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The map label for this gene is lysA [H]

Identifier: 154245684

GI number: 154245684

Start: 1957181

End: 1958449

Strand: Direct

Name: lysA [H]

Synonym: Xaut_1740

Alternate gene names: 154245684

Gene position: 1957181-1958449 (Clockwise)

Preceding gene: 154245683

Following gene: 154245690

Centisome position: 36.87

GC content: 70.13

Gene sequence:

>1269_bases
ATGCACCATTTCGACTACCGCAACGGCCGCCTTTTCGCCGAGGACGTGGACATCACCCCCCTCGCCGCCGAGGTGCGCAC
CCCCTTCTATTGCTATTCCAGCGCCACCCTGGAACGTCACTACCAGGTGTTCATGGAGGCGTTCAGCGGCCGCGACGTGC
TGCTGTGCTACGCCCTGAAGGCCAATTCCAACCAGTCAGTCATCGCAACGCTGGCCCGGCTCGGCGCGGGGGCGGACATC
GTCTCCGCCGGCGAGCTGGCGCGCGCCCGTGCCGCCGGCGTGCCGGCGGAGCGCATCGTCTTCTCCGGCGTGGGCAAGAC
CCGCGAGGAGATGGCGGCGGCGCTGGACGGCGGCATCCTGTGCTTCAACGTGGAGAGCGAGCCCGAGCTTGCGGCCCTCT
CCGAGGTGGCGACCGCCATGGGGGTGAGCGCCCCGGTCTCCATCCGCGTCAACCCGGACGTGGACGCCAAGACCCACAAG
AAGATCTCCACCGGCAAGTCCGCCACCAAGTTCGGCATTCCCATCTCGCGGGCCCGCGAGGTCTACGACTATGCCGCGCG
CCTGCCCGGCCTCGCCATCACCGGCGTGGACATGCACATCGGCAGCCAGATCACCGACATGGCGCCCTTCGACAATGCGG
TGACATTGCTGGCGGAACTGGCGCGCGACCTGCTCGCGGCGGGCCACAGGCTGCACCACATGGATCTCGGCGGCGGGCTC
GGCGTGCCCTACGCCGCCTCCGACCCGGTGCCGCCGCCGCCCAGCGCCTATGCTGAGGTGGTCAGCCGCGCCCTCGGCGA
CCTGAAGCTGCCGCTGGTGTTCGAGATGGGCCGCATGCTGGTGGCCAATGCCGGCATCCTCGTCACCAGGGTGATCTATG
TGAAGGAGGGCGAGGGCAAGACCTTCGTGGTGGTGGACGCCGCCATGAACGACCTCATCCGCCCCACCCTCTACGAGGCG
CACCACGACATCATTCCCGTGGTCGAGCCGGCGGCCGATGCACCGCTGGTGGTGGCGGACGTGGTGGGACCGGTGTGCGA
GACCGGCGATTTCCTCGCCCTCGACCGTCCGCTGCCGCGCCTGAAGGCCGGCGACCTGCTGGCGGTGATGACGGCCGGCG
CCTATGGCGCGGTGCAGGCGAGCACATACAATACCCGTCCGCTGGTGCCGGAGGTGCTGGTGCGCGGCGCGGCGGCGGCC
GTGGTGCGGCCGCGCCTGGAGGTGGCCGACCTCATCGCCCTCGACCGCCCCGCGCCCTGGCTGGCCTGA

Upstream 100 bases:

>100_bases
TGCTCTGAAAGCAGGACCCAAGAGGTATAGCTTCGCGCCCGGCGGACGGGCCCCGACCGTCCCGGCCCGAACGACAGCGC
GCACGGACCGCCCCCTCTCC

Downstream 100 bases:

>100_bases
GTCTGGAGGGCGTTATCCGCCTGCCCTCGTCCGCCTGCCCTCGATGACGCTGCACGCAGGCCGGACCGGGCCGGCGCTCA
GCTCGCCAGCCGGCGGTCGG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MHHFDYRNGRLFAEDVDITPLAAEVRTPFYCYSSATLERHYQVFMEAFSGRDVLLCYALKANSNQSVIATLARLGAGADI
VSAGELARARAAGVPAERIVFSGVGKTREEMAAALDGGILCFNVESEPELAALSEVATAMGVSAPVSIRVNPDVDAKTHK
KISTGKSATKFGIPISRAREVYDYAARLPGLAITGVDMHIGSQITDMAPFDNAVTLLAELARDLLAAGHRLHHMDLGGGL
GVPYAASDPVPPPPSAYAEVVSRALGDLKLPLVFEMGRMLVANAGILVTRVIYVKEGEGKTFVVVDAAMNDLIRPTLYEA
HHDIIPVVEPAADAPLVVADVVGPVCETGDFLALDRPLPRLKAGDLLAVMTAGAYGAVQASTYNTRPLVPEVLVRGAAAA
VVRPRLEVADLIALDRPAPWLA

Sequences:

