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The map label for this gene is bioI [H]

Identifier: 154686257

GI number: 154686257

Start: 1912927

End: 1914123

Strand: Reverse

Name: bioI [H]

Synonym: RBAM_018240

Alternate gene names: 154686257

Gene position: 1914123-1912927 (Counterclockwise)

Preceding gene: 154686258

Following gene: 154686256

Centisome position: 48.85

GC content: 46.87

Gene sequence:

>1197_bases
ATGACGGCGGACCTATCGATTGCACATCCGTCTCTCCATGCGGATTCGGGTTTTTGGAATGACCCTTACCCGTTTTATGA
CAAACTGCGATCCATTGATCCTGTTTATAAAGGAACCGTATTAAAATATCCGGGCTGGTATGTCACCGGGTACAAAGAAG
CGGCAGCGATTCTGAAAGACATTCGGTTTAAAAACCGCATTCCTCTTCCGGAAGCTTCAACGAAATATCAAAATCTATCG
CATATCCAGCACGATATGCTGTTATTTAAAAATCAATCAGACCATAAGCGGATGCGGATGCTTATCGGTAAAGAATTTAC
CGCAAAGACGGCGGAATCACTTCGCCCTTGTATAAAAGAAACGGTTCATGACTTGTTGGATCAAGTCCAAATCAAAAAAA
CCGCGGACCTTGTTTCAGAGTTTGCCTTTCCATTGGCAAGCCTTATCATTGCGGAGATACTCGGAGTGCCGAAAGAGGAG
AGATATCAATTCAGACAATGGACGGCAGACGTCATTCAGGCCATTGATCTTACCCGATCAAGAAAGACGTTAGTCAGAGC
AAGCGACACCGCAGGCAGGCTGACGTCATATTTCAGAGATTTGATTCACAAGCGGGAAGCGCACCCTCAGCAAGACTTGA
TCAGCAGGTTTATTATGGAGGAACAGCTTTCAAAAGAGGAAGTGCTCGCGACATGTATCTTACTTGTCATAGCCGGACAC
GAGACGACGGTAAACCTCATAAGCAACGGTGTGTTTACTTTATTGAAACACCCTGAACAGCTTAGCGCACTGAGAGAAAA
CCCCTCGCTTATTGAAACTGCAGTTGAGGAATGTCTGCGCTACGACAGCCCCGCGCAGCTGACGGCACGCACCGCCTCAG
AAGACTGCGAAATAAATGGGAAGACCATAAAAAAAGGAGAGCAGGTATATATCCTTTTAGGGGCAGCCAATCGCGATCCA
AGCATATTCGATCAACCTCACAAAATGGATATCCAAAGAAAACCGAATCCGCATCTTGCATTCGGAAGGAACGCCCATTT
TTGCATAGGCTCCTCATTAGCGCGCATCGAAGCACAAATTGCAATTCTCACACTGTTTGAGCGGATGCCTAAGCTTCGGC
TGGCTGCACACCGCCTTGAATACCGCAAGCTCATTGGTTTTAGGTCGCTCAAAGAGCTCCCGGTTGTCATTGGCTGA

Upstream 100 bases:

>100_bases
ACAGAGGATCATCAAATGCTCCATGATTTAGGTTTTGAAGTCGAATCCGTTGAAGAAATGAAAGCCGGCCTGCAATCCGC
CTGCAATACGGAGGTATAAG

Downstream 100 bases:

>100_bases
ATGACCATGCAGGAGGGCCGGATTTTATCGGTTCCTCTTGCAGGAAATAAATGAAAGAAAAAAGAATACATATTTATAAA
GCAAAAATCCTCTCTGATCC

Product: BioI

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTADLSIAHPSLHADSGFWNDPYPFYDKLRSIDPVYKGTVLKYPGWYVTGYKEAAAILKDIRFKNRIPLPEASTKYQNLS
HIQHDMLLFKNQSDHKRMRMLIGKEFTAKTAESLRPCIKETVHDLLDQVQIKKTADLVSEFAFPLASLIIAEILGVPKEE
RYQFRQWTADVIQAIDLTRSRKTLVRASDTAGRLTSYFRDLIHKREAHPQQDLISRFIMEEQLSKEEVLATCILLVIAGH
ETTVNLISNGVFTLLKHPEQLSALRENPSLIETAVEECLRYDSPAQLTARTASEDCEINGKTIKKGEQVYILLGAANRDP
SIFDQPHKMDIQRKPNPHLAFGRNAHFCIGSSLARIEAQIAILTLFERMPKLRLAAHRLEYRKLIGFRSLKELPVVIG

Sequences:

>Translated_398_residues
MTADLSIAHPSLHADSGFWNDPYPFYDKLRSIDPVYKGTVLKYPGWYVTGYKEAAAILKDIRFKNRIPLPEASTKYQNLS
HIQHDMLLFKNQSDHKRMRMLIGKEFTAKTAESLRPCIKETVHDLLDQVQIKKTADLVSEFAFPLASLIIAEILGVPKEE
RYQFRQWTADVIQAIDLTRSRKTLVRASDTAGRLTSYFRDLIHKREAHPQQDLISRFIMEEQLSKEEVLATCILLVIAGH
ETTVNLISNGVFTLLKHPEQLSALRENPSLIETAVEECLRYDSPAQLTARTASEDCEINGKTIKKGEQVYILLGAANRDP
SIFDQPHKMDIQRKPNPHLAFGRNAHFCIGSSLARIEAQIAILTLFERMPKLRLAAHRLEYRKLIGFRSLKELPVVIG
>Mature_397_residues
TADLSIAHPSLHADSGFWNDPYPFYDKLRSIDPVYKGTVLKYPGWYVTGYKEAAAILKDIRFKNRIPLPEASTKYQNLSH
IQHDMLLFKNQSDHKRMRMLIGKEFTAKTAESLRPCIKETVHDLLDQVQIKKTADLVSEFAFPLASLIIAEILGVPKEER
YQFRQWTADVIQAIDLTRSRKTLVRASDTAGRLTSYFRDLIHKREAHPQQDLISRFIMEEQLSKEEVLATCILLVIAGHE
TTVNLISNGVFTLLKHPEQLSALRENPSLIETAVEECLRYDSPAQLTARTASEDCEINGKTIKKGEQVYILLGAANRDPS
IFDQPHKMDIQRKPNPHLAFGRNAHFCIGSSLARIEAQIAILTLFERMPKLRLAAHRLEYRKLIGFRSLKELPVVIG

Specific function: Catalyzes the C-C bond cleavage of fatty acid linked to acyl carrier protein (ACP) to generate pimelic acid for biotin biosynthesis. It has high affinity for long-chain fatty acids with the greatest affinity for myristic acid [H]

COG id: COG2124

COG function: function code Q; Cytochrome P450

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytochrome P450 family [H]

Homologues:

Organism=Homo sapiens, GI4503213, Length=218, Percent_Identity=27.5229357798165, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001128
- InterPro:   IPR002397
- InterPro:   IPR017972 [H]

Pfam domain/function: PF00067 p450 [H]

EC number: NA

Molecular weight: Translated: 45356; Mature: 45225

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADLSIAHPSLHADSGFWNDPYPFYDKLRSIDPVYKGTVLKYPGWYVTGYKEAAAILKD
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHCCCEEECCCEEEECHHHHHHHHHH
IRFKNRIPLPEASTKYQNLSHIQHDMLLFKNQSDHKRMRMLIGKEFTAKTAESLRPCIKE
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
TVHDLLDQVQIKKTADLVSEFAFPLASLIIAEILGVPKEERYQFRQWTADVIQAIDLTRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RKTLVRASDTAGRLTSYFRDLIHKREAHPQQDLISRFIMEEQLSKEEVLATCILLVIAGH
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ETTVNLISNGVFTLLKHPEQLSALRENPSLIETAVEECLRYDSPAQLTARTASEDCEING
CHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCC
KTIKKGEQVYILLGAANRDPSIFDQPHKMDIQRKPNPHLAFGRNAHFCIGSSLARIEAQI
CEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEECCCHHHHHHHHH
AILTLFERMPKLRLAAHRLEYRKLIGFRSLKELPVVIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TADLSIAHPSLHADSGFWNDPYPFYDKLRSIDPVYKGTVLKYPGWYVTGYKEAAAILKD
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHCCCEEECCCEEEECHHHHHHHHHH
IRFKNRIPLPEASTKYQNLSHIQHDMLLFKNQSDHKRMRMLIGKEFTAKTAESLRPCIKE
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
TVHDLLDQVQIKKTADLVSEFAFPLASLIIAEILGVPKEERYQFRQWTADVIQAIDLTRS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
RKTLVRASDTAGRLTSYFRDLIHKREAHPQQDLISRFIMEEQLSKEEVLATCILLVIAGH
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ETTVNLISNGVFTLLKHPEQLSALRENPSLIETAVEECLRYDSPAQLTARTASEDCEING
CHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCC
KTIKKGEQVYILLGAANRDPSIFDQPHKMDIQRKPNPHLAFGRNAHFCIGSSLARIEAQI
CEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEECCCHHHHHHHHH
AILTLFERMPKLRLAAHRLEYRKLIGFRSLKELPVVIG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377 [H]