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The map label for this gene is ycgH [H]

Identifier: 154684803

GI number: 154684803

Start: 307805

End: 309133

Strand: Reverse

Name: ycgH [H]

Synonym: RBAM_003340

Alternate gene names: 154684803

Gene position: 309133-307805 (Counterclockwise)

Preceding gene: 154684806

Following gene: 154684799

Centisome position: 7.89

GC content: 50.11

Gene sequence:

>1329_bases
ATGGGTAAATCACAGGACCAGCCTAAAGGAAATCTCGCTTGGTGGCAGCTCTCCTTAATCGGCGTCGGCTGCACAATCGG
GACGGGCTTTTTTCTCGGGTCCAGCATCGCTATTGTCAAAAGCGGATATTCCGCGCTGATCTCATTTCTTATTGCCGGGC
TTGGCACCTATTTTGTCTTTGAGCAGCTCGCGAAGCTTTCGGCCAAACAGCCCGAAAAGGGGTCTTTTTGCGCTTATGCG
AGAAAGGCTTTCGGCACTTGGGCCGGTTTCAGCAACGGATGGGTGTACTGGTCGTCCGAGATGCTGATCACTGGAAGCCA
GCTGACAGCGATCTCGCTGTTTACAAAGCATTGGTTTCCGAATGTGCCGCTGTGGATTTTCGCCTCCATCTATGCGGTGC
TCGGTCTTTTGATTATATTTACGGGGCTGTCCGTTTTTCAAAAAACGGAAAATGTGCTCGCTGTTGTCAAGACAGCGGCG
ATTTTTATGTTTATCGTGATCGCCATATTGGCGCTGTGCGGTATATTTTCTCATAAACCGGATGTGCAGGTGCCGAACGA
ATCAAAGGATTTGTTCCCGCACGGAGCGATGGGGTTATGGACGGGATTGATTTATGCGTTTTACGCCTTCGGAGGAATTG
AAGTCTTGGGGCTGATGACCGTGCATTTGAAAAAGCCGGAGGAAGCCTCAAAGTCAGGCCGGCTGATGCTTGCCGTTCTT
GCGGTGATTTACGTCATTTCTCTCGGCCTGGCGCTGCTGTTAGTGCCGCTGGGCAAATTCACCGAACAGGACAGCCCGTT
TATTACATCGCTGAAGGGTTTTCATTTAGATATCATTCTTGATATTTTTAACGGGATTTTTATTATTGCGGGATTTTCCA
CGCTCGTCGCCTCGCTGTTTGCCGTGACGACATTGCTTTGTACGATGGCAGATGACGGAGATGCGCCGAAATGCTTCAGA
TTAAAGGAAAACAAAAAAATCTGCTGGCCTGCGCTCGGATTGACGTTTGCCGGACTCATCGTCTCCATCATCCTGTCATT
GGTGCTGCCGAAAAATATATATGAACACATGACAACCGCGGCGGGCCTGATGCTTCTTTATACGTGGCTGTTCATTTTGT
TCTCGGGCAAGAAACTGCTCGAAACGACAAAGATGGGAACCGTACAGATTGTTATCGCCCTTGTGCTGATTGTCGCGGCC
GTCTCCGGGACGCTGTTTGAGAAATCGAGCCGGCCCGGTTTTCTGGTCAGCCTTTGTTTTCTCGCCGTCATTGCGATCGT
GACATGGATCGTACAAAAAAAGCAGGGACACAGCCCTGCCGGATCATAG

Upstream 100 bases:

>100_bases
TTATGAACTTCGGCCGTTTGTTTCATGTAAAGCAATTTATTGGATGTATATTCCCCTTCTGACGGCCGCAATCTAAGCTT
TGATAAAGGGGTTGAACTTC

Downstream 100 bases:

>100_bases
CTTATTTCGTCGGTTTAAACAGCCTCTTTAAATAAGAAAAGGGACACTTTGACACTTCCGTCTCATCATCACGGAGGAAA
TATTGCTTCCATTCTAAATT

Product: YcgH

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MGKSQDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGYSALISFLIAGLGTYFVFEQLAKLSAKQPEKGSFCAYA
RKAFGTWAGFSNGWVYWSSEMLITGSQLTAISLFTKHWFPNVPLWIFASIYAVLGLLIIFTGLSVFQKTENVLAVVKTAA
IFMFIVIAILALCGIFSHKPDVQVPNESKDLFPHGAMGLWTGLIYAFYAFGGIEVLGLMTVHLKKPEEASKSGRLMLAVL
AVIYVISLGLALLLVPLGKFTEQDSPFITSLKGFHLDIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFR
LKENKKICWPALGLTFAGLIVSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSGKKLLETTKMGTVQIVIALVLIVAA
VSGTLFEKSSRPGFLVSLCFLAVIAIVTWIVQKKQGHSPAGS

Sequences:

>Translated_442_residues
MGKSQDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGYSALISFLIAGLGTYFVFEQLAKLSAKQPEKGSFCAYA
RKAFGTWAGFSNGWVYWSSEMLITGSQLTAISLFTKHWFPNVPLWIFASIYAVLGLLIIFTGLSVFQKTENVLAVVKTAA
IFMFIVIAILALCGIFSHKPDVQVPNESKDLFPHGAMGLWTGLIYAFYAFGGIEVLGLMTVHLKKPEEASKSGRLMLAVL
AVIYVISLGLALLLVPLGKFTEQDSPFITSLKGFHLDIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFR
LKENKKICWPALGLTFAGLIVSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSGKKLLETTKMGTVQIVIALVLIVAA
VSGTLFEKSSRPGFLVSLCFLAVIAIVTWIVQKKQGHSPAGS
>Mature_441_residues
GKSQDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGYSALISFLIAGLGTYFVFEQLAKLSAKQPEKGSFCAYAR
KAFGTWAGFSNGWVYWSSEMLITGSQLTAISLFTKHWFPNVPLWIFASIYAVLGLLIIFTGLSVFQKTENVLAVVKTAAI
FMFIVIAILALCGIFSHKPDVQVPNESKDLFPHGAMGLWTGLIYAFYAFGGIEVLGLMTVHLKKPEEASKSGRLMLAVLA
VIYVISLGLALLLVPLGKFTEQDSPFITSLKGFHLDIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFRL
KENKKICWPALGLTFAGLIVSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSGKKLLETTKMGTVQIVIALVLIVAAV
SGTLFEKSSRPGFLVSLCFLAVIAIVTWIVQKKQGHSPAGS

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of The Aromatic Amino Acids (Phenylalanine, Tyrosine, And Tryptophan). [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786302, Length=332, Percent_Identity=28.0120481927711, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI87081708, Length=458, Percent_Identity=23.7991266375546, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI1786789, Length=361, Percent_Identity=26.3157894736842, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081915, Length=381, Percent_Identity=26.7716535433071, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1790653, Length=441, Percent_Identity=25.1700680272109, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786602, Length=377, Percent_Identity=25.7294429708223, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1789017, Length=399, Percent_Identity=23.8095238095238, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI48994972, Length=457, Percent_Identity=22.1006564551422, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788480, Length=394, Percent_Identity=25.6345177664975, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6324061, Length=399, Percent_Identity=25.062656641604, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6320772, Length=403, Percent_Identity=23.5732009925558, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320251, Length=404, Percent_Identity=21.2871287128713, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6324553, Length=312, Percent_Identity=24.3589743589744, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319542, Length=403, Percent_Identity=21.3399503722084, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322967, Length=389, Percent_Identity=26.2210796915167, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324924, Length=349, Percent_Identity=24.0687679083095, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319824, Length=407, Percent_Identity=21.3759213759214, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321629, Length=398, Percent_Identity=23.3668341708543, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324990, Length=415, Percent_Identity=22.4096385542169, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320717, Length=403, Percent_Identity=21.3399503722084, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324059, Length=292, Percent_Identity=23.6301369863014, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321053, Length=384, Percent_Identity=22.3958333333333, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322892, Length=388, Percent_Identity=21.1340206185567, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666159, Length=327, Percent_Identity=22.0183486238532, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221512776, Length=327, Percent_Identity=22.0183486238532, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47915; Mature: 47783

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKSQDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGYSALISFLIAGLGTYFVF
CCCCCCCCCCCEEEEEEEEEEEHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHH
EQLAKLSAKQPEKGSFCAYARKAFGTWAGFSNGWVYWSSEMLITGSQLTAISLFTKHWFP
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCHHHHHHHHHHCCC
NVPLWIFASIYAVLGLLIIFTGLSVFQKTENVLAVVKTAAIFMFIVIAILALCGIFSHKP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DVQVPNESKDLFPHGAMGLWTGLIYAFYAFGGIEVLGLMTVHLKKPEEASKSGRLMLAVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
AVIYVISLGLALLLVPLGKFTEQDSPFITSLKGFHLDIILDIFNGIFIIAGFSTLVASLF
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AVTTLLCTMADDGDAPKCFRLKENKKICWPALGLTFAGLIVSIILSLVLPKNIYEHMTTA
HHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLMLLYTWLFILFSGKKLLETTKMGTVQIVIALVLIVAAVSGTLFEKSSRPGFLVSLCF
HHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LAVIAIVTWIVQKKQGHSPAGS
HHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GKSQDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGYSALISFLIAGLGTYFVF
CCCCCCCCCCEEEEEEEEEEEHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHH
EQLAKLSAKQPEKGSFCAYARKAFGTWAGFSNGWVYWSSEMLITGSQLTAISLFTKHWFP
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCHHHHHHHHHHCCC
NVPLWIFASIYAVLGLLIIFTGLSVFQKTENVLAVVKTAAIFMFIVIAILALCGIFSHKP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DVQVPNESKDLFPHGAMGLWTGLIYAFYAFGGIEVLGLMTVHLKKPEEASKSGRLMLAVL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
AVIYVISLGLALLLVPLGKFTEQDSPFITSLKGFHLDIILDIFNGIFIIAGFSTLVASLF
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AVTTLLCTMADDGDAPKCFRLKENKKICWPALGLTFAGLIVSIILSLVLPKNIYEHMTTA
HHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLMLLYTWLFILFSGKKLLETTKMGTVQIVIALVLIVAAVSGTLFEKSSRPGFLVSLCF
HHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LAVIAIVTWIVQKKQGHSPAGS
HHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]