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The map label for this gene is sdhA [H]

Identifier: 154686979

GI number: 154686979

Start: 2669747

End: 2671507

Strand: Reverse

Name: sdhA [H]

Synonym: RBAM_025510

Alternate gene names: 154686979

Gene position: 2671507-2669747 (Counterclockwise)

Preceding gene: 154686980

Following gene: 154686978

Centisome position: 68.18

GC content: 50.71

Gene sequence:

>1761_bases
ATGAGTCAATCAAGCATTATCGTAGTCGGCGGGGGTCTTGCCGGCCTCATGGCGACAATTAAAGCAGCGGAATCAGGCAC
GGCCGTTAAATTGTTTTCCATCGTTCCGGTCAAACGCTCTCACTCGGTCTGCGCGCAGGGCGGGATAAACGGAGCTGTCA
ACACAAAAGGGGAAGGAGACTCTCCGTTTGAGCATTTTGATGACACGGTATACGGAGGCGACTTTTTGGCAAACCAGCCT
CCTGTAAAAGCGATGTGTGAAGCGGCGCCGTCCATTATCCACTTATTGGACCGCATGGGGGTTATGTTTAACAGAACGCC
GGAAGGGCTCTTGGACTTCCGCCGTTTCGGGGGTACACAGCATCACAGAACCGCATACGCGGGAGCGACGACGGGTCAGC
AGCTTCTTTACGCACTGGACGAGCAGGTGCGCAGATATGAAGTGGCGGGTCTCGTCACAAAATACGAAGGCTGGGAATTC
CTCGGCGCCGTTCTTGACGATGAGCGCACGTGCCGCGGTATCGTAGCCCAAAATCTGACCAATATGCAAATCGAGTCATT
CCGTTCTGACGCCGTTATTATGGCGACGGGAGGACCCGGAATCGTATTCGGCAAATCAACAAACAGCATGATCAACACGG
GATCTGCCGCATCAATCGTTTATCAGCAGGGCGCTTATTATGCAAACGGCGAATTTATCCAAATTCACCCGACAGCAATC
CCGGGGGACGATAAACTGCGTTTGATGAGTGAATCGGCGCGCGGCGAGGGCGGAAGAGTCTGGACGTACAAAGACGGAAA
ACCTTGGTACTTCCTTGAGGAAAAATATCCGGCTTACGGAAACCTCGTGCCGCGGGATATTGCGACACGTGAAATCTTTG
ACGTGTGCGTGAATCAGAAACTCGGCATCAACGGAGAAAACATGGTGTATCTCGATCTGTCGCACAAAGATCCGAAAGAG
CTCGACGTTAAGCTTGGCGGCATTATCGAAATCTATGAAAAATTCATGGGCGATGACCCGCGCAAGCTTCCGATGAAAAT
TTTCCCTGCCGTTCACTATTCAATGGGCGGACTGTGGGTTGATTATGATCAGATGACAAGCATCCGCGGACTGTTCGCAG
CGGGTGAATGTGATTATTCAATGCACGGAGGAAACCGTTTAGGGGCGAACTCTCTGCTTTCCGCCATCTACGGAGGAATG
GTGGCCGGACCGAATGCGGTGAAATATGTTTCCGGACTTGAAACATCAGCGGAAGACCTGTCTTCTTCATTATTTGATTC
CTATGTGAAAAAAGAAGAAGAAAAATGGGCCGATATTATGAAGATGGACGGCGACGAAAATGCCTACGTGCTTCACCGTG
AGCTCGGAGAATGGATGACGGCCAACGTCACGGTGGTCCGCCACAACGACAAGCTTTTGAAAACGGATGACAAAATCCAA
GAGCTGATGGAACGCTTTAAGAAAATCAATATCAACGATACGACAAAATGGAGCAACCAAGGGGCGATGTTCACCCGCCA
GTTCTCCAATATGCTTCAGCTTGCCAGAGTTATCACGCTCGGCGCATATAACCGAAATGAAAGCCGGGGAGCGCACTATA
AACCGGATTTCCCTGAAAGAAATGACGATGAGTGGCTCAAAACGACGATGGCGAAACATGCCGGTCCGTTTGAAGCTCCG
GAATTTGAATATCAGGATGTCGATGTATCACTGATTGCGCCCCGTAAACGCGACTACTCGAAGAAGAAGGTGGCGAAATA
A

Upstream 100 bases:

>100_bases
CGTGACGCTGATTATATTTTTAGCGCTTTCATACGTAGGTTTAAAAGCGATTTTTGCGTTTGTGTAAGAGAACTAGATTA
CTAGAGGGAGAGGGGCTATC

Downstream 100 bases:

>100_bases
TCATGAGTGAGAAAAAGATACGGTTTATCATTACACGTCAGGATACGCCCGAAAGCGCGCCATACGATGAAGAATTCGAA
ATCAATTACCGCCCGAACCT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MSQSSIIVVGGGLAGLMATIKAAESGTAVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPFEHFDDTVYGGDFLANQP
PVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF
LGAVLDDERTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIVFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKE
LDVKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTSIRGLFAAGECDYSMHGGNRLGANSLLSAIYGGM
VAGPNAVKYVSGLETSAEDLSSSLFDSYVKKEEEKWADIMKMDGDENAYVLHRELGEWMTANVTVVRHNDKLLKTDDKIQ
ELMERFKKININDTTKWSNQGAMFTRQFSNMLQLARVITLGAYNRNESRGAHYKPDFPERNDDEWLKTTMAKHAGPFEAP
EFEYQDVDVSLIAPRKRDYSKKKVAK

Sequences:

>Translated_586_residues
MSQSSIIVVGGGLAGLMATIKAAESGTAVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPFEHFDDTVYGGDFLANQP
PVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF
LGAVLDDERTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIVFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKE
LDVKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTSIRGLFAAGECDYSMHGGNRLGANSLLSAIYGGM
VAGPNAVKYVSGLETSAEDLSSSLFDSYVKKEEEKWADIMKMDGDENAYVLHRELGEWMTANVTVVRHNDKLLKTDDKIQ
ELMERFKKININDTTKWSNQGAMFTRQFSNMLQLARVITLGAYNRNESRGAHYKPDFPERNDDEWLKTTMAKHAGPFEAP
EFEYQDVDVSLIAPRKRDYSKKKVAK
>Mature_585_residues
SQSSIIVVGGGLAGLMATIKAAESGTAVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGDSPFEHFDDTVYGGDFLANQPP
VKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEFL
GAVLDDERTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIVFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAIP
GDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKEL
DVKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTSIRGLFAAGECDYSMHGGNRLGANSLLSAIYGGMV
AGPNAVKYVSGLETSAEDLSSSLFDSYVKKEEEKWADIMKMDGDENAYVLHRELGEWMTANVTVVRHNDKLLKTDDKIQE
LMERFKKININDTTKWSNQGAMFTRQFSNMLQLARVITLGAYNRNESRGAHYKPDFPERNDDEWLKTTMAKHAGPFEAPE
FEYQDVDVSLIAPRKRDYSKKKVAK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=554, Percent_Identity=30.5054151624549, Blast_Score=212, Evalue=6e-55,
Organism=Escherichia coli, GI1790597, Length=570, Percent_Identity=33.3333333333333, Blast_Score=278, Evalue=1e-75,
Organism=Escherichia coli, GI1786942, Length=552, Percent_Identity=30.6159420289855, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788928, Length=569, Percent_Identity=27.768014059754, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17505833, Length=542, Percent_Identity=30.8118081180812, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17550100, Length=544, Percent_Identity=31.0661764705882, Blast_Score=215, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6322701, Length=557, Percent_Identity=32.4955116696589, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322416, Length=567, Percent_Identity=30.3350970017637, Blast_Score=216, Evalue=8e-57,
Organism=Drosophila melanogaster, GI17137288, Length=538, Percent_Identity=31.5985130111524, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655642, Length=538, Percent_Identity=31.5985130111524, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655647, Length=538, Percent_Identity=31.5985130111524, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24663005, Length=604, Percent_Identity=29.9668874172185, Blast_Score=218, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65076; Mature: 64944

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSSIIVVGGGLAGLMATIKAAESGTAVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCC
SPFEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQ
CCHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHCCCCC
HHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEFLGAVLDDERTCRGIVAQNLT
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCHHHHHHHHHCCC
NMQIESFRSDAVIMATGGPGIVFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
CHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCCCCEEEEEECCCEEECCCEEEEECCCC
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQK
CCCCCEEEEEHHCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCC
LGINGENMVYLDLSHKDPKELDVKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWV
CCCCCCCEEEEEECCCCCHHHHEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
DYDQMTSIRGLFAAGECDYSMHGGNRLGANSLLSAIYGGMVAGPNAVKYVSGLETSAEDL
EHHHHHHHHHEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHH
SSSLFDSYVKKEEEKWADIMKMDGDENAYVLHRELGEWMTANVTVVRHNDKLLKTDDKIQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCEEEEEEEEEECCCEECCCHHHH
ELMERFKKININDTTKWSNQGAMFTRQFSNMLQLARVITLGAYNRNESRGAHYKPDFPER
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDDEWLKTTMAKHAGPFEAPEFEYQDVDVSLIAPRKRDYSKKKVAK
CCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHCCC
>Mature Secondary Structure 
SQSSIIVVGGGLAGLMATIKAAESGTAVKLFSIVPVKRSHSVCAQGGINGAVNTKGEGD
CCCCEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCC
SPFEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVMFNRTPEGLLDFRRFGGTQ
CCHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHCCCCC
HHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEFLGAVLDDERTCRGIVAQNLT
CCCEEECCCCCHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCHHHHHHHHHCCC
NMQIESFRSDAVIMATGGPGIVFGKSTNSMINTGSAASIVYQQGAYYANGEFIQIHPTAI
CHHHHHCCCCEEEEEECCCEEEEECCCCCCCCCCCCEEEEEECCCEEECCCEEEEECCCC
PGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKYPAYGNLVPRDIATREIFDVCVNQK
CCCCCEEEEEHHCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCC
LGINGENMVYLDLSHKDPKELDVKLGGIIEIYEKFMGDDPRKLPMKIFPAVHYSMGGLWV
CCCCCCCEEEEEECCCCCHHHHEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEE
DYDQMTSIRGLFAAGECDYSMHGGNRLGANSLLSAIYGGMVAGPNAVKYVSGLETSAEDL
EHHHHHHHHHEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHH
SSSLFDSYVKKEEEKWADIMKMDGDENAYVLHRELGEWMTANVTVVRHNDKLLKTDDKIQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHCCCEEEEEEEEEECCCEECCCHHHH
ELMERFKKININDTTKWSNQGAMFTRQFSNMLQLARVITLGAYNRNESRGAHYKPDFPER
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
NDDEWLKTTMAKHAGPFEAPEFEYQDVDVSLIAPRKRDYSKKKVAK
CCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]