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The map label for this gene is lldD

Identifier: 154247852

GI number: 154247852

Start: 4347183

End: 4348349

Strand: Reverse

Name: lldD

Synonym: Xaut_3929

Alternate gene names: 154247852

Gene position: 4348349-4347183 (Counterclockwise)

Preceding gene: 154247853

Following gene: 154247850

Centisome position: 81.91

GC content: 67.95

Gene sequence:

>1167_bases
ATGATCATCTCGTCGTCCTCCGACTACCGGGAAGCCGCCCGCCGCCGCCTTCCGCCCTTCCTGTTCCACTATATCGACGG
CGGCGCCTATGCCGAGGCGACCCTGCGCCGGAACGTGGAGGATCTCTCCGACCTCGCCCTGCGCCAGCGCGTGCTGAAGA
GCGTGGGCGAGGTGGATCTCTCCACCACCCTGCTCAAGCAGCAGCTGTCCATGCCCGTAGGCCTCGCCCCCGTCGGCCTC
ACCGGCATGTATGCCCGGCGCGGCGAGGTGCAGGCGGCGCAGGCGGCCACCCAGAAGGGCATTCCCTTCACCCTCTCCAC
GGTCTCGGTCTGCTCCATCGAGGAGGTGCAGAGCCAGGTGGGCAAGCCCATCTGGTTCCAGCTCTACGTGCTGAAGGACC
GCGGCTTCATGAAGAACGCGCTGGAGCGCGCCTGGGCTGCAGGCATTCGCACCCTGGTCTTCACCGTCGACATGCCGGTG
CCCGGCGCGCGCTATCGCGATGCCCATTCGGGCATGTCCGGTCCGAACGCCGCGTTCCGGCGCATGGTGCAAGCCGTGCT
GCACCCGTTCTGGGCCTATGACGTGGGCCTGATGGGCACCCCGCACGATCTCGGCAACGTCTCCGCCTATCGCAAGGAGA
AGACCAGCCTTGAAGATTACGTGGGTTGGCTCGGCAACAATTTCGATCCGTCCATCGGCTGGAAGGATCTGGAATGGATC
CGCGAATTCTGGAAGGGCCCCATGGTCATCAAGGGTATCCTTGATCCCGAGGACGCCCGCGATGCGGTGCGCTTCGGTGC
CGACGGCATCATCGTGTCGAACCATGGCGGGCGCCAGCTCGACGGCGTGCTCTCCTCCGCCCGCGCCATGCCGGCCATCG
CCGACGCGGTGAAGGGCGAGATGACGCTTCTGGCCGATTCCGGCATCCGCTCGGGGCTCGACGTGGTGCGCATGCTGGCG
CAGGGCGCCGACGGCGTGCTGCTCGGCCGCGCCTTCGTCTATGCGCTGGCGGCGGCGGGCCGCGCGGGGGTGGAGAACCT
GCTCGACATCATCGCCAAGGAGATGCGGGTGGCCATGACCCTCACCGGCGCCCGCGCCATCTCCGACATCTCCCGCGACA
GCTTGGTGCGGGAGATCGAGCGGCCGCTCGCCCGCGCGGCGCAGTAG

Upstream 100 bases:

>100_bases
TCGTGGAGGACAGCCTGCGGCTCATAGAAGACGCCGCAGCGCGCGAGCGACGCTCGGTGCGGGCCCTTTCCCGGGCGGCG
ATGCAGAAGGAAGCAAGATC

Downstream 100 bases:

>100_bases
GGCGCCGGGGCAGCAACGTCCCCTCTCCTGCCTGCGGGGCTGGAGGTCGGGATCCGGTCACACATTTTTCGATTATGGCC
CCGCCAGAACGACAATGCCC

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MIISSSSDYREAARRRLPPFLFHYIDGGAYAEATLRRNVEDLSDLALRQRVLKSVGEVDLSTTLLKQQLSMPVGLAPVGL
TGMYARRGEVQAAQAATQKGIPFTLSTVSVCSIEEVQSQVGKPIWFQLYVLKDRGFMKNALERAWAAGIRTLVFTVDMPV
PGARYRDAHSGMSGPNAAFRRMVQAVLHPFWAYDVGLMGTPHDLGNVSAYRKEKTSLEDYVGWLGNNFDPSIGWKDLEWI
REFWKGPMVIKGILDPEDARDAVRFGADGIIVSNHGGRQLDGVLSSARAMPAIADAVKGEMTLLADSGIRSGLDVVRMLA
QGADGVLLGRAFVYALAAAGRAGVENLLDIIAKEMRVAMTLTGARAISDISRDSLVREIERPLARAAQ

Sequences:

>Translated_388_residues
MIISSSSDYREAARRRLPPFLFHYIDGGAYAEATLRRNVEDLSDLALRQRVLKSVGEVDLSTTLLKQQLSMPVGLAPVGL
TGMYARRGEVQAAQAATQKGIPFTLSTVSVCSIEEVQSQVGKPIWFQLYVLKDRGFMKNALERAWAAGIRTLVFTVDMPV
PGARYRDAHSGMSGPNAAFRRMVQAVLHPFWAYDVGLMGTPHDLGNVSAYRKEKTSLEDYVGWLGNNFDPSIGWKDLEWI
REFWKGPMVIKGILDPEDARDAVRFGADGIIVSNHGGRQLDGVLSSARAMPAIADAVKGEMTLLADSGIRSGLDVVRMLA
QGADGVLLGRAFVYALAAAGRAGVENLLDIIAKEMRVAMTLTGARAISDISRDSLVREIERPLARAAQ
>Mature_388_residues
MIISSSSDYREAARRRLPPFLFHYIDGGAYAEATLRRNVEDLSDLALRQRVLKSVGEVDLSTTLLKQQLSMPVGLAPVGL
TGMYARRGEVQAAQAATQKGIPFTLSTVSVCSIEEVQSQVGKPIWFQLYVLKDRGFMKNALERAWAAGIRTLVFTVDMPV
PGARYRDAHSGMSGPNAAFRRMVQAVLHPFWAYDVGLMGTPHDLGNVSAYRKEKTSLEDYVGWLGNNFDPSIGWKDLEWI
REFWKGPMVIKGILDPEDARDAVRFGADGIIVSNHGGRQLDGVLSSARAMPAIADAVKGEMTLLADSGIRSGLDVVRMLA
QGADGVLLGRAFVYALAAAGRAGVENLLDIIAKEMRVAMTLTGARAISDISRDSLVREIERPLARAAQ

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI11068137, Length=379, Percent_Identity=34.8284960422164, Blast_Score=221, Evalue=7e-58,
Organism=Homo sapiens, GI54234014, Length=374, Percent_Identity=34.2245989304813, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI7705393, Length=374, Percent_Identity=34.2245989304813, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1790033, Length=386, Percent_Identity=76.4248704663213, Blast_Score=616, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI193208036, Length=374, Percent_Identity=33.9572192513369, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=287, Percent_Identity=34.1463414634146, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323587, Length=382, Percent_Identity=30.6282722513089, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281363140, Length=379, Percent_Identity=35.3562005277045, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI78707190, Length=379, Percent_Identity=35.3562005277045, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI78707188, Length=379, Percent_Identity=35.3562005277045, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD_XANP2 (A7IMB0)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001418810.1
- ProteinModelPortal:   A7IMB0
- SMR:   A7IMB0
- STRING:   A7IMB0
- GeneID:   5422902
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_3929
- eggNOG:   COG1304
- HOGENOM:   HBG517781
- OMA:   NFDPSIG
- ProtClustDB:   CLSK2475528
- BioCyc:   XAUT78245:XAUT_3929-MONOMER
- HAMAP:   MF_01559
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 42335; Mature: 42335

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 275-275 BINDING 24-24 BINDING 106-106 BINDING 127-127 BINDING 129-129 BINDING 155-155 BINDING 164-164 BINDING 251-251 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISSSSDYREAARRRLPPFLFHYIDGGAYAEATLRRNVEDLSDLALRQRVLKSVGEVDL
CCCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHH
STTLLKQQLSMPVGLAPVGLTGMYARRGEVQAAQAATQKGIPFTLSTVSVCSIEEVQSQV
HHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHH
GKPIWFQLYVLKDRGFMKNALERAWAAGIRTLVFTVDMPVPGARYRDAHSGMSGPNAAFR
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHCCCCCCHHHHH
RMVQAVLHPFWAYDVGLMGTPHDLGNVSAYRKEKTSLEDYVGWLGNNFDPSIGWKDLEWI
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHH
REFWKGPMVIKGILDPEDARDAVRFGADGIIVSNHGGRQLDGVLSSARAMPAIADAVKGE
HHHCCCCEEEEECCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
MTLLADSGIRSGLDVVRMLAQGADGVLLGRAFVYALAAAGRAGVENLLDIIAKEMRVAMT
EEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LTGARAISDISRDSLVREIERPLARAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIISSSSDYREAARRRLPPFLFHYIDGGAYAEATLRRNVEDLSDLALRQRVLKSVGEVDL
CCCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHH
STTLLKQQLSMPVGLAPVGLTGMYARRGEVQAAQAATQKGIPFTLSTVSVCSIEEVQSQV
HHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHH
GKPIWFQLYVLKDRGFMKNALERAWAAGIRTLVFTVDMPVPGARYRDAHSGMSGPNAAFR
CCCEEEEEEEECCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHCCCCCCHHHHH
RMVQAVLHPFWAYDVGLMGTPHDLGNVSAYRKEKTSLEDYVGWLGNNFDPSIGWKDLEWI
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHH
REFWKGPMVIKGILDPEDARDAVRFGADGIIVSNHGGRQLDGVLSSARAMPAIADAVKGE
HHHCCCCEEEEECCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
MTLLADSGIRSGLDVVRMLAQGADGVLLGRAFVYALAAAGRAGVENLLDIIAKEMRVAMT
EEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LTGARAISDISRDSLVREIERPLARAAQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA