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The map label for this gene is lpxD

Identifier: 154248350

GI number: 154248350

Start: 4914168

End: 4915265

Strand: Reverse

Name: lpxD

Synonym: Xaut_4430

Alternate gene names: 154248350

Gene position: 4915265-4914168 (Counterclockwise)

Preceding gene: 154248351

Following gene: 154248349

Centisome position: 92.58

GC content: 69.58

Gene sequence:

>1098_bases
ATGAGCCACGACGTCTTCTTCCCGCTTCCGGCGCCCCTCACCCTTGCGGAGGTGGCGGCCCTCAGCGGGGCGCGGCTGGC
CGTCGCCGATGAGGCGCAGGCTGCCGAACTGGGTGCTCGCACCATCACCGGCGTCGGCACCCTGGAGACGGCGGGACCGG
ACGAACTCGCCTTCTGCGATACGGTCCAGTTCGCCGAGAAGCTCGGCACCGTGCGGGCCGGCGCTGTCATCACCGCCGAG
CGCTTCGCCGCCAAGGCGCCCCCCGGCCTCGTTGTGCTCATCGCGCCCCGTCCCGCTGCGGCCTTTCTCGCCGTCACGCG
CTTCCTGTTCCCCGGAGCCCTCAAGCCGCTGTCCATCTTCGGCCAGGACGGCGTGGCGCCGGGCGCTCAGGTGCATCCCA
AGGCGCGGCTCGAGGACGGGGTGACGGTGGATCCCGGCGCCGTGATCGGTCCCGGCGCTGAAATCGGCGCGGGCACTATC
GTTTGCGCGGGCGCCATCATCGGACCGAATGTCCGCATCGGCCGCAACTGTGCCATCGGGCCCGGCGCCAGCGTCATCCA
TGCGTTTCTCGGCAACGGCGTCATCATCCATGGCGGCGCGCGCATCGGCTCGGATGGCTTCGGCTACCAGCCAAGCCCCA
GGGGCCATGTGAAGGTGCCACAGATCGGCCGGGTGGTGATCCAGGACGACGTGGAAATCGGCGCCAATACCACCATCGAT
CGCGGCGCGTTGACCGATACGGTCATCGGCGAGGGCACCAAGATCGACAATCTGGTGCAGATCGCCCACAACGTGGTGAC
CGGCCGCCATTGCATCGTCGTGTCCCAGACCGGGATTTCCGGGTCCACCACGCTGGGGGATTTCGTGATGCTGGGCGGTC
AGGTGGGCGTGGTGGGCCATGCCACCATCGGCACGGGCGCGCAGATCGCGGCCTCCAGCAATGTGAAGGGCGATGTGCCA
CCCGGCGTGCGCTGGGGCGGTTCGCCGGCCAAGCCGGTGCGCGAATGGTTCCGCGAGGTAACGACCCTCAAGCGCCTCGC
CGCGGCCAGCGCCCGGCGCGGCGGCAATGACGGGGAAGGGGAAGGATCGGGGGAATGA

Upstream 100 bases:

>100_bases
TTCTGATCCCGAACCTGCAAGGCGGGCGCTGGAGGGGGGTGGCTTTGGCCCCAACCTTCCGGCGCCCGCCGCGTTCTTAG
CGCCCGGGCGTACCCTTTCC

Downstream 100 bases:

>100_bases
ACGATACGACGCATGCCGCCGAAGGTGCGGAGCCGAAGGTGCTCGCCAGCGCTGACATCCTGAAGGTGCTCACCTGTCTG
CCCCACCGCTATCCGTTCCT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MSHDVFFPLPAPLTLAEVAALSGARLAVADEAQAAELGARTITGVGTLETAGPDELAFCDTVQFAEKLGTVRAGAVITAE
RFAAKAPPGLVVLIAPRPAAAFLAVTRFLFPGALKPLSIFGQDGVAPGAQVHPKARLEDGVTVDPGAVIGPGAEIGAGTI
VCAGAIIGPNVRIGRNCAIGPGASVIHAFLGNGVIIHGGARIGSDGFGYQPSPRGHVKVPQIGRVVIQDDVEIGANTTID
RGALTDTVIGEGTKIDNLVQIAHNVVTGRHCIVVSQTGISGSTTLGDFVMLGGQVGVVGHATIGTGAQIAASSNVKGDVP
PGVRWGGSPAKPVREWFREVTTLKRLAAASARRGGNDGEGEGSGE

Sequences:

>Translated_365_residues
MSHDVFFPLPAPLTLAEVAALSGARLAVADEAQAAELGARTITGVGTLETAGPDELAFCDTVQFAEKLGTVRAGAVITAE
RFAAKAPPGLVVLIAPRPAAAFLAVTRFLFPGALKPLSIFGQDGVAPGAQVHPKARLEDGVTVDPGAVIGPGAEIGAGTI
VCAGAIIGPNVRIGRNCAIGPGASVIHAFLGNGVIIHGGARIGSDGFGYQPSPRGHVKVPQIGRVVIQDDVEIGANTTID
RGALTDTVIGEGTKIDNLVQIAHNVVTGRHCIVVSQTGISGSTTLGDFVMLGGQVGVVGHATIGTGAQIAASSNVKGDVP
PGVRWGGSPAKPVREWFREVTTLKRLAAASARRGGNDGEGEGSGE
>Mature_364_residues
SHDVFFPLPAPLTLAEVAALSGARLAVADEAQAAELGARTITGVGTLETAGPDELAFCDTVQFAEKLGTVRAGAVITAER
FAAKAPPGLVVLIAPRPAAAFLAVTRFLFPGALKPLSIFGQDGVAPGAQVHPKARLEDGVTVDPGAVIGPGAEIGAGTIV
CAGAIIGPNVRIGRNCAIGPGASVIHAFLGNGVIIHGGARIGSDGFGYQPSPRGHVKVPQIGRVVIQDDVEIGANTTIDR
GALTDTVIGEGTKIDNLVQIAHNVVTGRHCIVVSQTGISGSTTLGDFVMLGGQVGVVGHATIGTGAQIAASSNVKGDVPP
GVRWGGSPAKPVREWFREVTTLKRLAAASARRGGNDGEGEGSGE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=333, Percent_Identity=34.2342342342342, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1786378, Length=235, Percent_Identity=32.3404255319149, Blast_Score=76, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 36785; Mature: 36654

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDVFFPLPAPLTLAEVAALSGARLAVADEAQAAELGARTITGVGTLETAGPDELAFCD
CCCCEEECCCCCHHHHHHHHHCCCEEEEECCHHHHHHCCEEEECCCCCCCCCCCCHHHHH
TVQFAEKLGTVRAGAVITAERFAAKAPPGLVVLIAPRPAAAFLAVTRFLFPGALKPLSIF
HHHHHHHHCCCCCCEEEEHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEEE
GQDGVAPGAQVHPKARLEDGVTVDPGAVIGPGAEIGAGTIVCAGAIIGPNVRIGRNCAIG
CCCCCCCCCCCCCCHHCCCCCEECCCCEECCCCCCCCCEEEEECEEECCCEEECCCCCCC
PGASVIHAFLGNGVIIHGGARIGSDGFGYQPSPRGHVKVPQIGRVVIQDDVEIGANTTID
CCHHHHHHHHCCCEEEECCCEECCCCCCCCCCCCCCEECCCCCEEEEECCCCCCCCCCCC
RGALTDTVIGEGTKIDNLVQIAHNVVTGRHCIVVSQTGISGSTTLGDFVMLGGQVGVVGH
CCCCCHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHEEECCEEEEEEE
ATIGTGAQIAASSNVKGDVPPGVRWGGSPAKPVREWFREVTTLKRLAAASARRGGNDGEG
EECCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EGSGE
CCCCC
>Mature Secondary Structure 
SHDVFFPLPAPLTLAEVAALSGARLAVADEAQAAELGARTITGVGTLETAGPDELAFCD
CCCEEECCCCCHHHHHHHHHCCCEEEEECCHHHHHHCCEEEECCCCCCCCCCCCHHHHH
TVQFAEKLGTVRAGAVITAERFAAKAPPGLVVLIAPRPAAAFLAVTRFLFPGALKPLSIF
HHHHHHHHCCCCCCEEEEHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCEEE
GQDGVAPGAQVHPKARLEDGVTVDPGAVIGPGAEIGAGTIVCAGAIIGPNVRIGRNCAIG
CCCCCCCCCCCCCCHHCCCCCEECCCCEECCCCCCCCCEEEEECEEECCCEEECCCCCCC
PGASVIHAFLGNGVIIHGGARIGSDGFGYQPSPRGHVKVPQIGRVVIQDDVEIGANTTID
CCHHHHHHHHCCCEEEECCCEECCCCCCCCCCCCCCEECCCCCEEEEECCCCCCCCCCCC
RGALTDTVIGEGTKIDNLVQIAHNVVTGRHCIVVSQTGISGSTTLGDFVMLGGQVGVVGH
CCCCCHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHEEECCEEEEEEE
ATIGTGAQIAASSNVKGDVPPGVRWGGSPAKPVREWFREVTTLKRLAAASARRGGNDGEG
EECCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EGSGE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA