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The map label for this gene is trpE [H]

Identifier: 15602449

GI number: 15602449

Start: 672250

End: 673800

Strand: Reverse

Name: trpE [H]

Synonym: PM0584

Alternate gene names: 15602449

Gene position: 673800-672250 (Counterclockwise)

Preceding gene: 15602452

Following gene: 15602448

Centisome position: 29.85

GC content: 41.97

Gene sequence:

>1551_bases
ATGTCATTCGCTTTTATTCATACCTTAACTCAATCATTACCTTATTACGCCGATCCAACACATGTTTTTGCGGCACTCTG
TCAGGATAAAACCAACACGCTGTTACTCGAATCTGCTGAAATTCACAGTAAAAATAGTTTAAAAAGCCTCTTAGTTATAC
AACCCGCACTAAAAATTACCTGTCATGGATTACGTGTGACCTTCTGTGCTAAAACACAAAATGGCGTCGCTGTTTTGCAT
GCACTTATAGAGAAGTTACAATGTCACTATGAAATCAGTGCAGTCACAGAGAGTCAATTCTCAGTTATCTTTCCAAAACT
TGACAAAAACCTTGATGAAGACAACAAATTACATGCTTCAACTTGTTTTGATGCGCTACGTGCCCTGCTCTCACTTTATC
AACATAGTGAGGTCCCCGTTCTGTTAGGCGGTTTATTTGCTTATGATTTAGTGACCCAGTTTATCCCTATGGATAACATC
CAATTACAAGAGGATGGGCTCGATTGCCCTGACTATTGTTTCTACTTAGCGGAACATCAATTGACACTCGATCATCAATT
ACAACAAGCTCAGCTACACAGTTTCTGTTTTGCGCCACAATATCAAACAGCGCTACAGCAACAAGCTGATCAGATAATAC
AAAAATTTGCAAATATTGAACCGCACTTACATTGTGTTTCAGCGGACACTACGCTGACAACGAACCTTGATGATGTACAA
TTTAAACAAATTATTCAGGTATTAAAACAACATCTTTATCAAGGTGATGTATTTCAAATTGTGCCTTCCCGTCGCTTTTC
GTTAGCCTGTCCAAATACATTGGCAAGTTACCGACAGCTGAAACACACGAATCCGAGCCCTTATATGTTCTTTATGCAAG
ATGAAGACTTTACTCTCTTTGGCGCCTCACCAGAAAGTGCATTGAAATATACACAGCAAACCCGTCAGCTCGAGATTTAT
CCGATTGCGGGTTCACGCCCGCGCGGTTTTTATCCCAATGGTCAGATTGATCCAGAATTGGACGCTCGCTTAGAACTGGA
ATTACGTTTAGATCAAAAAGAACTCGCAGAACATTTGATGTTAGTGGATTTAGCCCGTAATGATATTGCACGGGTTTGTG
AAACCGGGACACGCCAAGTGGCGGATTTAATGCAGGTAGATCGCTATTCTCACATTATGCACTTAGTTTCTCGCGTGGTG
GGCAAATTACGACCTGAATTAGATGCGTTACACGCCTATCAAGCTTGCATGAACATGGGGACACTCACTGGTGCTCCAAA
AATTAAAGCAATGCAACTGCTCTATCAAGTTGAACAACAAAAACGACATAGTTATGGCGGTGCGGTAGGGTATCTCGCTT
CGAATGGCGATTTAGACACGTGTATTGTGATACGTTCCGCCTTTGTGCAACAAGGTATTGCCTACATCCAAGCCGGTTGT
GGCGAAGTGCTCGATTCAGATCCGCAAAAAGAAGCCGATGAAACACGACACAAAGCACAAGCCGTGATTAACGCGATTGT
TCAAACTCACCAAACACCTCGTCAAGCATAA

Upstream 100 bases:

>100_bases
TTTTTATTCATTCCATTTTTTATCATGTTCCACCTTGACACAAAAATAATAAACTAGTTTAATAGTTCAAAATTACAAAA
AAAAAGGACACACATATACT

Downstream 100 bases:

>100_bases
GGACAGCAGTATGGCAAAGATTGTATTTTTAGATAATTTTGACTCCTTTACCTATAACTTAGTGGATCAGTTGCGTTGTT
TAGGACATCAAGTCCACATC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MSFAFIHTLTQSLPYYADPTHVFAALCQDKTNTLLLESAEIHSKNSLKSLLVIQPALKITCHGLRVTFCAKTQNGVAVLH
ALIEKLQCHYEISAVTESQFSVIFPKLDKNLDEDNKLHASTCFDALRALLSLYQHSEVPVLLGGLFAYDLVTQFIPMDNI
QLQEDGLDCPDYCFYLAEHQLTLDHQLQQAQLHSFCFAPQYQTALQQQADQIIQKFANIEPHLHCVSADTTLTTNLDDVQ
FKQIIQVLKQHLYQGDVFQIVPSRRFSLACPNTLASYRQLKHTNPSPYMFFMQDEDFTLFGASPESALKYTQQTRQLEIY
PIAGSRPRGFYPNGQIDPELDARLELELRLDQKELAEHLMLVDLARNDIARVCETGTRQVADLMQVDRYSHIMHLVSRVV
GKLRPELDALHAYQACMNMGTLTGAPKIKAMQLLYQVEQQKRHSYGGAVGYLASNGDLDTCIVIRSAFVQQGIAYIQAGC
GEVLDSDPQKEADETRHKAQAVINAIVQTHQTPRQA

Sequences:

>Translated_516_residues
MSFAFIHTLTQSLPYYADPTHVFAALCQDKTNTLLLESAEIHSKNSLKSLLVIQPALKITCHGLRVTFCAKTQNGVAVLH
ALIEKLQCHYEISAVTESQFSVIFPKLDKNLDEDNKLHASTCFDALRALLSLYQHSEVPVLLGGLFAYDLVTQFIPMDNI
QLQEDGLDCPDYCFYLAEHQLTLDHQLQQAQLHSFCFAPQYQTALQQQADQIIQKFANIEPHLHCVSADTTLTTNLDDVQ
FKQIIQVLKQHLYQGDVFQIVPSRRFSLACPNTLASYRQLKHTNPSPYMFFMQDEDFTLFGASPESALKYTQQTRQLEIY
PIAGSRPRGFYPNGQIDPELDARLELELRLDQKELAEHLMLVDLARNDIARVCETGTRQVADLMQVDRYSHIMHLVSRVV
GKLRPELDALHAYQACMNMGTLTGAPKIKAMQLLYQVEQQKRHSYGGAVGYLASNGDLDTCIVIRSAFVQQGIAYIQAGC
GEVLDSDPQKEADETRHKAQAVINAIVQTHQTPRQA
>Mature_515_residues
SFAFIHTLTQSLPYYADPTHVFAALCQDKTNTLLLESAEIHSKNSLKSLLVIQPALKITCHGLRVTFCAKTQNGVAVLHA
LIEKLQCHYEISAVTESQFSVIFPKLDKNLDEDNKLHASTCFDALRALLSLYQHSEVPVLLGGLFAYDLVTQFIPMDNIQ
LQEDGLDCPDYCFYLAEHQLTLDHQLQQAQLHSFCFAPQYQTALQQQADQIIQKFANIEPHLHCVSADTTLTTNLDDVQF
KQIIQVLKQHLYQGDVFQIVPSRRFSLACPNTLASYRQLKHTNPSPYMFFMQDEDFTLFGASPESALKYTQQTRQLEIYP
IAGSRPRGFYPNGQIDPELDARLELELRLDQKELAEHLMLVDLARNDIARVCETGTRQVADLMQVDRYSHIMHLVSRVVG
KLRPELDALHAYQACMNMGTLTGAPKIKAMQLLYQVEQQKRHSYGGAVGYLASNGDLDTCIVIRSAFVQQGIAYIQAGCG
EVLDSDPQKEADETRHKAQAVINAIVQTHQTPRQA

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=511, Percent_Identity=51.8590998043053, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI1788114, Length=385, Percent_Identity=29.0909090909091, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87082077, Length=302, Percent_Identity=25.8278145695364, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786809, Length=224, Percent_Identity=29.9107142857143, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=392, Percent_Identity=36.2244897959184, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6324361, Length=383, Percent_Identity=22.1932114882507, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 58169; Mature: 58038

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFAFIHTLTQSLPYYADPTHVFAALCQDKTNTLLLESAEIHSKNSLKSLLVIQPALKIT
CCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECHHHCCCHHHHHHHHCCCCHHEE
CHGLRVTFCAKTQNGVAVLHALIEKLQCHYEISAVTESQFSVIFPKLDKNLDEDNKLHAS
EECEEEEEEECCCCCHHHHHHHHHHHHHHHHEEHCCCCCCEEECCHHCCCCCCCCCCHHH
TCFDALRALLSLYQHSEVPVLLGGLFAYDLVTQFIPMDNIQLQEDGLDCPDYCFYLAEHQ
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCC
LTLDHQLQQAQLHSFCFAPQYQTALQQQADQIIQKFANIEPHLHCVSADTTLTTNLDDVQ
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEECCCCHHH
FKQIIQVLKQHLYQGDVFQIVPSRRFSLACPNTLASYRQLKHTNPSPYMFFMQDEDFTLF
HHHHHHHHHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHHCCCCCCEEEEEECCCEEEE
GASPESALKYTQQTRQLEIYPIAGSRPRGFYPNGQIDPELDARLELELRLDQKELAEHLM
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHH
LVDLARNDIARVCETGTRQVADLMQVDRYSHIMHLVSRVVGKLRPELDALHAYQACMNMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
TLTGAPKIKAMQLLYQVEQQKRHSYGGAVGYLASNGDLDTCIVIRSAFVQQGIAYIQAGC
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
GEVLDSDPQKEADETRHKAQAVINAIVQTHQTPRQA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SFAFIHTLTQSLPYYADPTHVFAALCQDKTNTLLLESAEIHSKNSLKSLLVIQPALKIT
CCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECHHHCCCHHHHHHHHCCCCHHEE
CHGLRVTFCAKTQNGVAVLHALIEKLQCHYEISAVTESQFSVIFPKLDKNLDEDNKLHAS
EECEEEEEEECCCCCHHHHHHHHHHHHHHHHEEHCCCCCCEEECCHHCCCCCCCCCCHHH
TCFDALRALLSLYQHSEVPVLLGGLFAYDLVTQFIPMDNIQLQEDGLDCPDYCFYLAEHQ
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHCC
LTLDHQLQQAQLHSFCFAPQYQTALQQQADQIIQKFANIEPHLHCVSADTTLTTNLDDVQ
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEECCCCHHH
FKQIIQVLKQHLYQGDVFQIVPSRRFSLACPNTLASYRQLKHTNPSPYMFFMQDEDFTLF
HHHHHHHHHHHHCCCCEEEECCCCCEEEECCHHHHHHHHHHCCCCCCEEEEEECCCEEEE
GASPESALKYTQQTRQLEIYPIAGSRPRGFYPNGQIDPELDARLELELRLDQKELAEHLM
CCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHH
LVDLARNDIARVCETGTRQVADLMQVDRYSHIMHLVSRVVGKLRPELDALHAYQACMNMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
TLTGAPKIKAMQLLYQVEQQKRHSYGGAVGYLASNGDLDTCIVIRSAFVQQGIAYIQAGC
CCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
GEVLDSDPQKEADETRHKAQAVINAIVQTHQTPRQA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]