Click here to switch to the map view.

The map label for this gene is coaA

Identifier: 154686620

GI number: 154686620

Start: 2271331

End: 2272290

Strand: Reverse

Name: coaA

Synonym: RBAM_021890

Alternate gene names: 154686620

Gene position: 2272290-2271331 (Counterclockwise)

Preceding gene: 154686621

Following gene: 154686619

Centisome position: 57.99

GC content: 49.17

Gene sequence:

>960_bases
GTGAAAAGTAAAGAATTGAACTTACATACATTGTATACGCAGCACAGCCGCGAGTCGTGGGCCGGATTCGGCGGCCATCT
TTCCATTGCCGTTTCAGAGGAAGAAGCCAAGGCCGTAGAGGGGCTGAATGACTACCTGTCGGTGGAAGAAGTAGAAACGA
TTTACATTCCGCTTGTGCGCCTGCTCCATCTTCATGTCACGTCTGCCGCAAGACGGAATCAGCATGTCAATGTGTTTCTG
AAGCATCCGCATTCAGCGAAAATCCCGTTTATCATCGGAATCGCGGGCAGCGTCGCCGTCGGCAAAAGCACGACGGCGAG
AATTTTGCAAAAGCTTCTTTCCCGTCTGCCGGACAGGCCGAAGGTGAGCCTGGTGACAACCGACGGTTTCTTGTATCCGA
CGGCGGAATTAAAAAGGAAAAACCTTCTGTCCAGAAAGGGATTCCCGGAAAGCTACGACGTGAAAGCGCTGCTTGAATTT
CTGAACGATATAAAGTCAGGGAAAGAGAGAGTGGAGGCGCCCGTATATTCCCATCTTACGTATGACAGGGAAGAGGGCGC
CGTCGAGGTTGTCGAAGGTGCGGATATCGTTATTATCGAAGGAATCAATGTCCTGCAGTCGCCGACCTTAGAGGACGACA
GGGAAGATCCGCGGATTTTTGTATCGGATTTCTTTGATTTTTCGATCTATGTGGATGCCGAAGAAAGCCGGATTTTCACG
TGGTATTTGGAGCGTTTCCGCCTCTTAAGAGAAACCGCTTTTCAGGATCCGGCTTCTTATTTTCATAAATTTAAGGATTT
GTCTGATGCAGAAGCGGATACCATGGCCGCCTCCATTTGGGAGAGCGTCAACCGTCCGAATCTGTATGAAAATATCCTGC
CGACAAAATTCAGATCGGATTTGATTTTGAGAAAAGGTGATGGCCATAAAGTTGAAGAGGTGCTGGTAAGGCGGGTGTGA

Upstream 100 bases:

>100_bases
TTTGAAAAAAATGGGCAGACAGTGAAGCGGTTTTCCGTTACAATCTTTGTAAGCGTTTGTTTTTTTATCGGAAAGCCATA
CAGAGAGATTGGTGTGAATT

Downstream 100 bases:

>100_bases
TGTGAGGAGGAAGCGAATATTATGATGCATCATATTGAGTTGTATGTATCTGACTTGAAAGCCTCCGCCCGGTTTTGGGG
ATGGTTTTTAGGTGAGCTCG

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKSKELNLHTLYTQHSRESWAGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVRLLHLHVTSAARRNQHVNVFL
KHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRPKVSLVTTDGFLYPTAELKRKNLLSRKGFPESYDVKALLEF
LNDIKSGKERVEAPVYSHLTYDREEGAVEVVEGADIVIIEGINVLQSPTLEDDREDPRIFVSDFFDFSIYVDAEESRIFT
WYLERFRLLRETAFQDPASYFHKFKDLSDAEADTMAASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV

Sequences:

>Translated_319_residues
MKSKELNLHTLYTQHSRESWAGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVRLLHLHVTSAARRNQHVNVFL
KHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRPKVSLVTTDGFLYPTAELKRKNLLSRKGFPESYDVKALLEF
LNDIKSGKERVEAPVYSHLTYDREEGAVEVVEGADIVIIEGINVLQSPTLEDDREDPRIFVSDFFDFSIYVDAEESRIFT
WYLERFRLLRETAFQDPASYFHKFKDLSDAEADTMAASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV
>Mature_319_residues
MKSKELNLHTLYTQHSRESWAGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVRLLHLHVTSAARRNQHVNVFL
KHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRPKVSLVTTDGFLYPTAELKRKNLLSRKGFPESYDVKALLEF
LNDIKSGKERVEAPVYSHLTYDREEGAVEVVEGADIVIIEGINVLQSPTLEDDREDPRIFVSDFFDFSIYVDAEESRIFT
WYLERFRLLRETAFQDPASYFHKFKDLSDAEADTMAASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family

Homologues:

Organism=Homo sapiens, GI18699734, Length=232, Percent_Identity=29.3103448275862, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1790409, Length=319, Percent_Identity=50.1567398119122, Blast_Score=301, Evalue=4e-83,
Organism=Drosophila melanogaster, GI45550449, Length=228, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI28573516, Length=228, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28573514, Length=228, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28573512, Length=228, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAA_BACA2 (A7Z6C4)

Other databases:

- EMBL:   CP000560
- RefSeq:   YP_001421781.1
- ProteinModelPortal:   A7Z6C4
- SMR:   A7Z6C4
- STRING:   A7Z6C4
- EnsemblBacteria:   EBBACT00000005144
- GeneID:   5460191
- GenomeReviews:   CP000560_GR
- KEGG:   bay:RBAM_021890
- eggNOG:   COG1072
- GeneTree:   EBGT00050000002135
- HOGENOM:   HBG732538
- OMA:   GLNVLQP
- ProtClustDB:   PRK05439
- BioCyc:   BAMY326423:RBAM_021890-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00215
- InterPro:   IPR004566
- InterPro:   IPR006083
- PANTHER:   PTHR10285:SF7
- PIRSF:   PIRSF000545
- TIGRFAMs:   TIGR00554

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.33

Molecular weight: Translated: 36374; Mature: 36374

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKELNLHTLYTQHSRESWAGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVR
CCCCCCEEEEEEECCCCHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLHLHVTSAARRNQHVNVFLKHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRP
HHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCEEECCCHHHHHHHHHHHHCCCCC
KVSLVTTDGFLYPTAELKRKNLLSRKGFPESYDVKALLEFLNDIKSGKERVEAPVYSHLT
CEEEEEECCEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCC
YDREEGAVEVVEGADIVIIEGINVLQSPTLEDDREDPRIFVSDFFDFSIYVDAEESRIFT
CCCCCCCEEEECCCCEEEECCCHHHCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCHHH
WYLERFRLLRETAFQDPASYFHKFKDLSDAEADTMAASIWESVNRPNLYENILPTKFRSD
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHCCHHHHCC
LILRKGDGHKVEEVLVRRV
EEEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MKSKELNLHTLYTQHSRESWAGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVR
CCCCCCEEEEEEECCCCHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLHLHVTSAARRNQHVNVFLKHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRP
HHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCEEECCCHHHHHHHHHHHHCCCCC
KVSLVTTDGFLYPTAELKRKNLLSRKGFPESYDVKALLEFLNDIKSGKERVEAPVYSHLT
CEEEEEECCEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCC
YDREEGAVEVVEGADIVIIEGINVLQSPTLEDDREDPRIFVSDFFDFSIYVDAEESRIFT
CCCCCCCEEEECCCCEEEECCCHHHCCCCCCCCCCCCEEEEEECCEEEEEEECCCCCHHH
WYLERFRLLRETAFQDPASYFHKFKDLSDAEADTMAASIWESVNRPNLYENILPTKFRSD
HHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHCCHHHHCC
LILRKGDGHKVEEVLVRRV
EEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA