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The map label for this gene is ftsI [H]

Identifier: 15602001

GI number: 15602001

Start: 159800

End: 161605

Strand: Direct

Name: ftsI [H]

Synonym: PM0136

Alternate gene names: 15602001

Gene position: 159800-161605 (Clockwise)

Preceding gene: 15602000

Following gene: 15602002

Centisome position: 7.08

GC content: 40.53

Gene sequence:

>1806_bases
ATGGTTAAATTTAATACGACGAAGAAAATCAAAAAAGTCAGATTCGCTAAAAATGACGCAATTAAGCTAAATAAACCCAA
AATGGTTTATGAAAATAGCTTTTTAAAATGGCGTTATTTTTCGTCATTGCTCATCATTATTGGTTGCTTGGTGGTATTAA
TTGGAAAGGCTGCCAGCGTGCAAATCATCAATTCAGATACTTTAACTGATGAGGCAGATAAGCGTTCCTTACGTATTCAA
GAAATTCAATCAGTTCGTGGTTCGATTCTCGATCGGCATGGTCAATTACTCTCTGTGAGTGTACCAATGTATTCCATCGT
TGCGGATCCTAAAGATATTTTTGACAAAAATTCTTTCCTTGATAAAGAGCGTTGGAAAGCCTTGGCTGAAGTGCTCGGCA
TTTCATATCATGACATGATTAAACGGATTGAAAAAAATCCGAAATCACGCTTCGTTTATTTATCACGTCAAGTTTCTCCA
ACTGTGGCTGATTATGTCAGAGAGTTAAAATTAAAAGGTGTGGTGCTTAAAAATGAAGCACGCCGTTTTTATCCTCGTGT
CGAAGAAGTCGCACATTTAATTGGTTATACCAATATTGATGGGGATGGGATTGAAGGCATTGAAAAAAGCTTTAATTCAA
TGTTGATCGGTAAATCGGGTTCGCGTACGTATCGTAAAGATAAATTTGGTAATATCGTTGAAAATATCGCGGATGTGAAA
AAATACGATGCACAGGATGTGACGTTAAGTATTGATGAAAAATTACAATCCATGGTTTATCGCGAAATTAAAAAAGCAGT
GGCGGAAAATAAAGCCGAATCAGGTACGGCAGTATTAGTAGATGTAAGAACAGGTGAAGTGTTAGCGATGGCGAATGCCC
CGTCTTATAACCCAAATAATCGTGTCGGAGTCAAAGCTGATTTCATGCGTAACCGAGCGATTACAGATACCTTTGAACCG
GGCTCTACTGTCAAACCGTTTGTGGTGCTTGCCGCCCTTCAACGTGGTGCAGCCAAACGTAATGAAGTAATTAATACTGG
ACCTTTAGTGTTGAATGGACATGAAATTCGCGATGTGGCACCACGTGATCAATTAACATTAGATGGCATTTTAGAGCATT
CCAGTAACCGAGGGGTGAGCCGTTTAGCATTACGTATGCCACCCAGCGCGTTAATGGAAACTTATATGCATGCGGGACTT
GGTAAACCGACGGATCTGGGGTTAATTGGTGAACAATCTGGCTTACTTAATGCGAACCGTAAACGTTGGTCTGATATTGA
ACGTGCTAACGTGGCTTATGGTTACGGGATTAATGCGACACCATTACAAATTGCACGGGCTTACGTGACACTTGGTAGTT
TTGGTATTTATCGTCCACTTTCGATTACCAAAGTGGATCCTCCCGTAATTGGTCAACGCGTGTATCCAGAAAAGATTACC
CGTGAAGTGGTCAATATGATGGAAAAAGTGGCGATTAAAAATAAGAAAGCCATGGTGGAAGGTTACCGTGTCGGCATTAA
AACGGGGACGGCGAAAAAATTAGAAAATGGGCGTTATGTGGATAAATATATCGCTTATACTGCCGGCGTCGCACCTATTT
CTGATCCACGTTATGCGTTAATTGTCTTAATTAATGATCCAAAAGCGGGACAATATTATGGGGGCGCTATTTCAGCACCG
GTGTTCTCCAGTATTATGGGCTATGCGTTACGTGTGAATAATATTCCACCAGATGCGATGCCACAAGATAAAATGGCAAG
ACGCGTTGTGCGTTTGAATAGTGATAATGGAACAACGACAAACTAA

Upstream 100 bases:

>100_bases
ATAATACCCGCATTGAAGCCATTGCACGCCAATTAGGGATGAAGCGCGTTGAGCCAGAACAAGAAGTGTTGATCCTAGAG
TAGCATTTGGGGATAACAAG

Downstream 100 bases:

>100_bases
GAAGAAATTATGCGAAGATTAACCGCACTTTTGGGGCAAGTTGAACTTGCCCCAAATATTGAATTGACGGAAATGATTCT
AGACAGTCGGGCTGTAAAGC

Product: hypothetical protein

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MVKFNTTKKIKKVRFAKNDAIKLNKPKMVYENSFLKWRYFSSLLIIIGCLVVLIGKAASVQIINSDTLTDEADKRSLRIQ
EIQSVRGSILDRHGQLLSVSVPMYSIVADPKDIFDKNSFLDKERWKALAEVLGISYHDMIKRIEKNPKSRFVYLSRQVSP
TVADYVRELKLKGVVLKNEARRFYPRVEEVAHLIGYTNIDGDGIEGIEKSFNSMLIGKSGSRTYRKDKFGNIVENIADVK
KYDAQDVTLSIDEKLQSMVYREIKKAVAENKAESGTAVLVDVRTGEVLAMANAPSYNPNNRVGVKADFMRNRAITDTFEP
GSTVKPFVVLAALQRGAAKRNEVINTGPLVLNGHEIRDVAPRDQLTLDGILEHSSNRGVSRLALRMPPSALMETYMHAGL
GKPTDLGLIGEQSGLLNANRKRWSDIERANVAYGYGINATPLQIARAYVTLGSFGIYRPLSITKVDPPVIGQRVYPEKIT
REVVNMMEKVAIKNKKAMVEGYRVGIKTGTAKKLENGRYVDKYIAYTAGVAPISDPRYALIVLINDPKAGQYYGGAISAP
VFSSIMGYALRVNNIPPDAMPQDKMARRVVRLNSDNGTTTN

Sequences:

>Translated_601_residues
MVKFNTTKKIKKVRFAKNDAIKLNKPKMVYENSFLKWRYFSSLLIIIGCLVVLIGKAASVQIINSDTLTDEADKRSLRIQ
EIQSVRGSILDRHGQLLSVSVPMYSIVADPKDIFDKNSFLDKERWKALAEVLGISYHDMIKRIEKNPKSRFVYLSRQVSP
TVADYVRELKLKGVVLKNEARRFYPRVEEVAHLIGYTNIDGDGIEGIEKSFNSMLIGKSGSRTYRKDKFGNIVENIADVK
KYDAQDVTLSIDEKLQSMVYREIKKAVAENKAESGTAVLVDVRTGEVLAMANAPSYNPNNRVGVKADFMRNRAITDTFEP
GSTVKPFVVLAALQRGAAKRNEVINTGPLVLNGHEIRDVAPRDQLTLDGILEHSSNRGVSRLALRMPPSALMETYMHAGL
GKPTDLGLIGEQSGLLNANRKRWSDIERANVAYGYGINATPLQIARAYVTLGSFGIYRPLSITKVDPPVIGQRVYPEKIT
REVVNMMEKVAIKNKKAMVEGYRVGIKTGTAKKLENGRYVDKYIAYTAGVAPISDPRYALIVLINDPKAGQYYGGAISAP
VFSSIMGYALRVNNIPPDAMPQDKMARRVVRLNSDNGTTTN
>Mature_601_residues
MVKFNTTKKIKKVRFAKNDAIKLNKPKMVYENSFLKWRYFSSLLIIIGCLVVLIGKAASVQIINSDTLTDEADKRSLRIQ
EIQSVRGSILDRHGQLLSVSVPMYSIVADPKDIFDKNSFLDKERWKALAEVLGISYHDMIKRIEKNPKSRFVYLSRQVSP
TVADYVRELKLKGVVLKNEARRFYPRVEEVAHLIGYTNIDGDGIEGIEKSFNSMLIGKSGSRTYRKDKFGNIVENIADVK
KYDAQDVTLSIDEKLQSMVYREIKKAVAENKAESGTAVLVDVRTGEVLAMANAPSYNPNNRVGVKADFMRNRAITDTFEP
GSTVKPFVVLAALQRGAAKRNEVINTGPLVLNGHEIRDVAPRDQLTLDGILEHSSNRGVSRLALRMPPSALMETYMHAGL
GKPTDLGLIGEQSGLLNANRKRWSDIERANVAYGYGINATPLQIARAYVTLGSFGIYRPLSITKVDPPVIGQRVYPEKIT
REVVNMMEKVAIKNKKAMVEGYRVGIKTGTAKKLENGRYVDKYIAYTAGVAPISDPRYALIVLINDPKAGQYYGGAISAP
VFSSIMGYALRVNNIPPDAMPQDKMARRVVRLNSDNGTTTN

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=566, Percent_Identity=57.5971731448763, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI1786854, Length=489, Percent_Identity=27.6073619631902, Blast_Score=123, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 66900; Mature: 66900

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKFNTTKKIKKVRFAKNDAIKLNKPKMVYENSFLKWRYFSSLLIIIGCLVVLIGKAASV
CCCCCCHHHHHHHHHCCCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
QIINSDTLTDEADKRSLRIQEIQSVRGSILDRHGQLLSVSVPMYSIVADPKDIFDKNSFL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHEECCCCHHHHCCCCCC
DKERWKALAEVLGISYHDMIKRIEKNPKSRFVYLSRQVSPTVADYVRELKLKGVVLKNEA
CHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEECHH
RRFYPRVEEVAHLIGYTNIDGDGIEGIEKSFNSMLIGKSGSRTYRKDKFGNIVENIADVK
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHH
KYDAQDVTLSIDEKLQSMVYREIKKAVAENKAESGTAVLVDVRTGEVLAMANAPSYNPNN
HCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCC
RVGVKADFMRNRAITDTFEPGSTVKPFVVLAALQRGAAKRNEVINTGPLVLNGHEIRDVA
CCCEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCEEECCCHHCCCC
PRDQLTLDGILEHSSNRGVSRLALRMPPSALMETYMHAGLGKPTDLGLIGEQSGLLNANR
CCCCCCHHHHHHCCCCCCHHHEEEECCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCH
KRWSDIERANVAYGYGINATPLQIARAYVTLGSFGIYRPLSITKVDPPVIGQRVYPEKIT
HHHHHHHHCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHH
REVVNMMEKVAIKNKKAMVEGYRVGIKTGTAKKLENGRYVDKYIAYTAGVAPISDPRYAL
HHHHHHHHHHHHCCCHHHHHHEEEEEECCCHHHHCCCCHHHHHHHHHCCCCCCCCCCEEE
IVLINDPKAGQYYGGAISAPVFSSIMGYALRVNNIPPDAMPQDKMARRVVRLNSDNGTTT
EEEEECCCCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHEEEECCCCCCC
N
C
>Mature Secondary Structure
MVKFNTTKKIKKVRFAKNDAIKLNKPKMVYENSFLKWRYFSSLLIIIGCLVVLIGKAASV
CCCCCCHHHHHHHHHCCCCCEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
QIINSDTLTDEADKRSLRIQEIQSVRGSILDRHGQLLSVSVPMYSIVADPKDIFDKNSFL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHEECCCCHHHHCCCCCC
DKERWKALAEVLGISYHDMIKRIEKNPKSRFVYLSRQVSPTVADYVRELKLKGVVLKNEA
CHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEECHH
RRFYPRVEEVAHLIGYTNIDGDGIEGIEKSFNSMLIGKSGSRTYRKDKFGNIVENIADVK
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHH
KYDAQDVTLSIDEKLQSMVYREIKKAVAENKAESGTAVLVDVRTGEVLAMANAPSYNPNN
HCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCCCCCCCC
RVGVKADFMRNRAITDTFEPGSTVKPFVVLAALQRGAAKRNEVINTGPLVLNGHEIRDVA
CCCEEHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHCCCCCCCCEEECCCHHCCCC
PRDQLTLDGILEHSSNRGVSRLALRMPPSALMETYMHAGLGKPTDLGLIGEQSGLLNANR
CCCCCCHHHHHHCCCCCCHHHEEEECCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCH
KRWSDIERANVAYGYGINATPLQIARAYVTLGSFGIYRPLSITKVDPPVIGQRVYPEKIT
HHHHHHHHCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHH
REVVNMMEKVAIKNKKAMVEGYRVGIKTGTAKKLENGRYVDKYIAYTAGVAPISDPRYAL
HHHHHHHHHHHHCCCHHHHHHEEEEEECCCHHHHCCCCHHHHHHHHHCCCCCCCCCCEEE
IVLINDPKAGQYYGGAISAPVFSSIMGYALRVNNIPPDAMPQDKMARRVVRLNSDNGTTT
EEEEECCCCCCCCCCCCCHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHEEEECCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]