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The map label for this gene is dnaA [H]

Identifier: 15594782

GI number: 15594782

Start: 456576

End: 458036

Strand: Direct

Name: dnaA [H]

Synonym: BB0437

Alternate gene names: 15594782

Gene position: 456576-458036 (Clockwise)

Preceding gene: 15594777

Following gene: 15594783

Centisome position: 50.13

GC content: 27.79

Gene sequence:

>1461_bases
ATGGAAAAATCAAAAAATATATGGAGCTTGATTTTAACAGAAATAAAAAAAGAACTATCAGAAGAAGAATTTTATGTTTG
GTTTGAAAATTTGTGCTTTTTAGAATCAATAGGTGACAATATTAAAATATCTACTCCAAATTTATTTCATAAAAATCAAA
TAGAAAAAAGATTTACAAAAAAAATTAAAGAAATCCTTATAAAAAATGGCTACAATAACATAGTCATTGTATTTACAAAT
CAACCACCCAAAACTCATTCTAACAAACAAGAAACTAAAAACCCGGCTCTTAACGAAACTTTTTCAAAGTTCGACAAGCT
CAAAGAAAAAACAACTTCCAAAGAAGCAATCCAAAATATTCAAGATCGTATAAAAATGTATATCAAAAAAGAAGAAGAAG
AGCCCACAAATTTTAAAAACCCCTTTCTTAAAAAAAGATATACATTTGAAAATTTTATCATCGGGCCAAATAATAAACTT
GCTTACAATGCCAGCTTGTCAATCTCAAAAAATCCTGGGAAAAAATATAATCCGTGTTTAATTTATGGTGGAGTTGGACT
TGGAAAAACACATTTGCTTCAAAGCATAGGAAACAAAACAGAAGAATTACATCATAACCTTAAAATATTATATGTTACTG
CTGAAAATTTTTTAAATGAATTTGTAGAAAGCATAAAGACACACGAAACAAAAAAATTTAAAAAAAAATACAGATACTTA
GACATGCTACTTATAGACGATATCCACGACTTACAAAAAAAAGAAGGTATACAAGAAGAGCTTTTTCACACATTTAATGC
CCTTTATGAAGACAATAAACAACTAGTATTCACATGTGACCGATCTCCTTCTGAACTTACAAATTTTACAGATCGATTAA
AAAGCAGATTCACAAGGGGATTAAATGTTGATATATCAAAGCCCAATTTTGAACTCAGAGCAGCTATTGTCGAAAAAAAA
GCAGAAGAAGATGGCATAAATGTCCCTAAAAATATACTAAATCTGGTTGCTCAAAAAGTTACAACCAACGTAAGAGACCT
TGAAGCTGCTGTAACAAAACTAAAAGCATATATAGATTTAGACAATATAGAAATTGACATTGAAATTGTTGAAAAAATAA
TCAAAGAAATAATAATTTACGAAAAAGAAACAACCAATGAGCCAAACAATAAAATTAATATCGAAAATATAAAAAAAATA
CTCTTAAGAGAGCTAAAAATCACACACAAAGATATTGAGGGGCATAGTAAAAAACCAGAGATAACAAAAGCTAGACATAT
TTATGCGTACCTTTTGAGAAATTTTACAGAGCTATCAACAGTTGAAATTGGAAAAATTATTGGAGGGAAAACCCATTCAA
CAGTGCTTTATTCGATAAATAAAATAGATAGAGACAGAAATAATGACAAAGAAATTAACAATTTAATCACAGAACTTATG
AACAAAATAAAAAAAAATTAA

Upstream 100 bases:

>100_bases
AAACTTTTAAAAATTCACAAACAATTTAGATAGAATCCTAATTTAACATTATACTATATAATGTTAAAAGTATAGTGCTA
AAACCAACAAGGACAAAAAA

Downstream 100 bases:

>100_bases
ACTTAATTGAAGAATCAAAAATTATTTTAAACAATTGAACCAAATAATTTATCAAAAATACAACAAAAAAACAACCTACA
ATTTAACAAGATATTTACTT

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MEKSKNIWSLILTEIKKELSEEEFYVWFENLCFLESIGDNIKISTPNLFHKNQIEKRFTKKIKEILIKNGYNNIVIVFTN
QPPKTHSNKQETKNPALNETFSKFDKLKEKTTSKEAIQNIQDRIKMYIKKEEEEPTNFKNPFLKKRYTFENFIIGPNNKL
AYNASLSISKNPGKKYNPCLIYGGVGLGKTHLLQSIGNKTEELHHNLKILYVTAENFLNEFVESIKTHETKKFKKKYRYL
DMLLIDDIHDLQKKEGIQEELFHTFNALYEDNKQLVFTCDRSPSELTNFTDRLKSRFTRGLNVDISKPNFELRAAIVEKK
AEEDGINVPKNILNLVAQKVTTNVRDLEAAVTKLKAYIDLDNIEIDIEIVEKIIKEIIIYEKETTNEPNNKINIENIKKI
LLRELKITHKDIEGHSKKPEITKARHIYAYLLRNFTELSTVEIGKIIGGKTHSTVLYSINKIDRDRNNDKEINNLITELM
NKIKKN

Sequences:

