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The map label for this gene is comC [H]

Identifier: 154686942

GI number: 154686942

Start: 2628877

End: 2629629

Strand: Reverse

Name: comC [H]

Synonym: RBAM_025120

Alternate gene names: 154686942

Gene position: 2629629-2628877 (Counterclockwise)

Preceding gene: 154686943

Following gene: 154686941

Centisome position: 67.11

GC content: 49.93

Gene sequence:

>753_bases
GTGCTTTTGATTCTGTTTTTTCTAGGCTTGATTTTCGGTTCTTTTTTTTATACAGCAGCGTGCCGTATCCCGCTGCGAAT
CTCGGTTATTTCGCCGCGTTCAGCCTGTTCGTTTTGCCGCTTGCCGCTCTCCTGGGGGGAGCTTGTGCCCGTCGTTTCCT
ATATTCTGCAAAGAGGCAGATGCAGAAACTGCCGTGCGAAGCTGTCGGTTATGTATCCGGCGGCGGAATGCTGGACGGCA
TGTTTATTCACGGCTGCAGGCATTCATTTCGGTTTCTCAAAAGAACTGTTAGTCGCGCTGTTATTTCTGTCTCTGCTCAT
GATTGTTACTATGACGGATCTGCAATATATGCTGATTCCTGACAAAGTTCTGCTGTTTTTTCTTCCGCTTTTCATCGCCG
GGCGTATGTTTTCTCCGCTGGATTCATGGTATGCAGGGTTTGCCGGAGCCGTTTGCGGATTTTTTCTGCTTGTTTTTATC
ATGTTTGTCAGTAAAGGAGGCATCGGCGCAGGTGATGTGAAACTGTTTGGGGTGATCGGCCTGACGCTCGGCGTAAAGCT
CGTGCTCATTGCATTCTTTCTTTCCGTTATGATCGGAGCCGTATACGGTATGTGCGCCGCAGCCCGGGGCAGGCTTGGTA
AAAAGCAGCCATTTCCGTTTGCGCCGGCCATCTCAGCCGGGAGCGCTTTGAGTTATTTATACGGTGAAGAGCTGTTTTCG
TTTTACATCAAGCTCGCTTCAGGAGGGGCTTGA

Upstream 100 bases:

>100_bases
CCGGGTGTTTTTATGCTGAAAATATATTTTCAGCCATTTTAGTCATGGTGTTTTTCTTTGCTATAATCTGAGCCAGATTG
ATAGTAAAGGTGTGGTCTGA

Downstream 100 bases:

>100_bases
AAAATTTGGCGAACGTTTTTTGGACAAGACGACAAAAGTCTTGTTCTTTTTTTTTTCGCCTATGCTAAAGTGTGAACCAT
GATCAGTTCAAGGTACGGCC

Product: hypothetical protein

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MLLILFFLGLIFGSFFYTAACRIPLRISVISPRSACSFCRLPLSWGELVPVVSYILQRGRCRNCRAKLSVMYPAAECWTA
CLFTAAGIHFGFSKELLVALLFLSLLMIVTMTDLQYMLIPDKVLLFFLPLFIAGRMFSPLDSWYAGFAGAVCGFFLLVFI
MFVSKGGIGAGDVKLFGVIGLTLGVKLVLIAFFLSVMIGAVYGMCAAARGRLGKKQPFPFAPAISAGSALSYLYGEELFS
FYIKLASGGA

Sequences:

>Translated_250_residues
MLLILFFLGLIFGSFFYTAACRIPLRISVISPRSACSFCRLPLSWGELVPVVSYILQRGRCRNCRAKLSVMYPAAECWTA
CLFTAAGIHFGFSKELLVALLFLSLLMIVTMTDLQYMLIPDKVLLFFLPLFIAGRMFSPLDSWYAGFAGAVCGFFLLVFI
MFVSKGGIGAGDVKLFGVIGLTLGVKLVLIAFFLSVMIGAVYGMCAAARGRLGKKQPFPFAPAISAGSALSYLYGEELFS
FYIKLASGGA
>Mature_250_residues
MLLILFFLGLIFGSFFYTAACRIPLRISVISPRSACSFCRLPLSWGELVPVVSYILQRGRCRNCRAKLSVMYPAAECWTA
CLFTAAGIHFGFSKELLVALLFLSLLMIVTMTDLQYMLIPDKVLLFFLPLFIAGRMFSPLDSWYAGFAGAVCGFFLLVFI
MFVSKGGIGAGDVKLFGVIGLTLGVKLVLIAFFLSVMIGAVYGMCAAARGRLGKKQPFPFAPAISAGSALSYLYGEELFS
FYIKLASGGA

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=256, Percent_Identity=26.953125, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27220; Mature: 27220

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHCCCC
>Mature Secondary Structure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HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]