Click here to switch to the map view.

The map label for this gene is hflC [H]

Identifier: 154247313

GI number: 154247313

Start: 3772985

End: 3773905

Strand: Direct

Name: hflC [H]

Synonym: Xaut_3385

Alternate gene names: 154247313

Gene position: 3772985-3773905 (Clockwise)

Preceding gene: 154247312

Following gene: 154247314

Centisome position: 71.07

GC content: 68.95

Gene sequence:

>921_bases
ATGAAGCGCTATGGTTTCGTCGGGCTGGCGGCGGCGGCCATTCTCGGGGCCGTCGCCCTGTCCTTCGCCTTCACGGTGGA
GGAGACCCAGCGGGCGCTGGTGGTGCGCCTCGGCATGCCGCTGGCGGTCCATGACGACCCTGGCCTGTACTTCAAGGTGC
CGTTCATCGACACGGTGATCTTCTTCGAGCGTCGGCTGGTGTCGCTGGAGCCGCCCGCCGAGCAGATCATCCTGGGTGAC
CAGAAGCGGATCGAGGCGAGCACCTATACCCGCTTCCGCATCAGCGACCCGCTGGCCTTCTACCAGGCGGTGGGCGGCAT
CGAGCAGGGCCAGTCGCGCCTTGCGCAGATCGTCAATTCGGCGGTGCGCCGGGAACTGGGGCAGGCGAAGCTGGTGGACC
TCCTGTCCACCGAGCGCGACCGCATCATCGATGCCATCCGCTCCCAGGTGATCGAGCGCAGCCGGTCGCTGGGCGTGGAC
GTGGTGGAGGTGCGCCTCTTGCGCGCCGACCTGCCGGCGGAAACCAGCCAGGCCATCTACGACCGCATGAAATCCGAACG
CCAGCGCGAGGCCAAGGAACTGCGCGCCCAGGGCTTTGAATGGGCGCAGGAAATCCAGGCCCGCGCCGACCGCCAGAAGA
CCATCATCCTGGCCGAGGCGCAGCAGAAGGCGAAGGTGACGCGGGGCGAGGCCGATGCGGCGGCCTCCCAGATCCTCGGC
GACGCCTATGATCGCAGCCCCGCCTTCTACACCTTCCTGCGGACCCAGCAGACCTACCGCCAGACCCTGGCAGGGGCCTC
CCCCACGCTGCTGCTGTCGCCGGACGTGGACTTCCTCGGCGCGCTGACGAAGGGGCCGTCGCCGGAGCCCACGACCGGCG
AAAAGCCCAGCGCGCGGGCCGAAGGCGGCCCAAGGCCATGA

Upstream 100 bases:

>100_bases
TGTCGGCCCACGGCGGCGGCGTGGTGCCCTACCTGCCCCTGATGGAGCCGGGGCCGAAGCCGGCCGCGGTCGCCGAGGCC
CCGGTCGCGGGAGCGGTCAA

Downstream 100 bases:

>100_bases
GGGATGCCGGATGCCGCACCCGGCCCCGCGTGTTGACCGTAGAGGACGCACCCCATGGATCTCGGCGCTGATCTTTCCTG
GTTCGGCATCAGCCTGAAGA

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKRYGFVGLAAAAILGAVALSFAFTVEETQRALVVRLGMPLAVHDDPGLYFKVPFIDTVIFFERRLVSLEPPAEQIILGD
QKRIEASTYTRFRISDPLAFYQAVGGIEQGQSRLAQIVNSAVRRELGQAKLVDLLSTERDRIIDAIRSQVIERSRSLGVD
VVEVRLLRADLPAETSQAIYDRMKSERQREAKELRAQGFEWAQEIQARADRQKTIILAEAQQKAKVTRGEADAAASQILG
DAYDRSPAFYTFLRTQQTYRQTLAGASPTLLLSPDVDFLGALTKGPSPEPTTGEKPSARAEGGPRP

Sequences:

>Translated_306_residues
MKRYGFVGLAAAAILGAVALSFAFTVEETQRALVVRLGMPLAVHDDPGLYFKVPFIDTVIFFERRLVSLEPPAEQIILGD
QKRIEASTYTRFRISDPLAFYQAVGGIEQGQSRLAQIVNSAVRRELGQAKLVDLLSTERDRIIDAIRSQVIERSRSLGVD
VVEVRLLRADLPAETSQAIYDRMKSERQREAKELRAQGFEWAQEIQARADRQKTIILAEAQQKAKVTRGEADAAASQILG
DAYDRSPAFYTFLRTQQTYRQTLAGASPTLLLSPDVDFLGALTKGPSPEPTTGEKPSARAEGGPRP
>Mature_306_residues
MKRYGFVGLAAAAILGAVALSFAFTVEETQRALVVRLGMPLAVHDDPGLYFKVPFIDTVIFFERRLVSLEPPAEQIILGD
QKRIEASTYTRFRISDPLAFYQAVGGIEQGQSRLAQIVNSAVRRELGQAKLVDLLSTERDRIIDAIRSQVIERSRSLGVD
VVEVRLLRADLPAETSQAIYDRMKSERQREAKELRAQGFEWAQEIQARADRQKTIILAEAQQKAKVTRGEADAAASQILG
DAYDRSPAFYTFLRTQQTYRQTLAGASPTLLLSPDVDFLGALTKGPSPEPTTGEKPSARAEGGPRP

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=303, Percent_Identity=31.023102310231, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17569493, Length=173, Percent_Identity=28.9017341040462, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193209764, Length=173, Percent_Identity=28.9017341040462, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI32564147, Length=191, Percent_Identity=25.130890052356, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 33819; Mature: 33819

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRYGFVGLAAAAILGAVALSFAFTVEETQRALVVRLGMPLAVHDDPGLYFKVPFIDTVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCEEECHHHHHHH
FFERRLVSLEPPAEQIILGDQKRIEASTYTRFRISDPLAFYQAVGGIEQGQSRLAQIVNS
HHHHHHHCCCCCHHHEEECCHHHHHHHHEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHH
AVRRELGQAKLVDLLSTERDRIIDAIRSQVIERSRSLGVDVVEVRLLRADLPAETSQAIY
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHH
DRMKSERQREAKELRAQGFEWAQEIQARADRQKTIILAEAQQKAKVTRGEADAAASQILG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCHHHHHHHHHHH
DAYDRSPAFYTFLRTQQTYRQTLAGASPTLLLSPDVDFLGALTKGPSPEPTTGEKPSARA
HHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCC
EGGPRP
CCCCCC
>Mature Secondary Structure
MKRYGFVGLAAAAILGAVALSFAFTVEETQRALVVRLGMPLAVHDDPGLYFKVPFIDTVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEECCCCCEEECHHHHHHH
FFERRLVSLEPPAEQIILGDQKRIEASTYTRFRISDPLAFYQAVGGIEQGQSRLAQIVNS
HHHHHHHCCCCCHHHEEECCHHHHHHHHEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHH
AVRRELGQAKLVDLLSTERDRIIDAIRSQVIERSRSLGVDVVEVRLLRADLPAETSQAIY
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHH
DRMKSERQREAKELRAQGFEWAQEIQARADRQKTIILAEAQQKAKVTRGEADAAASQILG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCHHHHHHHHHHH
DAYDRSPAFYTFLRTQQTYRQTLAGASPTLLLSPDVDFLGALTKGPSPEPTTGEKPSARA
HHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCC
EGGPRP
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]