BacMap

Definition	Xanthobacter autotrophicus Py2 chromosome, complete genome.
Accession	NC_009720
Length	5,308,934

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The map label for this gene is lvr [H]

Identifier: 154246746

GI number: 154246746

Start: 3127278

End: 3128039

Strand: Direct

Name: lvr [H]

Synonym: Xaut_2807

Alternate gene names: 154246746

Gene position: 3127278-3128039 (Clockwise)

Preceding gene: 154246745

Following gene: 154246747

Centisome position: 58.91

GC content: 70.73

Gene sequence:

>762_bases
ATGAGCAGGATGCGAAGCGTGATCGTGACGGGAGGCGCCTCGGGCATCGGCCTCGCCGCGGTGGAGGCGCTTCTGGCGGA
AGGCTGGCGCGTGGTCGCGGCCGATCGGGACGTGCAGGCCGTGGAGAAGGCGCGGGCGCAGCTTGCCGGCCATGGCGAGC
GCGTGCGCGTCGAGGTGGCCGACATCTCCGACGAGGCGCAGGTGGTGGACCTCGTCACCCGCACCCAGGGGGAGTTCGGC
CCGCTGTGGGGCGTGGTCAATTCCGCCGGCATCGCCCGCGACGTGCCGGCGCTGGACACTTCGGCGGCGCTGTTCCGCGA
GATCCTCGACGTGAACCTCGTCGGCACCTTCCTGATGGCGCGGGAGGCGGCGCGGGTGATGAAGGAGAATGGCGGCGGCG
CCATCGTCAACATCGCCTCGGTCTCGGGCATCCGGGGCAATCTCGGCCGCTCGGCCTATGGCGCCTCCAAGGGCGGCGTG
CTGGTGCTGACGCAGATCCTCGCGGTGGAGTTCGCGCCCTTCAACATCCGCGTGAACGGCATCGCCCCCGGCCCCGTCGA
GACGCCCATGGTGAAGGCCATGCACACGGCGGAAGCCCGCGCCGGCTGGATGAAGACCGTGCCCATGCGCCGCTATGCGG
TGCCCTCCGAGGTGGCCGGCGGCATCGCCTTCCTGCTGGACGAGACCAAGTCCTCCTTCATCACCGGGCAGACCCTGAAC
GTGGACGGCGGCTTCACCGCCGGCGGCCTGATCGGGCTTTAG

Upstream 100 bases:

>100_bases
AGGCCTTGGCCGAACGCGGCCTGCTGGAGATGCCGCCCGCCACCCGCTCGGCCTGAAGCGCGCCGCGGCACCGCAAACCA
AGCCCCACGGGAGAGACGAG

Downstream 100 bases:

>100_bases
GCCTCGAAACCTTGGCGTTACCTCGCGGTGGGACATTGGTAATGCCTGCTGCGCAGGAGCCGTGCGCTGGGTCACGGATC
GGCGCTCCGGCTGTGCCGTC

Product: short-chain dehydrogenase/reductase SDR

Products: D-Gluconate; Nicotinamide adenine dinucleotide phosphate [C]

Alternate protein names: (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MSRMRSVIVTGGASGIGLAAVEALLAEGWRVVAADRDVQAVEKARAQLAGHGERVRVEVADISDEAQVVDLVTRTQGEFG
PLWGVVNSAGIARDVPALDTSAALFREILDVNLVGTFLMAREAARVMKENGGGAIVNIASVSGIRGNLGRSAYGASKGGV
LVLTQILAVEFAPFNIRVNGIAPGPVETPMVKAMHTAEARAGWMKTVPMRRYAVPSEVAGGIAFLLDETKSSFITGQTLN
VDGGFTAGGLIGL

Sequences:

>Translated_253_residues
MSRMRSVIVTGGASGIGLAAVEALLAEGWRVVAADRDVQAVEKARAQLAGHGERVRVEVADISDEAQVVDLVTRTQGEFG
PLWGVVNSAGIARDVPALDTSAALFREILDVNLVGTFLMAREAARVMKENGGGAIVNIASVSGIRGNLGRSAYGASKGGV
LVLTQILAVEFAPFNIRVNGIAPGPVETPMVKAMHTAEARAGWMKTVPMRRYAVPSEVAGGIAFLLDETKSSFITGQTLN
VDGGFTAGGLIGL
>Mature_252_residues
SRMRSVIVTGGASGIGLAAVEALLAEGWRVVAADRDVQAVEKARAQLAGHGERVRVEVADISDEAQVVDLVTRTQGEFGP
LWGVVNSAGIARDVPALDTSAALFREILDVNLVGTFLMAREAARVMKENGGGAIVNIASVSGIRGNLGRSAYGASKGGVL
VLTQILAVEFAPFNIRVNGIAPGPVETPMVKAMHTAEARAGWMKTVPMRRYAVPSEVAGGIAFLLDETKSSFITGQTLNV
DGGFTAGGLIGL

Specific function: Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=237, Percent_Identity=35.0210970464135, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=36.078431372549, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI19923817, Length=250, Percent_Identity=34.8, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI32483357, Length=241, Percent_Identity=33.195020746888, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=34.2857142857143, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI4758504, Length=250, Percent_Identity=34, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI10190704, Length=245, Percent_Identity=32.2448979591837, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI59889578, Length=233, Percent_Identity=33.4763948497854, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI126723750, Length=242, Percent_Identity=31.8181818181818, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI5031737, Length=243, Percent_Identity=31.6872427983539, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI83715985, Length=250, Percent_Identity=31.6, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI109715829, Length=233, Percent_Identity=30.4721030042918, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4503817, Length=188, Percent_Identity=29.2553191489362, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI33667109, Length=201, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI66933014, Length=230, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI31542939, Length=241, Percent_Identity=27.8008298755187, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI126723191, Length=177, Percent_Identity=31.0734463276836, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI7657478, Length=189, Percent_Identity=31.7460317460317, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI20149619, Length=207, Percent_Identity=28.0193236714976, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4504505, Length=185, Percent_Identity=35.1351351351351, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI150247226, Length=190, Percent_Identity=33.1578947368421, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI19743808, Length=212, Percent_Identity=29.7169811320755, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI44680136, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI44680133, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI17738292, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7706318, Length=191, Percent_Identity=28.2722513089005, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790717, Length=241, Percent_Identity=32.3651452282158, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1787335, Length=238, Percent_Identity=32.7731092436975, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=37.0967741935484, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=32.3770491803279, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=33.2, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1788459, Length=240, Percent_Identity=30.8333333333333, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI87082160, Length=242, Percent_Identity=29.7520661157025, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789057, Length=251, Percent_Identity=32.6693227091633, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI1787905, Length=240, Percent_Identity=29.5833333333333, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786812, Length=253, Percent_Identity=31.6205533596838, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=31.4741035856574, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=28.1124497991968, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1786701, Length=233, Percent_Identity=25.7510729613734, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1787820, Length=181, Percent_Identity=27.0718232044199, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787526, Length=255, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=240, Percent_Identity=36.6666666666667, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=35.2459016393443, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17561402, Length=252, Percent_Identity=34.1269841269841, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17562910, Length=255, Percent_Identity=28.6274509803922, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=31.6, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=28.2442748091603, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=29.6, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=32.5301204819277, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17538182, Length=261, Percent_Identity=30.6513409961686, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17560332, Length=263, Percent_Identity=29.6577946768061, Blast_Score=97, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17562990, Length=256, Percent_Identity=26.953125, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562908, Length=255, Percent_Identity=29.8039215686275, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=30.6818181818182, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193204405, Length=253, Percent_Identity=29.2490118577075, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=31.4516129032258, Blast_Score=90, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17562906, Length=258, Percent_Identity=27.906976744186, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=28.4615384615385, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=29.2307692307692, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=258, Percent_Identity=27.906976744186, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=254, Percent_Identity=27.1653543307087, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=26.1538461538462, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=259, Percent_Identity=29.7297297297297, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=254, Percent_Identity=25.9842519685039, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=254, Percent_Identity=25.5905511811024, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17536651, Length=262, Percent_Identity=30.5343511450382, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=257, Percent_Identity=26.4591439688716, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17536025, Length=258, Percent_Identity=26.3565891472868, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=29.1666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=256, Percent_Identity=26.171875, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=196, Percent_Identity=27.0408163265306, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=214, Percent_Identity=25.2336448598131, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=244, Percent_Identity=28.6885245901639, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322861, Length=195, Percent_Identity=30.7692307692308, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6322067, Length=187, Percent_Identity=29.9465240641711, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639444, Length=242, Percent_Identity=35.9504132231405, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=33.739837398374, Blast_Score=110, Evalue=7e-25,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=31.2741312741313, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=31.0756972111554, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=29.9180327868852, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28571526, Length=246, Percent_Identity=32.1138211382114, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=32.3886639676113, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=31.3008130081301, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24644337, Length=170, Percent_Identity=35.2941176470588, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641388, Length=233, Percent_Identity=30.9012875536481, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21356301, Length=190, Percent_Identity=28.4210526315789, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648693, Length=232, Percent_Identity=28.8793103448276, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355889, Length=232, Percent_Identity=28.8793103448276, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116007236, Length=222, Percent_Identity=28.8288288288288, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24663911, Length=193, Percent_Identity=31.6062176165803, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24586328, Length=202, Percent_Identity=26.2376237623762, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581726, Length=165, Percent_Identity=26.0606060606061, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI18859837, Length=195, Percent_Identity=31.2820512820513, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21358495, Length=190, Percent_Identity=25.7894736842105, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.69 [C]

Molecular weight: Translated: 26283; Mature: 26151

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRMRSVIVTGGASGIGLAAVEALLAEGWRVVAADRDVQAVEKARAQLAGHGERVRVEVA
CCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEEE
DISDEAQVVDLVTRTQGEFGPLWGVVNSAGIARDVPALDTSAALFREILDVNLVGTFLMA
CCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
REAARVMKENGGGAIVNIASVSGIRGNLGRSAYGASKGGVLVLTQILAVEFAPFNIRVNG
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCEEEECC
IAPGPVETPMVKAMHTAEARAGWMKTVPMRRYAVPSEVAGGIAFLLDETKSSFITGQTLN
CCCCCCCCHHHHHHHHHHHHCCCHHCCCCHHHCCCHHHHCCEEEEEECCCCCEECCCEEE
VDGGFTAGGLIGL
CCCCCCCCCCCCC
>Mature Secondary Structure 
SRMRSVIVTGGASGIGLAAVEALLAEGWRVVAADRDVQAVEKARAQLAGHGERVRVEVA
CCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEEE
DISDEAQVVDLVTRTQGEFGPLWGVVNSAGIARDVPALDTSAALFREILDVNLVGTFLMA
CCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
REAARVMKENGGGAIVNIASVSGIRGNLGRSAYGASKGGVLVLTQILAVEFAPFNIRVNG
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCEEEECC
IAPGPVETPMVKAMHTAEARAGWMKTVPMRRYAVPSEVAGGIAFLLDETKSSFITGQTLN
CCCCCCCCHHHHHHHHHHHHCCCHHCCCCHHHCCCHHHHCCEEEEEECCCCCEECCCEEE
VDGGFTAGGLIGL
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+; NADH; NADP+; NADPH [C]

Metal ions: Mn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.02 {NADP+}} 20 {D-gluconate}} 0.006 {NADPH}} 0.9 {5-keto-D-gluconate}} [C]

Substrates: 5-Dehydro-D-gluconate; H+; Nicotinamide adenine dinucleotide phosphate - reduced [C]

Specific reaction: 5-Dehydro-D-gluconate + H+ + Nicotinamide adenine dinucleotide phosphate - reduced <==> D-Gluconate + Nicotinamide adenine dinucleotide phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: Cd2+; Cs2+; Cu2+; Divalent metal ions; Hg2+; Ni2+; p-Chloromercuribenzoate; Sn2+; Sulfhydryl reagents [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11388460; 10508066 [H]