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The map label for this gene is uvrD [H]

Identifier: 15602276

GI number: 15602276

Start: 480549

End: 482729

Strand: Direct

Name: uvrD [H]

Synonym: PM0411

Alternate gene names: 15602276

Gene position: 480549-482729 (Clockwise)

Preceding gene: 15602275

Following gene: 15602277

Centisome position: 21.29

GC content: 42.37

Gene sequence:

>2181_bases
ATGGATATTTCAGCATTATTAGATGGGTTAAATGATAAACAACGTGATGCGGTTGCCGCGCCACTCGGCAATTACTTGGT
GTTGGCGGGGGCCGGGAGTGGTAAAACACGTGTTTTAACACATCGTATTGCTTGGTTAATTGCAGTAGAACAGGTTTCTG
AAGGGAGTATCATGGCAGTAACCTTCACCAATAAAGCCGCGGCTGAAATGCGTCATCGTATCGAAAGCACCTTAGCTAAT
CATGCTTCTCAACGTTTATTTGGTATGTGGGTGGGCACGTTCCACAGCATTGCCCACCGCTTATTGCGTGCCCATCATCT
TGATGCCAACTTACCCCAAGATTTCCAAATTCTCGATGCGGATGATCAACTGCGTTTAGTGAAGCGCCTACTCAAATTAC
ATAATTTTGATGAGAAAATTTTTATTCCTAAGCAAGTCTGCTGGTATATCAATAATAAAAAAGATGACGGGTTAAGAGCG
CACCAAATTGATGACAATAATGATCGACATGAGCGGGAATGGATAAAAATTTATCAGATTTATCAAGATACTTGTGATCG
TGCTGGTTTAGTGGATTTTGCGGAATTGTTATTACGTGCTTACGAATTATGGCTGAAAAAGCCTGTGATTTTACAGCGTT
ATCAACAACGTTTTCAGCACATTTTGGTCGATGAGTTCCAAGATACTAATAAGATCCAATATGCTTGGGTAAAATTGCTT
GCGGGGGAACAAGGCAAGGTGATGATCGTGGGAGATGATGATCAATCGATTTATGGTTGGCGCGGGGCAAAAATTGAAAA
TATCCAACGCTTTTTAGATGATTTTTCCAATGCGCAAACCATCCGTCTTGAACAAAATTATCGTTCCACGGGGAATATTT
TGGCAAGTGCCAACCAGCTTATTTCCAATAACAGCAATCGTCTTGGTAAAAATTTGTGGACGGACGGAGAAAAAGGTGAG
CCAGTAGGAATCTATGCGGCTTTTAATGAATTAGATGAAGCCTTATTTGTTTCCTCACAAATTAAACAATGGATAGAAAA
TGGCGGTAAGCTAAAAGATTGTGCCATTTTATACCGCAGTAATAGCCAATCCCGTGTGATTGAAGAGGCGTTAATTCGTT
CTCAATTACCTTATCGTATTTATGGCGGCATGCGTTTCTTCGAGCGTCAAGAGATTAAAGATGCCCTTGCTTATTTACGT
CTTATTGCCAATCGTCAAGACGACGCCGCGTTTGAACGGGTGGTCAATACGCCACCTCGTAGTATTGGTGAACGAACGTT
AGATATGCTGCGTAGTGTGACCCGCGAACGTGAAGTGACTTTGTGGCAAGCCACCCAATTAGCCATTCATGAAAATTTAC
TGACGGCGAGAGCAGCAACCGCACTACAACGCTTTTTAGAGTTGATTAATTCCTTACAGCAAGATACCAGTGAAATGCCC
TTATTTGCGCAAACCGATTTTGTGATTAAGCATTCTGGTTTATATGCCATGTATCAACAGGAAAAGGGGGAAAAGGGCGA
AGTGCGGATCGAAAACTTAGAAGAGTTAGTGACTGCCACAAAAGAATTTATTAAGCCAGATGAGGCAGAACAGTTATCTG
ATTTAACGGCCTTTTTAACTCATGCCTCCTTAGAAGCAGGGGAGGAACAAGCCTCACCGCATCAAGACTATGTTGAAATG
ATGACATTGCACTCTGCAAAGGGATTGGAATTCCCTCGGGTATTTATGGTGGGGGTTGAAGAAGGGCTATTTCCAAGTTT
CCGATCTTTTGAAGAACCGGGGCGTTTAGAAGAAGAGCGTCGCTTAGCTTATGTTGGGATCACGCGCGCAAAACAAAAGT
TGACGATTTGCTATGCGGAAAGTCGCCGTTTATATGCCAAAGAAGAACGTCATCTTCCTTCCCGTTTTATTGCTGAATTA
CCTACGGAATGTATTCAAGAAATCCGCTTACGTGGTACGGTGACACGTGCCATGAATCAGCAGAAAGTCGGATCGGTTGC
ACCGAGTTTACAGGAAAGTGAATGGAAAATGGGGCAAAAAGTGCTACATAGCAAATTTGGGCAAGGTACGATCATTAATG
TGGAAGGGGCGGAGAATAATACTCGCTTACAAATTGCATTCCAAAATCAAGGGATTAAATGGCTGATTGCCCATTTAGCC
AAATTAGAAAAAATTCGTTAA

Upstream 100 bases:

>100_bases
CAAGGTAGGCATAGTCTGCCTTGTTGCTTTTATGGCGACTGCTAAGCGACAAAAACATAGCATTCCTGAACTGAGATGAA
AACAGAAGGCAGATGACAGA

Downstream 100 bases:

>100_bases
AGGGATGTATAACTCCGTGTGGAAGTACGCTAGATAGCTTGCGTTTTTCACATGGGGTGATTTTTATCCCTTCATTTTTG
ACAGAATTCGCGCTTAAATT

Product: DNA-dependent helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 726; Mature: 726

Protein sequence:

>726_residues
MDISALLDGLNDKQRDAVAAPLGNYLVLAGAGSGKTRVLTHRIAWLIAVEQVSEGSIMAVTFTNKAAAEMRHRIESTLAN
HASQRLFGMWVGTFHSIAHRLLRAHHLDANLPQDFQILDADDQLRLVKRLLKLHNFDEKIFIPKQVCWYINNKKDDGLRA
HQIDDNNDRHEREWIKIYQIYQDTCDRAGLVDFAELLLRAYELWLKKPVILQRYQQRFQHILVDEFQDTNKIQYAWVKLL
AGEQGKVMIVGDDDQSIYGWRGAKIENIQRFLDDFSNAQTIRLEQNYRSTGNILASANQLISNNSNRLGKNLWTDGEKGE
PVGIYAAFNELDEALFVSSQIKQWIENGGKLKDCAILYRSNSQSRVIEEALIRSQLPYRIYGGMRFFERQEIKDALAYLR
LIANRQDDAAFERVVNTPPRSIGERTLDMLRSVTREREVTLWQATQLAIHENLLTARAATALQRFLELINSLQQDTSEMP
LFAQTDFVIKHSGLYAMYQQEKGEKGEVRIENLEELVTATKEFIKPDEAEQLSDLTAFLTHASLEAGEEQASPHQDYVEM
MTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERRLAYVGITRAKQKLTICYAESRRLYAKEERHLPSRFIAEL
PTECIQEIRLRGTVTRAMNQQKVGSVAPSLQESEWKMGQKVLHSKFGQGTIINVEGAENNTRLQIAFQNQGIKWLIAHLA
KLEKIR

Sequences:

