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The map label for this gene is trpB [H]

Identifier: 154245637

GI number: 154245637

Start: 1905593

End: 1906810

Strand: Direct

Name: trpB [H]

Synonym: Xaut_1693

Alternate gene names: 154245637

Gene position: 1905593-1906810 (Clockwise)

Preceding gene: 154245636

Following gene: 154245638

Centisome position: 35.89

GC content: 67.73

Gene sequence:

>1218_bases
GTGACCGCTCTCAATTCCTATCGCACCGGCCCCGATTTCCGGGGTCACTTCGGCATCCATGGCGGGCGCTTCGTCGCCGA
GACCCTGATGCCGCTGATCCTGGAGCTGGAGCAGGCCTACGAGGCGGCGAAGGCGGACCCGGCCTATCACGCCGAGATGG
CGGGCTATCTCACCCATTATGTGGGCCGCCCCTCCCCGCTCTATTTCGCCGAGCGCCTCACCGAGCATCTGGGCGGCGCC
AAGGTCTATCTGAAGCGCGAGGAGCTGAACCACACCGGCTCCCACAAGGTGAACAACGTGCTCGGCCAGATCCTGCTCGC
CCGCCGCATGGGCAAGGAGCGGATCATCGCCGAGACCGGCGCCGGCCAGCATGGCGTCGCCACCGCCACCATGTGCGCCC
GCTTCGGCCTGAAGTGCGTGGTCTACATGGGCGCCGTGGACGTGGAGCGGCAGGCCCCCAACGTGTTCCGCATGAAGATG
CTGGGCGCCGAGGTGGTCGCCGTGCAGTCCGGCTCGCGCACCCTGAAGGACGCCATGAACGAGGCGCTGCGCGACTGGGT
CACCAACGTGCACGACACCTTCTACTGCATCGGCACGGTGGCCGGTCCCCACCCCTATCCGGCCATGGTGCGCGACTTCC
AGTCCATCATCGGCCGCGAGACGCGCGAGCAGATGCAGGAGATGGAAGGCCGCCTGCCCGACAGCCTGATCGCCTGCGTG
GGTGGTGGCTCCAATGCCATGGGCCTGTTCCATCCCTTCCTCGACGATCCCACCGTGGCGATCTACGGGGTGGAGGCGGC
GGGTCGCGGCCTCGACACCCACGAGCATGCCGCCTCCATCGCCGGCGGGCGGCCGGGGGTGCTGCACGGCAACCGCACCT
ACCTGCTCATGGACGGCGACGGCCAGATCACCGAGGCCCATTCCATCTCGGCCGGCCTCGATTATCCCGGCATCGGGCCG
GAGCATTCCTGGCTCAACGACGTGGGCCGTGTGACCTACCTCTCCTGCACCGACCAGGAGGCGCTGGACGCCTTCCAGCT
GCTCACCCGGCTCGAGGGCATCATCCCGGCACTGGAATCCGCACATGCCATCGCCAAGGTGGTGGAGCTGGCACCCAAGC
TGCCGAAGGATCACCTGATGGTGGTCAACCTGTCCGGCCGCGGGGACAAGGACGTGCCCCAGGTGGCGGAAATTCTCGGC
ACCAGCCTGGGGGCTTAG

Upstream 100 bases:

>100_bases
TCCCGGAAGGCCACCTGCCCGACCAGCCGGCCGAAGCTGAACCGACCCGCGCGACAACGGCGCCGGGGCCTGAAGATCTC
TCATCGAAAGTGCGCGCGTC

Downstream 100 bases:

>100_bases
CCATGAAGTCGTTCTCCGCGGTTCTTGCGTTTGGCGTTGCCGCCTGTGTCGCGGGCGTTGCCGCCCCGGCATCGGCCCAG
TCTTCTGCCCAGTCTTCGGC

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MTALNSYRTGPDFRGHFGIHGGRFVAETLMPLILELEQAYEAAKADPAYHAEMAGYLTHYVGRPSPLYFAERLTEHLGGA
KVYLKREELNHTGSHKVNNVLGQILLARRMGKERIIAETGAGQHGVATATMCARFGLKCVVYMGAVDVERQAPNVFRMKM
LGAEVVAVQSGSRTLKDAMNEALRDWVTNVHDTFYCIGTVAGPHPYPAMVRDFQSIIGRETREQMQEMEGRLPDSLIACV
GGGSNAMGLFHPFLDDPTVAIYGVEAAGRGLDTHEHAASIAGGRPGVLHGNRTYLLMDGDGQITEAHSISAGLDYPGIGP
EHSWLNDVGRVTYLSCTDQEALDAFQLLTRLEGIIPALESAHAIAKVVELAPKLPKDHLMVVNLSGRGDKDVPQVAEILG
TSLGA

Sequences:

>Translated_405_residues
MTALNSYRTGPDFRGHFGIHGGRFVAETLMPLILELEQAYEAAKADPAYHAEMAGYLTHYVGRPSPLYFAERLTEHLGGA
KVYLKREELNHTGSHKVNNVLGQILLARRMGKERIIAETGAGQHGVATATMCARFGLKCVVYMGAVDVERQAPNVFRMKM
LGAEVVAVQSGSRTLKDAMNEALRDWVTNVHDTFYCIGTVAGPHPYPAMVRDFQSIIGRETREQMQEMEGRLPDSLIACV
GGGSNAMGLFHPFLDDPTVAIYGVEAAGRGLDTHEHAASIAGGRPGVLHGNRTYLLMDGDGQITEAHSISAGLDYPGIGP
EHSWLNDVGRVTYLSCTDQEALDAFQLLTRLEGIIPALESAHAIAKVVELAPKLPKDHLMVVNLSGRGDKDVPQVAEILG
TSLGA
>Mature_404_residues
TALNSYRTGPDFRGHFGIHGGRFVAETLMPLILELEQAYEAAKADPAYHAEMAGYLTHYVGRPSPLYFAERLTEHLGGAK
VYLKREELNHTGSHKVNNVLGQILLARRMGKERIIAETGAGQHGVATATMCARFGLKCVVYMGAVDVERQAPNVFRMKML
GAEVVAVQSGSRTLKDAMNEALRDWVTNVHDTFYCIGTVAGPHPYPAMVRDFQSIIGRETREQMQEMEGRLPDSLIACVG
GGSNAMGLFHPFLDDPTVAIYGVEAAGRGLDTHEHAASIAGGRPGVLHGNRTYLLMDGDGQITEAHSISAGLDYPGIGPE
HSWLNDVGRVTYLSCTDQEALDAFQLLTRLEGIIPALESAHAIAKVVELAPKLPKDHLMVVNLSGRGDKDVPQVAEILGT
SLGA

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine [H]

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family [H]

Homologues:

Organism=Escherichia coli, GI1787515, Length=385, Percent_Identity=54.5454545454545, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321412, Length=384, Percent_Identity=57.2916666666667, Blast_Score=477, Evalue=1e-135,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 43809; Mature: 43677

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALNSYRTGPDFRGHFGIHGGRFVAETLMPLILELEQAYEAAKADPAYHAEMAGYLTHY
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VGRPSPLYFAERLTEHLGGAKVYLKREELNHTGSHKVNNVLGQILLARRMGKERIIAETG
CCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHCCCHHEEEECC
AGQHGVATATMCARFGLKCVVYMGAVDVERQAPNVFRMKMLGAEVVAVQSGSRTLKDAMN
CCCCCHHHHHHHHHHCCCEEEEECCEEHHHCCCCHHHHHHHCCEEEEEECCCHHHHHHHH
EALRDWVTNVHDTFYCIGTVAGPHPYPAMVRDFQSIIGRETREQMQEMEGRLPDSLIACV
HHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHEEEE
GGGSNAMGLFHPFLDDPTVAIYGVEAAGRGLDTHEHAASIAGGRPGVLHGNRTYLLMDGD
CCCCCCCHHHHHCCCCCCEEEEEEHHCCCCCCCHHHHHHHCCCCCCEEECCEEEEEECCC
GQITEAHSISAGLDYPGIGPEHSWLNDVGRVTYLSCTDQEALDAFQLLTRLEGIIPALES
CCEEECCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
AHAIAKVVELAPKLPKDHLMVVNLSGRGDKDVPQVAEILGTSLGA
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TALNSYRTGPDFRGHFGIHGGRFVAETLMPLILELEQAYEAAKADPAYHAEMAGYLTHY
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
VGRPSPLYFAERLTEHLGGAKVYLKREELNHTGSHKVNNVLGQILLARRMGKERIIAETG
CCCCCHHHHHHHHHHHCCCCEEEEEHHHCCCCCCHHHHHHHHHHHHHHHCCCHHEEEECC
AGQHGVATATMCARFGLKCVVYMGAVDVERQAPNVFRMKMLGAEVVAVQSGSRTLKDAMN
CCCCCHHHHHHHHHHCCCEEEEECCEEHHHCCCCHHHHHHHCCEEEEEECCCHHHHHHHH
EALRDWVTNVHDTFYCIGTVAGPHPYPAMVRDFQSIIGRETREQMQEMEGRLPDSLIACV
HHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHEEEE
GGGSNAMGLFHPFLDDPTVAIYGVEAAGRGLDTHEHAASIAGGRPGVLHGNRTYLLMDGD
CCCCCCCHHHHHCCCCCCEEEEEEHHCCCCCCCHHHHHHHCCCCCCEEECCEEEEEECCC
GQITEAHSISAGLDYPGIGPEHSWLNDVGRVTYLSCTDQEALDAFQLLTRLEGIIPALES
CCEEECCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
AHAIAKVVELAPKLPKDHLMVVNLSGRGDKDVPQVAEILGTSLGA
HHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]