>Translated_422_residues
MHHFDYRNGRLFAEDVDITPLAAEVRTPFYCYSSATLERHYQVFMEAFSGRDVLLCYALKANSNQSVIATLARLGAGADI
VSAGELARARAAGVPAERIVFSGVGKTREEMAAALDGGILCFNVESEPELAALSEVATAMGVSAPVSIRVNPDVDAKTHK
KISTGKSATKFGIPISRAREVYDYAARLPGLAITGVDMHIGSQITDMAPFDNAVTLLAELARDLLAAGHRLHHMDLGGGL
GVPYAASDPVPPPPSAYAEVVSRALGDLKLPLVFEMGRMLVANAGILVTRVIYVKEGEGKTFVVVDAAMNDLIRPTLYEA
HHDIIPVVEPAADAPLVVADVVGPVCETGDFLALDRPLPRLKAGDLLAVMTAGAYGAVQASTYNTRPLVPEVLVRGAAAA
VVRPRLEVADLIALDRPAPWLA
>Mature_422_residues
MHHFDYRNGRLFAEDVDITPLAAEVRTPFYCYSSATLERHYQVFMEAFSGRDVLLCYALKANSNQSVIATLARLGAGADI
VSAGELARARAAGVPAERIVFSGVGKTREEMAAALDGGILCFNVESEPELAALSEVATAMGVSAPVSIRVNPDVDAKTHK
KISTGKSATKFGIPISRAREVYDYAARLPGLAITGVDMHIGSQITDMAPFDNAVTLLAELARDLLAAGHRLHHMDLGGGL
GVPYAASDPVPPPPSAYAEVVSRALGDLKLPLVFEMGRMLVANAGILVTRVIYVKEGEGKTFVVVDAAMNDLIRPTLYEA
HHDIIPVVEPAADAPLVVADVVGPVCETGDFLALDRPLPRLKAGDLLAVMTAGAYGAVQASTYNTRPLVPEVLVRGAAAA
VVRPRLEVADLIALDRPAPWLA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=361, Percent_Identity=26.8698060941828, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI16506287, Length=346, Percent_Identity=26.0115606936416, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1789203, Length=430, Percent_Identity=33.2558139534884, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1789307, Length=269, Percent_Identity=28.996282527881, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562780, Length=350, Percent_Identity=25.1428571428571, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24586472, Length=338, Percent_Identity=27.2189349112426, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24586474, Length=338, Percent_Identity=25.4437869822485, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44736; Mature: 44736

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHFDYRNGRLFAEDVDITPLAAEVRTPFYCYSSATLERHYQVFMEAFSGRDVLLCYALK
CCCCCCCCCEEEEECCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEEEEE
ANSNQSVIATLARLGAGADIVSAGELARARAAGVPAERIVFSGVGKTREEMAAALDGGIL
CCCCHHHHHHHHHHCCCCCHHCHHHHHHHHHCCCCHHHHEECCCCCCHHHHHHHHCCCEE
CFNVESEPELAALSEVATAMGVSAPVSIRVNPDVDAKTHKKISTGKSATKFGIPISRARE
EEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCCEECCCCHHHHHH
VYDYAARLPGLAITGVDMHIGSQITDMAPFDNAVTLLAELARDLLAAGHRLHHMDLGGGL
HHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVPYAASDPVPPPPSAYAEVVSRALGDLKLPLVFEMGRMLVANAGILVTRVIYVKEGEGK
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCC
TFVVVDAAMNDLIRPTLYEAHHDIIPVVEPAADAPLVVADVVGPVCETGDFLALDRPLPR
EEEEEEHHHHHHHCHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCEEEECCCCCC
LKAGDLLAVMTAGAYGAVQASTYNTRPLVPEVLVRGAAAAVVRPRLEVADLIALDRPAPW
CCCCCEEEEEECCCCCEEEECCCCCCCCHHHHHHCCHHHHHHCCCHHHHHHHHCCCCCCC
LA
CC
>Mature Secondary Structure
MHHFDYRNGRLFAEDVDITPLAAEVRTPFYCYSSATLERHYQVFMEAFSGRDVLLCYALK
CCCCCCCCCEEEEECCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHCCCCEEEEEEEE
ANSNQSVIATLARLGAGADIVSAGELARARAAGVPAERIVFSGVGKTREEMAAALDGGIL
CCCCHHHHHHHHHHCCCCCHHCHHHHHHHHHCCCCHHHHEECCCCCCHHHHHHHHCCCEE
CFNVESEPELAALSEVATAMGVSAPVSIRVNPDVDAKTHKKISTGKSATKFGIPISRARE
EEECCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCCEECCCCHHHHHH
VYDYAARLPGLAITGVDMHIGSQITDMAPFDNAVTLLAELARDLLAAGHRLHHMDLGGGL
HHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVPYAASDPVPPPPSAYAEVVSRALGDLKLPLVFEMGRMLVANAGILVTRVIYVKEGEGK
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEECCCC
TFVVVDAAMNDLIRPTLYEAHHDIIPVVEPAADAPLVVADVVGPVCETGDFLALDRPLPR
EEEEEEHHHHHHHCHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCEEEECCCCCC
LKAGDLLAVMTAGAYGAVQASTYNTRPLVPEVLVRGAAAAVVRPRLEVADLIALDRPAPW
CCCCCEEEEEECCCCCEEEECCCCCCCCHHHHHHCCHHHHHHCCCHHHHHHHHCCCCCCC
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]