>Translated_486_residues
MEKSKNIWSLILTEIKKELSEEEFYVWFENLCFLESIGDNIKISTPNLFHKNQIEKRFTKKIKEILIKNGYNNIVIVFTN
QPPKTHSNKQETKNPALNETFSKFDKLKEKTTSKEAIQNIQDRIKMYIKKEEEEPTNFKNPFLKKRYTFENFIIGPNNKL
AYNASLSISKNPGKKYNPCLIYGGVGLGKTHLLQSIGNKTEELHHNLKILYVTAENFLNEFVESIKTHETKKFKKKYRYL
DMLLIDDIHDLQKKEGIQEELFHTFNALYEDNKQLVFTCDRSPSELTNFTDRLKSRFTRGLNVDISKPNFELRAAIVEKK
AEEDGINVPKNILNLVAQKVTTNVRDLEAAVTKLKAYIDLDNIEIDIEIVEKIIKEIIIYEKETTNEPNNKINIENIKKI
LLRELKITHKDIEGHSKKPEITKARHIYAYLLRNFTELSTVEIGKIIGGKTHSTVLYSINKIDRDRNNDKEINNLITELM
NKIKKN
>Mature_486_residues
MEKSKNIWSLILTEIKKELSEEEFYVWFENLCFLESIGDNIKISTPNLFHKNQIEKRFTKKIKEILIKNGYNNIVIVFTN
QPPKTHSNKQETKNPALNETFSKFDKLKEKTTSKEAIQNIQDRIKMYIKKEEEEPTNFKNPFLKKRYTFENFIIGPNNKL
AYNASLSISKNPGKKYNPCLIYGGVGLGKTHLLQSIGNKTEELHHNLKILYVTAENFLNEFVESIKTHETKKFKKKYRYL
DMLLIDDIHDLQKKEGIQEELFHTFNALYEDNKQLVFTCDRSPSELTNFTDRLKSRFTRGLNVDISKPNFELRAAIVEKK
AEEDGINVPKNILNLVAQKVTTNVRDLEAAVTKLKAYIDLDNIEIDIEIVEKIIKEIIIYEKETTNEPNNKINIENIKKI
LLRELKITHKDIEGHSKKPEITKARHIYAYLLRNFTELSTVEIGKIIGGKTHSTVLYSINKIDRDRNNDKEINNLITELM
NKIKKN

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=484, Percent_Identity=31.8181818181818, Blast_Score=260, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 56784; Mature: 56784

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKSKNIWSLILTEIKKELSEEEFYVWFENLCFLESIGDNIKISTPNLFHKNQIEKRFTK
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
KIKEILIKNGYNNIVIVFTNQPPKTHSNKQETKNPALNETFSKFDKLKEKTTSKEAIQNI
HHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QDRIKMYIKKEEEEPTNFKNPFLKKRYTFENFIIGPNNKLAYNASLSISKNPGKKYNPCL
HHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEECCCCCEEEEEEEEEECCCCCCCCCEE
IYGGVGLGKTHLLQSIGNKTEELHHNLKILYVTAENFLNEFVESIKTHETKKFKKKYRYL
EECCCCCCHHHHHHHHCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DMLLIDDIHDLQKKEGIQEELFHTFNALYEDNKQLVFTCDRSPSELTNFTDRLKSRFTRG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCC
LNVDISKPNFELRAAIVEKKAEEDGINVPKNILNLVAQKVTTNVRDLEAAVTKLKAYIDL
CCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEE
DNIEIDIEIVEKIIKEIIIYEKETTNEPNNKINIENIKKILLRELKITHKDIEGHSKKPE
CCCEEHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCCCCCC
ITKARHIYAYLLRNFTELSTVEIGKIIGGKTHSTVLYSINKIDRDRNNDKEINNLITELM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEHHHHHCCCCCHHHHHHHHHHHH
NKIKKN
HHHHCC
>Mature Secondary Structure
MEKSKNIWSLILTEIKKELSEEEFYVWFENLCFLESIGDNIKISTPNLFHKNQIEKRFTK
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHH
KIKEILIKNGYNNIVIVFTNQPPKTHSNKQETKNPALNETFSKFDKLKEKTTSKEAIQNI
HHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QDRIKMYIKKEEEEPTNFKNPFLKKRYTFENFIIGPNNKLAYNASLSISKNPGKKYNPCL
HHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCEEECCCCCEEEEEEEEEECCCCCCCCCEE
IYGGVGLGKTHLLQSIGNKTEELHHNLKILYVTAENFLNEFVESIKTHETKKFKKKYRYL
EECCCCCCHHHHHHHHCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
DMLLIDDIHDLQKKEGIQEELFHTFNALYEDNKQLVFTCDRSPSELTNFTDRLKSRFTRG
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCC
LNVDISKPNFELRAAIVEKKAEEDGINVPKNILNLVAQKVTTNVRDLEAAVTKLKAYIDL
CCEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEE
DNIEIDIEIVEKIIKEIIIYEKETTNEPNNKINIENIKKILLRELKITHKDIEGHSKKPE
CCCEEHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHCCCCCCCCC
ITKARHIYAYLLRNFTELSTVEIGKIIGGKTHSTVLYSINKIDRDRNNDKEINNLITELM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEHHHHHCCCCCHHHHHHHHHHHH
NKIKKN
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA