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The map label for this gene is uppS [H]

Identifier: 154248355

GI number: 154248355

Start: 4921371

End: 4922138

Strand: Reverse

Name: uppS [H]

Synonym: Xaut_4435

Alternate gene names: 154248355

Gene position: 4922138-4921371 (Counterclockwise)

Preceding gene: 154248356

Following gene: 154248354

Centisome position: 92.71

GC content: 68.49

Gene sequence:

>768_bases
ATGTCCCTACGCGCCGCTGCGGGCGAGGCCACCGTTACCGAACGGTCGCCGGCTGTCGTCCCGGTGCATGTGGGCGTGAT
CATGGACGGCAACGGGCGCTGGGCCACTTCGCGCAAGCTGCCGCGGGTGGAGGGCCACCGGCGCGGGGTGGAGGCGCTGC
GCCGGTGCGTGCGCGCCGCCCGCGAGGTGGGCATCCGCTTCCTCACCATCTACAGCTTCTCGTCGGAGAACTGGTCGCGG
CCACTGACCGAGGTACGGGAGCTGATGGGGCTCCTGAAGCTGTTCCTGCGCCACGACCTCGCTGACCTGCATGCCGACAA
TGTGCGGGTGAAGGTGATCGGCGAGCGGGACAATCTCGCCCCCGACATCCGCCAGCTGCTGGTGGATGCCGAGGCCCTGA
CCTGCAACAACACCGGCCTCACCCTGGTGGTGGCGTTCAATTACGGCTCGCGGCAGGAGATCGCGGCCGCGGTCTCGCGC
ATCGCGGCGGATGTCGCCGCCGGCCGGGTGCGGCCGCAGGACGTGGATGTGGACATGATCTCCCAGCGGCTCGAGACCGC
AGGCATCCCCGATCCCGACCTCATCGTGCGCACCTCCGGCGAGCAGCGGCTCTCGAACTTCCTGCTGTGGCAGGCGGCTT
ATTCCGAATTCGTGTTCCTGCCCATCTACTGGCCCGATTTCGACAAGGCCGCCCTGCTTGCGGCCATTGACGAATATGCC
CGGCGGGATCGCCGCTTCGGCGGCGTCACCAAGTGTCCGGGACCCTGA

Upstream 100 bases:

>100_bases
GCCACCGACGAAACCATCGCCGAGATCGACCAGACGCTCGCCCAGAAGGAAAAGGAAATCCTTTCGGTTTGAGGAGCCGC
TCTTGAGCCCGGAGCAAGCC

Downstream 100 bases:

>100_bases
CCCCCGTGAATTTCGGTTCCGATCTGAAGCATCGGACGCTCTCCGCGCTCGTCCTCGTGCCGGTTGTGCTCCTCGCCGCC
TATCTGGGCGGCATTCCCTT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MSLRAAAGEATVTERSPAVVPVHVGVIMDGNGRWATSRKLPRVEGHRRGVEALRRCVRAAREVGIRFLTIYSFSSENWSR
PLTEVRELMGLLKLFLRHDLADLHADNVRVKVIGERDNLAPDIRQLLVDAEALTCNNTGLTLVVAFNYGSRQEIAAAVSR
IAADVAAGRVRPQDVDVDMISQRLETAGIPDPDLIVRTSGEQRLSNFLLWQAAYSEFVFLPIYWPDFDKAALLAAIDEYA
RRDRRFGGVTKCPGP

Sequences:

>Translated_255_residues
MSLRAAAGEATVTERSPAVVPVHVGVIMDGNGRWATSRKLPRVEGHRRGVEALRRCVRAAREVGIRFLTIYSFSSENWSR
PLTEVRELMGLLKLFLRHDLADLHADNVRVKVIGERDNLAPDIRQLLVDAEALTCNNTGLTLVVAFNYGSRQEIAAAVSR
IAADVAAGRVRPQDVDVDMISQRLETAGIPDPDLIVRTSGEQRLSNFLLWQAAYSEFVFLPIYWPDFDKAALLAAIDEYA
RRDRRFGGVTKCPGP
>Mature_254_residues
SLRAAAGEATVTERSPAVVPVHVGVIMDGNGRWATSRKLPRVEGHRRGVEALRRCVRAAREVGIRFLTIYSFSSENWSRP
LTEVRELMGLLKLFLRHDLADLHADNVRVKVIGERDNLAPDIRQLLVDAEALTCNNTGLTLVVAFNYGSRQEIAAAVSRI
AADVAAGRVRPQDVDVDMISQRLETAGIPDPDLIVRTSGEQRLSNFLLWQAAYSEFVFLPIYWPDFDKAALLAAIDEYAR
RDRRFGGVTKCPGP

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=241, Percent_Identity=36.5145228215768, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI45580738, Length=241, Percent_Identity=36.5145228215768, Blast_Score=151, Evalue=6e-37,
Organism=Escherichia coli, GI1786371, Length=243, Percent_Identity=43.2098765432099, Blast_Score=214, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=36.4444444444444, Blast_Score=133, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6319474, Length=222, Percent_Identity=35.1351351351351, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323748, Length=230, Percent_Identity=29.5652173913043, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18857969, Length=239, Percent_Identity=38.0753138075314, Blast_Score=147, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28322; Mature: 28191

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRAAAGEATVTERSPAVVPVHVGVIMDGNGRWATSRKLPRVEGHRRGVEALRRCVRAA
CCCCCCCCCCEEECCCCCEEEEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHH
REVGIRFLTIYSFSSENWSRPLTEVRELMGLLKLFLRHDLADLHADNVRVKVIGERDNLA
HHCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
PDIRQLLVDAEALTCNNTGLTLVVAFNYGSRQEIAAAVSRIAADVAAGRVRPQDVDVDMI
HHHHHHHHHHHHEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
SQRLETAGIPDPDLIVRTSGEQRLSNFLLWQAAYSEFVFLPIYWPDFDKAALLAAIDEYA
HHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHH
RRDRRFGGVTKCPGP
HHHHHCCCCCCCCCC
>Mature Secondary Structure 
SLRAAAGEATVTERSPAVVPVHVGVIMDGNGRWATSRKLPRVEGHRRGVEALRRCVRAA
CCCCCCCCCEEECCCCCEEEEEEEEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHH
REVGIRFLTIYSFSSENWSRPLTEVRELMGLLKLFLRHDLADLHADNVRVKVIGERDNLA
HHCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCC
PDIRQLLVDAEALTCNNTGLTLVVAFNYGSRQEIAAAVSRIAADVAAGRVRPQDVDVDMI
HHHHHHHHHHHHEEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
SQRLETAGIPDPDLIVRTSGEQRLSNFLLWQAAYSEFVFLPIYWPDFDKAALLAAIDEYA
HHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHH
RRDRRFGGVTKCPGP
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]