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The map label for this gene is ilvD [H]

Identifier: 154245941

GI number: 154245941

Start: 2253948

End: 2255762

Strand: Reverse

Name: ilvD [H]

Synonym: Xaut_1998

Alternate gene names: 154245941

Gene position: 2255762-2253948 (Counterclockwise)

Preceding gene: 154245942

Following gene: 154245940

Centisome position: 42.49

GC content: 67.11

Gene sequence:

>1815_bases
ATGTCCGGTCAAGGCGACCAGCCCGAGAAGCACGGCCTCAAGCTCAGGTCCCAGCTCTGGTTCGACAATCCCGACAATCC
CGGCATGACGGCGCTGTACCTGGAGCGCTACCTCAATTTCGGCCTCACCCGGGAAGAGCTGCAGTCGGGCAAGCCCATCA
TCGGCATCGCCCAGACCGGCTCGGACCTCTCGCCCTGCAACCGCCATCACCTCGACCTTGCCAAAAGGGTCCGCGACGGT
ATCGAGGCCATGGGCGGCGTGCCGTTCGAGTTCCCGGTCCATCCCATCCAGGAGACCGGCAAACGCCCCACCGCCGCCCT
TGACCGCAACCTCGCCTATCTCGGGCTGGTGGAGATCCTCTACGGCTATCCGCTCGACGGCGTGGTGCTGACCACCGGCT
GCGATAAGACCACGCCGGCCTGCATCATGGCGGCGGCGACCGTGAACATCCCGGCCATCGTCCTGTCCGGCGGCCCCATG
CTGAACGGCTGGTGGAAGGGCGAGCGCACCGGCTCCGGCACCGTGGTGTGGAAGAACCGCGAGCGCTTCGCCGCCGGCGA
GATCGATTATAACGAGTTCATGGACGTGGTGGCGTCGTCCGCCCCCTCGGTGGGCCATTGCAACACCATGGGCACCGCCT
CCACCATGAACGCGCTGGCCGAGGCGCTGGGCATGTCCCTACCCGGCTGCGCCGCCATCCCCGCCCCCTACCGCGAGCGC
GGCCAGATCGCCTACGACACCGGCAAACGCATCGTCGACATGGTGTGGGAGGACCTCAAACCCTCCGATATCCTTACCCG
CGAGGCGTTCGAGAACGCCATCCGCGTCAATTCCGCCATCGGCGGCTCCACCAATGCCCCTATCCACCTCAATGCCATCG
CCCGCCACGTGGGCGTGCCGCTGAACGTGGATGACTGGCAGGCCGTGGGCCACAAGATCCCGCTTCTGGTGAACCTCCAG
CCCGCCGGCGAATATCTGGGCGAGGAGTTCCACCGCGCCGGCGGCGTGCCGGCGGTGGTGGCCGAGCTGATCGAGAAGGG
CAAGATCCACGAGGGCGCGCTCACCGTGAACGGGCGCTCCATCGGCGAGAACTGCAAGGGCAAGCTCTCCTGGGACCGCG
AGGTCATCAAGACCTACGACGCGCCCCTGAAGGAGGATGCCGGCTTCATCGTGCTGCACGGCAACCTGTTCAACAATGCG
GTGATGAAGACCTCGGTGATCTCGCCGGAGTTCCGCGACCGCTTCCTCTCCAACCCGAACGATCCGGAGGCCTTCGAGGG
CCGCGCCGTGGTGTTCGAGGGGCCGGAGGACTACCACCACCGCATCGACGACCCGTCGCTCGGCATCGACGAATATACCC
TGCTGTTCATTCGTGGCACCGGCCCGCTGGGCTATCCCGGTGGTGCCGAGGTGGTGAACATGCAGCCGCCCACCGCCCTC
ATCAAGAAGGGCATCCACGCCCTGCCCTGCATCGGCGACGGCCGCCAGTCCGGCACCTCCGGCTCACCCTCCATCCTGAA
TGCCTCGCCGGAAGCGGCGGCCGGCGGCGGCCTCGCTTTGCTGAAGACCGGCGACCGGGTACGGATCGACCTCAACACCT
GCACCGCCGATATCCTCATCTCCCCCGAGGAGCTGGCGCAGCGCCGCGCCGACCTGCAGGGCCATGGCGGCTTCCCCATG
CCGCAGAGCCAGACCCCCTGGCAGGAGATCCAGCGCTCCATGGTGGCGCAGTTCGACGAGGGCATGGTGCTGAAGCCGGC
GGTGAAGTACCAGCGGGTGGCCCAGACCATGGGCGTTCCCCGCGACAACCACTGA

Upstream 100 bases:

>100_bases
TTGATTTCCGGCGCGCCGAGGCGCATATATCGCCAAAATCAAATCGATTAGAACCGGCGCGTCGGAACGTCGGAGCACGC
AGATTCCCATGGAGACGCCC

Downstream 100 bases:

>100_bases
GCGAGCAGACCCATGAGCGAACAGGCGGCGCCGGGCATCCGTTCCGGCGCGGTCCCCGGCGGGGTGCCCGGCACGATCCA
TGATGCGGTGCCTCTGGGCG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MSGQGDQPEKHGLKLRSQLWFDNPDNPGMTALYLERYLNFGLTREELQSGKPIIGIAQTGSDLSPCNRHHLDLAKRVRDG
IEAMGGVPFEFPVHPIQETGKRPTAALDRNLAYLGLVEILYGYPLDGVVLTTGCDKTTPACIMAAATVNIPAIVLSGGPM
LNGWWKGERTGSGTVVWKNRERFAAGEIDYNEFMDVVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPYRER
GQIAYDTGKRIVDMVWEDLKPSDILTREAFENAIRVNSAIGGSTNAPIHLNAIARHVGVPLNVDDWQAVGHKIPLLVNLQ
PAGEYLGEEFHRAGGVPAVVAELIEKGKIHEGALTVNGRSIGENCKGKLSWDREVIKTYDAPLKEDAGFIVLHGNLFNNA
VMKTSVISPEFRDRFLSNPNDPEAFEGRAVVFEGPEDYHHRIDDPSLGIDEYTLLFIRGTGPLGYPGGAEVVNMQPPTAL
IKKGIHALPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRIDLNTCTADILISPEELAQRRADLQGHGGFPM
PQSQTPWQEIQRSMVAQFDEGMVLKPAVKYQRVAQTMGVPRDNH

Sequences:

>Translated_604_residues
MSGQGDQPEKHGLKLRSQLWFDNPDNPGMTALYLERYLNFGLTREELQSGKPIIGIAQTGSDLSPCNRHHLDLAKRVRDG
IEAMGGVPFEFPVHPIQETGKRPTAALDRNLAYLGLVEILYGYPLDGVVLTTGCDKTTPACIMAAATVNIPAIVLSGGPM
LNGWWKGERTGSGTVVWKNRERFAAGEIDYNEFMDVVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPYRER
GQIAYDTGKRIVDMVWEDLKPSDILTREAFENAIRVNSAIGGSTNAPIHLNAIARHVGVPLNVDDWQAVGHKIPLLVNLQ
PAGEYLGEEFHRAGGVPAVVAELIEKGKIHEGALTVNGRSIGENCKGKLSWDREVIKTYDAPLKEDAGFIVLHGNLFNNA
VMKTSVISPEFRDRFLSNPNDPEAFEGRAVVFEGPEDYHHRIDDPSLGIDEYTLLFIRGTGPLGYPGGAEVVNMQPPTAL
IKKGIHALPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRIDLNTCTADILISPEELAQRRADLQGHGGFPM
PQSQTPWQEIQRSMVAQFDEGMVLKPAVKYQRVAQTMGVPRDNH
>Mature_603_residues
SGQGDQPEKHGLKLRSQLWFDNPDNPGMTALYLERYLNFGLTREELQSGKPIIGIAQTGSDLSPCNRHHLDLAKRVRDGI
EAMGGVPFEFPVHPIQETGKRPTAALDRNLAYLGLVEILYGYPLDGVVLTTGCDKTTPACIMAAATVNIPAIVLSGGPML
NGWWKGERTGSGTVVWKNRERFAAGEIDYNEFMDVVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPYRERG
QIAYDTGKRIVDMVWEDLKPSDILTREAFENAIRVNSAIGGSTNAPIHLNAIARHVGVPLNVDDWQAVGHKIPLLVNLQP
AGEYLGEEFHRAGGVPAVVAELIEKGKIHEGALTVNGRSIGENCKGKLSWDREVIKTYDAPLKEDAGFIVLHGNLFNNAV
MKTSVISPEFRDRFLSNPNDPEAFEGRAVVFEGPEDYHHRIDDPSLGIDEYTLLFIRGTGPLGYPGGAEVVNMQPPTALI
KKGIHALPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRIDLNTCTADILISPEELAQRRADLQGHGGFPMP
QSQTPWQEIQRSMVAQFDEGMVLKPAVKYQRVAQTMGVPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=555, Percent_Identity=30.6306306306306, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1788157, Length=443, Percent_Identity=30.4740406320542, Blast_Score=178, Evalue=1e-45,
Organism=Escherichia coli, GI2367371, Length=450, Percent_Identity=29.5555555555556, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1786464, Length=534, Percent_Identity=28.0898876404494, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322476, Length=528, Percent_Identity=31.0606060606061, Blast_Score=224, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65227; Mature: 65096

