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The map label for this gene is purL [H]

Identifier: 154248011

GI number: 154248011

Start: 4528049

End: 4530298

Strand: Reverse

Name: purL [H]

Synonym: Xaut_4090

Alternate gene names: 154248011

Gene position: 4530298-4528049 (Counterclockwise)

Preceding gene: 154248012

Following gene: 154248010

Centisome position: 85.33

GC content: 67.82

Gene sequence:

>2250_bases
GTGACCACGCCCCTCAATTCGGATCGAACCGCTGTGAATTCCATTCCCAACACGTCCCGCATCACCCCGGAGCTGGTGGC
CGAGCATGGCCTGAAGCCCGAGGAATACGAGCACTTCGTGAAGCTGATCGGCCGCGAGCCGTCGATCACGGAGCTTGGCA
TCGTCTCGGCCATGTGGAACGAGCACTGCTCCTACAAGTCATCCAAGGTCTGGCTGCGCACCCTGCCCACCAAAAGCCCG
CGGGTGATCCAGGGGCCGGGCGAGAATGCGGGCGTGGTGGACATCGGCAACGGCCTCGCGGTCGTCTTCAAGATGGAAAG
CCACAACCACCCCTCCTTCATCGAGCCTTACCAGGGTGCGGGGACGGGCGTGGGCGGCATCCTGCGCGACGTGTTCACCA
TGGGCGCGCGGCCCATCGCGGCGCTCAACTTCCTGCGCTTCGGCGACTGCCACAATGTGAAGACCCGCCGGCTGCTGGCG
GGCGTGGTGGCCGGCATCGGCGGCTATGGCAATTCCTTCGGCGTGCCCACGGTGGGTGGCTCGGTGGGCTTCCACAAGCG
CTACAACGGCAACATCCTGGTCAACGCCATGGCGGTGGGCCTCGCCAGGGCGGACGAGATCTTCTACGCCGCCGCCACCG
GTGTGGGCCGCGCCATCGTCTATCTGGGCTCCAAGACCGGCCGCGACGGCATCCACGGCGCCACCATGGCCTCGGCCGAG
TTCGGCGCCGATGCCGAGGAGAAGCGCCCCACGGTGCAGGTGGGCGACCCCTTCGCCGAGAAGCTGCTGCTGGAAGCGTG
CCTCGAAATCATGAAGGCGGGCTGCGTGGTGGCGATCCAGGACATGGGCGCTGCCGGCCTCACTAGCTCGGCGGTGGAGA
TGGGCGCCAAGGGCGGCCTCGGTGTGGAGCTGAACCTCGACGCCGTGCCCTGCCGCGAAACCGGCATGACCGCCTACGAG
ATGATGCTGTCCGAGAGCCAGGAGCGCATGCTCATGGTGATCGCCGACGGCAAGGAAGACGAGGCCGAAGCCATTTTCCG
CAAGTGGGGACTGGACTTCGCCATTGTCGGCCGCACCACCGATACCCTGCGCTTCGTGGTGAAGCACAATGGCGTGGTGG
AAGCCGACCTGCCCATCAAGGAACTCGGCGACCAGGCCCCCGAATACCGCCGCCCCTATGAGGAGCCGCTGCCGCGTCCG
GTGGTGGCGCCCGAGGACGTGCGCACCAACGCCTCCGTGGCCGATGCCCTGGAGCGGCTCATCGCCTCGCCGGACCTGTG
CTCCAAGCGCTGGGTGTGGGAGCAGTACGACCACCTGATCGGCGGCAATACCGTGCAGCGACCCGGCGGCGACGCCGCCG
TGGTGCGCATCGAGGACGGCCCCAAGGCCCTGGCGCTGACCACCGACGTGACGCCCCGCTATTGCGAGGCCGATCCCTTC
GAGGGCGGCAAGCAGGCAGTGGCCGAAGCCTGGCGCAACCTGACCGCAGTCGGCGCGACCCCCATCGCCGTCACCGACAA
CCTGAATTTCGGCAATCCCGAGAAGCCGGAGATCATGGGCCAGTTCGTGGCCTGTGTGAAAGGCATCGGCGCGGCCTGCG
AGGCGCTGGACTTCCCGGTCGTGTCCGGCAACGTCAGCCTCTACAACGAGACCAACGGCAAGGGCATCCTGCCGACCCCC
GCCATCGGCGGCGTCGGCCTGATCGAGGACCTGCACAAGTCCATGACGCTCGCCTTCAAGGCCGCTGGCGAGCCGGTGCT
GCTGGTGGGCAAGACCACGGGCTGGCTCGGGTCCTCGGCCTTCCTCAACACCGTGTGCGAGCGCGAGGACGGGGCGCCGC
CCCCGGTCGACCTCATCGCCGAGAAGCGCAACGGCGACTTCGTGCGCGGCCTGATCCGCGACGGCATCGCCACCGCCGTG
CATGATGTCTCCGACGGCGGACTGCTCATCGCCATCGCCGAGATGGCCATGGCCGGGCGCGTGGGCACCTCGCTCGAAGC
CCCGCCGGCCGGCATGGACCCTTATGCCTGGTGGTTCGGCGAGGACCAGGCCCGCTACGTGATCACCGTCCCCTCGGGAC
AGGGCGCCGAAGTGATCCACAAGGCGGAAATGGCCGGCGTGCCGATGGTCAAGATCGGCAAGACCGGCGGCGACCGCTTG
ATCCTCCCCGACGACCGCTCGATAGTCGTGGAATCGCTGCGCGACCGGCACGAGACGTGGCTGCCCATCTATATGGGTGC
CTCGTCCTGA

Upstream 100 bases:

>100_bases
TTGGAATGATGCCGCATCCCGAAAATTACATCGAACCGGAAATCGGCCCCACCGACGGCCGCGGCCTGTTCGAAAGCCTC
GCCGGAGCCCTGAAGGCGGC

Downstream 100 bases:

>100_bases
TCCTGTCCGCTGTTTTGAGGACCATGCGACCATGCCCATGAATGCCCGCGAGATCGAGCAGCTCATCAAGGATGCGCTGC
CCGACGCGACGGTGGTGATC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 749; Mature: 748

Protein sequence:

>749_residues
MTTPLNSDRTAVNSIPNTSRITPELVAEHGLKPEEYEHFVKLIGREPSITELGIVSAMWNEHCSYKSSKVWLRTLPTKSP
RVIQGPGENAGVVDIGNGLAVVFKMESHNHPSFIEPYQGAGTGVGGILRDVFTMGARPIAALNFLRFGDCHNVKTRRLLA
GVVAGIGGYGNSFGVPTVGGSVGFHKRYNGNILVNAMAVGLARADEIFYAAATGVGRAIVYLGSKTGRDGIHGATMASAE
FGADAEEKRPTVQVGDPFAEKLLLEACLEIMKAGCVVAIQDMGAAGLTSSAVEMGAKGGLGVELNLDAVPCRETGMTAYE
MMLSESQERMLMVIADGKEDEAEAIFRKWGLDFAIVGRTTDTLRFVVKHNGVVEADLPIKELGDQAPEYRRPYEEPLPRP
VVAPEDVRTNASVADALERLIASPDLCSKRWVWEQYDHLIGGNTVQRPGGDAAVVRIEDGPKALALTTDVTPRYCEADPF
EGGKQAVAEAWRNLTAVGATPIAVTDNLNFGNPEKPEIMGQFVACVKGIGAACEALDFPVVSGNVSLYNETNGKGILPTP
AIGGVGLIEDLHKSMTLAFKAAGEPVLLVGKTTGWLGSSAFLNTVCEREDGAPPPVDLIAEKRNGDFVRGLIRDGIATAV
HDVSDGGLLIAIAEMAMAGRVGTSLEAPPAGMDPYAWWFGEDQARYVITVPSGQGAEVIHKAEMAGVPMVKIGKTGGDRL
ILPDDRSIVVESLRDRHETWLPIYMGASS

Sequences:

