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The map label for this gene is mcl1 [H]

Identifier: 154247793

GI number: 154247793

Start: 4288239

End: 4289279

Strand: Reverse

Name: mcl1 [H]

Synonym: Xaut_3870

Alternate gene names: 154247793

Gene position: 4289279-4288239 (Counterclockwise)

Preceding gene: 154247795

Following gene: 154247792

Centisome position: 80.79

GC content: 65.71

Gene sequence:

>1041_bases
ATGAAGCTGCCACGCCAATTCTTCAAGCCGCTGGCCATCGGTGCGCCCGCACCTTACCGCGAGCTGCCGGTGCAGCTGGA
GCGCATGATTCACTTCGTGCCACCGCACCTCGAAAAGATGCGCGCGAAGGTGCCGGACATCGCCAAGCAGGTGGATGTGG
TGCTCGGCAACCTCGAGGACGCCATCCCTTCCGACGCCAAGGAAGCCGCCCGCCGGGGCTTCATCGAGATGGCCAAGGCC
ACCGATTTCGGCTCCACCGGCCTGTGGACCCGCATCAACTGTCTCAACAGCCCCTGGGTGCTGGACGATATCGTTGAGAT
CGTCAGCGAGATCGGCGGCAAGCTCGACGTGATCATGCTGCCCAAGGTGGAAGGCGCCTGGGACGTGCACTATCTCGACC
AGCTGCTGGCCCAGCTGGAGGCCAAGCACGCCATCGGCAAGCCCATCCTCATCCACGCCATCCTGGAGACCGCCGAGGGC
GTGAAGAATGTGGAGGAGATTGCCAGCGCCTCCCCGCGCATGCACGGCATGAGCCTCGGCCCGGCGGACCTTGCCGCCTC
CCGCGCCATGAAGACCACCCGCGTCGGCGGCGGCCATCCGGACTACAAAGTGCTAGCGGACGCGGACGGCGACAAGCCGC
GCGCCGGCTACCAGCAGGACCTGTGGCACTACACCGTCGGCAAGATGGTGGACGCCTGCGCCGCCAACGGCATCAAGCCC
TTCTACGGTCCGTTCGGCGACTTCTCGGATCTCGCCGCCTGCGAGAGCCAGTTCCGCAACGCCTTCCTGCAGGGCTGCGT
CGGCGCCTGGTCGCTGCACCCCACCCAGATCGACATCGCCAAGCGCGTGTTCTCCCCCGATCCGGGCGAGGTGGCCTTCG
CGCTCAAGATCCTGGAAGCCATGCCCGACGGCGCCGGCGCGGTGATGATCGACGGCAAGATGCAGGACGACGCCACCTGG
AAGCAGGCCAAGGTGATCGTCGATCTTGCCCGTATTGTCGCAGCCAAGGATCCGGAAATGGGCAAAGCCTACGGACTGTG
A

Upstream 100 bases:

>100_bases
CATGAAGTCGTGTTGCACCGGCCCGCCACCTATGCTGCATTGCATTCAAGAGGTTGGCGGCTCGGCACGGAGCCATGCCG
CCGGATCCACGGGGGGACAC

Downstream 100 bases:

>100_bases
CAGAATTGATTAACCTTGCAGTACATTGCCGTTACGGAAGGTCGATCGCGACGGCACAGTGAAGAGGCGGGACATGGGCA
GTCACGACAAAGCGCGCGCG

Product: HpcH/HpaI aldolase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKLPRQFFKPLAIGAPAPYRELPVQLERMIHFVPPHLEKMRAKVPDIAKQVDVVLGNLEDAIPSDAKEAARRGFIEMAKA
TDFGSTGLWTRINCLNSPWVLDDIVEIVSEIGGKLDVIMLPKVEGAWDVHYLDQLLAQLEAKHAIGKPILIHAILETAEG
VKNVEEIASASPRMHGMSLGPADLAASRAMKTTRVGGGHPDYKVLADADGDKPRAGYQQDLWHYTVGKMVDACAANGIKP
FYGPFGDFSDLAACESQFRNAFLQGCVGAWSLHPTQIDIAKRVFSPDPGEVAFALKILEAMPDGAGAVMIDGKMQDDATW
KQAKVIVDLARIVAAKDPEMGKAYGL

Sequences:

>Translated_346_residues
MKLPRQFFKPLAIGAPAPYRELPVQLERMIHFVPPHLEKMRAKVPDIAKQVDVVLGNLEDAIPSDAKEAARRGFIEMAKA
TDFGSTGLWTRINCLNSPWVLDDIVEIVSEIGGKLDVIMLPKVEGAWDVHYLDQLLAQLEAKHAIGKPILIHAILETAEG
VKNVEEIASASPRMHGMSLGPADLAASRAMKTTRVGGGHPDYKVLADADGDKPRAGYQQDLWHYTVGKMVDACAANGIKP
FYGPFGDFSDLAACESQFRNAFLQGCVGAWSLHPTQIDIAKRVFSPDPGEVAFALKILEAMPDGAGAVMIDGKMQDDATW
KQAKVIVDLARIVAAKDPEMGKAYGL
>Mature_346_residues
MKLPRQFFKPLAIGAPAPYRELPVQLERMIHFVPPHLEKMRAKVPDIAKQVDVVLGNLEDAIPSDAKEAARRGFIEMAKA
TDFGSTGLWTRINCLNSPWVLDDIVEIVSEIGGKLDVIMLPKVEGAWDVHYLDQLLAQLEAKHAIGKPILIHAILETAEG
VKNVEEIASASPRMHGMSLGPADLAASRAMKTTRVGGGHPDYKVLADADGDKPRAGYQQDLWHYTVGKMVDACAANGIKP
FYGPFGDFSDLAACESQFRNAFLQGCVGAWSLHPTQIDIAKRVFSPDPGEVAFALKILEAMPDGAGAVMIDGKMQDDATW
KQAKVIVDLARIVAAKDPEMGKAYGL

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=314, Percent_Identity=25.4777070063694, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 37604; Mature: 37604

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPRQFFKPLAIGAPAPYRELPVQLERMIHFVPPHLEKMRAKVPDIAKQVDVVLGNLED
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AIPSDAKEAARRGFIEMAKATDFGSTGLWTRINCLNSPWVLDDIVEIVSEIGGKLDVIML
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEE
PKVEGAWDVHYLDQLLAQLEAKHAIGKPILIHAILETAEGVKNVEEIASASPRMHGMSLG
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PADLAASRAMKTTRVGGGHPDYKVLADADGDKPRAGYQQDLWHYTVGKMVDACAANGIKP
HHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
FYGPFGDFSDLAACESQFRNAFLQGCVGAWSLHPTQIDIAKRVFSPDPGEVAFALKILEA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
MPDGAGAVMIDGKMQDDATWKQAKVIVDLARIVAAKDPEMGKAYGL
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCC
>Mature Secondary Structure
MKLPRQFFKPLAIGAPAPYRELPVQLERMIHFVPPHLEKMRAKVPDIAKQVDVVLGNLED
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AIPSDAKEAARRGFIEMAKATDFGSTGLWTRINCLNSPWVLDDIVEIVSEIGGKLDVIML
CCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEE
PKVEGAWDVHYLDQLLAQLEAKHAIGKPILIHAILETAEGVKNVEEIASASPRMHGMSLG
CCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PADLAASRAMKTTRVGGGHPDYKVLADADGDKPRAGYQQDLWHYTVGKMVDACAANGIKP
HHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
FYGPFGDFSDLAACESQFRNAFLQGCVGAWSLHPTQIDIAKRVFSPDPGEVAFALKILEA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
MPDGAGAVMIDGKMQDDATWKQAKVIVDLARIVAAKDPEMGKAYGL
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA