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The map label for this gene is trpC

Identifier: 154248295

GI number: 154248295

Start: 4850791

End: 4851582

Strand: Reverse

Name: trpC

Synonym: Xaut_4375

Alternate gene names: 154248295

Gene position: 4851582-4850791 (Counterclockwise)

Preceding gene: 154248296

Following gene: 154248294

Centisome position: 91.39

GC content: 68.18

Gene sequence:

>792_bases
ATGACCGATATTTTGAAGAAGATTGAAGCCTACAAGCGCGACGAGATTGCCGTCGCCAAGCATGCCCGTCCGCTGGGAGA
GATCGAGGCGGCGGCCCGTGCTGCGCCGCGCGTGCGGCCGTTTGCCGGAGCCATCGCCACCAGTCTGGCTGAAGGGCGCA
CCGCGCTCATTGCGGAGATCAAGAAGGCGAGTCCCTCCAAGGGCCTGATCCGGGCGGACTTCGATCCGCCGGCGCTGGCC
CGCGCCTACCAGCGCGGCGGCGCCACCTGCCTGTCCGTGCTCACCGACACTCCCTCCTTCCAGGGCGCGCCGGAATTCCT
CGGCTCCGCGCGCGCGGCGGTCGACCTGCCGGTGCTGCGCAAGGACTTCATGTACGACACCTACCAGGTGGCGGAGGCCC
GCGCCTGGGGGGCAGACTGCATCCTCATCATCATGGCCGGGGTGGACGACCTGCTCGCCCGTGACCTCGCTGATGCCGCC
GCCGCTTATGGCATGGACGCCATCGTGGAGGTGCACGACGACGCCGAGCTGGAACGGGCGCTGGACCTGCCGTGCCGGCT
CATCGGCATCAACAACCGCAACCTGCGCACCTTCGAGACCTCGCTCGAAACCTCCGAGCGCCTCGCACCCCGCGTGCCGA
AGGACCGGATCGCCATCGGCGAGAGCGGCATCTTCACGCCGCAGGACGTAGCGCGGCTCGCGAAGGTTGGCATCGGCACC
ATCCTCGTAGGCGAGAGCCTGATGCGGCAGGAGGATGTCGCTTCCGCCACGTCCCAGCTCCTTGCGGTCTAG

Upstream 100 bases:

>100_bases
GGGTCGAGATGGCACGGGTCAGCCTTGACACCGGCTCCGCCCGCGCGCGGCTGGAGCACCTCGTGGCCGTATCTGAGAAA
CTGGCGCCGGAGGCGGCCCA

Downstream 100 bases:

>100_bases
ACTTGCCGTATACGTAAAGTTCCGCCTTAATGGGCATGACGGTTCCGCAAGTGGGCCGCACCCAAGGGAGGACTTTCATG
AGATTGCGCCTGTTCGCCGG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MTDILKKIEAYKRDEIAVAKHARPLGEIEAAARAAPRVRPFAGAIATSLAEGRTALIAEIKKASPSKGLIRADFDPPALA
RAYQRGGATCLSVLTDTPSFQGAPEFLGSARAAVDLPVLRKDFMYDTYQVAEARAWGADCILIIMAGVDDLLARDLADAA
AAYGMDAIVEVHDDAELERALDLPCRLIGINNRNLRTFETSLETSERLAPRVPKDRIAIGESGIFTPQDVARLAKVGIGT
ILVGESLMRQEDVASATSQLLAV

Sequences:

>Translated_263_residues
MTDILKKIEAYKRDEIAVAKHARPLGEIEAAARAAPRVRPFAGAIATSLAEGRTALIAEIKKASPSKGLIRADFDPPALA
RAYQRGGATCLSVLTDTPSFQGAPEFLGSARAAVDLPVLRKDFMYDTYQVAEARAWGADCILIIMAGVDDLLARDLADAA
AAYGMDAIVEVHDDAELERALDLPCRLIGINNRNLRTFETSLETSERLAPRVPKDRIAIGESGIFTPQDVARLAKVGIGT
ILVGESLMRQEDVASATSQLLAV
>Mature_262_residues
TDILKKIEAYKRDEIAVAKHARPLGEIEAAARAAPRVRPFAGAIATSLAEGRTALIAEIKKASPSKGLIRADFDPPALAR
AYQRGGATCLSVLTDTPSFQGAPEFLGSARAAVDLPVLRKDFMYDTYQVAEARAWGADCILIIMAGVDDLLARDLADAAA
AYGMDAIVEVHDDAELERALDLPCRLIGINNRNLRTFETSLETSERLAPRVPKDRIAIGESGIFTPQDVARLAKVGIGTI
LVGESLMRQEDVASATSQLLAV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=261, Percent_Identity=38.3141762452107, Blast_Score=156, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322638, Length=234, Percent_Identity=35.8974358974359, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_XANP2 (A7INK2)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001419253.1
- ProteinModelPortal:   A7INK2
- SMR:   A7INK2
- STRING:   A7INK2
- GeneID:   5422938
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_4375
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   LRKDFMF
- ProtClustDB:   PRK00278
- BioCyc:   XAUT78245:XAUT_4375-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28170; Mature: 28038

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDILKKIEAYKRDEIAVAKHARPLGEIEAAARAAPRVRPFAGAIATSLAEGRTALIAEI
CHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHH
KKASPSKGLIRADFDPPALARAYQRGGATCLSVLTDTPSFQGAPEFLGSARAAVDLPVLR
HHCCCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHH
KDFMYDTYQVAEARAWGADCILIIMAGVDDLLARDLADAAAAYGMDAIVEVHDDAELERA
HHHHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHHH
LDLPCRLIGINNRNLRTFETSLETSERLAPRVPKDRIAIGESGIFTPQDVARLAKVGIGT
HCCCEEEEECCCCCCEEHHHHHHHHHHHCCCCCHHHEEECCCCCCCHHHHHHHHHHCHHH
ILVGESLMRQEDVASATSQLLAV
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDILKKIEAYKRDEIAVAKHARPLGEIEAAARAAPRVRPFAGAIATSLAEGRTALIAEI
HHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHH
KKASPSKGLIRADFDPPALARAYQRGGATCLSVLTDTPSFQGAPEFLGSARAAVDLPVLR
HHCCCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHH
KDFMYDTYQVAEARAWGADCILIIMAGVDDLLARDLADAAAAYGMDAIVEVHDDAELERA
HHHHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHHHHHHHHHHCCHHEEEECCCHHHHHH
LDLPCRLIGINNRNLRTFETSLETSERLAPRVPKDRIAIGESGIFTPQDVARLAKVGIGT
HCCCEEEEECCCCCCEEHHHHHHHHHHHCCCCCHHHEEECCCCCCCHHHHHHHHHHCHHH
ILVGESLMRQEDVASATSQLLAV
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA