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The map label for this gene is envZ [H]

Identifier: 154246500

GI number: 154246500

Start: 2852314

End: 2853696

Strand: Direct

Name: envZ [H]

Synonym: Xaut_2559

Alternate gene names: 154246500

Gene position: 2852314-2853696 (Clockwise)

Preceding gene: 154246499

Following gene: 154246501

Centisome position: 53.73

GC content: 67.97

Gene sequence:

>1383_bases
GTGGCCGAAAGCGGGCCGTCGGGACTGCGCCTGCTCGGCGGCTGGCTGAGGGACGCCAACACGCGCTTTGCCGCCTGGTT
CAACCGGGTGACACCAAAGGGGCTTTATCCGCGCTCGCTGCTGATCATCGTCACCCCCATGGTGATCCTGCAGTCGGTGG
TGGCCTTCGTCTTCATGGAGCGCCACTACAATACCGTCACGCGCCGCCTGTCCGCAGCTGTCAGCCAGGATATCTCGGCG
GTGGTGGCGCTCTACGACCTTTTGCCCAAGGACCGGGACTTCACCGAGCTGCGCCGCGTCGCCTGGCGCAACCTTGCCCT
CAACGTCACCGTGCTGCCGCCGGACCCGCTGCCGCCGCCGGGGCCCAAGCCCTTCTTTTCGGTGCTCGACAGTTCCCTGT
CGCGGGAGATCGGCCGCCGTATCCAGCAGCCGGTGTGGATCGACACGGTGGGGCGCTCCAACCTCATCGAGGTGCGCATC
AAGATGGACGACGCGGTTTTGCGCATCTTCGCCCCGCGCAACGCCGCCTATGCCTCCAACTCGCACATCTTCATCCTGTG
GATGGTGGGGACATCTCTGGTTTTGTTGACGGTGGCCATCCTGTTCCTGCGCAACCAGATCCGCCCCATCGAGAACCTGG
CCGATGCCGCCGAGGCCTTCGGCAAGGGGCGGGACGTGGAGAATTTCCGCCCGCGCGGCGCCCGCGAGGTGCGGCGCGCG
GCCATCGCCTTCCTGGAGATGAAGCGGCGCATCGAGCGGCAGATCGAGCAGCGCACCACCATGCTCGCCGGCGTTTCCCA
CGACATGCGCACCATCCTCACCCGCTTCAAGCTGGAGCTGGCCTTCCTGGGGGAGGGGCCGGAGACCGAGGCGCTGAAGA
AGGACGTGGACGAGCTCCAGGGCATGCTGGAGGCCTATCTCGCCTTCGCCCGCGGCGATCCCGGCGAGCAGGCCGTGCTC
ACCGACATGGCGGCGCTGGTGGAGGACCTGCGCCTCAATGCCGAACGCGACGGCGCCATCGCCGAAGCCAGCTTCATGGG
CCCGCCTCTGGTGGAGGTGAAGGGAGACCAGCTCAAGCGCTGCGTGGGCAATCTCGTGAACAATGCGGTGCGCCACGCCT
CCCGCGTCGCCATCACCGGCACCCGCGACGCCCGCTGGCTGATGGTGAGCGTGGACGACGACGGGCCGGGTATTCCGGAG
GAGAAGCGCGAGGAGGTGTTCCGCCCCTTCCTGCGGCTCGATGATGCGCGCAATCAGGATGACGGCGGCTCGGGCCTCGG
CCTCTCCATCGCCCGCGACATCGCCCGCGCCCATGGCGGGGAGGTGATCCTCGCCGACAGTCCCATGGGCGGGCTGCGGG
CCACTGTGCGCATCCCGGTGTGA

Upstream 100 bases:

>100_bases
TGAACCGCCTGCGCCGCAAGCTGGAGCGGGACCCGGCCAATCCGGTTTTCCTGCAGACGGTGCGTGGCATCGGCTATCGC
CTGGTGGTGACGCCTTGAGC

Downstream 100 bases:

>100_bases
GGCCGGACCGGCCTCTATCGCTTAAGTAATAGGCATGCCTTATTCATGGGCTTGCCATCGCGCCGGGGGTGGTGGTCCTA
TTCCCGGATGGACGAGACGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MAESGPSGLRLLGGWLRDANTRFAAWFNRVTPKGLYPRSLLIIVTPMVILQSVVAFVFMERHYNTVTRRLSAAVSQDISA
VVALYDLLPKDRDFTELRRVAWRNLALNVTVLPPDPLPPPGPKPFFSVLDSSLSREIGRRIQQPVWIDTVGRSNLIEVRI
KMDDAVLRIFAPRNAAYASNSHIFILWMVGTSLVLLTVAILFLRNQIRPIENLADAAEAFGKGRDVENFRPRGAREVRRA
AIAFLEMKRRIERQIEQRTTMLAGVSHDMRTILTRFKLELAFLGEGPETEALKKDVDELQGMLEAYLAFARGDPGEQAVL
TDMAALVEDLRLNAERDGAIAEASFMGPPLVEVKGDQLKRCVGNLVNNAVRHASRVAITGTRDARWLMVSVDDDGPGIPE
EKREEVFRPFLRLDDARNQDDGGSGLGLSIARDIARAHGGEVILADSPMGGLRATVRIPV

Sequences:

>Translated_460_residues
MAESGPSGLRLLGGWLRDANTRFAAWFNRVTPKGLYPRSLLIIVTPMVILQSVVAFVFMERHYNTVTRRLSAAVSQDISA
VVALYDLLPKDRDFTELRRVAWRNLALNVTVLPPDPLPPPGPKPFFSVLDSSLSREIGRRIQQPVWIDTVGRSNLIEVRI
KMDDAVLRIFAPRNAAYASNSHIFILWMVGTSLVLLTVAILFLRNQIRPIENLADAAEAFGKGRDVENFRPRGAREVRRA
AIAFLEMKRRIERQIEQRTTMLAGVSHDMRTILTRFKLELAFLGEGPETEALKKDVDELQGMLEAYLAFARGDPGEQAVL
TDMAALVEDLRLNAERDGAIAEASFMGPPLVEVKGDQLKRCVGNLVNNAVRHASRVAITGTRDARWLMVSVDDDGPGIPE
EKREEVFRPFLRLDDARNQDDGGSGLGLSIARDIARAHGGEVILADSPMGGLRATVRIPV
>Mature_459_residues
AESGPSGLRLLGGWLRDANTRFAAWFNRVTPKGLYPRSLLIIVTPMVILQSVVAFVFMERHYNTVTRRLSAAVSQDISAV
VALYDLLPKDRDFTELRRVAWRNLALNVTVLPPDPLPPPGPKPFFSVLDSSLSREIGRRIQQPVWIDTVGRSNLIEVRIK
MDDAVLRIFAPRNAAYASNSHIFILWMVGTSLVLLTVAILFLRNQIRPIENLADAAEAFGKGRDVENFRPRGAREVRRAA
IAFLEMKRRIERQIEQRTTMLAGVSHDMRTILTRFKLELAFLGEGPETEALKKDVDELQGMLEAYLAFARGDPGEQAVLT
DMAALVEDLRLNAERDGAIAEASFMGPPLVEVKGDQLKRCVGNLVNNAVRHASRVAITGTRDARWLMVSVDDDGPGIPEE
KREEVFRPFLRLDDARNQDDGGSGLGLSIARDIARAHGGEVILADSPMGGLRATVRIPV

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=325, Percent_Identity=33.5384615384615, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=31.1111111111111, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1787894, Length=275, Percent_Identity=29.0909090909091, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=27.536231884058, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082128, Length=283, Percent_Identity=28.2685512367491, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790861, Length=319, Percent_Identity=28.5266457680251, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=26.027397260274, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=290, Percent_Identity=27.2413793103448, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788279, Length=331, Percent_Identity=26.5861027190332, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=294, Percent_Identity=26.8707482993197, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786912, Length=256, Percent_Identity=27.734375, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=252, Percent_Identity=26.5873015873016, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=26.0330578512397, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51086; Mature: 50955

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESGPSGLRLLGGWLRDANTRFAAWFNRVTPKGLYPRSLLIIVTPMVILQSVVAFVFME
CCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RHYNTVTRRLSAAVSQDISAVVALYDLLPKDRDFTELRRVAWRNLALNVTVLPPDPLPPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEEEEECCCCCCCC
GPKPFFSVLDSSLSREIGRRIQQPVWIDTVGRSNLIEVRIKMDDAVLRIFAPRNAAYASN
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCEEEEEECCCCCCCCCC
SHIFILWMVGTSLVLLTVAILFLRNQIRPIENLADAAEAFGKGRDVENFRPRGAREVRRA
CCEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AIAFLEMKRRIERQIEQRTTMLAGVSHDMRTILTRFKLELAFLGEGPETEALKKDVDELQ
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHH
GMLEAYLAFARGDPGEQAVLTDMAALVEDLRLNAERDGAIAEASFMGPPLVEVKGDQLKR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEHHCCCCCCEEECHHHHHH
CVGNLVNNAVRHASRVAITGTRDARWLMVSVDDDGPGIPEEKREEVFRPFLRLDDARNQD
HHHHHHHHHHHHHHHEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCC
DGGSGLGLSIARDIARAHGGEVILADSPMGGLRATVRIPV
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECC
>Mature Secondary Structure 
AESGPSGLRLLGGWLRDANTRFAAWFNRVTPKGLYPRSLLIIVTPMVILQSVVAFVFME
CCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RHYNTVTRRLSAAVSQDISAVVALYDLLPKDRDFTELRRVAWRNLALNVTVLPPDPLPPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEEEEEEECCCCCCCC
GPKPFFSVLDSSLSREIGRRIQQPVWIDTVGRSNLIEVRIKMDDAVLRIFAPRNAAYASN
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECCEEEEEECCCCCCCCCC
SHIFILWMVGTSLVLLTVAILFLRNQIRPIENLADAAEAFGKGRDVENFRPRGAREVRRA
CCEEEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
AIAFLEMKRRIERQIEQRTTMLAGVSHDMRTILTRFKLELAFLGEGPETEALKKDVDELQ
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHH
GMLEAYLAFARGDPGEQAVLTDMAALVEDLRLNAERDGAIAEASFMGPPLVEVKGDQLKR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEHHCCCCCCEEECHHHHHH
CVGNLVNNAVRHASRVAITGTRDARWLMVSVDDDGPGIPEEKREEVFRPFLRLDDARNQD
HHHHHHHHHHHHHHHEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCC
DGGSGLGLSIARDIARAHGGEVILADSPMGGLRATVRIPV
CCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]