>Translated_749_residues
MTTPLNSDRTAVNSIPNTSRITPELVAEHGLKPEEYEHFVKLIGREPSITELGIVSAMWNEHCSYKSSKVWLRTLPTKSP
RVIQGPGENAGVVDIGNGLAVVFKMESHNHPSFIEPYQGAGTGVGGILRDVFTMGARPIAALNFLRFGDCHNVKTRRLLA
GVVAGIGGYGNSFGVPTVGGSVGFHKRYNGNILVNAMAVGLARADEIFYAAATGVGRAIVYLGSKTGRDGIHGATMASAE
FGADAEEKRPTVQVGDPFAEKLLLEACLEIMKAGCVVAIQDMGAAGLTSSAVEMGAKGGLGVELNLDAVPCRETGMTAYE
MMLSESQERMLMVIADGKEDEAEAIFRKWGLDFAIVGRTTDTLRFVVKHNGVVEADLPIKELGDQAPEYRRPYEEPLPRP
VVAPEDVRTNASVADALERLIASPDLCSKRWVWEQYDHLIGGNTVQRPGGDAAVVRIEDGPKALALTTDVTPRYCEADPF
EGGKQAVAEAWRNLTAVGATPIAVTDNLNFGNPEKPEIMGQFVACVKGIGAACEALDFPVVSGNVSLYNETNGKGILPTP
AIGGVGLIEDLHKSMTLAFKAAGEPVLLVGKTTGWLGSSAFLNTVCEREDGAPPPVDLIAEKRNGDFVRGLIRDGIATAV
HDVSDGGLLIAIAEMAMAGRVGTSLEAPPAGMDPYAWWFGEDQARYVITVPSGQGAEVIHKAEMAGVPMVKIGKTGGDRL
ILPDDRSIVVESLRDRHETWLPIYMGASS
>Mature_748_residues
TTPLNSDRTAVNSIPNTSRITPELVAEHGLKPEEYEHFVKLIGREPSITELGIVSAMWNEHCSYKSSKVWLRTLPTKSPR
VIQGPGENAGVVDIGNGLAVVFKMESHNHPSFIEPYQGAGTGVGGILRDVFTMGARPIAALNFLRFGDCHNVKTRRLLAG
VVAGIGGYGNSFGVPTVGGSVGFHKRYNGNILVNAMAVGLARADEIFYAAATGVGRAIVYLGSKTGRDGIHGATMASAEF
GADAEEKRPTVQVGDPFAEKLLLEACLEIMKAGCVVAIQDMGAAGLTSSAVEMGAKGGLGVELNLDAVPCRETGMTAYEM
MLSESQERMLMVIADGKEDEAEAIFRKWGLDFAIVGRTTDTLRFVVKHNGVVEADLPIKELGDQAPEYRRPYEEPLPRPV
VAPEDVRTNASVADALERLIASPDLCSKRWVWEQYDHLIGGNTVQRPGGDAAVVRIEDGPKALALTTDVTPRYCEADPFE
GGKQAVAEAWRNLTAVGATPIAVTDNLNFGNPEKPEIMGQFVACVKGIGAACEALDFPVVSGNVSLYNETNGKGILPTPA
IGGVGLIEDLHKSMTLAFKAAGEPVLLVGKTTGWLGSSAFLNTVCEREDGAPPPVDLIAEKRNGDFVRGLIRDGIATAVH
DVSDGGLLIAIAEMAMAGRVGTSLEAPPAGMDPYAWWFGEDQARYVITVPSGQGAEVIHKAEMAGVPMVKIGKTGGDRLI
LPDDRSIVVESLRDRHETWLPIYMGASS

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=698, Percent_Identity=26.647564469914, Blast_Score=111, Evalue=2e-24,
Organism=Escherichia coli, GI48994899, Length=805, Percent_Identity=24.8447204968944, Blast_Score=144, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17553022, Length=698, Percent_Identity=23.0659025787966, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6321498, Length=739, Percent_Identity=23.1393775372125, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24582111, Length=739, Percent_Identity=24.3572395128552, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24582109, Length=739, Percent_Identity=24.3572395128552, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17137292, Length=739, Percent_Identity=24.3572395128552, Blast_Score=107, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79741; Mature: 79610

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLNSDRTAVNSIPNTSRITPELVAEHGLKPEEYEHFVKLIGREPSITELGIVSAMWN
CCCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EHCSYKSSKVWLRTLPTKSPRVIQGPGENAGVVDIGNGLAVVFKMESHNHPSFIEPYQGA
HHCCCCCCCEEEEECCCCCCEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCC
GTGVGGILRDVFTMGARPIAALNFLRFGDCHNVKTRRLLAGVVAGIGGYGNSFGVPTVGG
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SVGFHKRYNGNILVNAMAVGLARADEIFYAAATGVGRAIVYLGSKTGRDGIHGATMASAE
CCCCCEECCCCEEEEEHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCEECCHH
FGADAEEKRPTVQVGDPFAEKLLLEACLEIMKAGCVVAIQDMGAAGLTSSAVEMGAKGGL
CCCCHHHCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCCCC
GVELNLDAVPCRETGMTAYEMMLSESQERMLMVIADGKEDEAEAIFRKWGLDFAIVGRTT
EEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCC
DTLRFVVKHNGVVEADLPIKELGDQAPEYRRPYEEPLPRPVVAPEDVRTNASVADALERL
HHEEEEEECCCEEEECCCHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
IASPDLCSKRWVWEQYDHLIGGNTVQRPGGDAAVVRIEDGPKALALTTDVTPRYCEADPF
HCCCCCHHHCCHHHHHHHHHCCCEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCC
EGGKQAVAEAWRNLTAVGATPIAVTDNLNFGNPEKPEIMGQFVACVKGIGAACEALDFPV
CCHHHHHHHHHHCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHCCCE
VSGNVSLYNETNGKGILPTPAIGGVGLIEDLHKSMTLAFKAAGEPVLLVGKTTGWLGSSA
EECCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCEEEEECCCCCCCCHH
FLNTVCEREDGAPPPVDLIAEKRNGDFVRGLIRDGIATAVHDVSDGGLLIAIAEMAMAGR
HHHHHHHHCCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCC
VGTSLEAPPAGMDPYAWWFGEDQARYVITVPSGQGAEVIHKAEMAGVPMVKIGKTGGDRL
CCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCEE
ILPDDRSIVVESLRDRHETWLPIYMGASS
EECCCHHHHHHHHHHCCCCEEEEEECCCC
>Mature Secondary Structure 
TTPLNSDRTAVNSIPNTSRITPELVAEHGLKPEEYEHFVKLIGREPSITELGIVSAMWN
CCCCCCCCHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EHCSYKSSKVWLRTLPTKSPRVIQGPGENAGVVDIGNGLAVVFKMESHNHPSFIEPYQGA
HHCCCCCCCEEEEECCCCCCEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCC
GTGVGGILRDVFTMGARPIAALNFLRFGDCHNVKTRRLLAGVVAGIGGYGNSFGVPTVGG
CCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SVGFHKRYNGNILVNAMAVGLARADEIFYAAATGVGRAIVYLGSKTGRDGIHGATMASAE
CCCCCEECCCCEEEEEHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCCCCCEECCHH
FGADAEEKRPTVQVGDPFAEKLLLEACLEIMKAGCVVAIQDMGAAGLTSSAVEMGAKGGL
CCCCHHHCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCCCC
GVELNLDAVPCRETGMTAYEMMLSESQERMLMVIADGKEDEAEAIFRKWGLDFAIVGRTT
EEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCC
DTLRFVVKHNGVVEADLPIKELGDQAPEYRRPYEEPLPRPVVAPEDVRTNASVADALERL
HHEEEEEECCCEEEECCCHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
IASPDLCSKRWVWEQYDHLIGGNTVQRPGGDAAVVRIEDGPKALALTTDVTPRYCEADPF
HCCCCCHHHCCHHHHHHHHHCCCEECCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCC
EGGKQAVAEAWRNLTAVGATPIAVTDNLNFGNPEKPEIMGQFVACVKGIGAACEALDFPV
CCHHHHHHHHHHCEEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHCCCE
VSGNVSLYNETNGKGILPTPAIGGVGLIEDLHKSMTLAFKAAGEPVLLVGKTTGWLGSSA
EECCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEECCCCEEEEECCCCCCCCHH
FLNTVCEREDGAPPPVDLIAEKRNGDFVRGLIRDGIATAVHDVSDGGLLIAIAEMAMAGR
HHHHHHHHCCCCCCCHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCC
VGTSLEAPPAGMDPYAWWFGEDQARYVITVPSGQGAEVIHKAEMAGVPMVKIGKTGGDRL
CCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCEE
ILPDDRSIVVESLRDRHETWLPIYMGASS
EECCCHHHHHHHHHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA