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The map label for this gene is gltT [H]

Identifier: 154685476

GI number: 154685476

Start: 1022583

End: 1023872

Strand: Reverse

Name: gltT [H]

Synonym: RBAM_010420

Alternate gene names: 154685476

Gene position: 1023872-1022583 (Counterclockwise)

Preceding gene: 154685477

Following gene: 154685474

Centisome position: 26.13

GC content: 46.67

Gene sequence:

>1290_bases
ATGAAAAAATTACGCTTTGGACTAGCGACGCAAATTTTCGTCGGACTCATACTAGGGGTTGTAGTCGGTGTCATCTGGTA
CGGCAATCCCGCCATTCCAACATATTTACAGCCTATCGGCGATTTGTTTTTACGCTTAATCAAAATGATAGTGATTCCAA
TTGTCGTCTCCAGCTTAATCATCGGCGTTGCCGGCGCGGGAAGCGGAAAACAAGTCGGAAAATTAGGCTTCAGAACGATT
TTGTATTTTGAGATCATTACCACTTTTGCCATTATTCTCGGGCTGGCTTTGGCGAATCTGTTTCAGCCGGGAGCAGGCGT
TAATATACATGAAGCTCAAAAGACAGATATCAGTCAATATGTTGAAACAGAAAAAGAACAAAGCGGTAAATCCGTTGCGG
ACACATTCCTGCATATCGTACCGACAAACTTCTTCCAATCATTAGCCGAAGGAGATCTGCTTGCCATCATCTGCTTTACC
GTGCTGTTTGCACTCGGCATCTCGGCAATCGGTGAAAAAGGAAAGCCCGTATTGGCCTTCTTTGAAGGTGTTTCTCATGC
GATGTTCCATGTTGTGAACCTCGTCATGAAAGTTGCGCCGTTTGGTGTTTTTGCGTTGATCGGTGTTACCGTTTCCAAAT
TTGGGCTCAGTTCCCTGCTTTCACTCGGTAAACTGGTCGGTTTAGTATATGTAGCTTTGGCTTTCTTTCTCATTGTTGTA
TTCGGAATCGTCGGAAAGCTTGCCGGTTTAAACATTTTCAAATTCCTCGCCTATATGAAGGATGAAATTTTATTGGCGTT
CAGTACGTCAAGCTCCGAAACCGTACTCCCCCGCATCATGGAGAAGATGGAGAAAATCGGCTGTCCGAAAGGTATTGTTT
CCTTTGTTGTGCCGATCGGATATACCTTTAACTTAGACGGATCTGTGCTGTACCAATCAATCGCCGCTTTATTCCTCGCT
CAGGTATACCACATTGACTTGACCATTTGGCAGCAGATTACCCTTGTGCTTGTCTTGATGGTCACTTCCAAAGGAATGGC
TGCCGTGCCCGGGACTTCTTTCGTCGTCCTGCTTGCGACACTCGGCACAATCGGCGTTCCTGCAGAAGGCCTTGCATTCA
TCGCCGGTGTTGACCGGATTATGGACATGGCCCGTACGGTCGTCAATCTGACCGGAAACGCGCTGGCATCCGTTGTGATG
TCAAAATGGGAAGGCCAGTATGATCCCGTTAAAGGCGCGAAGGTCATGAGCCTCGCCAAAACAGAACAAAACACAACCAT
CTCAGGTTAA

Upstream 100 bases:

>100_bases
TATTTTTCTATAGACGGATTGTTTTCTTTTCTATTATAATTTGTTCTAATAGCTATCTTTTTAGATACTTATTGCACTTT
TTTTCTTCGGGAGGTAATCT

Downstream 100 bases:

>100_bases
AATGAAAACCCTGCACGGAATGATTTCCGCGCAGGGTTTTTTATGCCATCGGCGATAAAACGTACCGGTGCAAAAGCTTC
GCCGTATTAAGAAGCGATAA

Product: GltT

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKKLRFGLATQIFVGLILGVVVGVIWYGNPAIPTYLQPIGDLFLRLIKMIVIPIVVSSLIIGVAGAGSGKQVGKLGFRTI
LYFEIITTFAIILGLALANLFQPGAGVNIHEAQKTDISQYVETEKEQSGKSVADTFLHIVPTNFFQSLAEGDLLAIICFT
VLFALGISAIGEKGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLSSLLSLGKLVGLVYVALAFFLIVV
FGIVGKLAGLNIFKFLAYMKDEILLAFSTSSSETVLPRIMEKMEKIGCPKGIVSFVVPIGYTFNLDGSVLYQSIAALFLA
QVYHIDLTIWQQITLVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTGNALASVVM
SKWEGQYDPVKGAKVMSLAKTEQNTTISG

Sequences:

>Translated_429_residues
MKKLRFGLATQIFVGLILGVVVGVIWYGNPAIPTYLQPIGDLFLRLIKMIVIPIVVSSLIIGVAGAGSGKQVGKLGFRTI
LYFEIITTFAIILGLALANLFQPGAGVNIHEAQKTDISQYVETEKEQSGKSVADTFLHIVPTNFFQSLAEGDLLAIICFT
VLFALGISAIGEKGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLSSLLSLGKLVGLVYVALAFFLIVV
FGIVGKLAGLNIFKFLAYMKDEILLAFSTSSSETVLPRIMEKMEKIGCPKGIVSFVVPIGYTFNLDGSVLYQSIAALFLA
QVYHIDLTIWQQITLVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTGNALASVVM
SKWEGQYDPVKGAKVMSLAKTEQNTTISG
>Mature_429_residues
MKKLRFGLATQIFVGLILGVVVGVIWYGNPAIPTYLQPIGDLFLRLIKMIVIPIVVSSLIIGVAGAGSGKQVGKLGFRTI
LYFEIITTFAIILGLALANLFQPGAGVNIHEAQKTDISQYVETEKEQSGKSVADTFLHIVPTNFFQSLAEGDLLAIICFT
VLFALGISAIGEKGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLSSLLSLGKLVGLVYVALAFFLIVV
FGIVGKLAGLNIFKFLAYMKDEILLAFSTSSSETVLPRIMEKMEKIGCPKGIVSFVVPIGYTFNLDGSVLYQSIAALFLA
QVYHIDLTIWQQITLVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTGNALASVVM
SKWEGQYDPVKGAKVMSLAKTEQNTTISG

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=445, Percent_Identity=28.7640449438202, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI4827012, Length=434, Percent_Identity=25.8064516129032, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI21314632, Length=437, Percent_Identity=28.8329519450801, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI40254478, Length=443, Percent_Identity=26.410835214447, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI169790839, Length=442, Percent_Identity=25.7918552036199, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI194239697, Length=467, Percent_Identity=25.6959314775161, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI5032093, Length=394, Percent_Identity=28.9340101522843, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI223468566, Length=262, Percent_Identity=28.2442748091603, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI223468564, Length=256, Percent_Identity=28.515625, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI262359914, Length=391, Percent_Identity=25.5754475703325, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI301601644, Length=175, Percent_Identity=30.8571428571429, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790514, Length=420, Percent_Identity=55.2380952380952, Blast_Score=460, Evalue=1e-131,
Organism=Escherichia coli, GI1789947, Length=419, Percent_Identity=38.6634844868735, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI1788024, Length=386, Percent_Identity=27.720207253886, Blast_Score=121, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17537407, Length=417, Percent_Identity=29.0167865707434, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71996953, Length=452, Percent_Identity=27.4336283185841, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71983106, Length=444, Percent_Identity=25.2252252252252, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI71983099, Length=444, Percent_Identity=25.2252252252252, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=412, Percent_Identity=27.9126213592233, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI193206654, Length=414, Percent_Identity=24.8792270531401, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=405, Percent_Identity=24.4444444444444, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24583025, Length=402, Percent_Identity=24.3781094527363, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17137668, Length=402, Percent_Identity=24.3781094527363, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24583023, Length=402, Percent_Identity=24.3781094527363, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281360481, Length=464, Percent_Identity=26.9396551724138, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281360483, Length=464, Percent_Identity=26.9396551724138, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17137666, Length=464, Percent_Identity=26.9396551724138, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45825; Mature: 45825

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLRFGLATQIFVGLILGVVVGVIWYGNPAIPTYLQPIGDLFLRLIKMIVIPIVVSSLI
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVAGAGSGKQVGKLGFRTILYFEIITTFAIILGLALANLFQPGAGVNIHEAQKTDISQY
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VETEKEQSGKSVADTFLHIVPTNFFQSLAEGDLLAIICFTVLFALGISAIGEKGKPVLAF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
FEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLSSLLSLGKLVGLVYVALAFFLIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGIVGKLAGLNIFKFLAYMKDEILLAFSTSSSETVLPRIMEKMEKIGCPKGIVSFVVPIG
HHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCC
YTFNLDGSVLYQSIAALFLAQVYHIDLTIWQQITLVLVLMVTSKGMAAVPGTSFVVLLAT
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LGTIGVPAEGLAFIAGVDRIMDMARTVVNLTGNALASVVMSKWEGQYDPVKGAKVMSLAK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
TEQNTTISG
HCCCCCCCC
>Mature Secondary Structure
MKKLRFGLATQIFVGLILGVVVGVIWYGNPAIPTYLQPIGDLFLRLIKMIVIPIVVSSLI
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGVAGAGSGKQVGKLGFRTILYFEIITTFAIILGLALANLFQPGAGVNIHEAQKTDISQY
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
VETEKEQSGKSVADTFLHIVPTNFFQSLAEGDLLAIICFTVLFALGISAIGEKGKPVLAF
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHH
FEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLSSLLSLGKLVGLVYVALAFFLIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FGIVGKLAGLNIFKFLAYMKDEILLAFSTSSSETVLPRIMEKMEKIGCPKGIVSFVVPIG
HHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCC
YTFNLDGSVLYQSIAALFLAQVYHIDLTIWQQITLVLVLMVTSKGMAAVPGTSFVVLLAT
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LGTIGVPAEGLAFIAGVDRIMDMARTVVNLTGNALASVVMSKWEGQYDPVKGAKVMSLAK
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
TEQNTTISG
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]