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The map label for this gene is codB [H]

Identifier: 15602429

GI number: 15602429

Start: 648219

End: 649445

Strand: Direct

Name: codB [H]

Synonym: PM0564

Alternate gene names: 15602429

Gene position: 648219-649445 (Clockwise)

Preceding gene: 15602428

Following gene: 15602430

Centisome position: 28.71

GC content: 42.71

Gene sequence:

>1227_bases
ATGAGTTTAGATAACTTTAGTTTGAAACCGGTACCACAACATGAGCGTAAAGGAGGTATTGCACTGACATTTGTGATGTT
AGGTTTGACATTTTTCTCTGCAAGTATGTGGACTGGTGGCACTTTAGGCACTTCACTGCACTATGACGATTTTTGGACCG
CTATTTTGATTGGTAACTTAATGCTAGGGGTCTATACCGCTTGTTTAGGTTATATTGGTGCCAAAACGGGGCTAACCACG
CATATTCTGGCACGTTATTCTTTTGGGGTAAAAGGCTCATGGTTACCGTCTTTATTGCTTGGTGGAACACAAGTTGGTTG
GTTTGGTGTTGGGGTGGCGATGTTCGCTATTCCGGTCAATAAAGTCACGGGAATTGATGTAAATACCTTAATTATTGCAT
CGGGATTATTAATGACCGTAACGGTGTATTTTGGGATTTCTGCCCTGACAGTATTATCTGCCGTTGCTGTGCCTGCGATT
GCTGTTTTAGGTTCTTATTCTGTGTATTTGGCGGTAACAGACGCAGGCGGACTAGATGTACTCAGAAGTATTGTTCCGAA
AGAGCAAATGCCTCTCTCTATGGCGATTACTCTAGTAGTGGGTTCTTTTATTAGTGCGGGGAGCTTAACTGCGGATTTTG
TCCGCTTTGGGCGTGTACCGAAACAAGCGATTCTTATCAGCATGATCGCGTTCTTTCTAGGTAACTCGTTGATGTTTATT
TTTGGTGCCGCTGGGGCGTCAGTAAAAGGCATGGCAGATATTTCTGATGTTATGGTCGCGCAAGGGTTGATCTTACCTGC
CATTATTGTATTAGGTTTAAACATTTGGACCACTAACGATAACGCGCTTTATGCATCAGGCTTAGGTTTTGCCAATATTA
CCGGGTTAAGTAGCCGTATTTTATCCATGGTGAATGGCGTGATTGGCACATTGTCTGCATTATGGCTATATAATAATTTT
GTTGGCTGGCTCACTTTCTTATCTTCAGCAATTCCACCTGTGGGGGGCGTTATTATTGCGGATTACTTGCTACGTCGTAA
ATCTTATCAAGATTTTGAACAAGCCAAATTCGTGACTATTAATTGGACCGCGATTATTGCTGTCGCGATTGGTGTCGCTT
GTGGTAAATATTTACCGGGCATTATTCCTGTCAACGCAGTATTGGGTGGGGCACTGTCTTATCTTCTTCTTAACCCATTC
TGTGCAAAAATCTTAGCAACCAAATAG

Upstream 100 bases:

>100_bases
GGTTAACTATTTTTGCATTTCTTAAAGCAAACGTTTGCCTTTCTAAATAAGCGGATTATAATACAGCGATTTTTTATTTT
TTGACCAAAAGGAATTAAAA

Downstream 100 bases:

>100_bases
GAGTGCATCATGTTAATTAAAAATGTTCATCTTGCTGATCGAGAAGGGCTTTGGCAAATTTTGATTGAGGATCAAAAAAT
AGTGCAAATTTGTGCCAATG

Product: cytosine permease

Products: Proton [Cytoplasm]; cytosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSLDNFSLKPVPQHERKGGIALTFVMLGLTFFSASMWTGGTLGTSLHYDDFWTAILIGNLMLGVYTACLGYIGAKTGLTT
HILARYSFGVKGSWLPSLLLGGTQVGWFGVGVAMFAIPVNKVTGIDVNTLIIASGLLMTVTVYFGISALTVLSAVAVPAI
AVLGSYSVYLAVTDAGGLDVLRSIVPKEQMPLSMAITLVVGSFISAGSLTADFVRFGRVPKQAILISMIAFFLGNSLMFI
FGAAGASVKGMADISDVMVAQGLILPAIIVLGLNIWTTNDNALYASGLGFANITGLSSRILSMVNGVIGTLSALWLYNNF
VGWLTFLSSAIPPVGGVIIADYLLRRKSYQDFEQAKFVTINWTAIIAVAIGVACGKYLPGIIPVNAVLGGALSYLLLNPF
CAKILATK

Sequences:

>Translated_408_residues
MSLDNFSLKPVPQHERKGGIALTFVMLGLTFFSASMWTGGTLGTSLHYDDFWTAILIGNLMLGVYTACLGYIGAKTGLTT
HILARYSFGVKGSWLPSLLLGGTQVGWFGVGVAMFAIPVNKVTGIDVNTLIIASGLLMTVTVYFGISALTVLSAVAVPAI
AVLGSYSVYLAVTDAGGLDVLRSIVPKEQMPLSMAITLVVGSFISAGSLTADFVRFGRVPKQAILISMIAFFLGNSLMFI
FGAAGASVKGMADISDVMVAQGLILPAIIVLGLNIWTTNDNALYASGLGFANITGLSSRILSMVNGVIGTLSALWLYNNF
VGWLTFLSSAIPPVGGVIIADYLLRRKSYQDFEQAKFVTINWTAIIAVAIGVACGKYLPGIIPVNAVLGGALSYLLLNPF
CAKILATK
>Mature_407_residues
SLDNFSLKPVPQHERKGGIALTFVMLGLTFFSASMWTGGTLGTSLHYDDFWTAILIGNLMLGVYTACLGYIGAKTGLTTH
ILARYSFGVKGSWLPSLLLGGTQVGWFGVGVAMFAIPVNKVTGIDVNTLIIASGLLMTVTVYFGISALTVLSAVAVPAIA
VLGSYSVYLAVTDAGGLDVLRSIVPKEQMPLSMAITLVVGSFISAGSLTADFVRFGRVPKQAILISMIAFFLGNSLMFIF
GAAGASVKGMADISDVMVAQGLILPAIIVLGLNIWTTNDNALYASGLGFANITGLSSRILSMVNGVIGTLSALWLYNNFV
GWLTFLSSAIPPVGGVIIADYLLRRKSYQDFEQAKFVTINWTAIIAVAIGVACGKYLPGIIPVNAVLGGALSYLLLNPFC
AKILATK

Specific function: Required for cytosine transport into the cell [H]

COG id: COG1457

COG function: function code F; Purine-cytosine permease and related proteins

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine-cytosine permease family [H]

Homologues:

Organism=Escherichia coli, GI1786530, Length=404, Percent_Identity=75.2475247524752, Blast_Score=594, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001248
- InterPro:   IPR012681 [H]

Pfam domain/function: PF02133 Transp_cyt_pur [H]

EC number: NA

Molecular weight: Translated: 42936; Mature: 42805

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDNFSLKPVPQHERKGGIALTFVMLGLTFFSASMWTGGTLGTSLHYDDFWTAILIGNL
CCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MLGVYTACLGYIGAKTGLTTHILARYSFGVKGSWLPSLLLGGTQVGWFGVGVAMFAIPVN
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHEECC
KVTGIDVNTLIIASGLLMTVTVYFGISALTVLSAVAVPAIAVLGSYSVYLAVTDAGGLDV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHH
LRSIVPKEQMPLSMAITLVVGSFISAGSLTADFVRFGRVPKQAILISMIAFFLGNSLMFI
HHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEE
FGAAGASVKGMADISDVMVAQGLILPAIIVLGLNIWTTNDNALYASGLGFANITGLSSRI
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCHHHHHHHHHH
LSMVNGVIGTLSALWLYNNFVGWLTFLSSAIPPVGGVIIADYLLRRKSYQDFEQAKFVTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHCEEEEE
NWTAIIAVAIGVACGKYLPGIIPVNAVLGGALSYLLLNPFCAKILATK
EHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLDNFSLKPVPQHERKGGIALTFVMLGLTFFSASMWTGGTLGTSLHYDDFWTAILIGNL
CCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MLGVYTACLGYIGAKTGLTTHILARYSFGVKGSWLPSLLLGGTQVGWFGVGVAMFAIPVN
HHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHEECC
KVTGIDVNTLIIASGLLMTVTVYFGISALTVLSAVAVPAIAVLGSYSVYLAVTDAGGLDV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHH
LRSIVPKEQMPLSMAITLVVGSFISAGSLTADFVRFGRVPKQAILISMIAFFLGNSLMFI
HHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEE
FGAAGASVKGMADISDVMVAQGLILPAIIVLGLNIWTTNDNALYASGLGFANITGLSSRI
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCHHHHHHHHHH
LSMVNGVIGTLSALWLYNNFVGWLTFLSSAIPPVGGVIIADYLLRRKSYQDFEQAKFVTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHCEEEEE
NWTAIIAVAIGVACGKYLPGIIPVNAVLGGALSYLLLNPFCAKILATK
EHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; cytosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + cytosine [Periplasm] = Proton [Cytoplasm] + cytosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]