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The map label for this gene is parC [H]

Identifier: 154247807

GI number: 154247807

Start: 4303751

End: 4305988

Strand: Reverse

Name: parC [H]

Synonym: Xaut_3884

Alternate gene names: 154247807

Gene position: 4305988-4303751 (Counterclockwise)

Preceding gene: 154247808

Following gene: 154247806

Centisome position: 81.11

GC content: 68.28

Gene sequence:

>2238_bases
ATGGCCACGCGCACACTTCCGCCCGGCGACGGGCACATCGAGAAAGTCACGCTCAAGGAGGCGCTGGAAGAGCGCTACCT
GGCTTACGCCCTCTCGACCATCATGCACCGCGCCCTGCCCGACGCGCGCGATGGTCTCAAGCCGGTGCACCGGCGCATCC
TCCACGCCATGCGCCAGCTGCGGCTGGATCCGGGCCAGGGCTTCAAGAAGTCCGCCCGCGTGGTGGGCGACGTGATCGGC
AAGTTCCATCCCCACGGCGACCAGTCGGTCTATGACGCGCTGGTGCGCCTTGCCCAGGATTTCGCCCAGCGCTACCCGCT
GGTGGACGGACAGGGCAATTTCGGCAACGTGGACGGCGATAACGCCGCCGCCATGCGATACACCGAGGCCCGCCTCACCG
AGACCGCCCGCCTGCTGCTGGACGGCATCGACGAGGACGCGGTCGACTTCCGCCCGACCTATGACGGCTCGGAAGAAGAG
CCTGCGGTGCTGCCGGCTGCCTTCCCGAACCTGCTGGCCAACGGCTCGCAGGGCATCGCGGTGGGTATGGCCACCTCCAT
CCCGCCCCATAATGCCGCCGAACTGCTGGACGCGGCGCTCCATCTCATCGACCATCCGGAGGCCCCGGCCTTCGACCTGC
TCCAGTTCGTCCCCGGCCCGGACTTCCCCACCGGTGGCGTGCTGGTGGAGGACCCGGTGGGCGTGGCCGAGGCCTATGCC
ACTGGCCGCGGCTCGTTCCGCGTGCGGGCGCGCTGGGAGAAGGAGGAGACCGGGCGCGGCACCTATGTGGTGGTGGTCAC
CGAGATCCCCTACGGCGTCGCCAAGTCCCGCCTCGTGGAGAAGATCGCGGAGCTGCTCACCGACAAGAAGCTGCCGCTGC
TCGCCGACGTGCGCGACGAGAGCGCCGAGGATATCCGCCTGGTGCTGGAGCCGCGCGCCCGCACGGTGGATGCCGAGGTG
CTCATGGAGAGCCTGTTCAAGCTCACCGAGCTTGAGGCCCGCATCCCGCTCAACATGAACGTGCTGGTGCGCGGGCAGGT
CCCCAAGGTGCTCTCCCTTTCGGAAGCGCTCCGGGAATGGCTCGACCACCGCCGCGACGTGCTGCTGCGTCGCTCGCGCT
ATCGGCTGGAGCAGATCGCGCACCGGCTGGAGGTGCTCGGCGGCTACCTCATCGCCTATCTCAACCTCGACGAGGTGATC
CGCATCATACGCGAGGAGGACGAGCCCAAGCAGGAATTGATGCGCACGTTCGAGCTGACCGACGTGCAGACGGAAGCCAT
CCTCAACATGCGGCTGCGCTCCCTGCGCCGGCTGGAGGAGATGGAGATCCGCAAGGAGCACGACGCCCTGAGCAAGGAGC
AGGACGGCCTGAACAAGCTGGTGGCCTCCGAGGCGGCGCAGTGGAAGTCCATCGCCAAGGAAATCCGCGAGACCCGCAAG
ACCTACGGCCCCGAGACTGCCATCGGCCGGCGCCGCACCACGTTCGCGGCGCCCCCCACCTTCCATGAGGACGCCTTCAC
CGAGGCACTGGTGGAGCGCGAGCCGGTGACCATCGTGGTCTCCGCCAAGGGCTGGATCCGGGCGCTCAAGGGCCATGTGC
AGGACCTGTCCAACCTGCAGTTCAAGGGCGACGACAGCCTGGGCCACGCCTTCTTCGCCGAGACCACCTCCAAGGTCATG
GTCTTCGCCTCCAACGGGCGCTTCTACACGCTGGAGGCCGCCAAGCTGCCCGGCGGGCGCGGCCACGGCGAGCCGGTGCG
CCTCATGATCGACCTGGAGCAGGAGGCGGAGATCGTCTCCGTCTTCGCCTATCAGCCCGGCCGCAAGCTGCTGTTGGCCT
CCAAGGAGGGACGCGGCTTCGTGGTGGGCGAGGACGACTGCCTCGCCAACACCCGCAAGGGCAAGCAGGTGCTCGTCACC
GATCCGCCGGACGCGGCGCTGGCGGTGCGCTTCGTGGAGGGCGACTGGGTGGCGGTGATCGGCGACAACCGCAAGCTGCT
GCTGTTCCCGCTCAACCAGGTTCCGGAAATGACCCGTGGGCGCGGCGTGCGTTTCCAACGATACCGCGAGGGCGGGCTGT
CGGACCTGAAGGCCTTCTCCATGGCCTCGGGCCTGACTTGGGAGGACACCTCCGGCCGCACCTGGACCGTGACGGAGTTG
CTGGAATGGCAGGGCGAGCGCGCCTCCGCCGGTCGGCTGCCGCCCAAGGGCTTCCCCCGCAGCAACAAATTCAGCTGA

Upstream 100 bases:

>100_bases
GTGGCACGCTTTTCATCGGGCGCTTGTGGGATGTGCCGATGATGCCCCCGGTCTAGAAAGGCAGCTTGTGGCTCGCCCCC
GCGCGCGGTAACTGGCAGGC

Downstream 100 bases:

>100_bases
GCTGATGGCCGGCCCGCCCGCCGATTCCGGATCTGCCGATCCTGCGCCGGCCGGTACCGGGGCGCCGGTCTCCATCCTCG
CCCGTTTTGTCGCCGCCGTC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MATRTLPPGDGHIEKVTLKEALEERYLAYALSTIMHRALPDARDGLKPVHRRILHAMRQLRLDPGQGFKKSARVVGDVIG
KFHPHGDQSVYDALVRLAQDFAQRYPLVDGQGNFGNVDGDNAAAMRYTEARLTETARLLLDGIDEDAVDFRPTYDGSEEE
PAVLPAAFPNLLANGSQGIAVGMATSIPPHNAAELLDAALHLIDHPEAPAFDLLQFVPGPDFPTGGVLVEDPVGVAEAYA
TGRGSFRVRARWEKEETGRGTYVVVVTEIPYGVAKSRLVEKIAELLTDKKLPLLADVRDESAEDIRLVLEPRARTVDAEV
LMESLFKLTELEARIPLNMNVLVRGQVPKVLSLSEALREWLDHRRDVLLRRSRYRLEQIAHRLEVLGGYLIAYLNLDEVI
RIIREEDEPKQELMRTFELTDVQTEAILNMRLRSLRRLEEMEIRKEHDALSKEQDGLNKLVASEAAQWKSIAKEIRETRK
TYGPETAIGRRRTTFAAPPTFHEDAFTEALVEREPVTIVVSAKGWIRALKGHVQDLSNLQFKGDDSLGHAFFAETTSKVM
VFASNGRFYTLEAAKLPGGRGHGEPVRLMIDLEQEAEIVSVFAYQPGRKLLLASKEGRGFVVGEDDCLANTRKGKQVLVT
DPPDAALAVRFVEGDWVAVIGDNRKLLLFPLNQVPEMTRGRGVRFQRYREGGLSDLKAFSMASGLTWEDTSGRTWTVTEL
LEWQGERASAGRLPPKGFPRSNKFS

Sequences:

>Translated_745_residues
MATRTLPPGDGHIEKVTLKEALEERYLAYALSTIMHRALPDARDGLKPVHRRILHAMRQLRLDPGQGFKKSARVVGDVIG
KFHPHGDQSVYDALVRLAQDFAQRYPLVDGQGNFGNVDGDNAAAMRYTEARLTETARLLLDGIDEDAVDFRPTYDGSEEE
PAVLPAAFPNLLANGSQGIAVGMATSIPPHNAAELLDAALHLIDHPEAPAFDLLQFVPGPDFPTGGVLVEDPVGVAEAYA
TGRGSFRVRARWEKEETGRGTYVVVVTEIPYGVAKSRLVEKIAELLTDKKLPLLADVRDESAEDIRLVLEPRARTVDAEV
LMESLFKLTELEARIPLNMNVLVRGQVPKVLSLSEALREWLDHRRDVLLRRSRYRLEQIAHRLEVLGGYLIAYLNLDEVI
RIIREEDEPKQELMRTFELTDVQTEAILNMRLRSLRRLEEMEIRKEHDALSKEQDGLNKLVASEAAQWKSIAKEIRETRK
TYGPETAIGRRRTTFAAPPTFHEDAFTEALVEREPVTIVVSAKGWIRALKGHVQDLSNLQFKGDDSLGHAFFAETTSKVM
VFASNGRFYTLEAAKLPGGRGHGEPVRLMIDLEQEAEIVSVFAYQPGRKLLLASKEGRGFVVGEDDCLANTRKGKQVLVT
DPPDAALAVRFVEGDWVAVIGDNRKLLLFPLNQVPEMTRGRGVRFQRYREGGLSDLKAFSMASGLTWEDTSGRTWTVTEL
LEWQGERASAGRLPPKGFPRSNKFS
>Mature_744_residues
ATRTLPPGDGHIEKVTLKEALEERYLAYALSTIMHRALPDARDGLKPVHRRILHAMRQLRLDPGQGFKKSARVVGDVIGK
FHPHGDQSVYDALVRLAQDFAQRYPLVDGQGNFGNVDGDNAAAMRYTEARLTETARLLLDGIDEDAVDFRPTYDGSEEEP
AVLPAAFPNLLANGSQGIAVGMATSIPPHNAAELLDAALHLIDHPEAPAFDLLQFVPGPDFPTGGVLVEDPVGVAEAYAT
GRGSFRVRARWEKEETGRGTYVVVVTEIPYGVAKSRLVEKIAELLTDKKLPLLADVRDESAEDIRLVLEPRARTVDAEVL
MESLFKLTELEARIPLNMNVLVRGQVPKVLSLSEALREWLDHRRDVLLRRSRYRLEQIAHRLEVLGGYLIAYLNLDEVIR
IIREEDEPKQELMRTFELTDVQTEAILNMRLRSLRRLEEMEIRKEHDALSKEQDGLNKLVASEAAQWKSIAKEIRETRKT
YGPETAIGRRRTTFAAPPTFHEDAFTEALVEREPVTIVVSAKGWIRALKGHVQDLSNLQFKGDDSLGHAFFAETTSKVMV
FASNGRFYTLEAAKLPGGRGHGEPVRLMIDLEQEAEIVSVFAYQPGRKLLLASKEGRGFVVGEDDCLANTRKGKQVLVTD
PPDAALAVRFVEGDWVAVIGDNRKLLLFPLNQVPEMTRGRGVRFQRYREGGLSDLKAFSMASGLTWEDTSGRTWTVTELL
EWQGERASAGRLPPKGFPRSNKFS

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=443, Percent_Identity=25.9593679458239, Blast_Score=87, Evalue=9e-17,
Organism=Homo sapiens, GI19913406, Length=398, Percent_Identity=23.8693467336683, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1789396, Length=678, Percent_Identity=42.6253687315634, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1788562, Length=737, Percent_Identity=36.9063772048847, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI212645845, Length=502, Percent_Identity=23.9043824701195, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17535065, Length=381, Percent_Identity=25.7217847769029, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=399, Percent_Identity=26.3157894736842, Blast_Score=76, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=410, Percent_Identity=24.1463414634146, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17136538, Length=177, Percent_Identity=29.9435028248588, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 83164; Mature: 83033

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRTLPPGDGHIEKVTLKEALEERYLAYALSTIMHRALPDARDGLKPVHRRILHAMRQL
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHH
RLDPGQGFKKSARVVGDVIGKFHPHGDQSVYDALVRLAQDFAQRYPLVDGQGNFGNVDGD
CCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NAAAMRYTEARLTETARLLLDGIDEDAVDFRPTYDGSEEEPAVLPAAFPNLLANGSQGIA
CCHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEE
VGMATSIPPHNAAELLDAALHLIDHPEAPAFDLLQFVPGPDFPTGGVLVEDPVGVAEAYA
EEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCHHHHHH
TGRGSFRVRARWEKEETGRGTYVVVVTEIPYGVAKSRLVEKIAELLTDKKLPLLADVRDE
CCCCCEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCC
SAEDIRLVLEPRARTVDAEVLMESLFKLTELEARIPLNMNVLVRGQVPKVLSLSEALREW
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHH
LDHRRDVLLRRSRYRLEQIAHRLEVLGGYLIAYLNLDEVIRIIREEDEPKQELMRTFELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCHHHHHHHHHHHH
DVQTEAILNMRLRSLRRLEEMEIRKEHDALSKEQDGLNKLVASEAAQWKSIAKEIRETRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYGPETAIGRRRTTFAAPPTFHEDAFTEALVEREPVTIVVSAKGWIRALKGHVQDLSNLQ
HCCCCHHCCCCCCEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCE
FKGDDSLGHAFFAETTSKVMVFASNGRFYTLEAAKLPGGRGHGEPVRLMIDLEQEAEIVS
ECCCCCCCHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCEEE
VFAYQPGRKLLLASKEGRGFVVGEDDCLANTRKGKQVLVTDPPDAALAVRFVEGDWVAVI
EEEECCCCEEEEEECCCCEEEECCCHHHCCCCCCCEEEEECCCCCEEEEEEECCCEEEEE
GDNRKLLLFPLNQVPEMTRGRGVRFQRYREGGLSDLKAFSMASGLTWEDTSGRTWTVTEL
ECCCEEEEEECCCCCHHHCCCCCCHHHHHCCCHHHHHHHHHHCCCCEECCCCCEEEHHHH
LEWQGERASAGRLPPKGFPRSNKFS
HHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATRTLPPGDGHIEKVTLKEALEERYLAYALSTIMHRALPDARDGLKPVHRRILHAMRQL
CCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHH
RLDPGQGFKKSARVVGDVIGKFHPHGDQSVYDALVRLAQDFAQRYPLVDGQGNFGNVDGD
CCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NAAAMRYTEARLTETARLLLDGIDEDAVDFRPTYDGSEEEPAVLPAAFPNLLANGSQGIA
CCHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEE
VGMATSIPPHNAAELLDAALHLIDHPEAPAFDLLQFVPGPDFPTGGVLVEDPVGVAEAYA
EEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCHHHHHH
TGRGSFRVRARWEKEETGRGTYVVVVTEIPYGVAKSRLVEKIAELLTDKKLPLLADVRDE
CCCCCEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCC
SAEDIRLVLEPRARTVDAEVLMESLFKLTELEARIPLNMNVLVRGQVPKVLSLSEALREW
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHH
LDHRRDVLLRRSRYRLEQIAHRLEVLGGYLIAYLNLDEVIRIIREEDEPKQELMRTFELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCHHHHHHHHHHHH
DVQTEAILNMRLRSLRRLEEMEIRKEHDALSKEQDGLNKLVASEAAQWKSIAKEIRETRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYGPETAIGRRRTTFAAPPTFHEDAFTEALVEREPVTIVVSAKGWIRALKGHVQDLSNLQ
HCCCCHHCCCCCCEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCE
FKGDDSLGHAFFAETTSKVMVFASNGRFYTLEAAKLPGGRGHGEPVRLMIDLEQEAEIVS
ECCCCCCCHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCEEEEEECCCCCCEEE
VFAYQPGRKLLLASKEGRGFVVGEDDCLANTRKGKQVLVTDPPDAALAVRFVEGDWVAVI
EEEECCCCEEEEEECCCCEEEECCCHHHCCCCCCCEEEEECCCCCEEEEEEECCCEEEEE
GDNRKLLLFPLNQVPEMTRGRGVRFQRYREGGLSDLKAFSMASGLTWEDTSGRTWTVTEL
ECCCEEEEEECCCCCHHHCCCCCCHHHHHCCCHHHHHHHHHHCCCCEECCCCCEEEHHHH
LEWQGERASAGRLPPKGFPRSNKFS
HHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]