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The map label for this gene is pcoA [H]

Identifier: 154248522

GI number: 154248522

Start: 5090228

End: 5091631

Strand: Direct

Name: pcoA [H]

Synonym: Xaut_4602

Alternate gene names: 154248522

Gene position: 5090228-5091631 (Clockwise)

Preceding gene: 154248521

Following gene: 154248523

Centisome position: 95.88

GC content: 64.1

Gene sequence:

>1404_bases
ATGACGGTTTCCCGAAGGAACTTCCTCGGAGCCTCCGGCGCCCTCGCGCTGGTGAGCGCCGGCGCTGTCTCCGGCCGCGT
CCAGGCGGCTTCCATCCCCGAGGCCGCCACCATGAAGGAGGCGACCATGCAGCCGCCACTCGTGCCCACATCCGGGCCGG
ACTACCAGCCGGTGGTCACCCTGAACGGCTGGACAGCGCCATGGCGGATGAACGGGGACTGGAAGGAATTCCACCTCGTT
GCCGAACCGGTGGTGCGCGAGATTGCCCCCGGCATGGTCGCGCACCTGTGGGGCTATAATGGCCAGTCCCCCGGCCCAAC
CATCGAGGCAGTGGAAGGCGACAAAGTCCGCATCTTCGTCACCAACCGCCTGCCCGAGCACACCACCATCCACTGGCACG
GGCAGATCCTGCCGAGCGGAATGGACGGGGTAGGCGGTCTCACCCAGCCGCACATCAAGCCAGGCAAGACTTTCGTCTAT
GAGTTCCAGCTCCGTAAGAGCGGCACGTTCATGTACCACCCCCATGCGGACGAGATGGTCCAGATGGCCATGGGGATGAT
GGGATTCTTCGTGGTGCACCCGAAGGACCCTGCCTTCCGGCGCGTGGACCGGGACTTCGTGTTCCTGCTGAATGCCTACG
ACATCGAGCCCGGCGCCTATGTGCCGAAGGTCAACACCATGCTCGACTTCAATCTGTGGACTTGGAACAGCCGCGCCTTT
CCCGGCATCGACCCGTTCGTGGTGGGCAAGGGCGACAAGGTGCGCATCCGGTTCGGTAATCTCACCATGACCAACCATCC
CATCCACATGCATGGCTACGACTTCAAGGTTTCCTGCACAGATGGGGGATGGGTTCCGGAGGAGGCGGCCTGGCCTGAGG
TGACCATCGACTGCGCGGTCGGCCAGATGCGCGCCTTCGATTTCGTGGCCGAGCATGCGGGGGACTGGGCGATCCACTGC
CACAAGTCCCACCATACCATGAACGCCATGGGCCACGACGTGCGCACCTATATCGGCGTCGACAAGAAGGAGCTGGCGAA
GAAGATCCGCAGGCTCGTGCCCGACTACATGCCCATGGGATCGACTGGCATGGCGGACATGGGCGAGATGGAGATGCCGC
TCCCCGACAACACGCTGCCCATGATGACCGGCTTCGCCCAGTTCGGAGCGGTGGAGATGGGCGGCATGTTCTCGGTGGTG
AAGGTGCGCGAAGGGATCGCCGCTGGCGACTACAGAGACCCGGGCTGGTTCAAGCACCCGGAAGGCACCGTCGCCTACGA
ATGGACGGGCGAGAGCAAGACGGTGGTTCGCGCCCCGTCTCCGGTTGTTGATTCCGCCACGACAACAGAAGTCCGCGTGG
TGAAGCCCGGCCGCGGCAGCTCAGGCGATCATGACGCCCACTGA

Upstream 100 bases:

>100_bases
TCGAGACGGCTATCCTCGGCGGGGGATCCGGCAGTGGAATCGGAACCGTCGTCGCATCTGCGGCTCCCGGCGGCGGCGAC
TGAAAGCAGGAGATGAAGGC

Downstream 100 bases:

>100_bases
TCCCTGACGATCAACACAGCAAAGGAGCACCATATGAAACTCAGGTCGTTGCTTGTTCCGGCCGTCGCCGCCGTTCTCGT
CGCCGGTGCCGCTTTGGCCT

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTVSRRNFLGASGALALVSAGAVSGRVQAASIPEAATMKEATMQPPLVPTSGPDYQPVVTLNGWTAPWRMNGDWKEFHLV
AEPVVREIAPGMVAHLWGYNGQSPGPTIEAVEGDKVRIFVTNRLPEHTTIHWHGQILPSGMDGVGGLTQPHIKPGKTFVY
EFQLRKSGTFMYHPHADEMVQMAMGMMGFFVVHPKDPAFRRVDRDFVFLLNAYDIEPGAYVPKVNTMLDFNLWTWNSRAF
PGIDPFVVGKGDKVRIRFGNLTMTNHPIHMHGYDFKVSCTDGGWVPEEAAWPEVTIDCAVGQMRAFDFVAEHAGDWAIHC
HKSHHTMNAMGHDVRTYIGVDKKELAKKIRRLVPDYMPMGSTGMADMGEMEMPLPDNTLPMMTGFAQFGAVEMGGMFSVV
KVREGIAAGDYRDPGWFKHPEGTVAYEWTGESKTVVRAPSPVVDSATTTEVRVVKPGRGSSGDHDAH

Sequences:

>Translated_467_residues
MTVSRRNFLGASGALALVSAGAVSGRVQAASIPEAATMKEATMQPPLVPTSGPDYQPVVTLNGWTAPWRMNGDWKEFHLV
AEPVVREIAPGMVAHLWGYNGQSPGPTIEAVEGDKVRIFVTNRLPEHTTIHWHGQILPSGMDGVGGLTQPHIKPGKTFVY
EFQLRKSGTFMYHPHADEMVQMAMGMMGFFVVHPKDPAFRRVDRDFVFLLNAYDIEPGAYVPKVNTMLDFNLWTWNSRAF
PGIDPFVVGKGDKVRIRFGNLTMTNHPIHMHGYDFKVSCTDGGWVPEEAAWPEVTIDCAVGQMRAFDFVAEHAGDWAIHC
HKSHHTMNAMGHDVRTYIGVDKKELAKKIRRLVPDYMPMGSTGMADMGEMEMPLPDNTLPMMTGFAQFGAVEMGGMFSVV
KVREGIAAGDYRDPGWFKHPEGTVAYEWTGESKTVVRAPSPVVDSATTTEVRVVKPGRGSSGDHDAH
>Mature_466_residues
TVSRRNFLGASGALALVSAGAVSGRVQAASIPEAATMKEATMQPPLVPTSGPDYQPVVTLNGWTAPWRMNGDWKEFHLVA
EPVVREIAPGMVAHLWGYNGQSPGPTIEAVEGDKVRIFVTNRLPEHTTIHWHGQILPSGMDGVGGLTQPHIKPGKTFVYE
FQLRKSGTFMYHPHADEMVQMAMGMMGFFVVHPKDPAFRRVDRDFVFLLNAYDIEPGAYVPKVNTMLDFNLWTWNSRAFP
GIDPFVVGKGDKVRIRFGNLTMTNHPIHMHGYDFKVSCTDGGWVPEEAAWPEVTIDCAVGQMRAFDFVAEHAGDWAIHCH
KSHHTMNAMGHDVRTYIGVDKKELAKKIRRLVPDYMPMGSTGMADMGEMEMPLPDNTLPMMTGFAQFGAVEMGGMFSVVK
VREGIAAGDYRDPGWFKHPEGTVAYEWTGESKTVVRAPSPVVDSATTTEVRVVKPGRGSSGDHDAH

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6323703, Length=104, Percent_Identity=42.3076923076923, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321067, Length=110, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI18859919, Length=108, Percent_Identity=41.6666666666667, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24650186, Length=140, Percent_Identity=33.5714285714286, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 51507; Mature: 51375

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSRRNFLGASGALALVSAGAVSGRVQAASIPEAATMKEATMQPPLVPTSGPDYQPVVT
CCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCEEEE
LNGWTAPWRMNGDWKEFHLVAEPVVREIAPGMVAHLWGYNGQSPGPTIEAVEGDKVRIFV
ECCCCCCEEECCCHHHEEEHHHHHHHHHCCCCEEHHCCCCCCCCCCEEEEECCCEEEEEE
TNRLPEHTTIHWHGQILPSGMDGVGGLTQPHIKPGKTFVYEFQLRKSGTFMYHPHADEMV
ECCCCCCCEEEEECEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEECCCHHHHH
QMAMGMMGFFVVHPKDPAFRRVDRDFVFLLNAYDIEPGAYVPKVNTMLDFNLWTWNSRAF
HHHHHHEEEEEECCCCHHHHHCCCCEEEEEEEEECCCCCCCCCCCEEEEEEEEEECCCCC
PGIDPFVVGKGDKVRIRFGNLTMTNHPIHMHGYDFKVSCTDGGWVPEEAAWPEVTIDCAV
CCCCCEEECCCCEEEEEECCEEEECCCEEECCCEEEEEECCCCCCCCCCCCCCEEEEEEC
GQMRAFDFVAEHAGDWAIHCHKSHHTMNAMGHDVRTYIGVDKKELAKKIRRLVPDYMPMG
CHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCHHHHHCCCHHHHHHHHHHHCCHHCCCC
STGMADMGEMEMPLPDNTLPMMTGFAQFGAVEMGGMFSVVKVREGIAAGDYRDPGWFKHP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEECCCCEEEEEHHCCCCCCCCCCCCCCCCC
EGTVAYEWTGESKTVVRAPSPVVDSATTTEVRVVKPGRGSSGDHDAH
CCCEEEEEECCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TVSRRNFLGASGALALVSAGAVSGRVQAASIPEAATMKEATMQPPLVPTSGPDYQPVVT
CCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCEEEE
LNGWTAPWRMNGDWKEFHLVAEPVVREIAPGMVAHLWGYNGQSPGPTIEAVEGDKVRIFV
ECCCCCCEEECCCHHHEEEHHHHHHHHHCCCCEEHHCCCCCCCCCCEEEEECCCEEEEEE
TNRLPEHTTIHWHGQILPSGMDGVGGLTQPHIKPGKTFVYEFQLRKSGTFMYHPHADEMV
ECCCCCCCEEEEECEECCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCEEEECCCHHHHH
QMAMGMMGFFVVHPKDPAFRRVDRDFVFLLNAYDIEPGAYVPKVNTMLDFNLWTWNSRAF
HHHHHHEEEEEECCCCHHHHHCCCCEEEEEEEEECCCCCCCCCCCEEEEEEEEEECCCCC
PGIDPFVVGKGDKVRIRFGNLTMTNHPIHMHGYDFKVSCTDGGWVPEEAAWPEVTIDCAV
CCCCCEEECCCCEEEEEECCEEEECCCEEECCCEEEEEECCCCCCCCCCCCCCEEEEEEC
GQMRAFDFVAEHAGDWAIHCHKSHHTMNAMGHDVRTYIGVDKKELAKKIRRLVPDYMPMG
CHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCHHHHHCCCHHHHHHHHHHHCCHHCCCC
STGMADMGEMEMPLPDNTLPMMTGFAQFGAVEMGGMFSVVKVREGIAAGDYRDPGWFKHP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEECCCCEEEEEHHCCCCCCCCCCCCCCCCC
EGTVAYEWTGESKTVVRAPSPVVDSATTTEVRVVKPGRGSSGDHDAH
CCCEEEEEECCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]