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The map label for this gene is wecB [H]

Identifier: 154245680

GI number: 154245680

Start: 1952949

End: 1954178

Strand: Reverse

Name: wecB [H]

Synonym: Xaut_1736

Alternate gene names: 154245680

Gene position: 1954178-1952949 (Counterclockwise)

Preceding gene: 154245681

Following gene: 154245679

Centisome position: 36.81

GC content: 70.57

Gene sequence:

>1230_bases
TTGAGAATTTTGTCGATCTTCGGCACGCGCCCGGAGGCCATCAAGATGGCGCCGCTGGTCCGCACCCTCGCGGGGGCGCC
TGAGGTCGTGTCCGTGGTCTGCGTCACCGGTCAGCACCGCGAGATGCTGGACCCGGTGCTGCGCCTGTTCGACATCCGCC
CCGATTTCGACCTCGGCCTCATGGCCCACAACCAGGGGCTCAGCGGCCTTGCCGCCGGCGCGCTCACCGGCCTTGATCAG
GTGCTGGCGCAGGTCCAGCCCGATCGCGTGCTGGTCCATGGCGACACCACCACCGCCATGGCGGCGGCGCTGGCCGCCTT
CCATCGTCGCATCCCGGTGGGGCATGTGGAAGCGGGCCTGCGCACCTATGATCTCGCCCAGCCCTTCCCGGAGGAGATGA
ACCGCCGGGTGGTGGATCTGGTCGCCGACCTTCTGTTCGCACCCACCGCCGGCGCCGGGGCGAACCTTGCCGCCGAGCGG
CTCGCCGGCCGGGTGGTGGTCACCGGCAATACCGTGATCGATGCCCTCCAGGCGACGCAGGCGCGGATCGATGGCGACCC
GGACCTCGCGGCCGCCCTCGACCGGGCGCTGCCGGCGCTTGATCCCGCCAAGCGCATCCTGCTCGTCACCGGCCACCGCC
GTGAGAATTTCGGCGACGGCTTCCGCTCCATTTGCGCCGCGCTGGCACAGATCGCCGGCCGGTCCGACGTGGAGATCGTC
TATCCCGTGCACCTCAACCCCAATGTGCGTGGGCCGGTGACAGAGGAACTTGCCGGCCGGGCCAACATCCATCTGGTGCC
GCCTCTCGATTACCTGCCGTTCCAGCGGCTGCTGCAGCGCGCCCACCTGGTGCTCACCGATTCCGGCGGCGTGCAGGAGG
AGGCGCCGGCGCTGGGCAAGCCGGTGCTGGTCATGCGCGAGGTGACCGAGCGGCCGGAAGCGGTGGAGGCGGGTACGGTG
GAGCTGGTCGGCACCGCCCGCGCCGCCATCGTCGCCGCCGTCACGCGACTGCTCGATGACCCCGACGCTTATGCCGCCTA
TAGCGGCCGCATCAATCCTTATGGCGACGGGCAGGCCTGTCGCCGCATCCTCGACTGCCTCTGCGGACGGCCGGTGGATG
AATTCGCTCCACTGTCCGCCGCCCCCACCTTCTCCGCCCCCGCCTTCCCCTCCGCTGCGCCTGCGCCCCGGCGTCCGGCC
GGCCTTGCTGCCATGCCCGTGAGAGACTGA

Upstream 100 bases:

>100_bases
CCAACGGTAAATTGCGTTCCACGTTCCGTCAGTGCTAAAAACTTGACCTTGACAACAATGGTTCGTGTTTTTTCCAAAAT
CGAATCGCCGGGGACGCGCC

Downstream 100 bases:

>100_bases
CATGAGACACCAACCCGCTTTCGCGCCGGCTCTCCCGCCCGCCGTGCTCCCGGCGCGCGGCCGCGCCAGGACTGGCAGAG
GGGCCTCCCGGACCCTCGCC

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MRILSIFGTRPEAIKMAPLVRTLAGAPEVVSVVCVTGQHREMLDPVLRLFDIRPDFDLGLMAHNQGLSGLAAGALTGLDQ
VLAQVQPDRVLVHGDTTTAMAAALAAFHRRIPVGHVEAGLRTYDLAQPFPEEMNRRVVDLVADLLFAPTAGAGANLAAER
LAGRVVVTGNTVIDALQATQARIDGDPDLAAALDRALPALDPAKRILLVTGHRRENFGDGFRSICAALAQIAGRSDVEIV
YPVHLNPNVRGPVTEELAGRANIHLVPPLDYLPFQRLLQRAHLVLTDSGGVQEEAPALGKPVLVMREVTERPEAVEAGTV
ELVGTARAAIVAAVTRLLDDPDAYAAYSGRINPYGDGQACRRILDCLCGRPVDEFAPLSAAPTFSAPAFPSAAPAPRRPA
GLAAMPVRD

Sequences:

>Translated_409_residues
MRILSIFGTRPEAIKMAPLVRTLAGAPEVVSVVCVTGQHREMLDPVLRLFDIRPDFDLGLMAHNQGLSGLAAGALTGLDQ
VLAQVQPDRVLVHGDTTTAMAAALAAFHRRIPVGHVEAGLRTYDLAQPFPEEMNRRVVDLVADLLFAPTAGAGANLAAER
LAGRVVVTGNTVIDALQATQARIDGDPDLAAALDRALPALDPAKRILLVTGHRRENFGDGFRSICAALAQIAGRSDVEIV
YPVHLNPNVRGPVTEELAGRANIHLVPPLDYLPFQRLLQRAHLVLTDSGGVQEEAPALGKPVLVMREVTERPEAVEAGTV
ELVGTARAAIVAAVTRLLDDPDAYAAYSGRINPYGDGQACRRILDCLCGRPVDEFAPLSAAPTFSAPAFPSAAPAPRRPA
GLAAMPVRD
>Mature_409_residues
MRILSIFGTRPEAIKMAPLVRTLAGAPEVVSVVCVTGQHREMLDPVLRLFDIRPDFDLGLMAHNQGLSGLAAGALTGLDQ
VLAQVQPDRVLVHGDTTTAMAAALAAFHRRIPVGHVEAGLRTYDLAQPFPEEMNRRVVDLVADLLFAPTAGAGANLAAER
LAGRVVVTGNTVIDALQATQARIDGDPDLAAALDRALPALDPAKRILLVTGHRRENFGDGFRSICAALAQIAGRSDVEIV
YPVHLNPNVRGPVTEELAGRANIHLVPPLDYLPFQRLLQRAHLVLTDSGGVQEEAPALGKPVLVMREVTERPEAVEAGTV
ELVGTARAAIVAAVTRLLDDPDAYAAYSGRINPYGDGQACRRILDCLCGRPVDEFAPLSAAPTFSAPAFPSAAPAPRRPA
GLAAMPVRD

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=369, Percent_Identity=57.7235772357724, Blast_Score=400, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 43362; Mature: 43362

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILSIFGTRPEAIKMAPLVRTLAGAPEVVSVVCVTGQHREMLDPVLRLFDIRPDFDLGL
CEEEEEECCCCHHHHHHHHHHHHCCCCHHEEEEEECCCHHHHHHHHHHHHCCCCCCCCEE
MAHNQGLSGLAAGALTGLDQVLAQVQPDRVLVHGDTTTAMAAALAAFHRRIPVGHVEAGL
EECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHCC
RTYDLAQPFPEEMNRRVVDLVADLLFAPTAGAGANLAAERLAGRVVVTGNTVIDALQATQ
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHH
ARIDGDPDLAAALDRALPALDPAKRILLVTGHRRENFGDGFRSICAALAQIAGRSDVEIV
HHCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
YPVHLNPNVRGPVTEELAGRANIHLVPPLDYLPFQRLLQRAHLVLTDSGGVQEEAPALGK
EEEEECCCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCC
PVLVMREVTERPEAVEAGTVELVGTARAAIVAAVTRLLDDPDAYAAYSGRINPYGDGQAC
CHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCHHHH
RRILDCLCGRPVDEFAPLSAAPTFSAPAFPSAAPAPRRPAGLAAMPVRD
HHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRILSIFGTRPEAIKMAPLVRTLAGAPEVVSVVCVTGQHREMLDPVLRLFDIRPDFDLGL
CEEEEEECCCCHHHHHHHHHHHHCCCCHHEEEEEECCCHHHHHHHHHHHHCCCCCCCCEE
MAHNQGLSGLAAGALTGLDQVLAQVQPDRVLVHGDTTTAMAAALAAFHRRIPVGHVEAGL
EECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHCC
RTYDLAQPFPEEMNRRVVDLVADLLFAPTAGAGANLAAERLAGRVVVTGNTVIDALQATQ
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCEEEEECCHHHHHHHHHH
ARIDGDPDLAAALDRALPALDPAKRILLVTGHRRENFGDGFRSICAALAQIAGRSDVEIV
HHCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
YPVHLNPNVRGPVTEELAGRANIHLVPPLDYLPFQRLLQRAHLVLTDSGGVQEEAPALGK
EEEEECCCCCCCCHHHHCCCCCEEEECCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCC
PVLVMREVTERPEAVEAGTVELVGTARAAIVAAVTRLLDDPDAYAAYSGRINPYGDGQAC
CHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCHHHH
RRILDCLCGRPVDEFAPLSAAPTFSAPAFPSAAPAPRRPAGLAAMPVRD
HHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]