWIAGILLSAILAAVMSTLSCQLLICSSAITEDFYKGMIRPNASQKELVWLGRIMVLVIALLAIYLAQDPNSK
VLGLVSYAWAGFGCAFGPVVIFSLFWKRMNMAGAMAGMLTGALVVVFWNDVVPQSGIYEMIPGFILAAVAIVVVSLITPA
PSQQTVSNFEQAELAYQQQK
>Mature_500_residues
MFGYNATIITFTIYILGMILIGFIAYRYTNNLSDYILGGRRLGSFVTGLSAGASDMSGWLLMGLPGAVYAAGLVEGWIAI
GLTIGAYLNWLFVAGRLRVYTEFNQNALTLPEYFQHRFHDQSKILKIVSATIILFFFAIYCASGVVAGARLFENLFEVPY
ATALWYGALATILYTFIGGFLAVSWTDTIQASLMLFALFLTPIFVLIHLGGFEATHTVIVNAGVAAQRDFTDLFTGTSFI
GLLSLSAWGLGYFGQPHILARFMSAKDAKSLVNARRISIMWMIICLFGAVGIGFFGQAYFFANPQVADTVNANHEQVFIE
LAKLLFNPWIAGILLSAILAAVMSTLSCQLLICSSAITEDFYKGMIRPNASQKELVWLGRIMVLVIALLAIYLAQDPNSK
VLGLVSYAWAGFGCAFGPVVIFSLFWKRMNMAGAMAGMLTGALVVVFWNDVVPQSGIYEMIPGFILAAVAIVVVSLITPA
PSQQTVSNFEQAELAYQQQK

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=505, Percent_Identity=45.7425742574257, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI110835708, Length=576, Percent_Identity=22.7430555555556, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI11141885, Length=457, Percent_Identity=26.0393873085339, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI14140236, Length=485, Percent_Identity=25.1546391752577, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4507031, Length=474, Percent_Identity=25.1054852320675, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI157671931, Length=439, Percent_Identity=25.0569476082005, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787251, Length=491, Percent_Identity=64.969450101833, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI87082237, Length=421, Percent_Identity=29.6912114014252, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790503, Length=442, Percent_Identity=24.4343891402715, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1790113, Length=514, Percent_Identity=22.568093385214, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI115533094, Length=386, Percent_Identity=25.9067357512953, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539284, Length=427, Percent_Identity=22.9508196721311, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221459584, Length=393, Percent_Identity=23.6641221374046, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221459588, Length=450, Percent_Identity=24.2222222222222, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221459586, Length=396, Percent_Identity=22.7272727272727, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24645928, Length=365, Percent_Identity=24.6575342465753, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573698, Length=458, Percent_Identity=25.764192139738, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24651741, Length=469, Percent_Identity=23.8805970149254, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221459582, Length=382, Percent_Identity=22.5130890052356, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 54604; Mature: 54604

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]