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The map label for this gene is dgk [H]

Identifier: 154684534

GI number: 154684534

Start: 24185

End: 24808

Strand: Reverse

Name: dgk [H]

Synonym: RBAM_000200

Alternate gene names: 154684534

Gene position: 24808-24185 (Counterclockwise)

Preceding gene: 154684535

Following gene: 154684533

Centisome position: 0.63

GC content: 42.15

Gene sequence:

>624_bases
ATGAACAGAGCCCCTTTTATCGCGGTAGAAGGTCCTATCGGGGCAGGAAAAACGACACTCGCTACGATGCTTTCTGAAGA
GCTCGGTTTTCCTATGATTAATGAGATTGTGGAAGACAACCCTTATCTCGATAAGTTTTATGACAATATCGAGGAGTGGA
GTTTCCAGCTTGAAATGTTTTTTCTATGTCACAGGTATAAACAGCTTGAAGACACCGATCGAGATTATTTAAAACAAGGA
CAGCCCGTTTTGTCCGATTATCATATTTATAAAAATGTTATTTTCGCAGAGCGTACATTGCACGGCCAAAAGCTTGAGAA
GTATAAGCAGATCTATCACCTGCTCACTCACGACCTGCCGAAGCCGAATATCATTGTATACATAAAGGCAAGCCTGCCGA
CATTGCTTCAACGCATCGAAAAACGCGGGCGCCCGTTTGAGAAAAATATCGAGCATCAATATCTGGAACGTCTCATTACA
GATTACGACACAGCCATCAGACAGCTTCAGGAAGAAGACCCGGATATATCTGTACTGACCATTGACGGTGATACTGAAGA
CTTTGTTTTGAATAAGACAGACTATGAAAGAATTGCCCGTCAGGTAAAGGAGCTTATTAAATGA

Upstream 100 bases:

>100_bases
GTTAATTGGAAGCGTCTTTTTTCATGGGCTTTTCTGAGAGTGTGATACAATATAAAGGCCGGCAGCTGACGGATGTTTGC
AGAATTAAGGAGGATTTTCA

Downstream 100 bases:

>100_bases
AAGACATTCATATTCCAAACAACGCCATTATAACAGTAGCGGGAACGGTAGGAGTCGGAAAATCGACTTTGACCAAAGCT
TTAGCAAAACGGCTCGGGTT

Product: deoxyguanosine kinase

Products: NA

Alternate protein names: DGUO kinase; dGK [H]

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MNRAPFIAVEGPIGAGKTTLATMLSEELGFPMINEIVEDNPYLDKFYDNIEEWSFQLEMFFLCHRYKQLEDTDRDYLKQG
QPVLSDYHIYKNVIFAERTLHGQKLEKYKQIYHLLTHDLPKPNIIVYIKASLPTLLQRIEKRGRPFEKNIEHQYLERLIT
DYDTAIRQLQEEDPDISVLTIDGDTEDFVLNKTDYERIARQVKELIK

Sequences:

>Translated_207_residues
MNRAPFIAVEGPIGAGKTTLATMLSEELGFPMINEIVEDNPYLDKFYDNIEEWSFQLEMFFLCHRYKQLEDTDRDYLKQG
QPVLSDYHIYKNVIFAERTLHGQKLEKYKQIYHLLTHDLPKPNIIVYIKASLPTLLQRIEKRGRPFEKNIEHQYLERLIT
DYDTAIRQLQEEDPDISVLTIDGDTEDFVLNKTDYERIARQVKELIK
>Mature_207_residues
MNRAPFIAVEGPIGAGKTTLATMLSEELGFPMINEIVEDNPYLDKFYDNIEEWSFQLEMFFLCHRYKQLEDTDRDYLKQG
QPVLSDYHIYKNVIFAERTLHGQKLEKYKQIYHLLTHDLPKPNIIVYIKASLPTLLQRIEKRGRPFEKNIEHQYLERLIT
DYDTAIRQLQEEDPDISVLTIDGDTEDFVLNKTDYERIARQVKELIK

Specific function: Plays an essential role in generating the deoxyribonucleotide precursors dGTP for DNA metabolism. Highly specific toward deoxyguanosine (dGuo) and deoxyinosine (dIno). Only marginal activity is observed with guanosine. UTP is slightly more efficient as ph

COG id: COG1428

COG function: function code F; Deoxynucleoside kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DCK/DGK family [H]

Homologues:

Organism=Homo sapiens, GI4758768, Length=186, Percent_Identity=26.3440860215054, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002624 [H]

Pfam domain/function: PF01712 dNK [H]

EC number: =2.7.1.113 [H]

Molecular weight: Translated: 24515; Mature: 24515

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRAPFIAVEGPIGAGKTTLATMLSEELGFPMINEIVEDNPYLDKFYDNIEEWSFQLEMF
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
FLCHRYKQLEDTDRDYLKQGQPVLSDYHIYKNVIFAERTLHGQKLEKYKQIYHLLTHDLP
HHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KPNIIVYIKASLPTLLQRIEKRGRPFEKNIEHQYLERLITDYDTAIRQLQEEDPDISVLT
CCCEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IDGDTEDFVLNKTDYERIARQVKELIK
ECCCCCCEEECCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNRAPFIAVEGPIGAGKTTLATMLSEELGFPMINEIVEDNPYLDKFYDNIEEWSFQLEMF
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
FLCHRYKQLEDTDRDYLKQGQPVLSDYHIYKNVIFAERTLHGQKLEKYKQIYHLLTHDLP
HHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KPNIIVYIKASLPTLLQRIEKRGRPFEKNIEHQYLERLITDYDTAIRQLQEEDPDISVLT
CCCEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
IDGDTEDFVLNKTDYERIARQVKELIK
ECCCCCCEEECCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]