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The map label for this gene is thrC [H]

Identifier: 154247452

GI number: 154247452

Start: 3930856

End: 3932268

Strand: Direct

Name: thrC [H]

Synonym: Xaut_3524

Alternate gene names: 154247452

Gene position: 3930856-3932268 (Clockwise)

Preceding gene: 154247451

Following gene: 154247453

Centisome position: 74.04

GC content: 68.86

Gene sequence:

>1413_bases
GTGCGTTACGTTTCCACCCGTGGTGAAGCTCCCGTTCTCTCCTTTTCCGACGCGCTGCTCGCGGGGCTTGCGCGCGACGG
CGGCCTCTATCTGCCCGAGGCCTGGCCGACCCTCTCCAGGGATGAGATCGCCGCGCTGGCGGGAAAACCCTACGCTGCCG
TCGCCAAGGCCGTGATCGGCCCGTTCGTGGGCGACGCGCTGCCGCCGCGCGCCCTCGACCTGATGATCGACGACGCCTAT
GCGGGCTTCCGTCATCCGGCCGTGGCCCCGCTGACCCAGATCGGCGCCAACCGCTTCCTCCTTGAGCTATTCCACGGCCC
GACCCTCGCCTTCAAGGACGTGGCGATGCAGCTGCTCGCCCGGCTGATGGACCATGTGCTGGCCTCGCGCGGCAGCCGGG
CCACCATCGTGGGCGCCACTTCCGGCGACACCGGCAGCGCGGCCATCGAGGCGTTCCGGCGCTCGGACGCGGTGGATGTC
TTCATCCTCTATCCCCACGGCCGGGTGTCCGAGGTGCAGCGCCGGCAGATGACCACGGTGAATTCGCCGAGCGTCCATGC
CATTGCCGTGGAAGGCACGTTCGACGACTGCCAGAACCTGGTCAAGGCCATGTTCAACCACCACGCCTTCCGCGACTCCC
TGGCGCTGGCAGGGGTGAATTCCATCAACTGGGCGCGGATCGTGGCCCAGGTGGTCTATTATTTCTATGCCGCCACCGCC
CTGGGCGCGCCCCATCGGGACGTCTCCTTCGTGGTGCCCACCGGCAATTTCGGCGATATCCTCGCCGGCTGGGTGGCGAA
GAAGATGGGCCTGCCGATCCGCGACCTCACCATCGCCACCAACGTCAACGACATCCTGGTGCGCACCCTGGACACCGGCC
GCTATGAGGTGAAGGGGGTGCTGCCCTCCTCCTCGCCGTCCATGGATATCCAGATCTCCTCCAATTTCGAGCGCCTGCTG
TTCGAGGCCCTGGACCGCGACAGCGCGGTGCTGCGCCAGCTGATGGATCAGCTCGCCCAGTCGGGCTCCTTCAGCGTGCC
GCGCGCTGCGCTCGCCGCCATCTGCGCCGACTTCTCCGCCGGCCGAGCCGACGAGCCGGAGACCGCTGCCACCATCGCCA
GGCTCTACCAGTCCGCCGGCTATCTCTGCGATCCGCACACGGCGGTGGGCCTTGCGGTGGCGGACAAGGTGGAGCACGCG
GCCAGGGTGCCGCAGGTGGTGCTCTCCACCGCCCACCCCGCCAAGTTCCCCGACGCGGTGGAAGCCGCCACCGGCCATCG
TCCGGCCCTGCCGCCGCACATGGCGGACCTCATGACCCGCCGGGAGAGCGTCAGCGTGCTGCCCAACGACCTTGCCGCCA
TCGAGACCTTCATTCGCGCCCATGCGCGCATCGCCCGGGGCGCGGCGGCATGA

Upstream 100 bases:

>100_bases
ACGAACGCCGCAGTCCGCACCAACCGCCTTTCGCCCAAGGCCGCTTGCGGGTAGTTTAGCCGGTGGCCCGATATGCGGCC
GAAGATCAGGTCGAGGCCCC

Downstream 100 bases:

>100_bases
GCGTGAAGATTTCGGTCCTCGACAACGGCGTCACCGTCATCACCGACGAGATGAGCCATCTCGGCACCGCCTCCCTCGGC
ATCTGGGTGGGCGCGGGGGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MRYVSTRGEAPVLSFSDALLAGLARDGGLYLPEAWPTLSRDEIAALAGKPYAAVAKAVIGPFVGDALPPRALDLMIDDAY
AGFRHPAVAPLTQIGANRFLLELFHGPTLAFKDVAMQLLARLMDHVLASRGSRATIVGATSGDTGSAAIEAFRRSDAVDV
FILYPHGRVSEVQRRQMTTVNSPSVHAIAVEGTFDDCQNLVKAMFNHHAFRDSLALAGVNSINWARIVAQVVYYFYAATA
LGAPHRDVSFVVPTGNFGDILAGWVAKKMGLPIRDLTIATNVNDILVRTLDTGRYEVKGVLPSSSPSMDIQISSNFERLL
FEALDRDSAVLRQLMDQLAQSGSFSVPRAALAAICADFSAGRADEPETAATIARLYQSAGYLCDPHTAVGLAVADKVEHA
ARVPQVVLSTAHPAKFPDAVEAATGHRPALPPHMADLMTRRESVSVLPNDLAAIETFIRAHARIARGAAA

Sequences:

>Translated_470_residues
MRYVSTRGEAPVLSFSDALLAGLARDGGLYLPEAWPTLSRDEIAALAGKPYAAVAKAVIGPFVGDALPPRALDLMIDDAY
AGFRHPAVAPLTQIGANRFLLELFHGPTLAFKDVAMQLLARLMDHVLASRGSRATIVGATSGDTGSAAIEAFRRSDAVDV
FILYPHGRVSEVQRRQMTTVNSPSVHAIAVEGTFDDCQNLVKAMFNHHAFRDSLALAGVNSINWARIVAQVVYYFYAATA
LGAPHRDVSFVVPTGNFGDILAGWVAKKMGLPIRDLTIATNVNDILVRTLDTGRYEVKGVLPSSSPSMDIQISSNFERLL
FEALDRDSAVLRQLMDQLAQSGSFSVPRAALAAICADFSAGRADEPETAATIARLYQSAGYLCDPHTAVGLAVADKVEHA
ARVPQVVLSTAHPAKFPDAVEAATGHRPALPPHMADLMTRRESVSVLPNDLAAIETFIRAHARIARGAAA
>Mature_470_residues
MRYVSTRGEAPVLSFSDALLAGLARDGGLYLPEAWPTLSRDEIAALAGKPYAAVAKAVIGPFVGDALPPRALDLMIDDAY
AGFRHPAVAPLTQIGANRFLLELFHGPTLAFKDVAMQLLARLMDHVLASRGSRATIVGATSGDTGSAAIEAFRRSDAVDV
FILYPHGRVSEVQRRQMTTVNSPSVHAIAVEGTFDDCQNLVKAMFNHHAFRDSLALAGVNSINWARIVAQVVYYFYAATA
LGAPHRDVSFVVPTGNFGDILAGWVAKKMGLPIRDLTIATNVNDILVRTLDTGRYEVKGVLPSSSPSMDIQISSNFERLL
FEALDRDSAVLRQLMDQLAQSGSFSVPRAALAAICADFSAGRADEPETAATIARLYQSAGYLCDPHTAVGLAVADKVEHA
ARVPQVVLSTAHPAKFPDAVEAATGHRPALPPHMADLMTRRESVSVLPNDLAAIETFIRAHARIARGAAA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=459, Percent_Identity=35.7298474945534, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI153792148, Length=479, Percent_Identity=34.8643006263048, Blast_Score=261, Evalue=7e-70,
Organism=Escherichia coli, GI1786185, Length=463, Percent_Identity=32.6133909287257, Blast_Score=228, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6319901, Length=456, Percent_Identity=42.7631578947368, Blast_Score=344, Evalue=1e-95,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50241; Mature: 50241

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYVSTRGEAPVLSFSDALLAGLARDGGLYLPEAWPTLSRDEIAALAGKPYAAVAKAVIG
CCCCCCCCCCCEEEHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
PFVGDALPPRALDLMIDDAYAGFRHPAVAPLTQIGANRFLLELFHGPTLAFKDVAMQLLA
HHHCCCCCCHHHHHEEHHHHHCCCCCCHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHH
RLMDHVLASRGSRATIVGATSGDTGSAAIEAFRRSDAVDVFILYPHGRVSEVQRRQMTTV
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCC
NSPSVHAIAVEGTFDDCQNLVKAMFNHHAFRDSLALAGVNSINWARIVAQVVYYFYAATA
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPHRDVSFVVPTGNFGDILAGWVAKKMGLPIRDLTIATNVNDILVRTLDTGRYEVKGV
CCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHEEEECCCCEEEEEE
LPSSSPSMDIQISSNFERLLFEALDRDSAVLRQLMDQLAQSGSFSVPRAALAAICADFSA
CCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
GRADEPETAATIARLYQSAGYLCDPHTAVGLAVADKVEHAARVPQVVLSTAHPAKFPDAV
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
EAATGHRPALPPHMADLMTRRESVSVLPNDLAAIETFIRAHARIARGAAA
HHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRYVSTRGEAPVLSFSDALLAGLARDGGLYLPEAWPTLSRDEIAALAGKPYAAVAKAVIG
CCCCCCCCCCCEEEHHHHHHHHHHCCCCEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHH
PFVGDALPPRALDLMIDDAYAGFRHPAVAPLTQIGANRFLLELFHGPTLAFKDVAMQLLA
HHHCCCCCCHHHHHEEHHHHHCCCCCCHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHH
RLMDHVLASRGSRATIVGATSGDTGSAAIEAFRRSDAVDVFILYPHGRVSEVQRRQMTTV
HHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCC
NSPSVHAIAVEGTFDDCQNLVKAMFNHHAFRDSLALAGVNSINWARIVAQVVYYFYAATA
CCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPHRDVSFVVPTGNFGDILAGWVAKKMGLPIRDLTIATNVNDILVRTLDTGRYEVKGV
CCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHEEEECCCCEEEEEE
LPSSSPSMDIQISSNFERLLFEALDRDSAVLRQLMDQLAQSGSFSVPRAALAAICADFSA
CCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
GRADEPETAATIARLYQSAGYLCDPHTAVGLAVADKVEHAARVPQVVLSTAHPAKFPDAV
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
EAATGHRPALPPHMADLMTRRESVSVLPNDLAAIETFIRAHARIARGAAA
HHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]