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The map label for this gene is hemN [H]

Identifier: 154245691

GI number: 154245691

Start: 1966829

End: 1968232

Strand: Reverse

Name: hemN [H]

Synonym: Xaut_1747

Alternate gene names: 154245691

Gene position: 1968232-1966829 (Counterclockwise)

Preceding gene: 154245692

Following gene: 154245689

Centisome position: 37.07

GC content: 70.66

Gene sequence:

>1404_bases
ATGACCCAAGCTTCCTCCTGCCCCGCCCCCAAGCTTGATGCCGCAACCCTCCTTGCCCGCTACGGGCAGCCGGTGCCGCG
CTATACGAGCTACCCCACCGCCCCCCATTTCTCCCCCGCCGTCGATGCCGCGACCTATGCCTCGTGGCTCGCTGCCGTGC
CGGGGGATGCACGCGTGTCGGCCTATGTGCATGTGCCGTTCTGCGCCGAGCTGTGCCTCTATTGCGGCTGCCAGACCGCG
GTGGCCCGCAGCCGCGCGCCGGTGAAGGCTTATGCGGAGCGCCTGGTGGAGGAGATCGGCCTTGTGGCCCGTCACCTGCC
GGGCCGATTGAAGCTGTCGCACCTGCATTTCGGCGGCGGCACGCCCACCATGCTCGCGGATGAGGACTTCGCCGCCATTC
TGGGCGCGTTGCGCGAGACCTTCGATTTCGCCCCGGACGCCGAGATCGCTATCGAGATCGACCCCCGCGTGATGGATGCG
GACAAGGTGGCGACGCTGGCCCGCGAGGGCTTCAACCGCGCCAGCCTCGGCGTGCAGGATTTCGATCCCGCCGTGCAGCA
GGCCATCGGCCGCCACCAGTCGTGCGAGGAGACGCAGGCGGTGGCGGATGCCCTGCGCGCCGCCGGCATCGCCGCCCTCA
ACCTCGACCTCATGTACGGCCTGCCCCATCAGGACGAAGCTTCCGTCCGCCGCACGGTGGAGGCGGCTCTCGGCCTCGAC
CCGGATCGGATCGCCGTGTTCGGCTATGCCCATGTGCCGTGGATGAAGAAGCATCAGGCCCTGATCCCGGAAGACGCGTT
GCCCGGCGCCGGTGCGCGCCTGGCGCAGGCGGAACTGGTGGCGGACGTGCTCGCCGCCCATGGCTACGTGCCGGTGGGGC
TCGACCATTTCGCCCGCGCCTCGGACGCCATGGCGGAACGGGCGGCGGCAGGGACGCTGAAGCGCAATTTTCAGGGCTAC
ACCACCGATGACGCCCCGGTGCTGATCGGCTTCGGCGCGTCCGCCATCGGCGCGCTGCCGCAGGGCTATGTGCAGAACCT
GCCCGCCACGCCCCAGTGGCACAAGGCGGTGGAGGCCGGCGCCCTTCCCATCGCGCGCGGCATCGCGCTGACCGACGAGG
ACCGGCTGCGCCGCCACGTCATCGAGCGGCTGATGTGCGACCTCGCGGTGGATCTGGATGAGGCCTGCATGCAGCACGGC
TTCCCGCGCGGCTTCTTCGCCGACGAGATTCACGCCCTGGAGCCGCTGATCGCCGACGGTCTCGCATGGCGCCACGGCGC
GGTGGTGGAGGTGCCGGAGGCGAGCCGCCCCTTCACCCGAGTGGTCTGCGCCGTGTTCGACACGCGCCTCATGGCAAGCC
GGGCCGCGGCCCCGGAGCAGAAGCGCCACGCCGCGGCGGTCTGA

Upstream 100 bases:

>100_bases
AGCGGGTGCGACAAAGGGGCATTCAAGGGGGTGGCCGCAGCGCCCGCCCCCTTGCGCCACATCAAGGCGCCGCAAGGGCC
GGCGCCGCAAGGTCGCGGCC

Downstream 100 bases:

>100_bases
CGGCGTCGCCATGAGCGAGCCGCGTGGCGGCTCGCCTTACTTCACCCCAAAAAAGAAAAGGCACGCGCCCGGAAGCGCGT
GCCGAAGGAGGTATGCCGCA

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MTQASSCPAPKLDAATLLARYGQPVPRYTSYPTAPHFSPAVDAATYASWLAAVPGDARVSAYVHVPFCAELCLYCGCQTA
VARSRAPVKAYAERLVEEIGLVARHLPGRLKLSHLHFGGGTPTMLADEDFAAILGALRETFDFAPDAEIAIEIDPRVMDA
DKVATLAREGFNRASLGVQDFDPAVQQAIGRHQSCEETQAVADALRAAGIAALNLDLMYGLPHQDEASVRRTVEAALGLD
PDRIAVFGYAHVPWMKKHQALIPEDALPGAGARLAQAELVADVLAAHGYVPVGLDHFARASDAMAERAAAGTLKRNFQGY
TTDDAPVLIGFGASAIGALPQGYVQNLPATPQWHKAVEAGALPIARGIALTDEDRLRRHVIERLMCDLAVDLDEACMQHG
FPRGFFADEIHALEPLIADGLAWRHGAVVEVPEASRPFTRVVCAVFDTRLMASRAAAPEQKRHAAAV

Sequences:

>Translated_467_residues
MTQASSCPAPKLDAATLLARYGQPVPRYTSYPTAPHFSPAVDAATYASWLAAVPGDARVSAYVHVPFCAELCLYCGCQTA
VARSRAPVKAYAERLVEEIGLVARHLPGRLKLSHLHFGGGTPTMLADEDFAAILGALRETFDFAPDAEIAIEIDPRVMDA
DKVATLAREGFNRASLGVQDFDPAVQQAIGRHQSCEETQAVADALRAAGIAALNLDLMYGLPHQDEASVRRTVEAALGLD
PDRIAVFGYAHVPWMKKHQALIPEDALPGAGARLAQAELVADVLAAHGYVPVGLDHFARASDAMAERAAAGTLKRNFQGY
TTDDAPVLIGFGASAIGALPQGYVQNLPATPQWHKAVEAGALPIARGIALTDEDRLRRHVIERLMCDLAVDLDEACMQHG
FPRGFFADEIHALEPLIADGLAWRHGAVVEVPEASRPFTRVVCAVFDTRLMASRAAAPEQKRHAAAV
>Mature_466_residues
TQASSCPAPKLDAATLLARYGQPVPRYTSYPTAPHFSPAVDAATYASWLAAVPGDARVSAYVHVPFCAELCLYCGCQTAV
ARSRAPVKAYAERLVEEIGLVARHLPGRLKLSHLHFGGGTPTMLADEDFAAILGALRETFDFAPDAEIAIEIDPRVMDAD
KVATLAREGFNRASLGVQDFDPAVQQAIGRHQSCEETQAVADALRAAGIAALNLDLMYGLPHQDEASVRRTVEAALGLDP
DRIAVFGYAHVPWMKKHQALIPEDALPGAGARLAQAELVADVLAAHGYVPVGLDHFARASDAMAERAAAGTLKRNFQGYT
TDDAPVLIGFGASAIGALPQGYVQNLPATPQWHKAVEAGALPIARGIALTDEDRLRRHVIERLMCDLAVDLDEACMQHGF
PRGFFADEIHALEPLIADGLAWRHGAVVEVPEASRPFTRVVCAVFDTRLMASRAAAPEQKRHAAAV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=173, Percent_Identity=31.7919075144509, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87082341, Length=437, Percent_Identity=39.1304347826087, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1789325, Length=189, Percent_Identity=29.6296296296296, Blast_Score=108, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49979; Mature: 49848

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQASSCPAPKLDAATLLARYGQPVPRYTSYPTAPHFSPAVDAATYASWLAAVPGDARVS
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
AYVHVPFCAELCLYCGCQTAVARSRAPVKAYAERLVEEIGLVARHLPGRLKLSHLHFGGG
EEEECHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
TPTMLADEDFAAILGALRETFDFAPDAEIAIEIDPRVMDADKVATLAREGFNRASLGVQD
CCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEECHHHHHHHHHHCCCHHHCCCHH
FDPAVQQAIGRHQSCEETQAVADALRAAGIAALNLDLMYGLPHQDEASVRRTVEAALGLD
CCHHHHHHHCCCCCHHHHHHHHHHHHHCCHHEEEEEHEECCCCCCHHHHHHHHHHHHCCC
PDRIAVFGYAHVPWMKKHQALIPEDALPGAGARLAQAELVADVLAAHGYVPVGLDHFARA
CCCEEEEEEECCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
SDAMAERAAAGTLKRNFQGYTTDDAPVLIGFGASAIGALPQGYVQNLPATPQWHKAVEAG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHCCCHHHHHCCCCCCHHHHHHHHC
ALPIARGIALTDEDRLRRHVIERLMCDLAVDLDEACMQHGFPRGFFADEIHALEPLIADG
CCHHHCCCEECCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
LAWRHGAVVEVPEASRPFTRVVCAVFDTRLMASRAAAPEQKRHAAAV
CHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
>Mature Secondary Structure 
TQASSCPAPKLDAATLLARYGQPVPRYTSYPTAPHFSPAVDAATYASWLAAVPGDARVS
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEE
AYVHVPFCAELCLYCGCQTAVARSRAPVKAYAERLVEEIGLVARHLPGRLKLSHLHFGGG
EEEECHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCC
TPTMLADEDFAAILGALRETFDFAPDAEIAIEIDPRVMDADKVATLAREGFNRASLGVQD
CCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCEECHHHHHHHHHHCCCHHHCCCHH
FDPAVQQAIGRHQSCEETQAVADALRAAGIAALNLDLMYGLPHQDEASVRRTVEAALGLD
CCHHHHHHHCCCCCHHHHHHHHHHHHHCCHHEEEEEHEECCCCCCHHHHHHHHHHHHCCC
PDRIAVFGYAHVPWMKKHQALIPEDALPGAGARLAQAELVADVLAAHGYVPVGLDHFARA
CCCEEEEEEECCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
SDAMAERAAAGTLKRNFQGYTTDDAPVLIGFGASAIGALPQGYVQNLPATPQWHKAVEAG
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHCCCHHHHHCCCCCCHHHHHHHHC
ALPIARGIALTDEDRLRRHVIERLMCDLAVDLDEACMQHGFPRGFFADEIHALEPLIADG
CCHHHCCCEECCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHC
LAWRHGAVVEVPEASRPFTRVVCAVFDTRLMASRAAAPEQKRHAAAV
CHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]