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The map label for this gene is trpF [H]

Identifier: 154245636

GI number: 154245636

Start: 1904784

End: 1905596

Strand: Direct

Name: trpF [H]

Synonym: Xaut_1692

Alternate gene names: 154245636

Gene position: 1904784-1905596 (Clockwise)

Preceding gene: 154245635

Following gene: 154245637

Centisome position: 35.88

GC content: 72.08

Gene sequence:

>813_bases
ATGGCAAAGGACGCAAGGAACCGCGACGCAGGGGCCCGCCAAACCGGGACCCGCGGCGCGCGGCACCTCGACGTGAAGAT
CTGCGGCATCACGACCGCAGACGCCCTCGACGCGGCGCTGGACGCGGGCGCCGACCTGGTGGGCTTCGTCCATTTTCCCA
AAAGCCCCCGCCACCTCACCCTCGCCGAGGCCCCGGGCCTCGTCGCCCGGGTCGAGGGGCGGGCGCGCAAGGTGGCGCTG
CTGGTGGATCCCGACGACGCCCTTTTGGCTCAGGTTGTGGCCGCCTTCTCCCCCGATCTCCTCCAGTTGCACGGCCACGA
GACGCCCGAGCGCGTCGCCGCCATCCGCGCCGCCTTCGGCCTGCCGGTCATGAAGGCGCTGCCGGTGGGCCGGCGGGAAG
ACCTCGCCCCGCTGCCGGCTTACGCCGCCGTGGCCGACCTGATCCTGTTCGACGCCAAGCCCGATCCCGGCGCCCTGCTC
CCCGGCGGCAACGGACGGCCCTTCGACTGGCGGCTGGTCGCCGGCCTTGACGCCGGCCGCCCGCTCATGCTTTCCGGTGG
CCTCACTGTCGACAATGTGTCGCAGGCCCTTTCCGAGGTCCGGATGGACGGGGTGGACGTATCGTCTGGCGTGGAAGATG
CCCCCGGCGTGAAGTCACCGGACAAGATCCGCGCCTTCGTCGCGGCGGTCCGGCGCGTCGAGGCCCGCCTCCCGGAAGGC
CACCTGCCCGACCAGCCGGCCGAAGCTGAACCGACCCGCGCGACAACGGCGCCGGGGCCTGAAGATCTCTCATCGAAAGT
GCGCGCGTCGTGA

Upstream 100 bases:

>100_bases
GCGCTTCCGCAAGGCCGGCCAGTTCACCCACGTGGAGACGTGATCGCAATGCGCCGGGGTCCGGACCTCGACCCGGAACG
GCGCACGCAAGGCTGAGACG

Downstream 100 bases:

>100_bases
CCGCTCTCAATTCCTATCGCACCGGCCCCGATTTCCGGGGTCACTTCGGCATCCATGGCGGGCGCTTCGTCGCCGAGACC
CTGATGCCGCTGATCCTGGA

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MAKDARNRDAGARQTGTRGARHLDVKICGITTADALDAALDAGADLVGFVHFPKSPRHLTLAEAPGLVARVEGRARKVAL
LVDPDDALLAQVVAAFSPDLLQLHGHETPERVAAIRAAFGLPVMKALPVGRREDLAPLPAYAAVADLILFDAKPDPGALL
PGGNGRPFDWRLVAGLDAGRPLMLSGGLTVDNVSQALSEVRMDGVDVSSGVEDAPGVKSPDKIRAFVAAVRRVEARLPEG
HLPDQPAEAEPTRATTAPGPEDLSSKVRAS

Sequences:

>Translated_270_residues
MAKDARNRDAGARQTGTRGARHLDVKICGITTADALDAALDAGADLVGFVHFPKSPRHLTLAEAPGLVARVEGRARKVAL
LVDPDDALLAQVVAAFSPDLLQLHGHETPERVAAIRAAFGLPVMKALPVGRREDLAPLPAYAAVADLILFDAKPDPGALL
PGGNGRPFDWRLVAGLDAGRPLMLSGGLTVDNVSQALSEVRMDGVDVSSGVEDAPGVKSPDKIRAFVAAVRRVEARLPEG
HLPDQPAEAEPTRATTAPGPEDLSSKVRAS
>Mature_269_residues
AKDARNRDAGARQTGTRGARHLDVKICGITTADALDAALDAGADLVGFVHFPKSPRHLTLAEAPGLVARVEGRARKVALL
VDPDDALLAQVVAAFSPDLLQLHGHETPERVAAIRAAFGLPVMKALPVGRREDLAPLPAYAAVADLILFDAKPDPGALLP
GGNGRPFDWRLVAGLDAGRPLMLSGGLTVDNVSQALSEVRMDGVDVSSGVEDAPGVKSPDKIRAFVAAVRRVEARLPEGH
LPDQPAEAEPTRATTAPGPEDLSSKVRAS

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=195, Percent_Identity=31.2820512820513, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320210, Length=229, Percent_Identity=30.5676855895196, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 28211; Mature: 28080

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKDARNRDAGARQTGTRGARHLDVKICGITTADALDAALDAGADLVGFVHFPKSPRHLT
CCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCEEE
LAEAPGLVARVEGRARKVALLVDPDDALLAQVVAAFSPDLLQLHGHETPERVAAIRAAFG
EECCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHC
LPVMKALPVGRREDLAPLPAYAAVADLILFDAKPDPGALLPGGNGRPFDWRLVAGLDAGR
CHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
PLMLSGGLTVDNVSQALSEVRMDGVDVSSGVEDAPGVKSPDKIRAFVAAVRRVEARLPEG
CEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
HLPDQPAEAEPTRATTAPGPEDLSSKVRAS
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
AKDARNRDAGARQTGTRGARHLDVKICGITTADALDAALDAGADLVGFVHFPKSPRHLT
CCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCEEE
LAEAPGLVARVEGRARKVALLVDPDDALLAQVVAAFSPDLLQLHGHETPERVAAIRAAFG
EECCCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHC
LPVMKALPVGRREDLAPLPAYAAVADLILFDAKPDPGALLPGGNGRPFDWRLVAGLDAGR
CHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCC
PLMLSGGLTVDNVSQALSEVRMDGVDVSSGVEDAPGVKSPDKIRAFVAAVRRVEARLPEG
CEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
HLPDQPAEAEPTRATTAPGPEDLSSKVRAS
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA