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The map label for this gene is ctaB [H]

Identifier: 154248565

GI number: 154248565

Start: 5133962

End: 5134909

Strand: Reverse

Name: ctaB [H]

Synonym: Xaut_4646

Alternate gene names: 154248565

Gene position: 5134909-5133962 (Counterclockwise)

Preceding gene: 154248566

Following gene: 154248564

Centisome position: 96.72

GC content: 67.72

Gene sequence:

>948_bases
ATGCGTGACGAACAAGCGAGCCTGACCAATCCCGAGCCGTATGCCTTCGCGGCGGCCGGAGAGGGACTGGCGTCGCCACG
CGACTATTTCGAGCTCCTGAAGCCGCGTGTGATGTCGCTCGTCATCTTCACGGCGCTGGTGGGTCTCGTCCGCGCGCCGG
GAGATGTGCACCCCATCATCGCCTTCACCGCCCTGTTGTGCATCGCCGTCGGCGCGGGTGCGGCCGGCGCCCTCAACATG
TGGTGGGACGCGGACATTGACGCCATCATGTCGCGCACCCGCAAGCGACCGGTGCCGTCGGGCCGGGTCACGGCCCATGA
GGCGCTGGCCTTCGGCCTCACCCTGTCGGCCTTCTCGGTGGTGGTGCTGGGGCTGCTGGTCAACGCGCTGGCAGGCGCGC
TGCTCGCCTTCACCATCTTCTTCTATGTGGTGATCTACACCATGTGGCTGAAGCGCTCGACGCCGCAGAACATCGTCATC
GGCGGCGCCGCCGGTGCGTTCCCGCCACTGGTGGCCTGGGCGGCGGCTTCTGGCACGGTGTCGCTGGAGCCGGTGCTGCT
GTTCGCCATCATCTTCTTCTGGACCCCGCCCCATTTCTGGGCCCTGGCCCTCTACCGGGCGGACGACTACGCCCGCGCCG
GCGTCCCCATGCTGCCGGTGACGGCGGGTCCCGACGAAACGCGCCTTCAGATCCTGCTCTACACCCTGTTCCTGGTGCCG
CTGGCTGCCAGTCCTGCCGTGCTCGGCTATGTCGGCTACGCCTATGGTGCGGTGGCGGTGCTGGCGGGGGCCTGGATGAT
CGCTCTGGCCTGGCGCGTCTATCGCCGCCGCGAGGGGGAGGCTGCCGTGAAGGCGGCAAAGGGCCTGTTCGGCTTCTCGA
TCGTTTATCTGTTCGCGTTGTTCGCCACACTCCTCGGCGAGGCGGTGATTGGTGGGCTGCTGCGATGA

Upstream 100 bases:

>100_bases
CGCCCGGAGAGGCGTGGGGAACCGCCAGACCGGTCCGGTCGGGGGCATGATCCTCCGGACGCACCGGGCTTGGGCCAGCA
GAGTTTGAGGGAGTTTCGGG

Downstream 100 bases:

>100_bases
GCAAGGACAAGAAGACGCCGCGTCCCTCGCAAGAGGAGGGCGTGGTGCTGACGCCGGAACAGCTCAGGCGGCGGCGAGCG
CGCAACATCGCCATCGCCTC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MRDEQASLTNPEPYAFAAAGEGLASPRDYFELLKPRVMSLVIFTALVGLVRAPGDVHPIIAFTALLCIAVGAGAAGALNM
WWDADIDAIMSRTRKRPVPSGRVTAHEALAFGLTLSAFSVVVLGLLVNALAGALLAFTIFFYVVIYTMWLKRSTPQNIVI
GGAAGAFPPLVAWAAASGTVSLEPVLLFAIIFFWTPPHFWALALYRADDYARAGVPMLPVTAGPDETRLQILLYTLFLVP
LAASPAVLGYVGYAYGAVAVLAGAWMIALAWRVYRRREGEAAVKAAKGLFGFSIVYLFALFATLLGEAVIGGLLR

Sequences:

>Translated_315_residues
MRDEQASLTNPEPYAFAAAGEGLASPRDYFELLKPRVMSLVIFTALVGLVRAPGDVHPIIAFTALLCIAVGAGAAGALNM
WWDADIDAIMSRTRKRPVPSGRVTAHEALAFGLTLSAFSVVVLGLLVNALAGALLAFTIFFYVVIYTMWLKRSTPQNIVI
GGAAGAFPPLVAWAAASGTVSLEPVLLFAIIFFWTPPHFWALALYRADDYARAGVPMLPVTAGPDETRLQILLYTLFLVP
LAASPAVLGYVGYAYGAVAVLAGAWMIALAWRVYRRREGEAAVKAAKGLFGFSIVYLFALFATLLGEAVIGGLLR
>Mature_315_residues
MRDEQASLTNPEPYAFAAAGEGLASPRDYFELLKPRVMSLVIFTALVGLVRAPGDVHPIIAFTALLCIAVGAGAAGALNM
WWDADIDAIMSRTRKRPVPSGRVTAHEALAFGLTLSAFSVVVLGLLVNALAGALLAFTIFFYVVIYTMWLKRSTPQNIVI
GGAAGAFPPLVAWAAASGTVSLEPVLLFAIIFFWTPPHFWALALYRADDYARAGVPMLPVTAGPDETRLQILLYTLFLVP
LAASPAVLGYVGYAYGAVAVLAGAWMIALAWRVYRRREGEAAVKAAKGLFGFSIVYLFALFATLLGEAVIGGLLR

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=264, Percent_Identity=32.5757575757576, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=29.0322580645161, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=273, Percent_Identity=30.4029304029304, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=269, Percent_Identity=29.7397769516729, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19921064, Length=291, Percent_Identity=31.6151202749141, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 33638; Mature: 33638

Theoretical pI: Translated: 9.17; Mature: 9.17

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDEQASLTNPEPYAFAAAGEGLASPRDYFELLKPRVMSLVIFTALVGLVRAPGDVHPII
CCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AFTALLCIAVGAGAAGALNMWWDADIDAIMSRTRKRPVPSGRVTAHEALAFGLTLSAFSV
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VVLGLLVNALAGALLAFTIFFYVVIYTMWLKRSTPQNIVIGGAAGAFPPLVAWAAASGTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCC
SLEPVLLFAIIFFWTPPHFWALALYRADDYARAGVPMLPVTAGPDETRLQILLYTLFLVP
CHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
LAASPAVLGYVGYAYGAVAVLAGAWMIALAWRVYRRREGEAAVKAAKGLFGFSIVYLFAL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FATLLGEAVIGGLLR
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MRDEQASLTNPEPYAFAAAGEGLASPRDYFELLKPRVMSLVIFTALVGLVRAPGDVHPII
CCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
AFTALLCIAVGAGAAGALNMWWDADIDAIMSRTRKRPVPSGRVTAHEALAFGLTLSAFSV
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
VVLGLLVNALAGALLAFTIFFYVVIYTMWLKRSTPQNIVIGGAAGAFPPLVAWAAASGTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCCC
SLEPVLLFAIIFFWTPPHFWALALYRADDYARAGVPMLPVTAGPDETRLQILLYTLFLVP
CHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
LAASPAVLGYVGYAYGAVAVLAGAWMIALAWRVYRRREGEAAVKAAKGLFGFSIVYLFAL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FATLLGEAVIGGLLR
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA