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The map label for this gene is purP [H]

Identifier: 15602379

GI number: 15602379

Start: 588283

End: 589557

Strand: Direct

Name: purP [H]

Synonym: PM0514

Alternate gene names: 15602379

Gene position: 588283-589557 (Clockwise)

Preceding gene: 15602378

Following gene: 15602380

Centisome position: 26.06

GC content: 41.25

Gene sequence:

>1275_bases
TTGACTGAGAAAAAAACAACCTTAAAAACAGAAATTATTGCCGGTATCACCACCTTTTTTACTATGGTGTATATTGTTTT
TGTTAACCCGTCTATTTTGGGCGACGCAGGCATGGATAAACAAGTCGTATTTGTCACGACCTGTTTAATTGCCGCATTGG
GTACTATTGCTATGGGATTGTTTAGCAATCTTCCTATTGCACTCGCACCTGCCATGGGCTTAAATGCATTTTTTGCTTAT
GTCGTTGTGGGAAAATTAGGCTATTCTTGGCAAATAGGTATGGGCACTATTTTTTGGGGATCGCTCGGTCTATTGGTATT
AACTATTTTCCAAATTCGTTATTGGCTCATGGCATCGATTCCGTTGGGATTGCGTGTGGGAATTGGTGCAGGAATTGGTT
TATTCATTGCTCTGATTGGTTTTAAAAATATGGGACTGGTGATCGCTAACCCTGTCACATTAGTTGCATTAGGTCATTTA
CATGATCCTAAAGTCCTTCTCGGTATTTTAGGTTTCTTTATTATCGTGGTCTTAGCTGCACGTAATATTTATTCTGGTGT
GTTAGTGTCGATTGCGGTTGTGACCGGTTTAGCCTTTTTTATTGACCCTAATGTGACATTTAATGGGATCATGTCTATGC
CACCAAGTTTAAGTCCGGTCGTTGGTAAAGTGGATATTGCGGGAGCATTAGATACAGCGTTACTGGGCATTATTTTCTCT
TTCTTGCTGGTCAATTTATTTGACTCATCAGGCACATTACTCGGTGTAACCGATAAAGCGGGCTTTAGTGATGAACGTGG
GCGTTTCCCTAAAATGAAACAAGCGCTTTATGTGGATAGTGTAAGTGCTGTAGCAGGGTCTTATATGGGGACTTCCGCCA
TCAGTACTTATATTGAAAGTGGCGCCGGTGTGTCAGTCGGAGGACGTACCGGATTAACTGCAATTACCGTTGGCGTATTA
TTCTTATTAACCATTTTCTTTTCGCCTTTAGCCAGTGTGGTGCCAGCTTATGCTACAGCAGGGGCATTGGTGTACGTTGG
AATTTTAATGGCATCTAGCCTGATTCGTGTTAAATGGGAAGATTTAACAGAAGCGACGCCTGCTTTTATTACGGCTGCCA
TGATGCCGTTTACCTATTCGATTACAGAAGGGATTGCATTTGGTTTTATTAGCTATTGTGTCATGAAAGCCTGTACCGGT
CGTGTGAAAGAAATCAATGCGCCAGTTTGGGTGGTATCTTTACTGTTTTTGATTAAATTTATTTGGGTAGGTTAA

Upstream 100 bases:

>100_bases
AAAAACACCGCTCATTTTATCCTGTTTTTCAGCATTTCATTTTCATCATCACTTAGGAATCATAATGGAAAATCAATCTT
TTCTTCATCGTTTTTTTAAA

Downstream 100 bases:

>100_bases
TGATGAAAAAATTCCTTTTTATTATTAGTGCTGCCCCTTATGGCAATGAAAATTTTTTTAGTGCCTTACGTTTAGCCTTA
CAGTTACAAGAGCAACACAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTEKKTTLKTEIIAGITTFFTMVYIVFVNPSILGDAGMDKQVVFVTTCLIAALGTIAMGLFSNLPIALAPAMGLNAFFAY
VVVGKLGYSWQIGMGTIFWGSLGLLVLTIFQIRYWLMASIPLGLRVGIGAGIGLFIALIGFKNMGLVIANPVTLVALGHL
HDPKVLLGILGFFIIVVLAARNIYSGVLVSIAVVTGLAFFIDPNVTFNGIMSMPPSLSPVVGKVDIAGALDTALLGIIFS
FLLVNLFDSSGTLLGVTDKAGFSDERGRFPKMKQALYVDSVSAVAGSYMGTSAISTYIESGAGVSVGGRTGLTAITVGVL
FLLTIFFSPLASVVPAYATAGALVYVGILMASSLIRVKWEDLTEATPAFITAAMMPFTYSITEGIAFGFISYCVMKACTG
RVKEINAPVWVVSLLFLIKFIWVG

Sequences:

>Translated_424_residues
MTEKKTTLKTEIIAGITTFFTMVYIVFVNPSILGDAGMDKQVVFVTTCLIAALGTIAMGLFSNLPIALAPAMGLNAFFAY
VVVGKLGYSWQIGMGTIFWGSLGLLVLTIFQIRYWLMASIPLGLRVGIGAGIGLFIALIGFKNMGLVIANPVTLVALGHL
HDPKVLLGILGFFIIVVLAARNIYSGVLVSIAVVTGLAFFIDPNVTFNGIMSMPPSLSPVVGKVDIAGALDTALLGIIFS
FLLVNLFDSSGTLLGVTDKAGFSDERGRFPKMKQALYVDSVSAVAGSYMGTSAISTYIESGAGVSVGGRTGLTAITVGVL
FLLTIFFSPLASVVPAYATAGALVYVGILMASSLIRVKWEDLTEATPAFITAAMMPFTYSITEGIAFGFISYCVMKACTG
RVKEINAPVWVVSLLFLIKFIWVG
>Mature_423_residues
TEKKTTLKTEIIAGITTFFTMVYIVFVNPSILGDAGMDKQVVFVTTCLIAALGTIAMGLFSNLPIALAPAMGLNAFFAYV
VVGKLGYSWQIGMGTIFWGSLGLLVLTIFQIRYWLMASIPLGLRVGIGAGIGLFIALIGFKNMGLVIANPVTLVALGHLH
DPKVLLGILGFFIIVVLAARNIYSGVLVSIAVVTGLAFFIDPNVTFNGIMSMPPSLSPVVGKVDIAGALDTALLGIIFSF
LLVNLFDSSGTLLGVTDKAGFSDERGRFPKMKQALYVDSVSAVAGSYMGTSAISTYIESGAGVSVGGRTGLTAITVGVLF
LLTIFFSPLASVVPAYATAGALVYVGILMASSLIRVKWEDLTEATPAFITAAMMPFTYSITEGIAFGFISYCVMKACTGR
VKEINAPVWVVSLLFLIKFIWVG

Specific function: High-affinity uptake of adenine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790150, Length=423, Percent_Identity=65.9574468085106, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI87082309, Length=421, Percent_Identity=64.3705463182898, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1790499, Length=413, Percent_Identity=38.7409200968523, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI48994909, Length=413, Percent_Identity=36.0774818401937, Blast_Score=248, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44811; Mature: 44680

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKKTTLKTEIIAGITTFFTMVYIVFVNPSILGDAGMDKQVVFVTTCLIAALGTIAMGL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FSNLPIALAPAMGLNAFFAYVVVGKLGYSWQIGMGTIFWGSLGLLVLTIFQIRYWLMASI
HHCCCEEEECHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
PLGLRVGIGAGIGLFIALIGFKNMGLVIANPVTLVALGHLHDPKVLLGILGFFIIVVLAA
CCCEEECCCCHHHHHHHHHHHCCCCEEEECCHHEEEECCCCCHHHHHHHHHHHHHHHHHH
RNIYSGVLVSIAVVTGLAFFIDPNVTFNGIMSMPPSLSPVVGKVDIAGALDTALLGIIFS
HHHHHHHHHHHHHHHHHHHEECCCCCCCHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHH
FLLVNLFDSSGTLLGVTDKAGFSDERGRFPKMKQALYVDSVSAVAGSYMGTSAISTYIES
HHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAGVSVGGRTGLTAITVGVLFLLTIFFSPLASVVPAYATAGALVYVGILMASSLIRVKWE
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHH
DLTEATPAFITAAMMPFTYSITEGIAFGFISYCVMKACTGRVKEINAPVWVVSLLFLIKF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHH
IWVG
HHCC
>Mature Secondary Structure 
TEKKTTLKTEIIAGITTFFTMVYIVFVNPSILGDAGMDKQVVFVTTCLIAALGTIAMGL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FSNLPIALAPAMGLNAFFAYVVVGKLGYSWQIGMGTIFWGSLGLLVLTIFQIRYWLMASI
HHCCCEEEECHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
PLGLRVGIGAGIGLFIALIGFKNMGLVIANPVTLVALGHLHDPKVLLGILGFFIIVVLAA
CCCEEECCCCHHHHHHHHHHHCCCCEEEECCHHEEEECCCCCHHHHHHHHHHHHHHHHHH
RNIYSGVLVSIAVVTGLAFFIDPNVTFNGIMSMPPSLSPVVGKVDIAGALDTALLGIIFS
HHHHHHHHHHHHHHHHHHHEECCCCCCCHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHH
FLLVNLFDSSGTLLGVTDKAGFSDERGRFPKMKQALYVDSVSAVAGSYMGTSAISTYIES
HHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAGVSVGGRTGLTAITVGVLFLLTIFFSPLASVVPAYATAGALVYVGILMASSLIRVKWE
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHH
DLTEATPAFITAAMMPFTYSITEGIAFGFISYCVMKACTGRVKEINAPVWVVSLLFLIKF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHH
IWVG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]