>Translated_726_residues
MDISALLDGLNDKQRDAVAAPLGNYLVLAGAGSGKTRVLTHRIAWLIAVEQVSEGSIMAVTFTNKAAAEMRHRIESTLAN
HASQRLFGMWVGTFHSIAHRLLRAHHLDANLPQDFQILDADDQLRLVKRLLKLHNFDEKIFIPKQVCWYINNKKDDGLRA
HQIDDNNDRHEREWIKIYQIYQDTCDRAGLVDFAELLLRAYELWLKKPVILQRYQQRFQHILVDEFQDTNKIQYAWVKLL
AGEQGKVMIVGDDDQSIYGWRGAKIENIQRFLDDFSNAQTIRLEQNYRSTGNILASANQLISNNSNRLGKNLWTDGEKGE
PVGIYAAFNELDEALFVSSQIKQWIENGGKLKDCAILYRSNSQSRVIEEALIRSQLPYRIYGGMRFFERQEIKDALAYLR
LIANRQDDAAFERVVNTPPRSIGERTLDMLRSVTREREVTLWQATQLAIHENLLTARAATALQRFLELINSLQQDTSEMP
LFAQTDFVIKHSGLYAMYQQEKGEKGEVRIENLEELVTATKEFIKPDEAEQLSDLTAFLTHASLEAGEEQASPHQDYVEM
MTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERRLAYVGITRAKQKLTICYAESRRLYAKEERHLPSRFIAEL
PTECIQEIRLRGTVTRAMNQQKVGSVAPSLQESEWKMGQKVLHSKFGQGTIINVEGAENNTRLQIAFQNQGIKWLIAHLA
KLEKIR
>Mature_726_residues
MDISALLDGLNDKQRDAVAAPLGNYLVLAGAGSGKTRVLTHRIAWLIAVEQVSEGSIMAVTFTNKAAAEMRHRIESTLAN
HASQRLFGMWVGTFHSIAHRLLRAHHLDANLPQDFQILDADDQLRLVKRLLKLHNFDEKIFIPKQVCWYINNKKDDGLRA
HQIDDNNDRHEREWIKIYQIYQDTCDRAGLVDFAELLLRAYELWLKKPVILQRYQQRFQHILVDEFQDTNKIQYAWVKLL
AGEQGKVMIVGDDDQSIYGWRGAKIENIQRFLDDFSNAQTIRLEQNYRSTGNILASANQLISNNSNRLGKNLWTDGEKGE
PVGIYAAFNELDEALFVSSQIKQWIENGGKLKDCAILYRSNSQSRVIEEALIRSQLPYRIYGGMRFFERQEIKDALAYLR
LIANRQDDAAFERVVNTPPRSIGERTLDMLRSVTREREVTLWQATQLAIHENLLTARAATALQRFLELINSLQQDTSEMP
LFAQTDFVIKHSGLYAMYQQEKGEKGEVRIENLEELVTATKEFIKPDEAEQLSDLTAFLTHASLEAGEEQASPHQDYVEM
MTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEERRLAYVGITRAKQKLTICYAESRRLYAKEERHLPSRFIAEL
PTECIQEIRLRGTVTRAMNQQKVGSVAPSLQESEWKMGQKVLHSKFGQGTIINVEGAENNTRLQIAFQNQGIKWLIAHLA
KLEKIR

Specific function: May process damage occurring in non-replicating regions of DNA to produce recombinational intermediates for sister strand recombinational exchange [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=726, Percent_Identity=67.9063360881543, Blast_Score=1034, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=636, Percent_Identity=38.5220125786164, Blast_Score=401, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322369, Length=736, Percent_Identity=27.7173913043478, Blast_Score=181, Evalue=4e-46,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 83316; Mature: 83316

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISALLDGLNDKQRDAVAAPLGNYLVLAGAGSGKTRVLTHRIAWLIAVEQVSEGSIMAV
CCHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
TFTNKAAAEMRHRIESTLANHASQRLFGMWVGTFHSIAHRLLRAHHLDANLPQDFQILDA
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECC
DDQLRLVKRLLKLHNFDEKIFIPKQVCWYINNKKDDGLRAHQIDDNNDRHEREWIKIYQI
CHHHHHHHHHHHHCCCCCCEECCHHHHEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHH
YQDTCDRAGLVDFAELLLRAYELWLKKPVILQRYQQRFQHILVDEFQDTNKIQYAWVKLL
HHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AGEQGKVMIVGDDDQSIYGWRGAKIENIQRFLDDFSNAQTIRLEQNYRSTGNILASANQL
CCCCCCEEEEECCCCCEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHH
ISNNSNRLGKNLWTDGEKGEPVGIYAAFNELDEALFVSSQIKQWIENGGKLKDCAILYRS
HHCCCCHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
NSQSRVIEEALIRSQLPYRIYGGMRFFERQEIKDALAYLRLIANRQDDAAFERVVNTPPR
CCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCH
SIGERTLDMLRSVTREREVTLWQATQLAIHENLLTARAATALQRFLELINSLQQDTSEMP
HHHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LFAQTDFVIKHSGLYAMYQQEKGEKGEVRIENLEELVTATKEFIKPDEAEQLSDLTAFLT
EEECCCEEEEECCEEEEHHHCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HASLEAGEEQASPHQDYVEMMTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEER
HHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCHHH
RLAYVGITRAKQKLTICYAESRRLYAKEERHLPSRFIAELPTECIQEIRLRGTVTRAMNQ
EEEEEEHHHCCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKVGSVAPSLQESEWKMGQKVLHSKFGQGTIINVEGAENNTRLQIAFQNQGIKWLIAHLA
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHH
KLEKIR
HHHHCC
>Mature Secondary Structure
MDISALLDGLNDKQRDAVAAPLGNYLVLAGAGSGKTRVLTHRIAWLIAVEQVSEGSIMAV
CCHHHHHHCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEE
TFTNKAAAEMRHRIESTLANHASQRLFGMWVGTFHSIAHRLLRAHHLDANLPQDFQILDA
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECC
DDQLRLVKRLLKLHNFDEKIFIPKQVCWYINNKKDDGLRAHQIDDNNDRHEREWIKIYQI
CHHHHHHHHHHHHCCCCCCEECCHHHHEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHH
YQDTCDRAGLVDFAELLLRAYELWLKKPVILQRYQQRFQHILVDEFQDTNKIQYAWVKLL
HHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AGEQGKVMIVGDDDQSIYGWRGAKIENIQRFLDDFSNAQTIRLEQNYRSTGNILASANQL
CCCCCCEEEEECCCCCEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHH
ISNNSNRLGKNLWTDGEKGEPVGIYAAFNELDEALFVSSQIKQWIENGGKLKDCAILYRS
HHCCCCHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
NSQSRVIEEALIRSQLPYRIYGGMRFFERQEIKDALAYLRLIANRQDDAAFERVVNTPPR
CCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCH
SIGERTLDMLRSVTREREVTLWQATQLAIHENLLTARAATALQRFLELINSLQQDTSEMP
HHHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LFAQTDFVIKHSGLYAMYQQEKGEKGEVRIENLEELVTATKEFIKPDEAEQLSDLTAFLT
EEECCCEEEEECCEEEEHHHCCCCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
HASLEAGEEQASPHQDYVEMMTLHSAKGLEFPRVFMVGVEEGLFPSFRSFEEPGRLEEER
HHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHCCCCCCCCCHHH
RLAYVGITRAKQKLTICYAESRRLYAKEERHLPSRFIAELPTECIQEIRLRGTVTRAMNQ
EEEEEEHHHCCCEEEEEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKVGSVAPSLQESEWKMGQKVLHSKFGQGTIINVEGAENNTRLQIAFQNQGIKWLIAHLA
HHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHH
KLEKIR
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8294031; 7542800; 3259573 [H]