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The map label for this gene is yngH [H]

Identifier: 154686270

GI number: 154686270

Start: 1924876

End: 1926225

Strand: Reverse

Name: yngH [H]

Synonym: RBAM_018370

Alternate gene names: 154686270

Gene position: 1926225-1924876 (Counterclockwise)

Preceding gene: 154686271

Following gene: 154686269

Centisome position: 49.16

GC content: 49.11

Gene sequence:

>1350_bases
TTGTTTAAAAAAGTCCTGATTGCCAACAGAGGAGAAATCGCCTTACGAATTATCCGCACCTGCAAACGTCTCGGCATCCC
CTCGGCAGCTGTGTATTCAGAAGCCGACCGGGACGCGCTGCATGTAAAAGCGGCTGATGAGGCCTATCCGATCGGTAAAT
CGAGAGTAAATGAAAGCTATTTACATATCGACAGAATCATAGAAGCCGCCAAATCCGCCGGAGCGGACGCCATTCATCCG
GGCTACGGGCTTCTGTCAGAAAACAGCCTGTTCGCCGAACGCTGCCGAAAAGAACAAATCACATTTATCGGTCCGCCCGG
TGATATCATCGCCAAGATGGGCAGCAAGATAGAAGCCCGAAAAACGATGCAAAAAGCAAAGGTCCCGATCGTTCCCGGTG
TTTCAGAGCCATTGCCCGATGTTCACTCCGCCTTAGCCGAAGCCCGTGCCATCGGTTTTCCGGTCATGCTGAAAGCGTCC
GCAGGAGGAGGCGGAATCGGCATGCAGATCGTACATTCAGAAGAAGAGCTGGCCAAAGCGTTTGAAGGCAATCAAAAGCG
GGCCGCCTCCTTTTTTGGAGACGGCGCAATGTATATGGAAAAGGTCATTGAAAATGCCCGTCATATTGAAATTCAGATAC
TCGCAGATTCTTTCGGCAACACCGTTCATCTGTTTGAACGTGACTGTTCAGTACAAAGGCGCCACCAAAAAGTGATAGAA
GAAGCGCCGTCGCCGTTTGTTGACGATGAATTAAGACAAAGACTCGGTGAAACCGCCATTAAAGCCGCAAAATCGATCGG
CTACCAAAATGCAGGCACAATAGAATTTCTCGTCGACGAAAAGAAACAAATCTATTTTTTAGAGATGAACACCAGACTGC
AGGTGGAGCATCCGGTGACAGAAGAAATTACAGGACTGGATCTTGTGGAAGAACAGCTGAAAATTGCCGCTGGGCAGGCG
CTGCCTTTCTCGCAGAAAGATATCAACCACCGCGGTCATGCGATAGAAGTGCGGATCTATGCGGAAGATCCGGTCACCTT
TTACCCGTCTCCCGGTACCATCTCGTCTTTTTCCGTTTTAAGACACCCGTCAGTGCGACACGAATGCGCCGTCGAAAAGG
GAAGCGTCATTTCTCCGTTTTACGATCCGATGATTGCCAAAATGGTCGTCACGGCGAATACGAGAAAACAAGCCATTGAA
CAACTGAAAACCGCCCTTGGCGAATATCATGTAGAAGGGATTAAAACCAACATTCCGCTGCTGACAAAAATTGCCCATTC
AGAAGTGTTTGAAAAGGGCGAGGCAACAACCGGTTTTTTACAAACAATGAACGAGGGGGCGTCAAAATGA

Upstream 100 bases:

>100_bases
ATATCCAATGACAGCCTCAGGAAAAATTCAGAAATTCAAGCTGCGGGAAAAAACGATTGAAGAGCTCAAGTTAACTTAAT
GAAAAAGGAGTGCTTCACAT

Downstream 100 bases:

>100_bases
GCGTCATAAAAATTCAGATGGCGGGAAACCTGTGGAAAATTCATGTGAAGCCGGGTGATGTCATTGAAGAAGGACAGGAA
GTGGCCATCTTGGAATCTAT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 2; ACC 2 [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFKKVLIANRGEIALRIIRTCKRLGIPSAAVYSEADRDALHVKAADEAYPIGKSRVNESYLHIDRIIEAAKSAGADAIHP
GYGLLSENSLFAERCRKEQITFIGPPGDIIAKMGSKIEARKTMQKAKVPIVPGVSEPLPDVHSALAEARAIGFPVMLKAS
AGGGGIGMQIVHSEEELAKAFEGNQKRAASFFGDGAMYMEKVIENARHIEIQILADSFGNTVHLFERDCSVQRRHQKVIE
EAPSPFVDDELRQRLGETAIKAAKSIGYQNAGTIEFLVDEKKQIYFLEMNTRLQVEHPVTEEITGLDLVEEQLKIAAGQA
LPFSQKDINHRGHAIEVRIYAEDPVTFYPSPGTISSFSVLRHPSVRHECAVEKGSVISPFYDPMIAKMVVTANTRKQAIE
QLKTALGEYHVEGIKTNIPLLTKIAHSEVFEKGEATTGFLQTMNEGASK

Sequences:

>Translated_449_residues
MFKKVLIANRGEIALRIIRTCKRLGIPSAAVYSEADRDALHVKAADEAYPIGKSRVNESYLHIDRIIEAAKSAGADAIHP
GYGLLSENSLFAERCRKEQITFIGPPGDIIAKMGSKIEARKTMQKAKVPIVPGVSEPLPDVHSALAEARAIGFPVMLKAS
AGGGGIGMQIVHSEEELAKAFEGNQKRAASFFGDGAMYMEKVIENARHIEIQILADSFGNTVHLFERDCSVQRRHQKVIE
EAPSPFVDDELRQRLGETAIKAAKSIGYQNAGTIEFLVDEKKQIYFLEMNTRLQVEHPVTEEITGLDLVEEQLKIAAGQA
LPFSQKDINHRGHAIEVRIYAEDPVTFYPSPGTISSFSVLRHPSVRHECAVEKGSVISPFYDPMIAKMVVTANTRKQAIE
QLKTALGEYHVEGIKTNIPLLTKIAHSEVFEKGEATTGFLQTMNEGASK
>Mature_449_residues
MFKKVLIANRGEIALRIIRTCKRLGIPSAAVYSEADRDALHVKAADEAYPIGKSRVNESYLHIDRIIEAAKSAGADAIHP
GYGLLSENSLFAERCRKEQITFIGPPGDIIAKMGSKIEARKTMQKAKVPIVPGVSEPLPDVHSALAEARAIGFPVMLKAS
AGGGGIGMQIVHSEEELAKAFEGNQKRAASFFGDGAMYMEKVIENARHIEIQILADSFGNTVHLFERDCSVQRRHQKVIE
EAPSPFVDDELRQRLGETAIKAAKSIGYQNAGTIEFLVDEKKQIYFLEMNTRLQVEHPVTEEITGLDLVEEQLKIAAGQA
LPFSQKDINHRGHAIEVRIYAEDPVTFYPSPGTISSFSVLRHPSVRHECAVEKGSVISPFYDPMIAKMVVTANTRKQAIE
QLKTALGEYHVEGIKTNIPLLTKIAHSEVFEKGEATTGFLQTMNEGASK

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=439, Percent_Identity=51.4806378132118, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=49.3212669683258, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=49.3212669683258, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=49.3212669683258, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=46.1711711711712, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=46.1711711711712, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=46.1711711711712, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI38679960, Length=504, Percent_Identity=31.1507936507937, Blast_Score=245, Evalue=8e-65,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=31.1507936507937, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=31.1507936507937, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI38679974, Length=504, Percent_Identity=31.1507936507937, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI38679971, Length=504, Percent_Identity=31.1507936507937, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=31.2871287128713, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI18105007, Length=195, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789654, Length=442, Percent_Identity=51.131221719457, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=47.0588235294118, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.5113122171946, Blast_Score=393, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17562816, Length=445, Percent_Identity=45.3932584269663, Blast_Score=374, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=30.6584362139918, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=510, Percent_Identity=28.4313725490196, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=510, Percent_Identity=28.4313725490196, Blast_Score=195, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=47.4157303370787, Blast_Score=401, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=44.1704035874439, Blast_Score=352, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=45.0892857142857, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6324343, Length=512, Percent_Identity=31.4453125, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6323863, Length=453, Percent_Identity=33.5540838852097, Blast_Score=249, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24651757, Length=441, Percent_Identity=47.8458049886621, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=47.4074074074074, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=45.045045045045, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=45.045045045045, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=45.045045045045, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=45.045045045045, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=45.045045045045, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=45.045045045045, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=45.045045045045, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=45.045045045045, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=45.045045045045, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=45.045045045045, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI161076409, Length=499, Percent_Identity=30.8617234468938, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI161076407, Length=499, Percent_Identity=30.8617234468938, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24586460, Length=499, Percent_Identity=30.8617234468938, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24586458, Length=499, Percent_Identity=30.8617234468938, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI45555749, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24642586, Length=195, Percent_Identity=27.1794871794872, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49384; Mature: 49384

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKVLIANRGEIALRIIRTCKRLGIPSAAVYSEADRDALHVKAADEAYPIGKSRVNESY
CCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEECCCCCCCCHHHCCHHH
LHIDRIIEAAKSAGADAIHPGYGLLSENSLFAERCRKEQITFIGPPGDIIAKMGSKIEAR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
KTMQKAKVPIVPGVSEPLPDVHSALAEARAIGFPVMLKASAGGGGIGMQIVHSEEELAKA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHHHH
FEGNQKRAASFFGDGAMYMEKVIENARHIEIQILADSFGNTVHLFERDCSVQRRHQKVIE
HCCCHHHHHHHHCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEHHCHHHHHHHHHHHH
EAPSPFVDDELRQRLGETAIKAAKSIGYQNAGTIEFLVDEKKQIYFLEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCEEEECCCCH
EEITGLDLVEEQLKIAAGQALPFSQKDINHRGHAIEVRIYAEDPVTFYPSPGTISSFSVL
HHHCCHHHHHHHHHHHCCCCCCCCHHCCCCCCCEEEEEEEECCCEEEECCCCCCCHHHHH
RHPSVRHECAVEKGSVISPFYDPMIAKMVVTANTRKQAIEQLKTALGEYHVEGIKTNIPL
CCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
LTKIAHSEVFEKGEATTGFLQTMNEGASK
HHHHHHHHHHHCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MFKKVLIANRGEIALRIIRTCKRLGIPSAAVYSEADRDALHVKAADEAYPIGKSRVNESY
CCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEECCCCCCCCHHHCCHHH
LHIDRIIEAAKSAGADAIHPGYGLLSENSLFAERCRKEQITFIGPPGDIIAKMGSKIEAR
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
KTMQKAKVPIVPGVSEPLPDVHSALAEARAIGFPVMLKASAGGGGIGMQIVHSEEELAKA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHHHH
FEGNQKRAASFFGDGAMYMEKVIENARHIEIQILADSFGNTVHLFERDCSVQRRHQKVIE
HCCCHHHHHHHHCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEHHCHHHHHHHHHHHH
EAPSPFVDDELRQRLGETAIKAAKSIGYQNAGTIEFLVDEKKQIYFLEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCEEEECCCCH
EEITGLDLVEEQLKIAAGQALPFSQKDINHRGHAIEVRIYAEDPVTFYPSPGTISSFSVL
HHHCCHHHHHHHHHHHCCCCCCCCHHCCCCCCCEEEEEEEECCCEEEECCCCCCCHHHHH
RHPSVRHECAVEKGSVISPFYDPMIAKMVVTANTRKQAIEQLKTALGEYHVEGIKTNIPL
CCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCH
LTKIAHSEVFEKGEATTGFLQTMNEGASK
HHHHHHHHHHHCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]