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The map label for this gene is yqjI [H]

Identifier: 154686648

GI number: 154686648

Start: 2354228

End: 2355637

Strand: Reverse

Name: yqjI [H]

Synonym: RBAM_022170

Alternate gene names: 154686648

Gene position: 2355637-2354228 (Counterclockwise)

Preceding gene: 154686649

Following gene: 154686646

Centisome position: 60.11

GC content: 47.16

Gene sequence:

>1410_bases
ATGTCAAAACAACAAATCGGAGTTATCGGTCTTGCGGTAATGGGTAAAAATCTGGCTCTTAACATCGAAAGCCGGGGATT
TTCTGTGTCTGTATACAACAGATCAAGCAGCAAAACGGAAGAGTTTTTAGAAGAGGCAAAAGGCAAAAATGTTGTCGGTA
CATACAGCATTGAGGAGTTTGTCCAGTCTCTTGAAACACCCCGTAAAATTTTATTAATGGTTAAAGCGGGAACTGCAACG
GATGCGACGATTCAATCTCTTCTTCCTCATCTGGAAAAAGACGATATTTTGATTGACGGCGGAAATACATACTATAAAGA
TACACAGCGCCGGAACAAAGAGCTTGCCGAAAGCGGCATTCACTTTATCGGAACGGGTGTATCAGGCGGTGAAGAGGGAG
CGCTGAAAGGGCCTTCTATTATGCCGGGCGGCCAAAAGGAAGCGCACGAACTCGTGAAACCGATTCTAGAAGCCATTTCT
GCTAAAGTGGACGGAGAAGCTTGTACGACATACATCGGCCCGGACGGAGCGGGGCACTATGTAAAAATGGTGCACAACGG
TATCGAATACGGTGACATGCAGCTGATCTCTGAGTCATATTTCATTTTGAAACAGGTGCTCGGATTGTCTGCCGAAGAGC
TTCACGAAGTATTCGCTGAGTGGAACAAAGGAGAGCTTGACAGCTATCTGATCGAAATCACGGCTGACATTTTCACTAAA
AAAGATGAAGAAACGGGCAAACCGCTTGTTGACGTGATCCTTGATAAAGCAGGCCAAAAAGGAACGGGTAAGTGGACAAG
CCAAAGCGCTCTTGACTTAGGCGTGCCGCTTCCGATTATCACTGAATCTGTTTTTGCGCGTTTCATTTCCGCAATGAAAG
AAGAGCGTGTGAAAGCAAGCAGCCTTCTGTCCGGGCCAGACGTTAAGCCGGTCACTGAAAATAAAGAAGAGCTGATTGAA
GCGGTCAGAAAAGCGCTCTTCATGAGTAAAATCTGTTCTTACGCACAAGGCTTCGCCCAAATGAAAGCCGCGTCTGAAGA
ATATAACTGGGATCTGAAATACGGTGAAATCGCGATGATTTTCCGCGGCGGCTGTATCATCCGCGCGGCGTTCCTGCAAA
AGATCAAAGACGCATATGACCGTGAACCGGAGCTTGACAACCTGCTGTTAGACAGCTACTTCAAAAACATTGCAGAAAGC
TACCAAGGCGCCCTTCGCCAAGTGATTTCACTTGCCGTAGCCCAAGGCGTGCCGGTACCTTCGTTCTCAAGCGCACTTGC
GTATTACGACAGCTACCGTACGGCAGTGCTTCCTGCAAACTTGATTCAAGCGCAGCGTGATTACTTCGGCGCGCATACGT
ATGAACGCACAGATAAAGAAGGCATTTTCCATACTGAATGGATGAAGTAA

Upstream 100 bases:

>100_bases
AAAAAAGGGGTTATGTATGATAATTTCTTTAGTATAAATATCATTTTATTTTAATTTAAATTTTAAAATGGTTAAACGTT
TGAAGAAGGGACGTTAGAAT

Downstream 100 bases:

>100_bases
TGAAGAAGCCCCCGCAGTTATTGCGGGGGCTTTTCTGATATTAAAAACCGCGGGCCGTCATGAACGGCGCCGCGGTTTTT
AATGTTTTCTTATATATTCC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: GNTZII [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLEEAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTAT
DATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS
AKVDGEACTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSAEELHEVFAEWNKGELDSYLIEITADIFTK
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKASSLLSGPDVKPVTENKEELIE
AVRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKDAYDREPELDNLLLDSYFKNIAES
YQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK

Sequences:

>Translated_469_residues
MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLEEAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTAT
DATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS
AKVDGEACTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSAEELHEVFAEWNKGELDSYLIEITADIFTK
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKASSLLSGPDVKPVTENKEELIE
AVRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKDAYDREPELDNLLLDSYFKNIAES
YQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK
>Mature_468_residues
SKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLEEAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATD
ATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAISA
KVDGEACTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSAEELHEVFAEWNKGELDSYLIEITADIFTKK
DEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKASSLLSGPDVKPVTENKEELIEA
VRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKDAYDREPELDNLLLDSYFKNIAESY
QGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=55.3191489361702, Blast_Score=514, Evalue=1e-146,
Organism=Escherichia coli, GI1788341, Length=469, Percent_Identity=70.5756929637527, Blast_Score=692, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=52.2292993630573, Blast_Score=521, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6321695, Length=459, Percent_Identity=54.0305010893246, Blast_Score=518, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=54.8672566371681, Blast_Score=503, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24639279, Length=471, Percent_Identity=56.0509554140127, Blast_Score=511, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51738; Mature: 51607

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLEEAKGKNVVGTYSIEEF
CCCCCEEEEEHEEECCCEEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCEEECCCHHHH
VQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGI
HHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
HFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAISAKVDGEACTTYIGPDGAGHY
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCCCHH
VKMVHNGIEYGDMQLISESYFILKQVLGLSAEELHEVFAEWNKGELDSYLIEITADIFTK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKAS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SLLSGPDVKPVTENKEELIEAVRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMI
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
FRGGCIIRAAFLQKIKDAYDREPELDNLLLDSYFKNIAESYQGALRQVISLAVAQGVPVP
EECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK
CHHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLEEAKGKNVVGTYSIEEF
CCCCEEEEEHEEECCCEEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCEEECCCHHHH
VQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGI
HHHHCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCC
HFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAISAKVDGEACTTYIGPDGAGHY
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCCCHH
VKMVHNGIEYGDMQLISESYFILKQVLGLSAEELHEVFAEWNKGELDSYLIEITADIFTK
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
KDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKAS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SLLSGPDVKPVTENKEELIEAVRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMI
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
FRGGCIIRAAFLQKIKDAYDREPELDNLLLDSYFKNIAESYQGALRQVISLAVAQGVPVP
EECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK
CHHHHHHHHHCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10568751; 9298659 [H]