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The map label for this gene is pqqL [C]

Identifier: 154247453

GI number: 154247453

Start: 3932265

End: 3933530

Strand: Direct

Name: pqqL [C]

Synonym: Xaut_3525

Alternate gene names: 154247453

Gene position: 3932265-3933530 (Clockwise)

Preceding gene: 154247452

Following gene: 154247454

Centisome position: 74.07

GC content: 68.72

Gene sequence:

>1266_bases
ATGAGCGTGAAGATTTCGGTCCTCGACAACGGCGTCACCGTCATCACCGACGAGATGAGCCATCTCGGCACCGCCTCCCT
CGGCATCTGGGTGGGCGCGGGGGCGCGGGACGAGCAGGAGGACGAGCACGGCATCTCCCATCTGCTGGAGCACATGGCCT
TCAAGGGCACGCGCCGGCGCTCCGCCCGCCGCATCGCCGAGGAGATCGAGCAGGTGGGCGGCGACATCAATGCCGCCACC
TCGGTGGAGCAGACCACCTACAATGTCCGCGTGCTGGGGGAGGATGTGGGCCTCGGCATCGACATCCTCGCCGACATCCT
CACCGAGCCGGCCTTCGCCCCCGACGAGCTGGAGCGGGAGAAGAACGTGATTGTGCAGGAGATCGGCGCGGTCATGGACA
CGCCCGACGACCTGGTGTTCGACCTGTTCCAGGAGCAGGCCTTCCCCGGCCAGAGCGTGGGCCGCTCTATCCTCGGCACG
CCGGACACGGTGCGCGCCTTCAGTCGGGACCAGCTCGGCGCCTATCTCGGGCGCACCTATCGCGGCCCCCGCATGGTGGT
GGCCGCCGCCGGCGCGGTGGAGCACGACCGGCTGGTGGAAGAGGCCGGCCAACGGCTGAAGATCATCGCCCCCGCCACCA
AGCCGGAGCTGCCCCAGGCCACCTATGGCGGCGGCACCCGACTGCTCGCCCGTGACCTGGAACAGGTGCATGTGTTGCTG
GGGCTGGAGGGCTGCTCCTTCAAGGACCCCGAATATCACGCCGTGCAGGTGCTCGCGAACGTGCTGGGCGGCGGCATGTC
CTCGCGCCTGTTCCAGGACGTGCGTGAGGATCGCGGCCTCTGCTATTCGATCTATGCTTTTCACTGGAGCTATCAGGATA
CCGGCCTGTTCGGCGTCTATGCCGGCACCGACACCGGCGACGTGGAGGAACTGTCCAACGCGGTCATCGACCAGATTCTC
GACACGGCCGAAACCGTGACCGAGCTGGAGGTGGCCCGCGCCAAGGCGCAGATGAAGGTGGGGCTGCTCGCCGCGCTGGA
AAGCTCCGGCGCGCGAGCGGACCAGCTCGCCCGGCAGATCCTCGGCTTCGGCCGGGTGATCCCGGTGGAGGAGATCGTGG
CGCGGGTGGATGCGGTGGACGTGGCAGGGGTGCGCCGGGCGGCGCAGGGCCTCATCGGCCGTGGCCGGCCCACATTGACC
GCCATCGGTCCGGGCGGCGGCCTTGAGCCTGCCGCACGGGCCGTGGAGCGTTTGAAGGTTCACTAG

Upstream 100 bases:

>100_bases
TCATGACCCGCCGGGAGAGCGTCAGCGTGCTGCCCAACGACCTTGCCGCCATCGAGACCTTCATTCGCGCCCATGCGCGC
ATCGCCCGGGGCGCGGCGGC

Downstream 100 bases:

>100_bases
AGTCCGCGCCGGTCAGCCTGCACCGCAGGCCGATCGGACACCGCGTTCTCTTTGTCGAGTTGAAGCGATCACCTGTTGGA
TCGCATCGCGTGCCAGCCGG

Product: peptidase M16 domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSVKISVLDNGVTVITDEMSHLGTASLGIWVGAGARDEQEDEHGISHLLEHMAFKGTRRRSARRIAEEIEQVGGDINAAT
SVEQTTYNVRVLGEDVGLGIDILADILTEPAFAPDELEREKNVIVQEIGAVMDTPDDLVFDLFQEQAFPGQSVGRSILGT
PDTVRAFSRDQLGAYLGRTYRGPRMVVAAAGAVEHDRLVEEAGQRLKIIAPATKPELPQATYGGGTRLLARDLEQVHVLL
GLEGCSFKDPEYHAVQVLANVLGGGMSSRLFQDVREDRGLCYSIYAFHWSYQDTGLFGVYAGTDTGDVEELSNAVIDQIL
DTAETVTELEVARAKAQMKVGLLAALESSGARADQLARQILGFGRVIPVEEIVARVDAVDVAGVRRAAQGLIGRGRPTLT
AIGPGGGLEPAARAVERLKVH

Sequences:

>Translated_421_residues
MSVKISVLDNGVTVITDEMSHLGTASLGIWVGAGARDEQEDEHGISHLLEHMAFKGTRRRSARRIAEEIEQVGGDINAAT
SVEQTTYNVRVLGEDVGLGIDILADILTEPAFAPDELEREKNVIVQEIGAVMDTPDDLVFDLFQEQAFPGQSVGRSILGT
PDTVRAFSRDQLGAYLGRTYRGPRMVVAAAGAVEHDRLVEEAGQRLKIIAPATKPELPQATYGGGTRLLARDLEQVHVLL
GLEGCSFKDPEYHAVQVLANVLGGGMSSRLFQDVREDRGLCYSIYAFHWSYQDTGLFGVYAGTDTGDVEELSNAVIDQIL
DTAETVTELEVARAKAQMKVGLLAALESSGARADQLARQILGFGRVIPVEEIVARVDAVDVAGVRRAAQGLIGRGRPTLT
AIGPGGGLEPAARAVERLKVH
>Mature_420_residues
SVKISVLDNGVTVITDEMSHLGTASLGIWVGAGARDEQEDEHGISHLLEHMAFKGTRRRSARRIAEEIEQVGGDINAATS
VEQTTYNVRVLGEDVGLGIDILADILTEPAFAPDELEREKNVIVQEIGAVMDTPDDLVFDLFQEQAFPGQSVGRSILGTP
DTVRAFSRDQLGAYLGRTYRGPRMVVAAAGAVEHDRLVEEAGQRLKIIAPATKPELPQATYGGGTRLLARDLEQVHVLLG
LEGCSFKDPEYHAVQVLANVLGGGMSSRLFQDVREDRGLCYSIYAFHWSYQDTGLFGVYAGTDTGDVEELSNAVIDQILD
TAETVTELEVARAKAQMKVGLLAALESSGARADQLARQILGFGRVIPVEEIVARVDAVDVAGVRRAAQGLIGRGRPTLTA
IGPGGGLEPAARAVERLKVH

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=417, Percent_Identity=34.7721822541966, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI46593007, Length=417, Percent_Identity=31.4148681055156, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI24308013, Length=433, Percent_Identity=29.0993071593533, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI50592988, Length=419, Percent_Identity=24.582338902148, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71999683, Length=411, Percent_Identity=31.6301703163017, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17553678, Length=399, Percent_Identity=27.8195488721804, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17510601, Length=437, Percent_Identity=25.629290617849, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17569737, Length=359, Percent_Identity=24.2339832869081, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323192, Length=398, Percent_Identity=33.6683417085427, Blast_Score=230, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321813, Length=440, Percent_Identity=27.5, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319426, Length=408, Percent_Identity=24.0196078431373, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21357875, Length=415, Percent_Identity=35.1807228915663, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24646943, Length=415, Percent_Identity=35.1807228915663, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI19921772, Length=435, Percent_Identity=25.5172413793103, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24665395, Length=409, Percent_Identity=26.6503667481663, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 45245; Mature: 45114

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS50065 HMG_COA_REDUCTASE_4 ; PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVKISVLDNGVTVITDEMSHLGTASLGIWVGAGARDEQEDEHGISHLLEHMAFKGTRRR
CCEEEEEECCCEEEEECCHHHCCCCHHHEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHH
SARRIAEEIEQVGGDINAATSVEQTTYNVRVLGEDVGLGIDILADILTEPAFAPDELERE
HHHHHHHHHHHHCCCCCCCCCHHHHEEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHH
KNVIVQEIGAVMDTPDDLVFDLFQEQAFPGQSVGRSILGTPDTVRAFSRDQLGAYLGRTY
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHCHHHCCCCHHHHHHHHHHHHHHHHCCC
RGPRMVVAAAGAVEHDRLVEEAGQRLKIIAPATKPELPQATYGGGTRLLARDLEQVHVLL
CCCEEEEEECCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GLEGCSFKDPEYHAVQVLANVLGGGMSSRLFQDVREDRGLCYSIYAFHWSYQDTGLFGVY
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEEEE
AGTDTGDVEELSNAVIDQILDTAETVTELEVARAKAQMKVGLLAALESSGARADQLARQI
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LGFGRVIPVEEIVARVDAVDVAGVRRAAQGLIGRGRPTLTAIGPGGGLEPAARAVERLKV
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCC
H
C
>Mature Secondary Structure 
SVKISVLDNGVTVITDEMSHLGTASLGIWVGAGARDEQEDEHGISHLLEHMAFKGTRRR
CEEEEEECCCEEEEECCHHHCCCCHHHEEECCCCCCCCHHHHHHHHHHHHHHHCCHHHH
SARRIAEEIEQVGGDINAATSVEQTTYNVRVLGEDVGLGIDILADILTEPAFAPDELERE
HHHHHHHHHHHHCCCCCCCCCHHHHEEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHH
KNVIVQEIGAVMDTPDDLVFDLFQEQAFPGQSVGRSILGTPDTVRAFSRDQLGAYLGRTY
HHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHCHHHCCCCHHHHHHHHHHHHHHHHCCC
RGPRMVVAAAGAVEHDRLVEEAGQRLKIIAPATKPELPQATYGGGTRLLARDLEQVHVLL
CCCEEEEEECCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GLEGCSFKDPEYHAVQVLANVLGGGMSSRLFQDVREDRGLCYSIYAFHWSYQDTGLFGVY
CCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEEEEECCCCCEEEEE
AGTDTGDVEELSNAVIDQILDTAETVTELEVARAKAQMKVGLLAALESSGARADQLARQI
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LGFGRVIPVEEIVARVDAVDVAGVRRAAQGLIGRGRPTLTAIGPGGGLEPAARAVERLKV
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA