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The map label for this gene is proC [H]

Identifier: 154246479

GI number: 154246479

Start: 2834833

End: 2835669

Strand: Direct

Name: proC [H]

Synonym: Xaut_2538

Alternate gene names: 154246479

Gene position: 2834833-2835669 (Clockwise)

Preceding gene: 154246478

Following gene: 154246480

Centisome position: 53.4

GC content: 73.12

Gene sequence:

>837_bases
ATGAGCGAGAGCGTGCTGAAATCCCTGTCCGGTCCCGTGGTGCTGCTGGGCGCCGGAAAGATGGGCGGGGCCATGCTGGA
GGGCTGGCTGAAGCTGGGCCTGCCCGCCGGCAAGGCCGTGGTGCTCGATCCGAACCTGCCGGCGGATGCCGCCGCCGCCC
TGGCCGCGCGGGGCGTCGCCGTCAATCCTGCTCTCGCCGACATTCCGGCGCCGTCCGTGCTGCTGCTGGCGGTGAAGCCG
CAGGTGGCGCCCGATGCGCTGCCGCCGCTGGCGCCGCTGGTGGGGGCGGGGACGCTGGTGGTCTCCATCATGGCCGGGCG
CACGCTGGCCTTCATGTCCGCCATCTTCGGTGCGGGGGCGGCCATCGTCCGCTCCATTCCCAACACCCCGGCCGCCATCG
GGCGAGGGGTGAGCGTCTGCGTGCCCGGGGCGAACGTGTCCGCCGCCCAGCGCGACCTTGCCAGCGCCCTGCTCGGCGCC
ATCGGCATCGTGGAATGGATCGACGACGAGGCGCTTATGGATGCCGCCACCGCCGTTTCCGGCTCCGGTCCCGCCTATGC
GTTCCTGCTGGCGGAGGTGATGGCGCAGGCGGGTGCCGCCGCCGGCCTGCCGCCGGAGCTGGCCGCCCGCATCGCCCGCG
CCACCGTGGCCGGGGCCGGTGCGCTCATGGACCAATCGGACCTTCCCGCCGCCACCCTGCGCCAGAACGTCACCTCGCCG
GGCGGCACCACCGCGGCGGCCCTTGGGGTTCTGATGAACGAGACCGCCGGTTTCGGCCCGCTGATGGTGGAAGCGGTTGC
CGCCGCCACCAGAAGGGGCAAAGAATTGGCGGGCTAG

Upstream 100 bases:

>100_bases
TGAGGCCGGCGCGGTTCACGCCTGCGGGGTCCCGGCGTTATAAGGCTGTCCGGTATCAAGGCGCGTTTGCCATGCGGCGC
GCCGGTCCAACGAGGCGGAA

Downstream 100 bases:

>100_bases
AGCACGCGCCAAGCAGATTGCGAAGCAAGCGGATTGGATGACGTATTCTTCTTCTTAAGGTCCAAGGCGCGCCGTTCCCC
ATTGCGAGGAAAAGACATGA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MSESVLKSLSGPVVLLGAGKMGGAMLEGWLKLGLPAGKAVVLDPNLPADAAAALAARGVAVNPALADIPAPSVLLLAVKP
QVAPDALPPLAPLVGAGTLVVSIMAGRTLAFMSAIFGAGAAIVRSIPNTPAAIGRGVSVCVPGANVSAAQRDLASALLGA
IGIVEWIDDEALMDAATAVSGSGPAYAFLLAEVMAQAGAAAGLPPELAARIARATVAGAGALMDQSDLPAATLRQNVTSP
GGTTAAALGVLMNETAGFGPLMVEAVAAATRRGKELAG

Sequences:

>Translated_278_residues
MSESVLKSLSGPVVLLGAGKMGGAMLEGWLKLGLPAGKAVVLDPNLPADAAAALAARGVAVNPALADIPAPSVLLLAVKP
QVAPDALPPLAPLVGAGTLVVSIMAGRTLAFMSAIFGAGAAIVRSIPNTPAAIGRGVSVCVPGANVSAAQRDLASALLGA
IGIVEWIDDEALMDAATAVSGSGPAYAFLLAEVMAQAGAAAGLPPELAARIARATVAGAGALMDQSDLPAATLRQNVTSP
GGTTAAALGVLMNETAGFGPLMVEAVAAATRRGKELAG
>Mature_277_residues
SESVLKSLSGPVVLLGAGKMGGAMLEGWLKLGLPAGKAVVLDPNLPADAAAALAARGVAVNPALADIPAPSVLLLAVKPQ
VAPDALPPLAPLVGAGTLVVSIMAGRTLAFMSAIFGAGAAIVRSIPNTPAAIGRGVSVCVPGANVSAAQRDLASALLGAI
GIVEWIDDEALMDAATAVSGSGPAYAFLLAEVMAQAGAAAGLPPELAARIARATVAGAGALMDQSDLPAATLRQNVTSPG
GTTAAALGVLMNETAGFGPLMVEAVAAATRRGKELAG

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=267, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI24797095, Length=267, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI21361454, Length=267, Percent_Identity=32.5842696629214, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI198041662, Length=267, Percent_Identity=31.8352059925094, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1786585, Length=266, Percent_Identity=30.8270676691729, Blast_Score=98, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17569021, Length=262, Percent_Identity=29.7709923664122, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17540664, Length=287, Percent_Identity=28.9198606271777, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320861, Length=210, Percent_Identity=31.9047619047619, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21358587, Length=271, Percent_Identity=35.4243542435424, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI24647700, Length=173, Percent_Identity=39.3063583815029, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24648116, Length=284, Percent_Identity=27.112676056338, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27029; Mature: 26898

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVLKSLSGPVVLLGAGKMGGAMLEGWLKLGLPAGKAVVLDPNLPADAAAALAARGVA
CCHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCC
VNPALADIPAPSVLLLAVKPQVAPDALPPLAPLVGAGTLVVSIMAGRTLAFMSAIFGAGA
CCCCHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCHH
AIVRSIPNTPAAIGRGVSVCVPGANVSAAQRDLASALLGAIGIVEWIDDEALMDAATAVS
HHHHHCCCCHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
GSGPAYAFLLAEVMAQAGAAAGLPPELAARIARATVAGAGALMDQSDLPAATLRQNVTSP
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHHHCCCC
GGTTAAALGVLMNETAGFGPLMVEAVAAATRRGKELAG
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SESVLKSLSGPVVLLGAGKMGGAMLEGWLKLGLPAGKAVVLDPNLPADAAAALAARGVA
CHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHCCCC
VNPALADIPAPSVLLLAVKPQVAPDALPPLAPLVGAGTLVVSIMAGRTLAFMSAIFGAGA
CCCCHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHCHH
AIVRSIPNTPAAIGRGVSVCVPGANVSAAQRDLASALLGAIGIVEWIDDEALMDAATAVS
HHHHHCCCCHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
GSGPAYAFLLAEVMAQAGAAAGLPPELAARIARATVAGAGALMDQSDLPAATLRQNVTSP
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCHHHHHHHCCCC
GGTTAAALGVLMNETAGFGPLMVEAVAAATRRGKELAG
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]