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The map label for this gene is lpxB

Identifier: 154248346

GI number: 154248346

Start: 4910766

End: 4911959

Strand: Reverse

Name: lpxB

Synonym: Xaut_4426

Alternate gene names: 154248346

Gene position: 4911959-4910766 (Counterclockwise)

Preceding gene: 154248347

Following gene: 154248341

Centisome position: 92.52

GC content: 71.11

Gene sequence:

>1194_bases
ATGAGGGCGGACGGGGAGAAGGCGCTCCGCGTCTTCATGGTCGCAGGCGAAGAATCGGGCGACCAGCTCGGCGGTGCGCT
GATGGAGAACCTCCATGCCGCGGCACCTGGCATCGCCTTTCGCGGTGTGGGGGGCCGGCGCATGGCGGCGGCGGGGCTCA
CAAGCCTTTTTCCCATGGAGGACCTCACCGCCATCGGCATCGCCGCCGTGCTCGGCAAGCTGCCCACCATCCTGCGGCGG
CTTCGGGAAACGGTGGCGGCGGTGCTGGCTGATCCTCCGGACGTGCTGGTGCTGGTGGATGCGCCCGATTTCACCCATCG
CGTCGCCGCGCGGGTGCGGGCGGCCAATCCGAACATCCCCATCGTGAAATATGTTTCCCCCACCGTGTGGATCTGGCGTC
CGGGACGGGCGGCGGCCATGCGCCCGCATGTGGATGCGCTGCTGGCGCTGCTGCCGTTCGAGCCGGAGGTGCATCGCCGC
CTCGGCGGGCCGCCGACCTTCTATGTGGGCCACCCTTTGCTGGAGCGGCTCGACGAACTGCGCCCCTCGGAGGCGGAGGC
CGAGCGCCGGCGTGAGCCGCCGCCCCTGGTTCTGGTGCTGCCGGGGAGCCGCCGGCGCGAGATCGTCCGGCTCGGGGCGG
ACTTCGGCGCCGCGCTGGCGCAGGTGGGCCGGAACCGGCCCATGGACCTCGTCCTTCCCACCTTGCCGCGCCTGGAACCG
CTGGTGCGCCAGACCATCGCCTCCTGGCCGCTGAAGCCGCGCATCGTCACCACGGAGGCGGAGAAGTACGCCGCGTTCCG
CAGCGCGCGGGCCGCGCTCGCCGCATCGGGAACGGTCACTCTGGAACTGGCGCTGGCCGGCATTCCCCATGTGGCGGCCT
ATCGCGTGGGGTGGCTCGAGGCGCAGATCGCCCGGCGCATCCTGCAGGGCACCACGGTCATCCTCGCCAATCTGGTGGCA
GGCGAAAATGTGGTGCCTGAATATCTGCAGGAATATCTGACCGTGCCGGTGCTCGCGGACGCCCTCGACAAGGTCATCGG
CGACACGCCCGAGCGGGCGCGGCAGGACGCCACCTTCGCACGGTTCGATGATATTTTCGGCATCACCGGGCCGAGCCCCA
GCGCGCGTGCGGCCGAGGTGGTCCTGCGCCTCGCCCGCGGCGGGCGCACCGGCGCGTTGCCGCCACCAGCCTGA

Upstream 100 bases:

>100_bases
GCGCCATCGTGCCGGATGTGCAGGCGCTGGTGGCGGGGGCCGACGCGGCCGGCCTGTTCATCTACGGCATGGACCGGAGC
GGACCGGTGAGCGGCCAGCC

Downstream 100 bases:

>100_bases
CGCGATCGCCCGACGACACCGGCTCCGGCGTCGCGCGCCCAAATGTCTTGGCGCAGCCCAATGTCCTGCACACAAACGAA
AAGCGCGGCCCTGAGGCCGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MRADGEKALRVFMVAGEESGDQLGGALMENLHAAAPGIAFRGVGGRRMAAAGLTSLFPMEDLTAIGIAAVLGKLPTILRR
LRETVAAVLADPPDVLVLVDAPDFTHRVAARVRAANPNIPIVKYVSPTVWIWRPGRAAAMRPHVDALLALLPFEPEVHRR
LGGPPTFYVGHPLLERLDELRPSEAEAERRREPPPLVLVLPGSRRREIVRLGADFGAALAQVGRNRPMDLVLPTLPRLEP
LVRQTIASWPLKPRIVTTEAEKYAAFRSARAALAASGTVTLELALAGIPHVAAYRVGWLEAQIARRILQGTTVILANLVA
GENVVPEYLQEYLTVPVLADALDKVIGDTPERARQDATFARFDDIFGITGPSPSARAAEVVLRLARGGRTGALPPPA

Sequences:

>Translated_397_residues
MRADGEKALRVFMVAGEESGDQLGGALMENLHAAAPGIAFRGVGGRRMAAAGLTSLFPMEDLTAIGIAAVLGKLPTILRR
LRETVAAVLADPPDVLVLVDAPDFTHRVAARVRAANPNIPIVKYVSPTVWIWRPGRAAAMRPHVDALLALLPFEPEVHRR
LGGPPTFYVGHPLLERLDELRPSEAEAERRREPPPLVLVLPGSRRREIVRLGADFGAALAQVGRNRPMDLVLPTLPRLEP
LVRQTIASWPLKPRIVTTEAEKYAAFRSARAALAASGTVTLELALAGIPHVAAYRVGWLEAQIARRILQGTTVILANLVA
GENVVPEYLQEYLTVPVLADALDKVIGDTPERARQDATFARFDDIFGITGPSPSARAAEVVLRLARGGRTGALPPPA
>Mature_397_residues
MRADGEKALRVFMVAGEESGDQLGGALMENLHAAAPGIAFRGVGGRRMAAAGLTSLFPMEDLTAIGIAAVLGKLPTILRR
LRETVAAVLADPPDVLVLVDAPDFTHRVAARVRAANPNIPIVKYVSPTVWIWRPGRAAAMRPHVDALLALLPFEPEVHRR
LGGPPTFYVGHPLLERLDELRPSEAEAERRREPPPLVLVLPGSRRREIVRLGADFGAALAQVGRNRPMDLVLPTLPRLEP
LVRQTIASWPLKPRIVTTEAEKYAAFRSARAALAASGTVTLELALAGIPHVAAYRVGWLEAQIARRILQGTTVILANLVA
GENVVPEYLQEYLTVPVLADALDKVIGDTPERARQDATFARFDDIFGITGPSPSARAAEVVLRLARGGRTGALPPPA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=332, Percent_Identity=33.433734939759, Blast_Score=144, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42728; Mature: 42728

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS00732 RIBOSOMAL_S16

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRADGEKALRVFMVAGEESGDQLGGALMENLHAAAPGIAFRGVGGRRMAAAGLTSLFPME
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCHH
DLTAIGIAAVLGKLPTILRRLRETVAAVLADPPDVLVLVDAPDFTHRVAARVRAANPNIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCC
IVKYVSPTVWIWRPGRAAAMRPHVDALLALLPFEPEVHRRLGGPPTFYVGHPLLERLDEL
EEEECCCEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCEEEECCHHHHHHHHC
RPSEAEAERRREPPPLVLVLPGSRRREIVRLGADFGAALAQVGRNRPMDLVLPTLPRLEP
CCCHHHHHHCCCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHCCCCCCEEECCCCCHHHH
LVRQTIASWPLKPRIVTTEAEKYAAFRSARAALAASGTVTLELALAGIPHVAAYRVGWLE
HHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHH
AQIARRILQGTTVILANLVAGENVVPEYLQEYLTVPVLADALDKVIGDTPERARQDATFA
HHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHH
RFDDIFGITGPSPSARAAEVVLRLARGGRTGALPPPA
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRADGEKALRVFMVAGEESGDQLGGALMENLHAAAPGIAFRGVGGRRMAAAGLTSLFPME
CCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCHH
DLTAIGIAAVLGKLPTILRRLRETVAAVLADPPDVLVLVDAPDFTHRVAARVRAANPNIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCC
IVKYVSPTVWIWRPGRAAAMRPHVDALLALLPFEPEVHRRLGGPPTFYVGHPLLERLDEL
EEEECCCEEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCCEEEECCHHHHHHHHC
RPSEAEAERRREPPPLVLVLPGSRRREIVRLGADFGAALAQVGRNRPMDLVLPTLPRLEP
CCCHHHHHHCCCCCCEEEECCCCCCHHHHHHCCHHHHHHHHHCCCCCCEEECCCCCHHHH
LVRQTIASWPLKPRIVTTEAEKYAAFRSARAALAASGTVTLELALAGIPHVAAYRVGWLE
HHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHH
AQIARRILQGTTVILANLVAGENVVPEYLQEYLTVPVLADALDKVIGDTPERARQDATFA
HHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHH
RFDDIFGITGPSPSARAAEVVLRLARGGRTGALPPPA
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]