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The map label for this gene is kefC [H]

Identifier: 154248486

GI number: 154248486

Start: 5046861

End: 5048597

Strand: Direct

Name: kefC [H]

Synonym: Xaut_4566

Alternate gene names: 154248486

Gene position: 5046861-5048597 (Clockwise)

Preceding gene: 154248485

Following gene: 154248487

Centisome position: 95.06

GC content: 72.14

Gene sequence:

>1737_bases
GTGAGTGACGCCTTCCTGAAGGACGCGTTCGTCTATCTCCTCGCCGCCGGAATCCTCGTTCCGTTGTTTCACCGTGCCCG
AATCGGCGCCGTGGTGGGCTTCATTGCCGCCGGAGCGCTCATCGGCCCCCACGGTCTCGGCCGGCTGGCGGACAGCCTGC
CCTTCGTGCGCTTCATCACCATTTCCAGTCCCGAGCGCGCCGCCCCCTTCGGCGAACTGGGGGTGGTGTTCCTGCTGTTC
CTGCTGGGCCTTGAGTTCTCGGCCCCCCGCCTGTGGAAGCTGCGGCGGGAGGTGTTCGGCGTCGGCGCCCTGCAGGTGCT
GTTCTGCGGCGTCCCGCTGGCCCTCGGGCTGGCATTGGTGGCCGTGCCGGAGCCGGAGGTGGCGCTGGTGCTTGGCTTCG
CCCTCGCCCTGTCGTCCACCGCGCTGGTCAGCCAGCTGCTCATCGACCAGCACCGCTCTTTGGCGCCGCTGGGGCAGCTG
GTCATCGCCGTGCTGCTGTTCCAGGACCTGATGGTGGTGCCCATCCTGCTCGCGGCCGAGCTTTTGAGCGGGCCGGCGAC
CGATGTCCTCACCCTCGCAGCCATGGCGCTGGCAAAGGCCACGGGCGCGGTGGCGCTCATCCTGGTGGCCGGGCGCTTCG
TGCTGGCGCCGCTGGTGGCGGTGGCCGCCTCCACCCGCTCGCGCGAGCTGATCATGGCCATCACCCTGGTGGTGGTGGTG
GGCTCGGCGGCGGTGACCCATGCCGCTGGGCTGTCCAGCGCGCTCGGCGCCTTCCTCGCCGGCATGGCGCTCTCGGAAAC
CGCCTATCGCCACCAGATCGAGGTGGACCTGGAGCCGTTCAAGGGCCTGCTGGTGGGTGTGTTCTTCGTTACCGTGGGCA
TGAGCCTTGATTTCGCGGCTGTGCTGCCGCGCGCCCTGTGGGTGGTGGCTGGGGTCGCCGCGCTGATCGCGGTGAAGGCC
GCCTGCACCTATGGCGCCGCCCGGTTGCTGCGCGTGAGCGCGCCCGCCGCCGCCGAGGCCGCCCTGCTGTTGTCCCAGAC
CGGGGAATTCGCCTTCGTGGTGCTGGGGCTGCTCGCCGCCAAGGGCGTGCTGGGCGCGCAGGATGCCGCCACCCTCGTCG
CCGTGGTCAGCCTCAGCCTTGCCGCAACGCCGGTGCTGGCCCGTGTCGCGGCAAGGCTCGGGCGCACGCTGGATGCAAGG
CTGCATGACGCCCTGGCGCCGGTGGCCAGCACCGCCAGCGGCCATGTGATCATCGGTGGGTTCGGCCGGGTGGGCCGCAC
CATCGCCGACGCACTGGACGAGGAAGGCGTGCCCTATGTGGCGGTGGACGCCGACCCGAGACGGGTGGCGCAGGCCCGGA
CGGCGGGACGACCGGTGTTCTTCGGCGATGCCGGGCGGGCCGAGATCCTCGACCGTCTGGGGGCGGAGCGCGCGCTCGCC
TTCGTGGCGACGCTGGACGCGCCCAACGCCGCCGAGCGCATGGTGGCAGCGGTGCGCCAGCACTGGCCCGGCACGGCGGT
GATCGCCCGCGCCAAGGATGCCGAGCATGCCCGCCGCCTCGCCGCGCTCGGGGTGGCCGGCGTCATTCCGGAGGCGGCGG
AGGCGAGCCTCCAGCTCATGGCCCAGCTTCTGTCCAGCCTCGGGCTTGCCGACGAGGCGGTGGCCGCCCGCACCGAGCAG
ACGCGGGCGCGCATCCGCGACGACATCGAGCGGCGCACCGGCGCGGAAGGGATCTGA

Upstream 100 bases:

>100_bases
CCGTTCCGCGTGGTCATCTCCCGCGACCATCGAAGGCCGAAGCACGGCCGGGTGAAGCGTGCGGACGGGACTTAAGGATG
CCGGGTCGAGGGAAAAGAAG

Downstream 100 bases:

>100_bases
CGGCATGAGGTGGAGAAAGCTGCGCCGCAGCGTCTTCGACATTCTGGAGCGGGACCTGCCTGGCGACCATATCGCCGATG
CGGTCCACTATTTCCTCATC

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 578; Mature: 577

Protein sequence:

>578_residues
MSDAFLKDAFVYLLAAGILVPLFHRARIGAVVGFIAAGALIGPHGLGRLADSLPFVRFITISSPERAAPFGELGVVFLLF
LLGLEFSAPRLWKLRREVFGVGALQVLFCGVPLALGLALVAVPEPEVALVLGFALALSSTALVSQLLIDQHRSLAPLGQL
VIAVLLFQDLMVVPILLAAELLSGPATDVLTLAAMALAKATGAVALILVAGRFVLAPLVAVAASTRSRELIMAITLVVVV
GSAAVTHAAGLSSALGAFLAGMALSETAYRHQIEVDLEPFKGLLVGVFFVTVGMSLDFAAVLPRALWVVAGVAALIAVKA
ACTYGAARLLRVSAPAAAEAALLLSQTGEFAFVVLGLLAAKGVLGAQDAATLVAVVSLSLAATPVLARVAARLGRTLDAR
LHDALAPVASTASGHVIIGGFGRVGRTIADALDEEGVPYVAVDADPRRVAQARTAGRPVFFGDAGRAEILDRLGAERALA
FVATLDAPNAAERMVAAVRQHWPGTAVIARAKDAEHARRLAALGVAGVIPEAAEASLQLMAQLLSSLGLADEAVAARTEQ
TRARIRDDIERRTGAEGI

Sequences:

>Translated_578_residues
MSDAFLKDAFVYLLAAGILVPLFHRARIGAVVGFIAAGALIGPHGLGRLADSLPFVRFITISSPERAAPFGELGVVFLLF
LLGLEFSAPRLWKLRREVFGVGALQVLFCGVPLALGLALVAVPEPEVALVLGFALALSSTALVSQLLIDQHRSLAPLGQL
VIAVLLFQDLMVVPILLAAELLSGPATDVLTLAAMALAKATGAVALILVAGRFVLAPLVAVAASTRSRELIMAITLVVVV
GSAAVTHAAGLSSALGAFLAGMALSETAYRHQIEVDLEPFKGLLVGVFFVTVGMSLDFAAVLPRALWVVAGVAALIAVKA
ACTYGAARLLRVSAPAAAEAALLLSQTGEFAFVVLGLLAAKGVLGAQDAATLVAVVSLSLAATPVLARVAARLGRTLDAR
LHDALAPVASTASGHVIIGGFGRVGRTIADALDEEGVPYVAVDADPRRVAQARTAGRPVFFGDAGRAEILDRLGAERALA
FVATLDAPNAAERMVAAVRQHWPGTAVIARAKDAEHARRLAALGVAGVIPEAAEASLQLMAQLLSSLGLADEAVAARTEQ
TRARIRDDIERRTGAEGI
>Mature_577_residues
SDAFLKDAFVYLLAAGILVPLFHRARIGAVVGFIAAGALIGPHGLGRLADSLPFVRFITISSPERAAPFGELGVVFLLFL
LGLEFSAPRLWKLRREVFGVGALQVLFCGVPLALGLALVAVPEPEVALVLGFALALSSTALVSQLLIDQHRSLAPLGQLV
IAVLLFQDLMVVPILLAAELLSGPATDVLTLAAMALAKATGAVALILVAGRFVLAPLVAVAASTRSRELIMAITLVVVVG
SAAVTHAAGLSSALGAFLAGMALSETAYRHQIEVDLEPFKGLLVGVFFVTVGMSLDFAAVLPRALWVVAGVAALIAVKAA
CTYGAARLLRVSAPAAAEAALLLSQTGEFAFVVLGLLAAKGVLGAQDAATLVAVVSLSLAATPVLARVAARLGRTLDARL
HDALAPVASTASGHVIIGGFGRVGRTIADALDEEGVPYVAVDADPRRVAQARTAGRPVFFGDAGRAEILDRLGAERALAF
VATLDAPNAAERMVAAVRQHWPGTAVIARAKDAEHARRLAALGVAGVIPEAAEASLQLMAQLLSSLGLADEAVAARTEQT
RARIRDDIERRTGAEGI

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=285, Percent_Identity=28.7719298245614, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786232, Length=576, Percent_Identity=37.5, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI1789749, Length=546, Percent_Identity=37.5457875457875, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1786685, Length=555, Percent_Identity=30.0900900900901, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 59565; Mature: 59434

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAFLKDAFVYLLAAGILVPLFHRARIGAVVGFIAAGALIGPHGLGRLADSLPFVRFIT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEE
ISSPERAAPFGELGVVFLLFLLGLEFSAPRLWKLRREVFGVGALQVLFCGVPLALGLALV
ECCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHE
AVPEPEVALVLGFALALSSTALVSQLLIDQHRSLAPLGQLVIAVLLFQDLMVVPILLAAE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLSGPATDVLTLAAMALAKATGAVALILVAGRFVLAPLVAVAASTRSRELIMAITLVVVV
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GSAAVTHAAGLSSALGAFLAGMALSETAYRHQIEVDLEPFKGLLVGVFFVTVGMSLDFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHCCCCCHHH
VLPRALWVVAGVAALIAVKAACTYGAARLLRVSAPAAAEAALLLSQTGEFAFVVLGLLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
KGVLGAQDAATLVAVVSLSLAATPVLARVAARLGRTLDARLHDALAPVASTASGHVIIGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEC
FGRVGRTIADALDEEGVPYVAVDADPRRVAQARTAGRPVFFGDAGRAEILDRLGAERALA
CHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCEEECCCCHHHHHHHHCHHHHHH
FVATLDAPNAAERMVAAVRQHWPGTAVIARAKDAEHARRLAALGVAGVIPEAAEASLQLM
HHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
AQLLSSLGLADEAVAARTEQTRARIRDDIERRTGAEGI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDAFLKDAFVYLLAAGILVPLFHRARIGAVVGFIAAGALIGPHGLGRLADSLPFVRFIT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEE
ISSPERAAPFGELGVVFLLFLLGLEFSAPRLWKLRREVFGVGALQVLFCGVPLALGLALV
ECCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHE
AVPEPEVALVLGFALALSSTALVSQLLIDQHRSLAPLGQLVIAVLLFQDLMVVPILLAAE
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLSGPATDVLTLAAMALAKATGAVALILVAGRFVLAPLVAVAASTRSRELIMAITLVVVV
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GSAAVTHAAGLSSALGAFLAGMALSETAYRHQIEVDLEPFKGLLVGVFFVTVGMSLDFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHCCCCCHHH
VLPRALWVVAGVAALIAVKAACTYGAARLLRVSAPAAAEAALLLSQTGEFAFVVLGLLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
KGVLGAQDAATLVAVVSLSLAATPVLARVAARLGRTLDARLHDALAPVASTASGHVIIGG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEC
FGRVGRTIADALDEEGVPYVAVDADPRRVAQARTAGRPVFFGDAGRAEILDRLGAERALA
CHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCEEECCCCHHHHHHHHCHHHHHH
FVATLDAPNAAERMVAAVRQHWPGTAVIARAKDAEHARRLAALGVAGVIPEAAEASLQLM
HHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
AQLLSSLGLADEAVAARTEQTRARIRDDIERRTGAEGI
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA