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The map label for this gene is hemA [H]

Identifier: 154686953

GI number: 154686953

Start: 2642332

End: 2643708

Strand: Reverse

Name: hemA [H]

Synonym: RBAM_025230

Alternate gene names: 154686953

Gene position: 2643708-2642332 (Counterclockwise)

Preceding gene: 154686955

Following gene: 154686952

Centisome position: 67.47

GC content: 48.8

Gene sequence:

>1377_bases
ATGAAAGCGATGCATATTCTTGTTGTGGGAGTAGATTATAAATCCGCCCCTATTGAAATACGCGAAAAAATAAGTTTTCA
GCCGGATGAGCTTGCAGAAGCGATGCTCCGTTTAAAAGGAGAAAAAAGTGTTCTTGAAAACATTATCGTGTCAACCTGCA
ACCGCACCGAAATATATGCGGTGGTCGACCAGCTTCATACCGGCCGTTATTATATAAAGACATTTTTATCCGAATGGTTC
TCGCTGCCGAAAGAAGAGCTGTCTCCGTTTCTGAAATTTTATGAGAGCGACGCGGCGATCGAGCATTTATTCCGTGTGGC
GTGCGGCTTGGATTCCATGGTCATCGGAGAAACGCAAATACTCGGCCAGGTCCGCTCAAGCTTTAAAACGGCGCAGGCAG
AAAAGACGATCGGCACCATTTTCAATGAGCTGTTTAAACAGGCGGTGACCGTCGGCAAACGCACGCATGCCGAAACCGAT
ATCGGCGCCAATGCCGTTTCCGTCAGTTACGCCGCCGTTGAACTCGCGAAAAAAATCTTCGGCTCATTGTCAAATAAGCA
CATTTTGATTCTCGGTGCGGGAAAAATGGGCGAGCTCGCCGCAGAAAACCTGCACGGTCAGGGCATCGGCAAAGTAACGG
TCATCAACAGAACGTTTTTGAAGGCAAAAGCGCTTGCTGACCGTTTCTCCGGAGAAGCGCGCAGCTTAAACCAGCTTGAA
CATGCACTTGCTGAAGCTGATATTTTAATCAGTTCGACAGGCGCAAGTGATTTCGTCGTGTCTAAAGAAATGATGGAGAG
AGCGGGCAGACAGCGGAAAGGCCGCCCGTTATTTATGGTGGATATCGCTGTGCCGAGGGACCTCGATCCGGCGCTGAACG
ATCTTGAAGGTGTTTTTCTGTACGATATTGATGACCTTGAAGGAATCGTTGAAGCCAACTTACAAGAACGCCGTGAAACC
GCTGAAAAAGTCGAGCTGTTTATTGAAGCGGCAATTGTTGAGTTTAAGCAGTGGCTTAATACGCTCGGCGTCGTGCCGGT
CATTTCGGCGCTGCGTGAAAAGGCGCTGTCCATCCAGTCCGATACGATGCAGAGCATTGAGCGCAAGCTGCCTCATCTGA
CGGTAAGAGAGAAAAAACTTCTCAGCAAACATACGAAAAGCATCATTAACCAAATGCTGCGCGACCCGATTCTGAAAGCG
AAAGAGCTTGCGGCTGAAGCGGATTCGGAAGAAAAGCTGAAGCTGTTTATGCAAATATTCGATATTGAGGAAGAGGCCGG
CCGCCAGCTGGACAAAAGCCTGGATAACCGCCAGACGGTTCATTCGTTTCAAAAGGCAGAAGCAAAAACGGGCTTACGTC
CGCTTGTAAGTGAGTGA

Upstream 100 bases:

>100_bases
AATCTGTTCACATTTTCCCGAAGAAACTATGTTATAATCATTATAAATAATAAATTCTATGTTAGAATGATTATAAATAA
ATTGCGATGTACGGGGGTGC

Downstream 100 bases:

>100_bases
GGGCTGTATGATTGATACAGCAATGGCAAGACTTAATGAAGCGACAATTGTTATTTATGCAGTAAGCGTCCTTTTTTACT
TTATAGATTTTCTTCAACAC

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKAMHILVVGVDYKSAPIEIREKISFQPDELAEAMLRLKGEKSVLENIIVSTCNRTEIYAVVDQLHTGRYYIKTFLSEWF
SLPKEELSPFLKFYESDAAIEHLFRVACGLDSMVIGETQILGQVRSSFKTAQAEKTIGTIFNELFKQAVTVGKRTHAETD
IGANAVSVSYAAVELAKKIFGSLSNKHILILGAGKMGELAAENLHGQGIGKVTVINRTFLKAKALADRFSGEARSLNQLE
HALAEADILISSTGASDFVVSKEMMERAGRQRKGRPLFMVDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANLQERRET
AEKVELFIEAAIVEFKQWLNTLGVVPVISALREKALSIQSDTMQSIERKLPHLTVREKKLLSKHTKSIINQMLRDPILKA
KELAAEADSEEKLKLFMQIFDIEEEAGRQLDKSLDNRQTVHSFQKAEAKTGLRPLVSE

Sequences:

>Translated_458_residues
MKAMHILVVGVDYKSAPIEIREKISFQPDELAEAMLRLKGEKSVLENIIVSTCNRTEIYAVVDQLHTGRYYIKTFLSEWF
SLPKEELSPFLKFYESDAAIEHLFRVACGLDSMVIGETQILGQVRSSFKTAQAEKTIGTIFNELFKQAVTVGKRTHAETD
IGANAVSVSYAAVELAKKIFGSLSNKHILILGAGKMGELAAENLHGQGIGKVTVINRTFLKAKALADRFSGEARSLNQLE
HALAEADILISSTGASDFVVSKEMMERAGRQRKGRPLFMVDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANLQERRET
AEKVELFIEAAIVEFKQWLNTLGVVPVISALREKALSIQSDTMQSIERKLPHLTVREKKLLSKHTKSIINQMLRDPILKA
KELAAEADSEEKLKLFMQIFDIEEEAGRQLDKSLDNRQTVHSFQKAEAKTGLRPLVSE
>Mature_458_residues
MKAMHILVVGVDYKSAPIEIREKISFQPDELAEAMLRLKGEKSVLENIIVSTCNRTEIYAVVDQLHTGRYYIKTFLSEWF
SLPKEELSPFLKFYESDAAIEHLFRVACGLDSMVIGETQILGQVRSSFKTAQAEKTIGTIFNELFKQAVTVGKRTHAETD
IGANAVSVSYAAVELAKKIFGSLSNKHILILGAGKMGELAAENLHGQGIGKVTVINRTFLKAKALADRFSGEARSLNQLE
HALAEADILISSTGASDFVVSKEMMERAGRQRKGRPLFMVDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANLQERRET
AEKVELFIEAAIVEFKQWLNTLGVVPVISALREKALSIQSDTMQSIERKLPHLTVREKKLLSKHTKSIINQMLRDPILKA
KELAAEADSEEKLKLFMQIFDIEEEAGRQLDKSLDNRQTVHSFQKAEAKTGLRPLVSE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=352, Percent_Identity=38.6363636363636, Blast_Score=257, Evalue=9e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 51129; Mature: 51129

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMHILVVGVDYKSAPIEIREKISFQPDELAEAMLRLKGEKSVLENIIVSTCNRTEIYA
CCCEEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
VVDQLHTGRYYIKTFLSEWFSLPKEELSPFLKFYESDAAIEHLFRVACGLDSMVIGETQI
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHH
LGQVRSSFKTAQAEKTIGTIFNELFKQAVTVGKRTHAETDIGANAVSVSYAAVELAKKIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GSLSNKHILILGAGKMGELAAENLHGQGIGKVTVINRTFLKAKALADRFSGEARSLNQLE
HCCCCCEEEEEECCCHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHH
HALAEADILISSTGASDFVVSKEMMERAGRQRKGRPLFMVDIAVPRDLDPALNDLEGVFL
HHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHCCCCEEE
YDIDDLEGIVEANLQERRETAEKVELFIEAAIVEFKQWLNTLGVVPVISALREKALSIQS
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
DTMQSIERKLPHLTVREKKLLSKHTKSIINQMLRDPILKAKELAAEADSEEKLKLFMQIF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DIEEEAGRQLDKSLDNRQTVHSFQKAEAKTGLRPLVSE
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKAMHILVVGVDYKSAPIEIREKISFQPDELAEAMLRLKGEKSVLENIIVSTCNRTEIYA
CCCEEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
VVDQLHTGRYYIKTFLSEWFSLPKEELSPFLKFYESDAAIEHLFRVACGLDSMVIGETQI
HHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHH
LGQVRSSFKTAQAEKTIGTIFNELFKQAVTVGKRTHAETDIGANAVSVSYAAVELAKKIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GSLSNKHILILGAGKMGELAAENLHGQGIGKVTVINRTFLKAKALADRFSGEARSLNQLE
HCCCCCEEEEEECCCHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHH
HALAEADILISSTGASDFVVSKEMMERAGRQRKGRPLFMVDIAVPRDLDPALNDLEGVFL
HHHHHHHHEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHCCCCEEE
YDIDDLEGIVEANLQERRETAEKVELFIEAAIVEFKQWLNTLGVVPVISALREKALSIQS
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
DTMQSIERKLPHLTVREKKLLSKHTKSIINQMLRDPILKAKELAAEADSEEKLKLFMQIF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
DIEEEAGRQLDKSLDNRQTVHSFQKAEAKTGLRPLVSE
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA