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The map label for this gene is glpK

Identifier: 154246748

GI number: 154246748

Start: 3129779

End: 3131272

Strand: Direct

Name: glpK

Synonym: Xaut_2809

Alternate gene names: 154246748

Gene position: 3129779-3131272 (Clockwise)

Preceding gene: 154246747

Following gene: 154246749

Centisome position: 58.95

GC content: 70.82

Gene sequence:

>1494_bases
TTGGCCGCCTACATCCTCGCCATCGACCAGGGCACCACCTCCTCCCGCGCCCTGCTGGTGCGGCGCGACGGCACCATCGC
GGCGCTGGCGCAGGAGGAGCTACCCCAGCATTTTCCGGCCTCCGGCGAGGTGGAGCAGGAAGCGGAGGACATCTGGAATA
CGGTGCTTTCCTGCTGCCGCGTGGTGCTGCGGCAGGCAGGGGTGGGGCCATCCGACATTGCCGCCATCGGCATCACCAAC
CAGCGCGAGACGACGCTGGTGTGGGAGCGCGCCACCGGCCGCGCCATCCACCGCGCCATCGTCTGGCAGGACCGGCGCAC
GGCCGACACCTGCGCCCGCCTTGAGGCGGAGGGCCATGGCGCGCTGATCCGCGCTCGCACCGGCTTGCTCATCGATCCCT
ATTTCTCCGCCACCAAGATCGCCCACATCCTCGAAAAGGTGCCGGGCGCCCGCGCGCGGGCGGAGAAGGGCGAACTGGCC
TTCGGCACGGTGGACAGTTTCCTCCTGTTCCGCCTCACCGGCGGCCGGGTGCATGCCACCGACGCCACCAATGCGTCGCG
CACCATGCTGTTCGATATCCATAAGGGGGCCTGGGACGACGACCTGCTGGCCCTGTTCGGGGTGCCGCGCGCGCTGCTGC
CGGAGGTGCGCGATTGCGCGGCCGAATTCGGCGCCACCGATCCGGAGATGTTCGGCGCGCCCATTCCCATCCGCGGCATG
GCAGGCGACCAGCAGGCAGCCATGGTGGGGCAGGCGTGCTTCCAGCCGGGCATGGTGAAATCCACCTACGGCACCGGCTG
CTTCGCCCTGCTCAACACGGGCGAAACGCCGGTGGCCTCACGCCATCGCCTCATCACCACCATCGCCTACCAGATCGAAG
GGCGGCGCACCTATGCGCTGGAAGGCTCGATCTTCGTGGCCGGCGCGGCGGTGCAATGGCTGCGCGACGGGCTGAAGATG
ATCTCCCATGCCGCCGAGAGCGACCGCCTCGCCGCCGAGGCGGACGAGGGGCAGGACGTGATCCTGGTGCCGGCCTTCGT
GGGCCTTGGCGCGCCCTATTGGCGGCCACAGGTGCGCGGCGCCCTGTTCGGCCTCACCCGCGCCACCGGACCGGCCGAGC
TGGCGCGGGCGGCGCTGGAGGCGGTGTGCTTCCAGACCTGCGACCTCATCGATGCCATGCATGCGGACTGGCCGGGGCAA
AGCGGTGCCACCGTGCTGCGGGTGGACGGCGGCATGTCGGCCTCCGACTTCACCATGCAGCGCCTCGCCGACCTCCTCGG
CGCGCCGGTGGACCGTCCGGCGGAGACGGAGACCACGGTGCTGGGCGCCGCCTATCTCGCGGGCCTGCAGTGTGGCTTCT
TCCCGCCGCCGGATATCTTCGCGCAGGGCTGGCGGCTGGAGCGGCGGTTCGTGCCGGCCATGGCGGACGAGGTGCGCGCC
ATGCGGCTCGCGGCCTGGCGCTCCGCCGTGGAATGCCTCATCGGCAGGGATTGA

Upstream 100 bases:

>100_bases
CGAAGCTCGGCCTGCGCACCCGTCATGAGGAAGCGCGGACGCTCGACGCCTACATGGCCGCCCGGCGCGGCGGCTGAAAA
CAACAATCCGGGAGGAGCTA

Downstream 100 bases:

>100_bases
CCTTGTCCGCCGAGTGGGTGCCTGCTTGCCGCCCACTCGGCGACACCGGTCGCGATCGCCGCGAAACAAAAAGGGGAGGG
CGCCCGGATGATGGAGGAAG

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MAAYILAIDQGTTSSRALLVRRDGTIAALAQEELPQHFPASGEVEQEAEDIWNTVLSCCRVVLRQAGVGPSDIAAIGITN
QRETTLVWERATGRAIHRAIVWQDRRTADTCARLEAEGHGALIRARTGLLIDPYFSATKIAHILEKVPGARARAEKGELA
FGTVDSFLLFRLTGGRVHATDATNASRTMLFDIHKGAWDDDLLALFGVPRALLPEVRDCAAEFGATDPEMFGAPIPIRGM
AGDQQAAMVGQACFQPGMVKSTYGTGCFALLNTGETPVASRHRLITTIAYQIEGRRTYALEGSIFVAGAAVQWLRDGLKM
ISHAAESDRLAAEADEGQDVILVPAFVGLGAPYWRPQVRGALFGLTRATGPAELARAALEAVCFQTCDLIDAMHADWPGQ
SGATVLRVDGGMSASDFTMQRLADLLGAPVDRPAETETTVLGAAYLAGLQCGFFPPPDIFAQGWRLERRFVPAMADEVRA
MRLAAWRSAVECLIGRD

Sequences:

>Translated_497_residues
MAAYILAIDQGTTSSRALLVRRDGTIAALAQEELPQHFPASGEVEQEAEDIWNTVLSCCRVVLRQAGVGPSDIAAIGITN
QRETTLVWERATGRAIHRAIVWQDRRTADTCARLEAEGHGALIRARTGLLIDPYFSATKIAHILEKVPGARARAEKGELA
FGTVDSFLLFRLTGGRVHATDATNASRTMLFDIHKGAWDDDLLALFGVPRALLPEVRDCAAEFGATDPEMFGAPIPIRGM
AGDQQAAMVGQACFQPGMVKSTYGTGCFALLNTGETPVASRHRLITTIAYQIEGRRTYALEGSIFVAGAAVQWLRDGLKM
ISHAAESDRLAAEADEGQDVILVPAFVGLGAPYWRPQVRGALFGLTRATGPAELARAALEAVCFQTCDLIDAMHADWPGQ
SGATVLRVDGGMSASDFTMQRLADLLGAPVDRPAETETTVLGAAYLAGLQCGFFPPPDIFAQGWRLERRFVPAMADEVRA
MRLAAWRSAVECLIGRD
>Mature_496_residues
AAYILAIDQGTTSSRALLVRRDGTIAALAQEELPQHFPASGEVEQEAEDIWNTVLSCCRVVLRQAGVGPSDIAAIGITNQ
RETTLVWERATGRAIHRAIVWQDRRTADTCARLEAEGHGALIRARTGLLIDPYFSATKIAHILEKVPGARARAEKGELAF
GTVDSFLLFRLTGGRVHATDATNASRTMLFDIHKGAWDDDLLALFGVPRALLPEVRDCAAEFGATDPEMFGAPIPIRGMA
GDQQAAMVGQACFQPGMVKSTYGTGCFALLNTGETPVASRHRLITTIAYQIEGRRTYALEGSIFVAGAAVQWLRDGLKMI
SHAAESDRLAAEADEGQDVILVPAFVGLGAPYWRPQVRGALFGLTRATGPAELARAALEAVCFQTCDLIDAMHADWPGQS
GATVLRVDGGMSASDFTMQRLADLLGAPVDRPAETETTVLGAAYLAGLQCGFFPPPDIFAQGWRLERRFVPAMADEVRAM
RLAAWRSAVECLIGRD

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family

Homologues:

Organism=Homo sapiens, GI4504007, Length=502, Percent_Identity=43.2270916334661, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI189409120, Length=502, Percent_Identity=43.2270916334661, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI42794763, Length=507, Percent_Identity=43.1952662721894, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI41393575, Length=507, Percent_Identity=41.8145956607495, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI88196792, Length=516, Percent_Identity=30.4263565891473, Blast_Score=269, Evalue=4e-72,
Organism=Escherichia coli, GI1790361, Length=491, Percent_Identity=50.9164969450102, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1789987, Length=452, Percent_Identity=27.8761061946903, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1787789, Length=484, Percent_Identity=22.9338842975207, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789168, Length=500, Percent_Identity=24.6, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17535599, Length=494, Percent_Identity=39.6761133603239, Blast_Score=338, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI71986140, Length=519, Percent_Identity=23.3140655105973, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71986147, Length=299, Percent_Identity=24.7491638795987, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321755, Length=479, Percent_Identity=35.6993736951983, Blast_Score=264, Evalue=2e-71,
Organism=Drosophila melanogaster, GI17864214, Length=507, Percent_Identity=40.6311637080868, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI24655555, Length=507, Percent_Identity=37.0808678500986, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24655560, Length=507, Percent_Identity=37.0808678500986, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24655570, Length=507, Percent_Identity=37.0808678500986, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24655574, Length=507, Percent_Identity=37.0808678500986, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24655565, Length=507, Percent_Identity=37.0808678500986, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI24654573, Length=458, Percent_Identity=41.0480349344978, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI19922058, Length=535, Percent_Identity=31.4018691588785, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24652871, Length=503, Percent_Identity=32.0079522862823, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24656367, Length=507, Percent_Identity=28.5996055226824, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI21357867, Length=523, Percent_Identity=28.1070745697897, Blast_Score=192, Evalue=5e-49,
Organism=Drosophila melanogaster, GI24656372, Length=345, Percent_Identity=31.304347826087, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45552909, Length=292, Percent_Identity=30.1369863013699, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): GLPK_XANP2 (A7IJ56)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001417706.1
- ProteinModelPortal:   A7IJ56
- SMR:   A7IJ56
- STRING:   A7IJ56
- GeneID:   5422029
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_2809
- eggNOG:   COG0554
- HOGENOM:   HBG511469
- OMA:   GWVEHEP
- BioCyc:   XAUT78245:XAUT_2809-MONOMER
- HAMAP:   MF_00186
- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999
- PANTHER:   PTHR10196
- PANTHER:   PTHR10196:SF9
- TIGRFAMs:   TIGR01311

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N

EC number: =2.7.1.30

Molecular weight: Translated: 53506; Mature: 53374

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00933 FGGY_KINASES_1; PS00445 FGGY_KINASES_2

Important sites: BINDING 12-12 BINDING 16-16 BINDING 82-82 BINDING 134-134 BINDING 243-243 BINDING 265-265 BINDING 308-308

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAYILAIDQGTTSSRALLVRRDGTIAALAQEELPQHFPASGEVEQEAEDIWNTVLSCCR
CEEEEEEEECCCCCCCEEEEECCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VVLRQAGVGPSDIAAIGITNQRETTLVWERATGRAIHRAIVWQDRRTADTCARLEAEGHG
HHHHHCCCCHHHEEEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHCCCCCC
ALIRARTGLLIDPYFSATKIAHILEKVPGARARAEKGELAFGTVDSFLLFRLTGGRVHAT
EEEEECCCCEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHEEEEEEECCEEEEC
DATNASRTMLFDIHKGAWDDDLLALFGVPRALLPEVRDCAAEFGATDPEMFGAPIPIRGM
CCCCCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCC
AGDQQAAMVGQACFQPGMVKSTYGTGCFALLNTGETPVASRHRLITTIAYQIEGRRTYAL
CCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHEEEEEEEEECCCEEEEE
EGSIFVAGAAVQWLRDGLKMISHAAESDRLAAEADEGQDVILVPAFVGLGAPYWRPQVRG
CCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHCCCCCCCHHHHH
ALFGLTRATGPAELARAALEAVCFQTCDLIDAMHADWPGQSGATVLRVDGGMSASDFTMQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHH
RLADLLGAPVDRPAETETTVLGAAYLAGLQCGFFPPPDIFAQGWRLERRFVPAMADEVRA
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
MRLAAWRSAVECLIGRD
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAYILAIDQGTTSSRALLVRRDGTIAALAQEELPQHFPASGEVEQEAEDIWNTVLSCCR
EEEEEEEECCCCCCCEEEEECCCCEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
VVLRQAGVGPSDIAAIGITNQRETTLVWERATGRAIHRAIVWQDRRTADTCARLEAEGHG
HHHHHCCCCHHHEEEEECCCCCCEEEEEECCCCHHHHHHHHCCCCCCHHHHHHHCCCCCC
ALIRARTGLLIDPYFSATKIAHILEKVPGARARAEKGELAFGTVDSFLLFRLTGGRVHAT
EEEEECCCCEECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEHHHHEEEEEEECCEEEEC
DATNASRTMLFDIHKGAWDDDLLALFGVPRALLPEVRDCAAEFGATDPEMFGAPIPIRGM
CCCCCCCEEEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCC
AGDQQAAMVGQACFQPGMVKSTYGTGCFALLNTGETPVASRHRLITTIAYQIEGRRTYAL
CCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHEEEEEEEEECCCEEEEE
EGSIFVAGAAVQWLRDGLKMISHAAESDRLAAEADEGQDVILVPAFVGLGAPYWRPQVRG
CCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHCCCCCCCHHHHH
ALFGLTRATGPAELARAALEAVCFQTCDLIDAMHADWPGQSGATVLRVDGGMSASDFTMQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHH
RLADLLGAPVDRPAETETTVLGAAYLAGLQCGFFPPPDIFAQGWRLERRFVPAMADEVRA
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
MRLAAWRSAVECLIGRD
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA