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The map label for this gene is gltP [H]

Identifier: 154684744

GI number: 154684744

Start: 246983

End: 248233

Strand: Reverse

Name: gltP [H]

Synonym: RBAM_002750

Alternate gene names: 154684744

Gene position: 248233-246983 (Counterclockwise)

Preceding gene: 154684746

Following gene: 154684734

Centisome position: 6.33

GC content: 51.4

Gene sequence:

>1251_bases
TTGAAAAAATTTATCGCATTCCAGATTTTGATCGCTTTAGCCATCGGAGCATTGATCGGCCACTTCTTCCCGGATTTCGG
GATGGCGCTGCGGCCCGTCGGAGACGGATTTATCCGCCTGATTAAAATGATTGTCGTGCCGATCGTGTTTTCGACCATTG
TTATCGGAGCCGCCGGCAGCGGCAGTATGAAAAAGATGGGCAGTCTCGGCATCAAAACGATTATTTGGTTTGAAGTGATT
ACGACGCTTGTTCTGGCGCTCGGTCTGTTATTGGCGAACGTGCTGAAGCCGGGAGTCGGACTTAACCTCTCTCATCTTGC
TAAAAAAGATATTCACGAGCTTTCCGGCTATACGGAAAAAGTAGTCGACCTGAAACAAATGCTTCTTGATATTATCCCCG
TTAACATTATTGACGTCATGGCGAAAAACGATCTTCTCGCCGTCATTTTTTTCGCGATTTTATTCGGTGTTGCCGCAGCC
GGCATCGGCAAAGCCTCCGCACCTGTCATGAGTTTCTTCGAATCCACGGCAAATATTATGTTCAAGCTGACGCAAATGGT
AATGGTCACCGCTCCGATCGGCGTTCTCGCCCTGATGGCCGCCTCTGTCGGGCAATTCGGAATCGCGCTTTTGCTTCCGA
TGCTGAAGCTGATCGGCACTGTGTTCCTCGGGCTGTTCCTGATACTCTTCGTTCTGTTTCCGATCGTGGGGCTTATCTTT
AAAATCAAATACTTTGAAGTGCTGAAAATGATTTGGGACCTGTTTTTGATCGCTTTCTCCACGACAAGCACAGAAACCAT
TCTGCCTCAGCTGATGGATCGGATGGAGAAATACGGCTGTCCGAAGCGGGTCGTCTCCTTTGTGGTTCCGTCAGGTTTAT
CGCTGAACTGTGACGGCTCAAGCCTCTATTTATCGGTGTCCTGTATTTTCCTGGCGCAGGCGTTTCATGTGGAAATGCCG
CTTTCTCAGCAGCTTCTGATGATGCTTGTCCTCGTCATGACAAGCAAAGGCATTGCCGCCGTCCCGTCAGGCTCACTCGT
CGTGCTTCTGGCGACAGCGAATGCCGTCGGTCTCCCCGCGGAAGGCGTCGCCATCATTGCCGGTGTCGACCGCGTCATGG
ACATGGCGAGAACCGGCGTCAACGTGCCCGGCCATGCGGTCGCCTGCATCGTCGTGTCCAAGTGGGAAAAAGCATTCAAA
TATAAAGGACCCGTCACGGCAGACCAGACCGCCCGGACAGAAAGTATGTAA

Upstream 100 bases:

>100_bases
CGCACAGTCAATCATGTGACAAATTTATGGCGAATAGGAAGGTGGTTGCCGACTGCTTCACGAATTACGTAAGAAATGCG
CAAGTAAAAGGGGGATTCGC

Downstream 100 bases:

