BacMap

Definition	Xanthobacter autotrophicus Py2 chromosome, complete genome.
Accession	NC_009720
Length	5,308,934

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The map label for this gene is kduD [H]

Identifier: 154245655

GI number: 154245655

Start: 1926775

End: 1927530

Strand: Direct

Name: kduD [H]

Synonym: Xaut_1711

Alternate gene names: 154245655

Gene position: 1926775-1927530 (Clockwise)

Preceding gene: 154245654

Following gene: 154245656

Centisome position: 36.29

GC content: 68.92

Gene sequence:

>756_bases
ATGAGCATCGAGAACGGCCACCAGGACGGCCACAGGGGCAAGGTGGCGGTGGTGACGGGGGGCGGCTCCGGGCTTGGGCT
GGCCTGCGCGCGGCGCCTCGCCAGCCAGGGCTTCCGCGTCCATGCCCTCGGCAAGGATCTGGAGATCAACCTGGAGACGG
AGCCGGCGGCCGCAGGCAACGATGCCGCCTTCACCTTCACCGATTTCGACGTGACGGACGAAGCCACCGTCCTCGCCTTC
GCCTCGCGGCTCGATGGCTTGGACGTGCTCATCAACGCCGCCGGCCTCATCCTGCACGACATGGCGGAATATGCCCCGAC
GGGCTTTCGCCGGGTGATCGACGTGAACCTCAACGGCAGCCAGCTGATGGCCTGGTCGCTGCACGATCACCTCAAAGCTC
GCAGGGGCTGCGTGGTGAACTTCGCCTCCATGTGGTCCACCTTCGGATCGGGCCGCAACCCGGCCTATTCGGCGAGCAAG
GGCGCGGTGCTCCAGCTCACCCGGTCGCTGGCGGTGGGCTGGGCGGCGGATGGCATCCGCGTCAACGCGGTGGCGCCGGG
CTGGATCAAGACTCGCATGTCGGTGAACGCCATGAGCGATCCCGTCCGCGCCGAGCCCATCATGCGCCGCATCCCGCTCG
GCCAGTGGGGCGAGCCGGAGGACATCGCGGCGGCGGTCAGCTTCCTCGTCTCCCCCGAGGCCCGCTACGTCACCGGCGCC
ATGCTTCCGGTGGACGGCGGCTATTCCATCTCCTGA

Upstream 100 bases:

>100_bases
CTTGAAAACGGACAGATCTCCCTGTCCGGCACCGGCCCGGACCTGCTCGCCGACGCGCACCTGCGCGCCACCTATCTCGG
ACTGTGAGCGAGGCGTTTCC

Downstream 100 bases:

>100_bases
AAAATCCGCGAGAAGCCCGCCATGCCATCGCCCAATGAAACGCCGTCCTTCTCCCATCTGCGGGACAAAGCCCTGCAGCT
GCGCCGCAACATGCTGATCC

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSIENGHQDGHRGKVAVVTGGGSGLGLACARRLASQGFRVHALGKDLEINLETEPAAAGNDAAFTFTDFDVTDEATVLAF
ASRLDGLDVLINAAGLILHDMAEYAPTGFRRVIDVNLNGSQLMAWSLHDHLKARRGCVVNFASMWSTFGSGRNPAYSASK
GAVLQLTRSLAVGWAADGIRVNAVAPGWIKTRMSVNAMSDPVRAEPIMRRIPLGQWGEPEDIAAAVSFLVSPEARYVTGA
MLPVDGGYSIS

Sequences:

>Translated_251_residues
MSIENGHQDGHRGKVAVVTGGGSGLGLACARRLASQGFRVHALGKDLEINLETEPAAAGNDAAFTFTDFDVTDEATVLAF
ASRLDGLDVLINAAGLILHDMAEYAPTGFRRVIDVNLNGSQLMAWSLHDHLKARRGCVVNFASMWSTFGSGRNPAYSASK
GAVLQLTRSLAVGWAADGIRVNAVAPGWIKTRMSVNAMSDPVRAEPIMRRIPLGQWGEPEDIAAAVSFLVSPEARYVTGA
MLPVDGGYSIS
>Mature_250_residues
SIENGHQDGHRGKVAVVTGGGSGLGLACARRLASQGFRVHALGKDLEINLETEPAAAGNDAAFTFTDFDVTDEATVLAFA
SRLDGLDVLINAAGLILHDMAEYAPTGFRRVIDVNLNGSQLMAWSLHDHLKARRGCVVNFASMWSTFGSGRNPAYSASKG
AVLQLTRSLAVGWAADGIRVNAVAPGWIKTRMSVNAMSDPVRAEPIMRRIPLGQWGEPEDIAAAVSFLVSPEARYVTGAM
LPVDGGYSIS

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=31.7829457364341, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=32.1285140562249, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI7705925, Length=242, Percent_Identity=30.9917355371901, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI19923817, Length=252, Percent_Identity=30.1587301587302, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=32.6612903225806, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=31.6205533596838, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI66933014, Length=189, Percent_Identity=31.2169312169312, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=32.5490196078431, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI59889578, Length=197, Percent_Identity=33.502538071066, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI10190704, Length=244, Percent_Identity=30.7377049180328, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4503301, Length=166, Percent_Identity=29.5180722891566, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI109715829, Length=244, Percent_Identity=27.8688524590164, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI83715985, Length=187, Percent_Identity=35.2941176470588, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI33667109, Length=193, Percent_Identity=31.6062176165803, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI31542939, Length=225, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=31.5789473684211, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=34.4262295081967, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=31.8725099601594, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790717, Length=246, Percent_Identity=31.3008130081301, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=33.7301587301587, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=30.7086614173228, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788459, Length=249, Percent_Identity=32.1285140562249, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=30.5555555555556, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787905, Length=243, Percent_Identity=31.2757201646091, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI2367365, Length=250, Percent_Identity=29.6, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=30.5882352941176, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=26.8, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=34.8178137651822, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17561402, Length=248, Percent_Identity=29.4354838709677, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17555706, Length=246, Percent_Identity=34.1463414634146, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17538480, Length=262, Percent_Identity=30.9160305343511, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17538486, Length=261, Percent_Identity=30.6513409961686, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17551412, Length=261, Percent_Identity=30.2681992337165, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560676, Length=242, Percent_Identity=30.5785123966942, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=31.4176245210728, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17538182, Length=259, Percent_Identity=33.5907335907336, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=265, Percent_Identity=29.4339622641509, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115534694, Length=245, Percent_Identity=30.2040816326531, Blast_Score=91, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71994604, Length=253, Percent_Identity=30.0395256916996, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=262, Percent_Identity=29.3893129770992, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=28.3524904214559, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=29.6577946768061, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=253, Percent_Identity=28.4584980237154, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=29.0076335877863, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI193204405, Length=271, Percent_Identity=30.6273062730627, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=29.277566539924, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=30.2681992337165, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=28.735632183908, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=27.9693486590038, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=29.4820717131474, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17560220, Length=266, Percent_Identity=29.6992481203008, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=260, Percent_Identity=27.6923076923077, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562908, Length=260, Percent_Identity=28.8461538461538, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508651, Length=255, Percent_Identity=30.9803921568627, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=262, Percent_Identity=25.5725190839695, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=257, Percent_Identity=30.3501945525292, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=250, Percent_Identity=32, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538482, Length=160, Percent_Identity=33.125, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=31.0756972111554, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322861, Length=251, Percent_Identity=28.6852589641434, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=33.8709677419355, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=33.8775510204082, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24643142, Length=240, Percent_Identity=32.5, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=31.7073170731707, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21355319, Length=259, Percent_Identity=30.5019305019305, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24644337, Length=183, Percent_Identity=36.6120218579235, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=31.7073170731707, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI28571526, Length=247, Percent_Identity=31.9838056680162, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17737361, Length=260, Percent_Identity=31.9230769230769, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI21358495, Length=203, Percent_Identity=30.0492610837438, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 26595; Mature: 26464

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIENGHQDGHRGKVAVVTGGGSGLGLACARRLASQGFRVHALGKDLEINLETEPAAAGN
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCC
DAAFTFTDFDVTDEATVLAFASRLDGLDVLINAAGLILHDMAEYAPTGFRRVIDVNLNGS
CCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
QLMAWSLHDHLKARRGCVVNFASMWSTFGSGRNPAYSASKGAVLQLTRSLAVGWAADGIR
EEEEEEHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHEEECCCEE
VNAVAPGWIKTRMSVNAMSDPVRAEPIMRRIPLGQWGEPEDIAAAVSFLVSPEARYVTGA
EEEECCCCEEEEEEECCCCCCCHHCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEE
MLPVDGGYSIS
EEECCCCCCCC
>Mature Secondary Structure 
SIENGHQDGHRGKVAVVTGGGSGLGLACARRLASQGFRVHALGKDLEINLETEPAAAGN
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCCCC
DAAFTFTDFDVTDEATVLAFASRLDGLDVLINAAGLILHDMAEYAPTGFRRVIDVNLNGS
CCEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
QLMAWSLHDHLKARRGCVVNFASMWSTFGSGRNPAYSASKGAVLQLTRSLAVGWAADGIR
EEEEEEHHHHHHHHCCEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHEEECCCEE
VNAVAPGWIKTRMSVNAMSDPVRAEPIMRRIPLGQWGEPEDIAAAVSFLVSPEARYVTGA
EEEECCCCEEEEEEECCCCCCCHHCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEE
MLPVDGGYSIS
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]