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The map label for this gene is pbpA [H]

Identifier: 154686762

GI number: 154686762

Start: 2452456

End: 2454603

Strand: Reverse

Name: pbpA [H]

Synonym: RBAM_023320

Alternate gene names: 154686762

Gene position: 2454603-2452456 (Counterclockwise)

Preceding gene: 154686763

Following gene: 154686759

Centisome position: 62.64

GC content: 40.36

Gene sequence:

>2148_bases
ATGAGGAGAAATAAAAAGAAAATAGCTGTAAACAAAGAAAAGAAAAAATCACTGCCGATCCGGCTTAATTTTTTGTTTTT
GGCCGCGTTTCTTATTTTTACTTGGATTATCGTCGAGCTTGGCATCAAGCAGATCGTTCAGGGTGATGATTATAAAAACG
CCGCTAATAAGCAGGAGGAGTCTGATGTCAGCACGGCGGTTCCGAGAGGGAAAATATACGACCGGAACCTAAATCCCATC
GTAACGAATAAAGCATTAAATGCGATTACATATACACGTTCAGCCTCAACCACCCAGGCGCAGCGTTTAAAAATCGCAAA
AAAACTGTCGGGTATGATTAAGGTAAGCACCAAAAAGGTGACTGAGCGGGATAAAAAAGACTATTGGATGTTAACGAGGC
CTGATGAAGCGAAAAAACTGATTACGGCCGAAGAAAAGCAAAAAGCTGAAGACAAAAAACTGTCTGACGATGATTTATAT
CAGCTTCAGCTGAAACGCATCACAGACAAACAGCTGAATGAGCTCACTTCAAAAGACATGCAGATCCTTGCGATCAAAAG
GCAGATGGATTCAGGCTACTCCCTGACGCCTCAATACATCAAAAATGAAGGCGTGTCGGCAAAAGAAATGGCCGTCGTCA
GCGAACATTTAGATGAACTGCCGGGAGTTGACGTGACGTCTGACTGGGAACGGTCTTATCCAAATAAAGGGTTGTTAAAA
TCAGTTCTCGGCAGTGTCTCGAGCTCCAACGAAGGACTCCCTTCAAATCTTCTTGAGCATTATTTGTCACTTGGCTACAG
CAGGAATGACAGAGTAGGAAAAAGTTATTTAGAGTATCAATATGAAAATCTGCTGCAGGGCCAAAAAGAGAAAGTGAGAA
ATGTGACAGATTCCTCTGGAAACGTAACAGATACAGAAACGGTTTCAAAAGGTAAAGCCGGGGATGATTTAGTGCTCACT
ATAGATACCGAATTGCAAAAAGACGTTGAAAAAATTATTGAGAAAAATTTAAGGGCTGCAAAGGCAAGACCGAGTACACA
GTTGCTTGACAGAGCATTTGTCGTAATGATGGATCCCCGTAATGGAGAAGTGCTTACAATGGCGGGTAAACAGATTAAAC
AAGTAGACGGCAAATATAAAATCGATGATTATGCACTAGGAACAATGACTTCCTCTTATAACATGGGCTCAGCTGTAAAA
GGGGCAACATTGTTAACAGGTTATCAAACAGGTGCTATAAAAATCGGAAATATATTTACGGATGAAGTTTTAAATATTAA
AGACTCTCCTCCTAAAAAATCGGTAAGTGTAATGGGGCCGATAAATGATTTAACTGCACTTGAGCGTTCATCTAACGTTT
ATATGTTCAAAACTGCGATTGCAATTGGTAAGGGTAAATATATATCAGGACATCCACTTCCGCTTGATTACAGCGCATTT
GATAAATTTCGTTATTACTTCAGTGAATTCGGTTTAGGGGTAAAAACAGGAATTGACCTGCCTAACGAAGCTACAGGATA
TGTGGGAACTAAAAGACAGTCAGGTTTCTTGCTTGATTTTGCGATCGGCCAATATGACACATACACTCCGCTTCAAATGG
CTCAGTATGTATCGACCATTGCTAATGGCGGCTATCGTATGAAGCCCCAAGTCGTGAAAGAAGTAAGAAAACCTTCAAAA
AAAGGTATCGGGGCCGTCGTTGAATCTGTTAATCCGGAAGTGATGAACCGTCTTGATATGACGGAAAGTGAAATTGAACG
TGTTCAACAAGGCTTTAAACTTGTTATGAATGGAGCTCAAGGGACTGCGAGAGCAAATTTTGCTAATAAAAGTTATCACC
CTGCCGGTAAAACTGGAACAGCACAAGCTTTCTATGATGGACCTATAAAATCAAGAACTGGTGCTTCTACTTATAACACA
ACTTTGGTGGCTTATGCTCCCGCAGATCATCCTGAAGTTGCTATTTCAGTAGTGGTTCCATGGGCTTATGAAAATTATAA
TGACAGGTATTCAATAACTAATGACATTGGGGAAGCAGCTCTGGACAAATACTTTGAGCTGAAAAAGAAACAAGAAGATA
ATAATACGAAGCAGAAAAACGAAGATAAAATTCAGGAAGACGCTGAAAACGGCAATACAAATCACTAA

Upstream 100 bases:

>100_bases
AGGGTTATCTGTAGAAAAATATCGAAAAAACCTTTAGAATGAAAAATGGCACCTGAACAGAAGGTGTCATTTCTTTCTGT
AAATAAGAAAAGGTGATGTC

Downstream 100 bases:

>100_bases
CAGAAAAACGCTCACAACTTGGGGACTGCCCCCCGTTTTTGAGACAGGGGTCAAAACACCTTTTAAACAGCCAATTGCCG
ATAGTTTATCGGTGATTGGT

Product: PbpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 715; Mature: 715

Protein sequence:

>715_residues
MRRNKKKIAVNKEKKKSLPIRLNFLFLAAFLIFTWIIVELGIKQIVQGDDYKNAANKQEESDVSTAVPRGKIYDRNLNPI
VTNKALNAITYTRSASTTQAQRLKIAKKLSGMIKVSTKKVTERDKKDYWMLTRPDEAKKLITAEEKQKAEDKKLSDDDLY
QLQLKRITDKQLNELTSKDMQILAIKRQMDSGYSLTPQYIKNEGVSAKEMAVVSEHLDELPGVDVTSDWERSYPNKGLLK
SVLGSVSSSNEGLPSNLLEHYLSLGYSRNDRVGKSYLEYQYENLLQGQKEKVRNVTDSSGNVTDTETVSKGKAGDDLVLT
IDTELQKDVEKIIEKNLRAAKARPSTQLLDRAFVVMMDPRNGEVLTMAGKQIKQVDGKYKIDDYALGTMTSSYNMGSAVK
GATLLTGYQTGAIKIGNIFTDEVLNIKDSPPKKSVSVMGPINDLTALERSSNVYMFKTAIAIGKGKYISGHPLPLDYSAF
DKFRYYFSEFGLGVKTGIDLPNEATGYVGTKRQSGFLLDFAIGQYDTYTPLQMAQYVSTIANGGYRMKPQVVKEVRKPSK
KGIGAVVESVNPEVMNRLDMTESEIERVQQGFKLVMNGAQGTARANFANKSYHPAGKTGTAQAFYDGPIKSRTGASTYNT
TLVAYAPADHPEVAISVVVPWAYENYNDRYSITNDIGEAALDKYFELKKKQEDNNTKQKNEDKIQEDAENGNTNH

Sequences:

>Translated_715_residues
MRRNKKKIAVNKEKKKSLPIRLNFLFLAAFLIFTWIIVELGIKQIVQGDDYKNAANKQEESDVSTAVPRGKIYDRNLNPI
VTNKALNAITYTRSASTTQAQRLKIAKKLSGMIKVSTKKVTERDKKDYWMLTRPDEAKKLITAEEKQKAEDKKLSDDDLY
QLQLKRITDKQLNELTSKDMQILAIKRQMDSGYSLTPQYIKNEGVSAKEMAVVSEHLDELPGVDVTSDWERSYPNKGLLK
SVLGSVSSSNEGLPSNLLEHYLSLGYSRNDRVGKSYLEYQYENLLQGQKEKVRNVTDSSGNVTDTETVSKGKAGDDLVLT
IDTELQKDVEKIIEKNLRAAKARPSTQLLDRAFVVMMDPRNGEVLTMAGKQIKQVDGKYKIDDYALGTMTSSYNMGSAVK
GATLLTGYQTGAIKIGNIFTDEVLNIKDSPPKKSVSVMGPINDLTALERSSNVYMFKTAIAIGKGKYISGHPLPLDYSAF
DKFRYYFSEFGLGVKTGIDLPNEATGYVGTKRQSGFLLDFAIGQYDTYTPLQMAQYVSTIANGGYRMKPQVVKEVRKPSK
KGIGAVVESVNPEVMNRLDMTESEIERVQQGFKLVMNGAQGTARANFANKSYHPAGKTGTAQAFYDGPIKSRTGASTYNT
TLVAYAPADHPEVAISVVVPWAYENYNDRYSITNDIGEAALDKYFELKKKQEDNNTKQKNEDKIQEDAENGNTNH
>Mature_715_residues
MRRNKKKIAVNKEKKKSLPIRLNFLFLAAFLIFTWIIVELGIKQIVQGDDYKNAANKQEESDVSTAVPRGKIYDRNLNPI
VTNKALNAITYTRSASTTQAQRLKIAKKLSGMIKVSTKKVTERDKKDYWMLTRPDEAKKLITAEEKQKAEDKKLSDDDLY
QLQLKRITDKQLNELTSKDMQILAIKRQMDSGYSLTPQYIKNEGVSAKEMAVVSEHLDELPGVDVTSDWERSYPNKGLLK
SVLGSVSSSNEGLPSNLLEHYLSLGYSRNDRVGKSYLEYQYENLLQGQKEKVRNVTDSSGNVTDTETVSKGKAGDDLVLT
IDTELQKDVEKIIEKNLRAAKARPSTQLLDRAFVVMMDPRNGEVLTMAGKQIKQVDGKYKIDDYALGTMTSSYNMGSAVK
GATLLTGYQTGAIKIGNIFTDEVLNIKDSPPKKSVSVMGPINDLTALERSSNVYMFKTAIAIGKGKYISGHPLPLDYSAF
DKFRYYFSEFGLGVKTGIDLPNEATGYVGTKRQSGFLLDFAIGQYDTYTPLQMAQYVSTIANGGYRMKPQVVKEVRKPSK
KGIGAVVESVNPEVMNRLDMTESEIERVQQGFKLVMNGAQGTARANFANKSYHPAGKTGTAQAFYDGPIKSRTGASTYNT
TLVAYAPADHPEVAISVVVPWAYENYNDRYSITNDIGEAALDKYFELKKKQEDNNTKQKNEDKIQEDAENGNTNH

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=530, Percent_Identity=24.3396226415094, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI1786272, Length=461, Percent_Identity=25.5965292841649, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 79802; Mature: 79802

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRNKKKIAVNKEKKKSLPIRLNFLFLAAFLIFTWIIVELGIKQIVQGDDYKNAANKQEE
CCCCCCCEEECCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
SDVSTAVPRGKIYDRNLNPIVTNKALNAITYTRSASTTQAQRLKIAKKLSGMIKVSTKKV
HHHHHCCCCCCEECCCCCCEEEHHHHHHEEEECCCCCHHHHHHHHHHHHCCCEEEHHHHH
TERDKKDYWMLTRPDEAKKLITAEEKQKAEDKKLSDDDLYQLQLKRITDKQLNELTSKDM
HHCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
QILAIKRQMDSGYSLTPQYIKNEGVSAKEMAVVSEHLDELPGVDVTSDWERSYPNKGLLK
EEEEEHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHH
SVLGSVSSSNEGLPSNLLEHYLSLGYSRNDRVGKSYLEYQYENLLQGQKEKVRNVTDSSG
HHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCC
NVTDTETVSKGKAGDDLVLTIDTELQKDVEKIIEKNLRAAKARPSTQLLDRAFVVMMDPR
CCCCCHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHCCEEEEEECCC
NGEVLTMAGKQIKQVDGKYKIDDYALGTMTSSYNMGSAVKGATLLTGYQTGAIKIGNIFT
CCCEEEECCHHHHHCCCCEEECCEEEECEECCCCCCCCCCCCEEEEECCCCCEEECCEEC
DEVLNIKDSPPKKSVSVMGPINDLTALERSSNVYMFKTAIAIGKGKYISGHPLPLDYSAF
CHHCCCCCCCCCCCEEEECCCHHHHHHHCCCCEEEEEEEEEECCCCEECCCCCCCCHHHH
DKFRYYFSEFGLGVKTGIDLPNEATGYVGTKRQSGFLLDFAIGQYDTYTPLQMAQYVSTI
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHH
ANGGYRMKPQVVKEVRKPSKKGIGAVVESVNPEVMNRLDMTESEIERVQQGFKLVMNGAQ
HCCCEEECHHHHHHHHCCHHCCHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
GTARANFANKSYHPAGKTGTAQAFYDGPIKSRTGASTYNTTLVAYAPADHPEVAISVVVP
CCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEE
WAYENYNDRYSITNDIGEAALDKYFELKKKQEDNNTKQKNEDKIQEDAENGNTNH
EHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRRNKKKIAVNKEKKKSLPIRLNFLFLAAFLIFTWIIVELGIKQIVQGDDYKNAANKQEE
CCCCCCCEEECCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
SDVSTAVPRGKIYDRNLNPIVTNKALNAITYTRSASTTQAQRLKIAKKLSGMIKVSTKKV
HHHHHCCCCCCEECCCCCCEEEHHHHHHEEEECCCCCHHHHHHHHHHHHCCCEEEHHHHH
TERDKKDYWMLTRPDEAKKLITAEEKQKAEDKKLSDDDLYQLQLKRITDKQLNELTSKDM
HHCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
QILAIKRQMDSGYSLTPQYIKNEGVSAKEMAVVSEHLDELPGVDVTSDWERSYPNKGLLK
EEEEEHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHH
SVLGSVSSSNEGLPSNLLEHYLSLGYSRNDRVGKSYLEYQYENLLQGQKEKVRNVTDSSG
HHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCC
NVTDTETVSKGKAGDDLVLTIDTELQKDVEKIIEKNLRAAKARPSTQLLDRAFVVMMDPR
CCCCCHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHCCEEEEEECCC
NGEVLTMAGKQIKQVDGKYKIDDYALGTMTSSYNMGSAVKGATLLTGYQTGAIKIGNIFT
CCCEEEECCHHHHHCCCCEEECCEEEECEECCCCCCCCCCCCEEEEECCCCCEEECCEEC
DEVLNIKDSPPKKSVSVMGPINDLTALERSSNVYMFKTAIAIGKGKYISGHPLPLDYSAF
CHHCCCCCCCCCCCEEEECCCHHHHHHHCCCCEEEEEEEEEECCCCEECCCCCCCCHHHH
DKFRYYFSEFGLGVKTGIDLPNEATGYVGTKRQSGFLLDFAIGQYDTYTPLQMAQYVSTI
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHH
ANGGYRMKPQVVKEVRKPSKKGIGAVVESVNPEVMNRLDMTESEIERVQQGFKLVMNGAQ
HCCCEEECHHHHHHHHCCHHCCHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
GTARANFANKSYHPAGKTGTAQAFYDGPIKSRTGASTYNTTLVAYAPADHPEVAISVVVP
CCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEE
WAYENYNDRYSITNDIGEAALDKYFELKKKQEDNNTKQKNEDKIQEDAENGNTNH
EHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]