>100_bases
ACACAAAAAAGACCACCTTATTGGTGGTCTTTTCTTTAATCAATCGCCGCATGATCCTCTTTTTCAATCAAAGCAAGGCG
TTCATTGATTTCTTCCTGAG

Product: hypothetical protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKKFIAFQILIALAIGALIGHFFPDFGMALRPVGDGFIRLIKMIVVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVI
TTLVLALGLLLANVLKPGVGLNLSHLAKKDIHELSGYTEKVVDLKQMLLDIIPVNIIDVMAKNDLLAVIFFAILFGVAAA
GIGKASAPVMSFFESTANIMFKLTQMVMVTAPIGVLALMAASVGQFGIALLLPMLKLIGTVFLGLFLILFVLFPIVGLIF
KIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRMEKYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFHVEMP
LSQQLLMMLVLVMTSKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAVACIVVSKWEKAFK
YKGPVTADQTARTESM

Sequences:

>Translated_416_residues
MKKFIAFQILIALAIGALIGHFFPDFGMALRPVGDGFIRLIKMIVVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVI
TTLVLALGLLLANVLKPGVGLNLSHLAKKDIHELSGYTEKVVDLKQMLLDIIPVNIIDVMAKNDLLAVIFFAILFGVAAA
GIGKASAPVMSFFESTANIMFKLTQMVMVTAPIGVLALMAASVGQFGIALLLPMLKLIGTVFLGLFLILFVLFPIVGLIF
KIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRMEKYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFHVEMP
LSQQLLMMLVLVMTSKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAVACIVVSKWEKAFK
YKGPVTADQTARTESM
>Mature_416_residues
MKKFIAFQILIALAIGALIGHFFPDFGMALRPVGDGFIRLIKMIVVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVI
TTLVLALGLLLANVLKPGVGLNLSHLAKKDIHELSGYTEKVVDLKQMLLDIIPVNIIDVMAKNDLLAVIFFAILFGVAAA
GIGKASAPVMSFFESTANIMFKLTQMVMVTAPIGVLALMAASVGQFGIALLLPMLKLIGTVFLGLFLILFVLFPIVGLIF
KIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRMEKYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFHVEMP
LSQQLLMMLVLVMTSKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAVACIVVSKWEKAFK
YKGPVTADQTARTESM

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=408, Percent_Identity=26.2254901960784, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI40254478, Length=432, Percent_Identity=26.3888888888889, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI66773030, Length=419, Percent_Identity=25.5369928400955, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI169790839, Length=450, Percent_Identity=22.8888888888889, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4827012, Length=266, Percent_Identity=27.4436090225564, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI223468566, Length=251, Percent_Identity=27.8884462151394, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI223468564, Length=250, Percent_Identity=28, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI194239697, Length=253, Percent_Identity=28.0632411067194, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI5032093, Length=385, Percent_Identity=25.7142857142857, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI262359914, Length=383, Percent_Identity=22.7154046997389, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI301601644, Length=189, Percent_Identity=28.042328042328, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1790514, Length=422, Percent_Identity=43.3649289099526, Blast_Score=347, Evalue=6e-97,
Organism=Escherichia coli, GI1789947, Length=406, Percent_Identity=39.4088669950739, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1788024, Length=386, Percent_Identity=28.4974093264249, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17537407, Length=394, Percent_Identity=26.6497461928934, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=444, Percent_Identity=25, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71983106, Length=445, Percent_Identity=26.0674157303371, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71983099, Length=445, Percent_Identity=26.0674157303371, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193206505, Length=422, Percent_Identity=26.5402843601896, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193206654, Length=426, Percent_Identity=25.3521126760563, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17541374, Length=404, Percent_Identity=25.7425742574257, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583025, Length=399, Percent_Identity=23.5588972431078, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137668, Length=399, Percent_Identity=23.5588972431078, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24583023, Length=399, Percent_Identity=23.5588972431078, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281360481, Length=438, Percent_Identity=25.5707762557078, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281360483, Length=438, Percent_Identity=25.5707762557078, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137666, Length=438, Percent_Identity=25.5707762557078, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44577; Mature: 44577

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure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CCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7751298; 9384377 [H]