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The map label for this gene is algC [H]

Identifier: 154245873

GI number: 154245873

Start: 2182460

End: 2183959

Strand: Reverse

Name: algC [H]

Synonym: Xaut_1929

Alternate gene names: 154245873

Gene position: 2183959-2182460 (Counterclockwise)

Preceding gene: 154245874

Following gene: 154245872

Centisome position: 41.14

GC content: 65.53

Gene sequence:

>1500_bases
ATGTTCCCCACACCCAAGCCGGTCTTGACCCCCAACACCTATGCCTACGAGTCCGAGCCCATGGTGAAGCCGACCGGCTT
CCGGGAATATGACGCGCGCTGGTTGTTCCAGAAGGAAATCAACCTGATGGGCGTGCAGGCGCTGGGCATGGGCCTCGGCA
CCCTGATGCACGAGATGGGCGTGAAGCCGGAGATCGTGACCGGCCACGACTTCCGCAGCTATTCCTCGTCCATCAAGCTG
GCGCTGGCCTCCGGCCTCATGGCGGCCGGCATCAAGGTGCACGACATCGGCCTCGCCATGTCGCCCATGGCCTATTTCGC
CCAGTTCGCCCTGGACGTGCCGGCGGTGGCCATGGTGACCGCCTCCCACAACGACAACGGCTGGACCGGCGTGAAGATGG
GCGTCAACCGCCCCCTCACCTTCGGCCCCGACGAGATGACGAAGCTCAAGGAGATCGTCCTCGGCGCCAAGTTCAACCTG
AAGGGCGGCGGCTCCTACGTGTTCGTGGAGAACTTCCCGGACGTCTACATCAAGGACCTCACCGACCGTCCCAAGCTGAA
GAACCCCATCAAGGCGGTGGTGGCCTGCGGCAACGGCACGGCGGGCGCGTTCGCGCCGAAGATCCTCGAGGCGCTGGGCG
TCGAGGTGATCCCGCTCGACACCGAGCTCGACCACACCTTCCCCAAGTACAACCCGAACCCCGAGGACATGGAGATGCTC
CATGCCATGCGGGACGCGGTGCTGGAGCACAAGGCGGACGTGGCGCTGGGCTTCGACGGCGACGGCGACCGCTGCGGCGT
GGTGGACAATACCGGCGAGGAGATCTTCGCCGACAAGGTGGGCGTGCTGCTCGCCCGCGACCTCGCCAAGATCTATCCCG
AGCCCACCTTCGTGGTGGACGTGAAGTCCACCGGCCTGTTCGCCACCGACCCCGAGCTGATCAAGCTCGGCGTGAAGGCG
GACTACTGGAAGACCGGCCACTCCTACATGAAGCGCCGGGTGAACGAGACCGGCGCCCTCGTCGGCTTCGAGAAGAGCGG
CCATTATTTCTTCAACAAGCCCATCGGCCGCGGCTATGACGATGGCCTCATCTCCGCCATCGCCGTGCTCGACATGCTGG
ACCGCAACCCCGGCAGGAAGCTCTCCGACCTGCGCGAGGCGCTGCCCAAGACGTGGTCCTCGCCCACCATGTCGCCCCAC
TGCACCGACGAGGCCAAGTACGGCATCGTCGCCAAGGTGGTGGAGCACTACGAGAAGCTCGCCAAGGACGGCGCCCTCGT
CACCGGCCAGAAGATCCGCGACCTCGTGACGGTGAACGGCGTGCGCGTCACCTGCGAGGACGGCTCCTGGGGCCTGGTGC
GCGCCTCCTCCAACAAGCCCGAGCTGGTGGTGGTGGTGGAGAGCCCGGTCTCCAACGCCCGCATGCGCGAGATGTTCAAG
GAAATCGACGGCGTGCTGCGCACCTTCCCGGAAGTGGGCGAGTACAACCAGACCATCTGA

Upstream 100 bases:

>100_bases
TTGCCGTCTCGGGAGCTATTCTCAAGCTTCCAGCGTTCGTTCAGTCACGAAACCGTGCTATCTCGCAGCTGCGAAATTCA
GGCCCGCAGGAGCTCTCTGC

Downstream 100 bases:

>100_bases
GCGCCAGGGCCCGCCGCCTCTTTTTCGGCGCGCGGGTGCTCTAGCTTTGCAAGTCTGCGACCCTCCGCCGTCGTCCGGCG
GAGGGTTTCTCGTTTTCAGG

Product: phosphoglucomutase/phosphomannomutase subunit alpha/beta

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MFPTPKPVLTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMGVKPEIVTGHDFRSYSSSIKL
ALASGLMAAGIKVHDIGLAMSPMAYFAQFALDVPAVAMVTASHNDNGWTGVKMGVNRPLTFGPDEMTKLKEIVLGAKFNL
KGGGSYVFVENFPDVYIKDLTDRPKLKNPIKAVVACGNGTAGAFAPKILEALGVEVIPLDTELDHTFPKYNPNPEDMEML
HAMRDAVLEHKADVALGFDGDGDRCGVVDNTGEEIFADKVGVLLARDLAKIYPEPTFVVDVKSTGLFATDPELIKLGVKA
DYWKTGHSYMKRRVNETGALVGFEKSGHYFFNKPIGRGYDDGLISAIAVLDMLDRNPGRKLSDLREALPKTWSSPTMSPH
CTDEAKYGIVAKVVEHYEKLAKDGALVTGQKIRDLVTVNGVRVTCEDGSWGLVRASSNKPELVVVVESPVSNARMREMFK
EIDGVLRTFPEVGEYNQTI

Sequences:

>Translated_499_residues
MFPTPKPVLTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMGVKPEIVTGHDFRSYSSSIKL
ALASGLMAAGIKVHDIGLAMSPMAYFAQFALDVPAVAMVTASHNDNGWTGVKMGVNRPLTFGPDEMTKLKEIVLGAKFNL
KGGGSYVFVENFPDVYIKDLTDRPKLKNPIKAVVACGNGTAGAFAPKILEALGVEVIPLDTELDHTFPKYNPNPEDMEML
HAMRDAVLEHKADVALGFDGDGDRCGVVDNTGEEIFADKVGVLLARDLAKIYPEPTFVVDVKSTGLFATDPELIKLGVKA
DYWKTGHSYMKRRVNETGALVGFEKSGHYFFNKPIGRGYDDGLISAIAVLDMLDRNPGRKLSDLREALPKTWSSPTMSPH
CTDEAKYGIVAKVVEHYEKLAKDGALVTGQKIRDLVTVNGVRVTCEDGSWGLVRASSNKPELVVVVESPVSNARMREMFK
EIDGVLRTFPEVGEYNQTI
>Mature_499_residues
MFPTPKPVLTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMGVKPEIVTGHDFRSYSSSIKL
ALASGLMAAGIKVHDIGLAMSPMAYFAQFALDVPAVAMVTASHNDNGWTGVKMGVNRPLTFGPDEMTKLKEIVLGAKFNL
KGGGSYVFVENFPDVYIKDLTDRPKLKNPIKAVVACGNGTAGAFAPKILEALGVEVIPLDTELDHTFPKYNPNPEDMEML
HAMRDAVLEHKADVALGFDGDGDRCGVVDNTGEEIFADKVGVLLARDLAKIYPEPTFVVDVKSTGLFATDPELIKLGVKA
DYWKTGHSYMKRRVNETGALVGFEKSGHYFFNKPIGRGYDDGLISAIAVLDMLDRNPGRKLSDLREALPKTWSSPTMSPH
CTDEAKYGIVAKVVEHYEKLAKDGALVTGQKIRDLVTVNGVRVTCEDGSWGLVRASSNKPELVVVVESPVSNARMREMFK
EIDGVLRTFPEVGEYNQTI

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=483, Percent_Identity=30.2277432712215, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1789566, Length=189, Percent_Identity=29.6296296296296, Blast_Score=79, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 54688; Mature: 54688

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPTPKPVLTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCHHEEEEHHCCHHHHHHHHHHHHHHHHHHC
VKPEIVTGHDFRSYSSSIKLALASGLMAAGIKVHDIGLAMSPMAYFAQFALDVPAVAMVT
CCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ASHNDNGWTGVKMGVNRPLTFGPDEMTKLKEIVLGAKFNLKGGGSYVFVENFPDVYIKDL
ECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCEEEEECCCCEEEECC
TDRPKLKNPIKAVVACGNGTAGAFAPKILEALGVEVIPLDTELDHTFPKYNPNPEDMEML
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHH
HAMRDAVLEHKADVALGFDGDGDRCGVVDNTGEEIFADKVGVLLARDLAKIYPEPTFVVD
HHHHHHHHHCCCCEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VKSTGLFATDPELIKLGVKADYWKTGHSYMKRRVNETGALVGFEKSGHYFFNKPIGRGYD
ECCCCCEECCHHHEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCC
DGLISAIAVLDMLDRNPGRKLSDLREALPKTWSSPTMSPHCTDEAKYGIVAKVVEHYEKL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AKDGALVTGQKIRDLVTVNGVRVTCEDGSWGLVRASSNKPELVVVVESPVSNARMREMFK
HHCCCEEECHHHHHHEEECCEEEEEECCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHH
EIDGVLRTFPEVGEYNQTI
HHHHHHHHCHHHCCCCCCC
>Mature Secondary Structure
MFPTPKPVLTPNTYAYESEPMVKPTGFREYDARWLFQKEINLMGVQALGMGLGTLMHEMG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCHHEEEEHHCCHHHHHHHHHHHHHHHHHHC
VKPEIVTGHDFRSYSSSIKLALASGLMAAGIKVHDIGLAMSPMAYFAQFALDVPAVAMVT
CCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEE
ASHNDNGWTGVKMGVNRPLTFGPDEMTKLKEIVLGAKFNLKGGGSYVFVENFPDVYIKDL
ECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEECCCCCEEEEECCCCEEEECC
TDRPKLKNPIKAVVACGNGTAGAFAPKILEALGVEVIPLDTELDHTFPKYNPNPEDMEML
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHH
HAMRDAVLEHKADVALGFDGDGDRCGVVDNTGEEIFADKVGVLLARDLAKIYPEPTFVVD
HHHHHHHHHCCCCEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
VKSTGLFATDPELIKLGVKADYWKTGHSYMKRRVNETGALVGFEKSGHYFFNKPIGRGYD
ECCCCCEECCHHHEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCCCCCC
DGLISAIAVLDMLDRNPGRKLSDLREALPKTWSSPTMSPHCTDEAKYGIVAKVVEHYEKL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AKDGALVTGQKIRDLVTVNGVRVTCEDGSWGLVRASSNKPELVVVVESPVSNARMREMFK
HHCCCEEECHHHHHHEEECCEEEEEECCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHH
EIDGVLRTFPEVGEYNQTI
HHHHHHHHCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]