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The map label for this gene is mraY

Identifier: 15602004

GI number: 15602004

Start: 164468

End: 165550

Strand: Direct

Name: mraY

Synonym: PM0139

Alternate gene names: 15602004

Gene position: 164468-165550 (Clockwise)

Preceding gene: 15602003

Following gene: 15602005

Centisome position: 7.29

GC content: 43.12

Gene sequence:

>1083_bases
ATGTTAGTTTGGCTCGGTGAGTTTTTACAACAATATTACAGCGGATTTAATGTGATCTCTTATATCACAGTACGTGCCAT
TTTAGCGTTATTAACCGCACTTTTGGTCTCGTTGTGGATTGGTCCGAAAGTCATTCGTCGTTTACAGCTACTCAAATTTG
GTCAAGAAGTTCGTCATGATGGACCGGAAAGTCATTTTAGTAAACGTGGCACACCAACTATGGGCGGTGTCATGATTTTA
TTTGCGATTACTGTAAGTACTTTATTATGGGCAAATTTGGCGAATCCTTACGTCTGGTTTAGCTTGTTTGTGTTATTAGG
TTATGGGGCAATTGGGTTCGTGGATGATTACCGTAAGATTACCCGTAAAAATACCGATGGCTTAATTGCACGCTGGAAAT
ATTTCTGGTTATCTGTGATTGCGCTTGTTGCCGCCTTTGGCATGTATGCGATTGGTAAAGATACGGATGCAACCCGTTTA
GTCGTGCCTTTCTTTAAAGAAATCATGCCACAATTAGGTTTATTCTATATTATTCTGACCTACTTTGTGATTGTGGGGAC
CAGCAACGCCGTCAACCTCACTGACGGTTTAGATGGATTAGCAATTATGCCGACGGTCTTAGTCGCGGGAGCATTTGCGT
TGATTGCGTGGGCAACCGGTAACGTGAATTTTGCAGAATATTTACACATTCCTTATATCAAATTTAGTGCTGAATTAGTG
GTGTTCTGTACGGCGATTGTGGGCGCAGGGCTTGGTTTTCTCTGGTTTAATACTTATCCGGCGCAAGTTTTCATGGGCGA
TGTTGGCTCATTAGCCTTAGGGGGCGCCTTGGGAGTGGTTGCGGTGTTAGTCCGCCAAGAATTCTTATTAGTCATTATGG
GCGGGGTATTTGTGGTCGAGACACTCTCCGTTATCTTACAGGTGGGGTCTTATAAATTACGTAAACAGCGTATTTTTCGT
ATGGCACCCATTCATCATCATTTTGAGTTAAAAGGCTGGCCAGAACCACGCGTGATCGTCCGCTTTTGGATTATTTCCTT
AATGCTGGTCCTTGTTGGGCTCGTTACCTTAAAACTTCGCTAA

Upstream 100 bases:

>100_bases
GTGAAAAATTAAAAGAAAACCAAAAAATCGTTTTATTAGCAAAAGGATCACGTCGAATGCAAATGGAGGATGTGATTAAT
ACTTTAAGGGAAAACTTTGT

Downstream 100 bases:

>100_bases
AACACAAAACGATATCTTATGCAAACGTCTTATAAAAATAAAAAAGTTACCGTGATTGGTTTGGGGAAAACAGGGCTATC
TTGTGTTGATTTCCTACTGG

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MLVWLGEFLQQYYSGFNVISYITVRAILALLTALLVSLWIGPKVIRRLQLLKFGQEVRHDGPESHFSKRGTPTMGGVMIL
FAITVSTLLWANLANPYVWFSLFVLLGYGAIGFVDDYRKITRKNTDGLIARWKYFWLSVIALVAAFGMYAIGKDTDATRL
VVPFFKEIMPQLGLFYIILTYFVIVGTSNAVNLTDGLDGLAIMPTVLVAGAFALIAWATGNVNFAEYLHIPYIKFSAELV
VFCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGVVAVLVRQEFLLVIMGGVFVVETLSVILQVGSYKLRKQRIFR
MAPIHHHFELKGWPEPRVIVRFWIISLMLVLVGLVTLKLR

Sequences:

>Translated_360_residues
MLVWLGEFLQQYYSGFNVISYITVRAILALLTALLVSLWIGPKVIRRLQLLKFGQEVRHDGPESHFSKRGTPTMGGVMIL
FAITVSTLLWANLANPYVWFSLFVLLGYGAIGFVDDYRKITRKNTDGLIARWKYFWLSVIALVAAFGMYAIGKDTDATRL
VVPFFKEIMPQLGLFYIILTYFVIVGTSNAVNLTDGLDGLAIMPTVLVAGAFALIAWATGNVNFAEYLHIPYIKFSAELV
VFCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGVVAVLVRQEFLLVIMGGVFVVETLSVILQVGSYKLRKQRIFR
MAPIHHHFELKGWPEPRVIVRFWIISLMLVLVGLVTLKLR
>Mature_360_residues
MLVWLGEFLQQYYSGFNVISYITVRAILALLTALLVSLWIGPKVIRRLQLLKFGQEVRHDGPESHFSKRGTPTMGGVMIL
FAITVSTLLWANLANPYVWFSLFVLLGYGAIGFVDDYRKITRKNTDGLIARWKYFWLSVIALVAAFGMYAIGKDTDATRL
VVPFFKEIMPQLGLFYIILTYFVIVGTSNAVNLTDGLDGLAIMPTVLVAGAFALIAWATGNVNFAEYLHIPYIKFSAELV
VFCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGVVAVLVRQEFLLVIMGGVFVVETLSVILQVGSYKLRKQRIFR
MAPIHHHFELKGWPEPRVIVRFWIISLMLVLVGLVTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=360, Percent_Identity=80, Blast_Score=579, Evalue=1e-167,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_PASMU (P57816)

Other databases:

- EMBL:   AE004439
- RefSeq:   NP_245076.1
- GeneID:   1243486
- GenomeReviews:   AE004439_GR
- KEGG:   pmu:PM0139
- NMPDR:   fig|272843.1.peg.139
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- ProtClustDB:   PRK00108
- BioCyc:   PMUL272843:PM0139-MONOMER
- BRENDA:   2.7.8.13
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 40156; Mature: 40156

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc1df598)-; HASH(0xc6ee708)-; HASH(0xbe68714)-; HASH(0xbccd6b0)-; HASH(0xbe6aae4)-; HASH(0xc6ebf8c)-; HASH(0xc6e3570)-; HASH(0xc395b88)-; HASH(0xbe799fc)-; HASH(0xc6ebde8)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVWLGEFLQQYYSGFNVISYITVRAILALLTALLVSLWIGPKVIRRLQLLKFGQEVRHD
CEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
GPESHFSKRGTPTMGGVMILFAITVSTLLWANLANPYVWFSLFVLLGYGAIGFVDDYRKI
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHH
TRKNTDGLIARWKYFWLSVIALVAAFGMYAIGKDTDATRLVVPFFKEIMPQLGLFYIILT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
YFVIVGTSNAVNLTDGLDGLAIMPTVLVAGAFALIAWATGNVNFAEYLHIPYIKFSAELV
HHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHH
VFCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGVVAVLVRQEFLLVIMGGVFVVE
HHHHHHHHCCHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSVILQVGSYKLRKQRIFRMAPIHHHFELKGWPEPRVIVRFWIISLMLVLVGLVTLKLR
HHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MLVWLGEFLQQYYSGFNVISYITVRAILALLTALLVSLWIGPKVIRRLQLLKFGQEVRHD
CEEEHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
GPESHFSKRGTPTMGGVMILFAITVSTLLWANLANPYVWFSLFVLLGYGAIGFVDDYRKI
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHH
TRKNTDGLIARWKYFWLSVIALVAAFGMYAIGKDTDATRLVVPFFKEIMPQLGLFYIILT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
YFVIVGTSNAVNLTDGLDGLAIMPTVLVAGAFALIAWATGNVNFAEYLHIPYIKFSAELV
HHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHH
VFCTAIVGAGLGFLWFNTYPAQVFMGDVGSLALGGALGVVAVLVRQEFLLVIMGGVFVVE
HHHHHHHHCCHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSVILQVGSYKLRKQRIFRMAPIHHHFELKGWPEPRVIVRFWIISLMLVLVGLVTLKLR
HHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11248100