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The map label for this gene is dsbC

Identifier: 15602056

GI number: 15602056

Start: 214049

End: 214732

Strand: Direct

Name: dsbC

Synonym: PM0191

Alternate gene names: 15602056

Gene position: 214049-214732 (Clockwise)

Preceding gene: 15602045

Following gene: 15602057

Centisome position: 9.48

GC content: 39.62

Gene sequence:

>684_bases
ATGAAAAAGATCTTGAGCACACTTTTGATGTTGGGGATGTCGAGTTTGACGTTTGCCAATTCACAGCAAGTGGTAGAACA
GTTGCAAAAAATGGGCTTATCTGGTGTAGAAGTGAGCGATTCGCCTGTGAAAGGCATCAAAACCGCAGTGACGGACAATG
GTATTTTTTACATCACAGAGGACGCGAAATATATTCTTGATGGTAAGTTATATGCACTGTCAGAAAAAGGATTACGCGAT
GTGTCATCAAGCTTATTACTAGATAAATTAACAGCTTATAAAAATGAAATGGTCGTTTATCCCGCAAAAGACGAAAAACA
TGTGATTACCGTGTTCATGGATACTTCGTGCCATTACTGCAAAGTGTTACATAAACAAATTAAAGAATATAATGATCTCG
GTATTACAGTACGTTACCTTGCTTTCCCGCGTGGTGGCGTGCAATCGAAAACAGCACGTGAAATGGAAGCGATCTTTACT
GCACAAGATCCTCAGTTTGCATTAACTGAAGCGATTAATGGTAATCCACCAAAAACGTTGAAAGACGCTAATATCACCAA
AAAACATTACCAGTTAGGCTTACAATTTGGTGTGAATGGTACCCCAAGTATTGTGACCGAGAAAGGCGAATTGATTGGAG
GGTATTTAAAACCCGCAGATTTATTGTCGGAGTTAGCCCAGTAA

Upstream 100 bases:

>100_bases
ATGGTAGGCAATTTTTTAGGTGCTACTTGCACAAATATTGGATCTCTTTATAATTGCTCAATTCGCTATTTGTATTTTTA
TTGTTAACAATGGGACCAAA

Downstream 100 bases:

>100_bases
TCGGCTATTAAATAAGGACGCTTTCTGCGTCCTCATTTATTCTTGTCTTAGGAATGTCTTTAGTGAATAAATTAATCCAA
CGTCGTGCTGTTCCCTTAGG

Product: DsbC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKKILSTLLMLGMSSLTFANSQQVVEQLQKMGLSGVEVSDSPVKGIKTAVTDNGIFYITEDAKYILDGKLYALSEKGLRD
VSSSLLLDKLTAYKNEMVVYPAKDEKHVITVFMDTSCHYCKVLHKQIKEYNDLGITVRYLAFPRGGVQSKTAREMEAIFT
AQDPQFALTEAINGNPPKTLKDANITKKHYQLGLQFGVNGTPSIVTEKGELIGGYLKPADLLSELAQ

Sequences:

>Translated_227_residues
MKKILSTLLMLGMSSLTFANSQQVVEQLQKMGLSGVEVSDSPVKGIKTAVTDNGIFYITEDAKYILDGKLYALSEKGLRD
VSSSLLLDKLTAYKNEMVVYPAKDEKHVITVFMDTSCHYCKVLHKQIKEYNDLGITVRYLAFPRGGVQSKTAREMEAIFT
AQDPQFALTEAINGNPPKTLKDANITKKHYQLGLQFGVNGTPSIVTEKGELIGGYLKPADLLSELAQ
>Mature_227_residues
MKKILSTLLMLGMSSLTFANSQQVVEQLQKMGLSGVEVSDSPVKGIKTAVTDNGIFYITEDAKYILDGKLYALSEKGLRD
VSSSLLLDKLTAYKNEMVVYPAKDEKHVITVFMDTSCHYCKVLHKQIKEYNDLGITVRYLAFPRGGVQSKTAREMEAIFT
AQDPQFALTEAINGNPPKTLKDANITKKHYQLGLQFGVNGTPSIVTEKGELIGGYLKPADLLSELAQ

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily

Homologues:

Organism=Escherichia coli, GI1789260, Length=215, Percent_Identity=42.3255813953488, Blast_Score=184, Evalue=3e-48,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): DSBC_PASMU (Q9CP65)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245128.1
- ProteinModelPortal:   Q9CP65
- SMR:   Q9CP65
- GeneID:   1243538
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0191
- NMPDR:   fig|272843.1.peg.191
- HOGENOM:   HBG469935
- OMA:   HYELGIK
- ProtClustDB:   CLSK870006
- BioCyc:   PMUL272843:PM0191-MONOMER
- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.10.450.70
- Gene3D:   G3DSA:3.40.30.10

Pfam domain/function: PF10411 DsbC_N; SSF54423 Disulfide_bond_isomerase_N; SSF52833 Thiordxn-like_fd

EC number: 5.3.4.1

Molecular weight: Translated: 25029; Mature: 25029

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILSTLLMLGMSSLTFANSQQVVEQLQKMGLSGVEVSDSPVKGIKTAVTDNGIFYITE
CHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHEEECCCEEEEEC
DAKYILDGKLYALSEKGLRDVSSSLLLDKLTAYKNEMVVYPAKDEKHVITVFMDTSCHYC
CCEEEECCEEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCHHH
KVLHKQIKEYNDLGITVRYLAFPRGGVQSKTAREMEAIFTAQDPQFALTEAINGNPPKTL
HHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCC
KDANITKKHYQLGLQFGVNGTPSIVTEKGELIGGYLKPADLLSELAQ
CCCCCCHHHHHEEEEECCCCCCCEEECCCHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKKILSTLLMLGMSSLTFANSQQVVEQLQKMGLSGVEVSDSPVKGIKTAVTDNGIFYITE
CHHHHHHHHHHCCHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHEEECCCEEEEEC
DAKYILDGKLYALSEKGLRDVSSSLLLDKLTAYKNEMVVYPAKDEKHVITVFMDTSCHYC
CCEEEECCEEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCHHH
KVLHKQIKEYNDLGITVRYLAFPRGGVQSKTAREMEAIFTAQDPQFALTEAINGNPPKTL
HHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCC
KDANITKKHYQLGLQFGVNGTPSIVTEKGELIGGYLKPADLLSELAQ
CCCCCCHHHHHEEEEECCCCCCCEEECCCHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100