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The map label for this gene is tlyC [H]

Identifier: 15594405

GI number: 15594405

Start: 55501

End: 56280

Strand: Reverse

Name: tlyC [H]

Synonym: BB0059

Alternate gene names: 15594405

Gene position: 56280-55501 (Counterclockwise)

Preceding gene: 15594406

Following gene: 15594404

Centisome position: 6.18

GC content: 31.41

Gene sequence:

>780_bases
ATGTTGGGATTTTTTAATTTTAAAAACAAAAAGAAGAAAAAAGGAAGCCCAGAAAATGATCTTGAAGATAAGTCGAATAT
TGAAACTTCTTTGATAAAAAACTTCAATGCGCTTAAAGAGACTGTTGTAAAAGAGATTATGATTCCTAGGATAGGAGTTA
TATTTGTTGATTATGCTAAGAGCAAGGACGAGCTTTTAAAAGTTGTAACATCTAGCAGTCATTCAAGATTTCCTGTGTAT
CATGGTACCATTGACAATATTGTTGGGATAATTCATACAAGAGACATACTATTACATATGTGTAAAAAAGATTTCTACGA
AATAGACTTAAAAGATATTATGCGAAAGGTCATGTTTGTCCCCGAAAGCAAAAAAACAGACTCTCTTTTAAAAGAATTTC
AAGAAAATCATGTTCATATTGCAATTGTGGTTGATGAGTATGGTGGGGTTTCGGGGCTTGTAACTCTTGAAGATATTCTT
GAAGAGATAGTAGGTGACATTCAAGATGAATTTGACAATGAGCTTGATGAAATAGTTCGTCTTGATGATGGATCTTATCT
TTGTGATGCAAGAATTTTAATAGAGGATTTAAATGAGAAACTTAATTTAAATTTGCCAAATGGAGACTTTGATACTCTTG
GCGGTTTCGTTTATGATCTTTTTGGGAGGATTCCTTTGAAAAATGAAAAGGTGGAATATAACAATTTGGTTTTTTCGATT
AAAAATATGCATCAAAGAAATATTAAGGTGATAAAGATTTCCGAGAAGGAAGGTTTATGA

Upstream 100 bases:

>100_bases
GCATTTAATGGGATATAAACATGAAACTAATGATTTTCAAAAGGAAGGTATGTTGATTCTTCAAGAAAATATCTTAAAAG
AAAATAAAAGGGTATTTTAG

Downstream 100 bases:

>100_bases
ATTTTAATTGGTTTTTAATGTTATTCCTTTTTAATTTTAGTGTTCTATTAGGAAGTGATACTACAGCATTAGGACATTAT
CAAAGGGCTAATGAGTATTA

Product: hemolysin C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MLGFFNFKNKKKKKGSPENDLEDKSNIETSLIKNFNALKETVVKEIMIPRIGVIFVDYAKSKDELLKVVTSSSHSRFPVY
HGTIDNIVGIIHTRDILLHMCKKDFYEIDLKDIMRKVMFVPESKKTDSLLKEFQENHVHIAIVVDEYGGVSGLVTLEDIL
EEIVGDIQDEFDNELDEIVRLDDGSYLCDARILIEDLNEKLNLNLPNGDFDTLGGFVYDLFGRIPLKNEKVEYNNLVFSI
KNMHQRNIKVIKISEKEGL

Sequences:

>Translated_259_residues
MLGFFNFKNKKKKKGSPENDLEDKSNIETSLIKNFNALKETVVKEIMIPRIGVIFVDYAKSKDELLKVVTSSSHSRFPVY
HGTIDNIVGIIHTRDILLHMCKKDFYEIDLKDIMRKVMFVPESKKTDSLLKEFQENHVHIAIVVDEYGGVSGLVTLEDIL
EEIVGDIQDEFDNELDEIVRLDDGSYLCDARILIEDLNEKLNLNLPNGDFDTLGGFVYDLFGRIPLKNEKVEYNNLVFSI
KNMHQRNIKVIKISEKEGL
>Mature_259_residues
MLGFFNFKNKKKKKGSPENDLEDKSNIETSLIKNFNALKETVVKEIMIPRIGVIFVDYAKSKDELLKVVTSSSHSRFPVY
HGTIDNIVGIIHTRDILLHMCKKDFYEIDLKDIMRKVMFVPESKKTDSLLKEFQENHVHIAIVVDEYGGVSGLVTLEDIL
EEIVGDIQDEFDNELDEIVRLDDGSYLCDARILIEDLNEKLNLNLPNGDFDTLGGFVYDLFGRIPLKNEKVEYNNLVFSI
KNMHQRNIKVIKISEKEGL

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined [H]

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=193, Percent_Identity=34.7150259067358, Blast_Score=124, Evalue=6e-29,
Organism=Escherichia coli, GI1786879, Length=236, Percent_Identity=38.135593220339, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI145693175, Length=218, Percent_Identity=30.2752293577982, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI87082033, Length=231, Percent_Identity=25.5411255411255, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790664, Length=215, Percent_Identity=27.4418604651163, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788119, Length=243, Percent_Identity=26.3374485596708, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 29770; Mature: 29770

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGFFNFKNKKKKKGSPENDLEDKSNIETSLIKNFNALKETVVKEIMIPRIGVIFVDYAK
CCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
SKDELLKVVTSSSHSRFPVYHGTIDNIVGIIHTRDILLHMCKKDFYEIDLKDIMRKVMFV
CHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHCC
PESKKTDSLLKEFQENHVHIAIVVDEYGGVSGLVTLEDILEEIVGDIQDEFDNELDEIVR
CCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHC
LDDGSYLCDARILIEDLNEKLNLNLPNGDFDTLGGFVYDLFGRIPLKNEKVEYNNLVFSI
CCCCCEEEHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHEEEE
KNMHQRNIKVIKISEKEGL
HHHHHCCEEEEEECCCCCC
>Mature Secondary Structure
MLGFFNFKNKKKKKGSPENDLEDKSNIETSLIKNFNALKETVVKEIMIPRIGVIFVDYAK
CCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
SKDELLKVVTSSSHSRFPVYHGTIDNIVGIIHTRDILLHMCKKDFYEIDLKDIMRKVMFV
CHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHCC
PESKKTDSLLKEFQENHVHIAIVVDEYGGVSGLVTLEDILEEIVGDIQDEFDNELDEIVR
CCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHC
LDDGSYLCDARILIEDLNEKLNLNLPNGDFDTLGGFVYDLFGRIPLKNEKVEYNNLVFSI
CCCCCEEEHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEHHHHEEEE
KNMHQRNIKVIKISEKEGL
HHHHHCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968456 [H]