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The map label for this gene is murZ

Identifier: 15602045

GI number: 15602045

Start: 202125

End: 203402

Strand: Direct

Name: murZ

Synonym: PM0180

Alternate gene names: 15602045

Gene position: 202125-203402 (Clockwise)

Preceding gene: 15602044

Following gene: 15602056

Centisome position: 8.95

GC content: 43.58

Gene sequence:

>1278_bases
ATGCAAAAATTTCGTGTGTACGGTCAGTCACGTTTAAGAGGTTCTGTGAATATTTCAGGGGCAAAGAATGCAGCGTTGCC
TATTTTATTTGCAGCGATTTTAGCGCAAGAGCCAGTTAAATTGACCAATGTACCAGAATTAAAAGATATTGAAACCACCT
TAAAAATTCTGCGCAAACTCGGTGTCGTTGTTGAACGTGATGCTGAAGGGGCGGTGCACTTAGATGCGTCAAAAATTGAT
CATTTCGTTGCACCTTATGAACTGGTCAAAACCATGCGTGCGTCAATTTGGGCATTAGCCCCGTTAGTGGCGCGTTTTCA
TCGTGGTCAAGTGTCTTTACCGGGAGGCTGTTCTATTGGTGCTCGTCCAGTGGATCTGCATATCAGTGGTTTAGAACGTT
TAGGGGCAAGCATCATTTTAGAAGATGGTTATGTAAAAGCCTATGTTGATCACTGCTTAGTCGGTACTCGTATTGTGATG
GAAAAAGTGAGTGTGGGCGCAACGTTATCTATTATGATGGCGGCAACACTGGCCAAAGGGAAAACCATCATTGAGAATGC
TGCACGTGAACCGGAAATTACGGATACAGCACTGTTTTTGAATAAAATGGGAGCTAAAATTGTAGGGGCTGGTACTGATA
CTATTACCGTGGAAGGCGTTGAGCGTTTAGGCGGTTGTGAGCATAGTATTGTGCCTGATCGCATTGAAACAGGGACTTTC
TTAGTGGCTGCCGCCATTTCAGGTGGACGCATTGAATGTAAAAATACCAAAGCAGATACTTTGGATGCGGTAATTGATAA
ATTACGTGAGGCAGGAGCCCAAGTGGATGTGACAGAAAACAGCATTACTTTGGATATGCTGGGTAATCGACCACGAGCTG
TCAATATTCGTACTGCACCTTATCCCGGTTTTCCAACGGATATGCAAGCGCAATTTACTTTATTAAACATGGTGGCATGT
GGTACCAGTATCATTACTGAAACCATTTTTGAAAATCGCTTTATGCATATCCCAGAGCTTATTCGTATGGGGGGCAAAGC
TGAAATTGAAGGCAATACAGCGATTTGCCATGGTGTTGATCATTTAAGTGGTGCTGAAGTGATGGCAACGGATTTACGGG
CTTCTATCAGTTTAGTTCTGGCTGGATGTATTGCTACCGGTGAAACCATTGTCGATCGTATTTATCACATTGATCGTGGC
TACGAGCGAATCGAAGAAAAACTGCGTGGCTTAGGCGCACGTATCGAACGTTTTTCAGCACAAAGTGAAGAAAGTTAA

Upstream 100 bases:

>100_bases
ATGCAATTCATGCATTAACAATTAAAACCTATACAGTTGAAAAATGGAAGCGTGAACGCTTACTCAATCAGCCGTCTTGA
AATAAAAGATAGGATATTTT

Downstream 100 bases:

>100_bases
GCCATGGTTTAATAAGAAAAAGAAAGGGAAATCAGTGATTTCCCTTTTTTACATTTAACAAAGAGTGCCGACAATACTAC
GCGTTTCTTCTTTCACGTCC

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MQKFRVYGQSRLRGSVNISGAKNAALPILFAAILAQEPVKLTNVPELKDIETTLKILRKLGVVVERDAEGAVHLDASKID
HFVAPYELVKTMRASIWALAPLVARFHRGQVSLPGGCSIGARPVDLHISGLERLGASIILEDGYVKAYVDHCLVGTRIVM
EKVSVGATLSIMMAATLAKGKTIIENAAREPEITDTALFLNKMGAKIVGAGTDTITVEGVERLGGCEHSIVPDRIETGTF
LVAAAISGGRIECKNTKADTLDAVIDKLREAGAQVDVTENSITLDMLGNRPRAVNIRTAPYPGFPTDMQAQFTLLNMVAC
GTSIITETIFENRFMHIPELIRMGGKAEIEGNTAICHGVDHLSGAEVMATDLRASISLVLAGCIATGETIVDRIYHIDRG
YERIEEKLRGLGARIERFSAQSEES

Sequences:

>Translated_425_residues
MQKFRVYGQSRLRGSVNISGAKNAALPILFAAILAQEPVKLTNVPELKDIETTLKILRKLGVVVERDAEGAVHLDASKID
HFVAPYELVKTMRASIWALAPLVARFHRGQVSLPGGCSIGARPVDLHISGLERLGASIILEDGYVKAYVDHCLVGTRIVM
EKVSVGATLSIMMAATLAKGKTIIENAAREPEITDTALFLNKMGAKIVGAGTDTITVEGVERLGGCEHSIVPDRIETGTF
LVAAAISGGRIECKNTKADTLDAVIDKLREAGAQVDVTENSITLDMLGNRPRAVNIRTAPYPGFPTDMQAQFTLLNMVAC
GTSIITETIFENRFMHIPELIRMGGKAEIEGNTAICHGVDHLSGAEVMATDLRASISLVLAGCIATGETIVDRIYHIDRG
YERIEEKLRGLGARIERFSAQSEES
>Mature_425_residues
MQKFRVYGQSRLRGSVNISGAKNAALPILFAAILAQEPVKLTNVPELKDIETTLKILRKLGVVVERDAEGAVHLDASKID
HFVAPYELVKTMRASIWALAPLVARFHRGQVSLPGGCSIGARPVDLHISGLERLGASIILEDGYVKAYVDHCLVGTRIVM
EKVSVGATLSIMMAATLAKGKTIIENAAREPEITDTALFLNKMGAKIVGAGTDTITVEGVERLGGCEHSIVPDRIETGTF
LVAAAISGGRIECKNTKADTLDAVIDKLREAGAQVDVTENSITLDMLGNRPRAVNIRTAPYPGFPTDMQAQFTLLNMVAC
GTSIITETIFENRFMHIPELIRMGGKAEIEGNTAICHGVDHLSGAEVMATDLRASISLVLAGCIATGETIVDRIYHIDRG
YERIEEKLRGLGARIERFSAQSEES

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=421, Percent_Identity=71.7339667458432, Blast_Score=615, Evalue=1e-177,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_PASMU (P57821)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245117.1
- ProteinModelPortal:   P57821
- SMR:   P57821
- PRIDE:   P57821
- GeneID:   1243527
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0180
- NMPDR:   fig|272843.1.peg.180
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- BioCyc:   PMUL272843:PM0180-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45813; Mature: 45813

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: ACT_SITE 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKFRVYGQSRLRGSVNISGAKNAALPILFAAILAQEPVKLTNVPELKDIETTLKILRKL
CCCEEECCHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GVVVERDAEGAVHLDASKIDHFVAPYELVKTMRASIWALAPLVARFHRGQVSLPGGCSIG
CCEEEECCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ARPVDLHISGLERLGASIILEDGYVKAYVDHCLVGTRIVMEKVSVGATLSIMMAATLAKG
CCEEEEEEHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
KTIIENAAREPEITDTALFLNKMGAKIVGAGTDTITVEGVERLGGCEHSIVPDRIETGTF
HHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCEEEEECHHHHCCCCCCCCCCCCCCCCE
LVAAAISGGRIECKNTKADTLDAVIDKLREAGAQVDVTENSITLDMLGNRPRAVNIRTAP
EEEEECCCCEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCEEEEEECC
YPGFPTDMQAQFTLLNMVACGTSIITETIFENRFMHIPELIRMGGKAEIEGNTAICHGVD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEECCCEEEEECCC
HLSGAEVMATDLRASISLVLAGCIATGETIVDRIYHIDRGYERIEEKLRGLGARIERFSA
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QSEES
CCCCC
>Mature Secondary Structure
MQKFRVYGQSRLRGSVNISGAKNAALPILFAAILAQEPVKLTNVPELKDIETTLKILRKL
CCCEEECCHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
GVVVERDAEGAVHLDASKIDHFVAPYELVKTMRASIWALAPLVARFHRGQVSLPGGCSIG
CCEEEECCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
ARPVDLHISGLERLGASIILEDGYVKAYVDHCLVGTRIVMEKVSVGATLSIMMAATLAKG
CCEEEEEEHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCC
KTIIENAAREPEITDTALFLNKMGAKIVGAGTDTITVEGVERLGGCEHSIVPDRIETGTF
HHHHHHCCCCCCCHHHHHHHHHCCCEEEECCCCEEEEECHHHHCCCCCCCCCCCCCCCCE
LVAAAISGGRIECKNTKADTLDAVIDKLREAGAQVDVTENSITLDMLGNRPRAVNIRTAP
EEEEECCCCEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCCCCEEEEEECC
YPGFPTDMQAQFTLLNMVACGTSIITETIFENRFMHIPELIRMGGKAEIEGNTAICHGVD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEECCCEEEEECCC
HLSGAEVMATDLRASISLVLAGCIATGETIVDRIYHIDRGYERIEEKLRGLGARIERFSA
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QSEES
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100