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The map label for this gene is moeA [H]

Identifier: 154248292

GI number: 154248292

Start: 4848399

End: 4849661

Strand: Reverse

Name: moeA [H]

Synonym: Xaut_4372

Alternate gene names: 154248292

Gene position: 4849661-4848399 (Counterclockwise)

Preceding gene: 154248293

Following gene: 154248291

Centisome position: 91.35

GC content: 71.89

Gene sequence:

>1263_bases
ATGGAACCGAGCACGACAACGGGCGCCGGGAAGCCGGCGGGCAAGAAGGCGCCCCTCATGACCGTCGAGGAGGCCATAAG
CCTCGTGACGGCCGGGGTATCGGCCCTGGGTGTCGAGCAGGTGCCCGTGGCGCTGGCAGATGGGCGCGTGCTGGCGCAGG
ACCTGCCCGCCCGCCGCACCCAGCCGCCCGCCGACATGTCGGCCATGGACGGCTATGCGGTGCGCGGGAGCGACATCGCA
CAGACCCCTGCCCGCCTCACCGTGATCGGCGAATCGGCGGCCGGCCGGCCATTCGCGGGCGCCGTGGGGCCGAGCCAGGC
GGTGCGCATCTTCACCGGCGCAGTGGTGCCGGAGGGCGCCGACACGGTGGTGATCCAGGAGAACACCAGCCGCGACGGCG
ATACCCTCACCACCACGGCCCCCACCGCTGCCCTGCGCAACGTGCGCAAGAAGGGCTGCGATTTCACCGCGGGCACGCCG
GGCCTGTTGGCCGGGCGGCGGCTGACTGGCCGCGACGTGATGCTTGCCGCCGCTATGGATCATGCGGTCCTGCCGGTGGC
GCGGCGCCCGCGCGTGGCGGTGCTGCAGACTGGCGACGAACTGGTGCTGCCCGGCACCGGCACCGGTCAGGACAGCGAGA
TCGTCGTTTCCAACGCCTTCGGCCTCGCCACCCTCGCCCGCCGCGCCGGCGCGGAGGTGACGGACCTCGGGCTGGTGCGG
GATGACCTTGCCGCCATCCGTGCCGTGGTGGCGCAGGCGCTTTCGGGCGACTTCGATCTCGTCATCTCCTCCGGTGGCGC
CTCGGTGGGCGACCATGATCTGATGGCGCCGGCGCTGCGCGCCGAGGGGGTGGAGCTGTTCGTGCACAAGATCGCCCTGC
GCCCGGGCAAGCCGCTGATGTTCGGTGGCAAGGACGGCGTGCGGGTGCTCGGCCTGCCGGGCAATCCGGTCTCGTCCCAC
GTCTGCGCCATGGTATTTCTGGTGCCGTTGCTGCGCGCGCTTCAGGGCGACGCCATGCCTGGTCCCCTGACGGCGCCGGC
GCGCCTCGCGGTGGACATCCCGGCCAACGACGTGCGCCGTGATTTCATGCGCGCCCGCATGGACCGCCACCCCGACGGAA
CGGTGCATGTGACGCCCTGCGCCTCCCAGGACAGCGCCATGCTGAGCGTTCTGGCCGCCGCCGACTGCCTGCTCATCCGC
CCGCCCTTCGCGCCTGCCGCCACGGCCGGAGACCCTTGCGAGATCATTCCCTTCGATGATTGA

Upstream 100 bases:

>100_bases
GGCATGCGCATTGAAGGGATCCGGCTTCTGGAGAAATCCGGCGGCGCCAGCGGGCATTTCCGCGCGGAACCGCCCACGGA
CTGAAGAGGCCGAACCACTG

Downstream 100 bases:

>100_bases
GCGGTCTTAACCCTGCCTTCACCCCTTGCGGAACACAAAAGGAACAGATAGAAACTGTTCATGATTTGTTTCGCGGCGCA
CAGGCGGGCGCCAGCAGGGG

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MEPSTTTGAGKPAGKKAPLMTVEEAISLVTAGVSALGVEQVPVALADGRVLAQDLPARRTQPPADMSAMDGYAVRGSDIA
QTPARLTVIGESAAGRPFAGAVGPSQAVRIFTGAVVPEGADTVVIQENTSRDGDTLTTTAPTAALRNVRKKGCDFTAGTP
GLLAGRRLTGRDVMLAAAMDHAVLPVARRPRVAVLQTGDELVLPGTGTGQDSEIVVSNAFGLATLARRAGAEVTDLGLVR
DDLAAIRAVVAQALSGDFDLVISSGGASVGDHDLMAPALRAEGVELFVHKIALRPGKPLMFGGKDGVRVLGLPGNPVSSH
VCAMVFLVPLLRALQGDAMPGPLTAPARLAVDIPANDVRRDFMRARMDRHPDGTVHVTPCASQDSAMLSVLAAADCLLIR
PPFAPAATAGDPCEIIPFDD

Sequences:

>Translated_420_residues
MEPSTTTGAGKPAGKKAPLMTVEEAISLVTAGVSALGVEQVPVALADGRVLAQDLPARRTQPPADMSAMDGYAVRGSDIA
QTPARLTVIGESAAGRPFAGAVGPSQAVRIFTGAVVPEGADTVVIQENTSRDGDTLTTTAPTAALRNVRKKGCDFTAGTP
GLLAGRRLTGRDVMLAAAMDHAVLPVARRPRVAVLQTGDELVLPGTGTGQDSEIVVSNAFGLATLARRAGAEVTDLGLVR
DDLAAIRAVVAQALSGDFDLVISSGGASVGDHDLMAPALRAEGVELFVHKIALRPGKPLMFGGKDGVRVLGLPGNPVSSH
VCAMVFLVPLLRALQGDAMPGPLTAPARLAVDIPANDVRRDFMRARMDRHPDGTVHVTPCASQDSAMLSVLAAADCLLIR
PPFAPAATAGDPCEIIPFDD
>Mature_420_residues
MEPSTTTGAGKPAGKKAPLMTVEEAISLVTAGVSALGVEQVPVALADGRVLAQDLPARRTQPPADMSAMDGYAVRGSDIA
QTPARLTVIGESAAGRPFAGAVGPSQAVRIFTGAVVPEGADTVVIQENTSRDGDTLTTTAPTAALRNVRKKGCDFTAGTP
GLLAGRRLTGRDVMLAAAMDHAVLPVARRPRVAVLQTGDELVLPGTGTGQDSEIVVSNAFGLATLARRAGAEVTDLGLVR
DDLAAIRAVVAQALSGDFDLVISSGGASVGDHDLMAPALRAEGVELFVHKIALRPGKPLMFGGKDGVRVLGLPGNPVSSH
VCAMVFLVPLLRALQGDAMPGPLTAPARLAVDIPANDVRRDFMRARMDRHPDGTVHVTPCASQDSAMLSVLAAADCLLIR
PPFAPAATAGDPCEIIPFDD

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=414, Percent_Identity=32.6086956521739, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI10880983, Length=414, Percent_Identity=32.6086956521739, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI1787049, Length=383, Percent_Identity=38.1201044386423, Blast_Score=222, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI25147659, Length=383, Percent_Identity=30.2872062663185, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17562606, Length=346, Percent_Identity=26.5895953757225, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136978, Length=439, Percent_Identity=27.3348519362187, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24638841, Length=439, Percent_Identity=27.3348519362187, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43133; Mature: 43133

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPSTTTGAGKPAGKKAPLMTVEEAISLVTAGVSALGVEQVPVALADGRVLAQDLPARRT
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHCCHHHCCEEEECCEEEHHCCCCCCC
QPPADMSAMDGYAVRGSDIAQTPARLTVIGESAAGRPFAGAVGPSQAVRIFTGAVVPEGA
CCCCCHHHCCCEEECCCCHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCC
DTVVIQENTSRDGDTLTTTAPTAALRNVRKKGCDFTAGTPGLLAGRRLTGRDVMLAAAMD
CEEEEECCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCEEEEEHHC
HAVLPVARRPRVAVLQTGDELVLPGTGTGQDSEIVVSNAFGLATLARRAGAEVTDLGLVR
HHHCCCCCCCCEEEEECCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHH
DDLAAIRAVVAQALSGDFDLVISSGGASVGDHDLMAPALRAEGVELFVHKIALRPGKPLM
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCHHEEHHHHHCCCCCCEE
FGGKDGVRVLGLPGNPVSSHVCAMVFLVPLLRALQGDAMPGPLTAPARLAVDIPANDVRR
ECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHH
DFMRARMDRHPDGTVHVTPCASQDSAMLSVLAAADCLLIRPPFAPAATAGDPCEIIPFDD
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MEPSTTTGAGKPAGKKAPLMTVEEAISLVTAGVSALGVEQVPVALADGRVLAQDLPARRT
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHCCHHHCCEEEECCEEEHHCCCCCCC
QPPADMSAMDGYAVRGSDIAQTPARLTVIGESAAGRPFAGAVGPSQAVRIFTGAVVPEGA
CCCCCHHHCCCEEECCCCHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCC
DTVVIQENTSRDGDTLTTTAPTAALRNVRKKGCDFTAGTPGLLAGRRLTGRDVMLAAAMD
CEEEEECCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCEEEEEHHC
HAVLPVARRPRVAVLQTGDELVLPGTGTGQDSEIVVSNAFGLATLARRAGAEVTDLGLVR
HHHCCCCCCCCEEEEECCCEEEECCCCCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHH
DDLAAIRAVVAQALSGDFDLVISSGGASVGDHDLMAPALRAEGVELFVHKIALRPGKPLM
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCHHEEHHHHHCCCCCCEE
FGGKDGVRVLGLPGNPVSSHVCAMVFLVPLLRALQGDAMPGPLTAPARLAVDIPANDVRR
ECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHH
DFMRARMDRHPDGTVHVTPCASQDSAMLSVLAAADCLLIRPPFAPAATAGDPCEIIPFDD
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]