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQGDQPEKHGLKLRSQLWFDNPDNPGMTALYLERYLNFGLTREELQSGKPIIGIAQTG
CCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCC
SDLSPCNRHHLDLAKRVRDGIEAMGGVPFEFPVHPIQETGKRPTAALDRNLAYLGLVEIL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHCCHHHHHHHHHH
YGYPLDGVVLTTGCDKTTPACIMAAATVNIPAIVLSGGPMLNGWWKGERTGSGTVVWKNR
HCCCCCCEEEECCCCCCCCHHEEEEHHCCCCEEEEECCCEECCEECCCCCCCCEEEEECC
ERFAAGEIDYNEFMDVVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPYRER
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHC
GQIAYDTGKRIVDMVWEDLKPSDILTREAFENAIRVNSAIGGSTNAPIHLNAIARHVGVP
CCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCC
LNVDDWQAVGHKIPLLVNLQPAGEYLGEEFHRAGGVPAVVAELIEKGKIHEGALTVNGRS
CCCCHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCC
IGENCKGKLSWDREVIKTYDAPLKEDAGFIVLHGNLFNNAVMKTSVISPEFRDRFLSNPN
CCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEECCHHCCHHHHHHCCCHHHHHHHCCCCC
DPEAFEGRAVVFEGPEDYHHRIDDPSLGIDEYTLLFIRGTGPLGYPGGAEVVNMQPPTAL
CCCCCCCCEEEEECCHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCHHH
IKKGIHALPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRIDLNTCTADILI
HHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCEEEEEEEECEEEEEE
SPEELAQRRADLQGHGGFPMPQSQTPWQEIQRSMVAQFDEGMVLKPAVKYQRVAQTMGVP
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCC
RDNH
CCCC
>Mature Secondary Structure 
SGQGDQPEKHGLKLRSQLWFDNPDNPGMTALYLERYLNFGLTREELQSGKPIIGIAQTG
CCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCC
SDLSPCNRHHLDLAKRVRDGIEAMGGVPFEFPVHPIQETGKRPTAALDRNLAYLGLVEIL
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHCCHHHHHHHHHH
YGYPLDGVVLTTGCDKTTPACIMAAATVNIPAIVLSGGPMLNGWWKGERTGSGTVVWKNR
HCCCCCCEEEECCCCCCCCHHEEEEHHCCCCEEEEECCCEECCEECCCCCCCCEEEEECC
ERFAAGEIDYNEFMDVVASSAPSVGHCNTMGTASTMNALAEALGMSLPGCAAIPAPYRER
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHC
GQIAYDTGKRIVDMVWEDLKPSDILTREAFENAIRVNSAIGGSTNAPIHLNAIARHVGVP
CCEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHCCC
LNVDDWQAVGHKIPLLVNLQPAGEYLGEEFHRAGGVPAVVAELIEKGKIHEGALTVNGRS
CCCCHHHHCCCCCCEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCCC
IGENCKGKLSWDREVIKTYDAPLKEDAGFIVLHGNLFNNAVMKTSVISPEFRDRFLSNPN
CCCCCCCCCCCCHHHHHHCCCCCCCCCCEEEEECCHHCCHHHHHHCCCHHHHHHHCCCCC
DPEAFEGRAVVFEGPEDYHHRIDDPSLGIDEYTLLFIRGTGPLGYPGGAEVVNMQPPTAL
CCCCCCCCEEEEECCHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEECCCCHHH
IKKGIHALPCIGDGRQSGTSGSPSILNASPEAAAGGGLALLKTGDRVRIDLNTCTADILI
HHCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCEEEEECCCEEEEEEEECEEEEEE
SPEELAQRRADLQGHGGFPMPQSQTPWQEIQRSMVAQFDEGMVLKPAVKYQRVAQTMGVP
CHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHCCC
RDNH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]